Heavy Alcohol Consumption and Risk of Atrial Fibrillation

Background— Evidence on the relationship of a wide range of alcohol consumption with risk of incident atrial fibrillation has been limited. Methods— Between 1991 and 1995, 8602 Japanese men and women aged 30 to 80 years and free of clinical atrial fibrillation took part in the first examination of the Circulatory Risk in Communities Study(CIRCS)- a population based cohort study of cardiovascular risk factors, cardiovascular disease incidence, and their trends in Japanese communities. In the first examination, we checked a detailed medical history, physical examination, blood and urine examination, and electrocardiogram (ECG). An interviewer obtained histories in detail for weekly alcohol intake. In the follow-up period, incident atrial fibrillations were ascertained by annual ECG record and medical history of treatment of atrial fibrillation. ECGs were coded with the Minnesota Code by trained physician-epidemiologists. Differences in baseline characteristics between atrial fibrillation cases and controls were compared using Student t-tests or chi-squared tests. The hazard ratios (HRs) of incidence of atrial fibrillation and 95% confidence interval (CI) relative to the never-drinking group were calculated with adjustment for age and other potential confounding factors using the Cox proportional hazard model. Results— During an average follow-up of 6.4 years, 290 incident atrial fibrillation occurred. The higher incidence rate of atrial fibrillation was observed among participants with more than 69 g of ethanol drinking per week, compared with less than 69 g of ethanol drinking per week. On the other hand, light to moderate alcohol consumption was not associated with risk of atrial fibrillation. Compared with the never drinking group, the multivariable-adjusted HRs of past, light (<23 g), light moderate (23-46 g), moderate (46-69 g), and heavy (>69 g) drinking groups were 1.20 (95% CI, 0.61-2.35), 0.85 (95% CI, 0.57-1.27), 1.05 (95% CI, 0.63-1.75), 1.34 (95% CI, 0.78-2.32), and 2.92 (95% CI, 1.61-5.28), respectively. Conclusions— Heavy alcohol consumption was associated with the higher risk of atrial fibrillation, whereas there was no association of less than moderate alcohol consumption and atrial fibrillation.

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Effect of alcohol consumption on the risk of adverse events in atrial fibrillation: from the COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF) registry

EP Europace ◽

10.1093/europace/euaa340 ◽

2020 ◽

Author(s):

Chewan Lim ◽

Tae-Hoon Kim ◽

Hee Tae Yu ◽

So-Ryoung Lee ◽

Myung-Jin Cha ◽

...

Keyword(s):

Atrial Fibrillation ◽

Alcohol Consumption ◽

Adverse Events ◽

Reference Group ◽

Symptom Control ◽

Adverse Outcomes ◽

Heavy Alcohol ◽

Hazard Ratios ◽

Increased Risk ◽

Heavy Alcohol Consumption

Abstract Aims The aim of this study is to determine the relationship between alcohol consumption and atrial fibrillation (AF)-related adverse events in the AF population. Methods and results A total of 9411 patients with nonvalvular AF in a prospective observational registry were categorized into four groups according to the amount of alcohol consumption—abstainer-rare, light (<100 g/week), moderate (100–200 g/week), and heavy (≥200 g/week). Data on adverse events (ischaemic stroke, transient ischaemic attack, systemic embolic event, or AF hospitalization including for AF rate or rhythm control and heart failure management) were collected for 17.4 ± 7.3 months. A Cox proportional hazard models was performed to calculate hazard ratios (HRs), and propensity score matching was conducted to validate the results. The heavy alcohol consumption group showed an increased risk of composite adverse outcomes [adjusted hazard ratio (aHR) 1.32, 95% confidence interval (CI) 1.06–1.66] compared with the reference group (abstainer-rare group). However, no significant increased risk for adverse outcomes was observed in the light (aHR 0.88, 95% CI 0.68–1.13) and moderate (aHR 0.91, 95% CI 0.63–1.33) groups. In subgroup analyses, adverse effect of heavy alcohol consumption was significant, especially among patients with low CHA2DS2-VASc score, without hypertension, and in whom β-blocker were not prescribed. Conclusion Our findings suggest that heavy alcohol consumption increases the risk of adverse events in patients with AF, whereas light or moderate alcohol consumption does not.

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Alcohol Abstinence and the Risk of Atrial Fibrillation in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Nationwide Population-Based Study

10.2337/figshare.13956677.v1 ◽

2021 ◽

Author(s):

You-jung Choi ◽

Kyung-Do Han ◽

Eue-Keun Choi ◽

Jin-Hyeung Jung ◽

So-Ryoung Lee ◽

...

Keyword(s):

Diabetes Mellitus ◽

Atrial Fibrillation ◽

Alcohol Consumption ◽

Alcohol Intake ◽

Newly Diagnosed ◽

Heavy Alcohol ◽

Alcohol Abstinence ◽

Heavy Alcohol Consumption ◽

New Onset

Objectives: To investigate the effects of alcohol abstinence in preventing new-onset atrial fibrillation (AF) in patients with type 2 diabetes mellitus (T2DM). Research Design and Methods: A total of 1,112,682 patients newly diagnosed with T2DM between 2011–2014, were identified from the Korean National Health Insurance Service database. After excluding a previous history of AF, 175,100 subjects were included. The primary outcome was new-onset AF. Results: During a mean follow-up of 4.0 years, AF occurred in 4,174 patients. Heavy alcohol consumption (alcohol intake ≥40 g/day) before a T2DM diagnosis had a higher risk of AF (adjusted hazard ratio [aHR] 1.22, 95% confidence interval [CI] 1.06–1.41) compared to no alcohol consumption. After a T2DM diagnosis, moderate-to-heavy alcohol consumption (alcohol intake ≥20 g/day) who abstained from alcohol had a lower risk of AF (aHR 0.81, 95% CI 0.68–0.97) than did constant drinkers. Alcohol abstinence showed consistent trends toward lower incident AF in all subgroups and was statistically significant in men (aHR 0.80, 95% CI 0.67–0.96), those aged >65 years (aHR 0.69, 95% CI 0.52–0.91), those with CHA2DS2-VASc score <3 points (aHR 0.71, 95% CI 0.59–0.86), non-insulin users (aHR 0.77, 95% CI 0.63–0.94), and body mass index < 25 mg/k2 (aHR 0.68, 95% CI 0.53–0.88). Conclusions: In patients with newly diagnosed T2DM, alcohol abstinence was associated with a low risk of AF development. Lifestyle modifications, such as alcohol abstinence, in patients newly diagnosed with T2DM should be recommended to reduce the risk of AF.

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A Dose-Response Meta-Analysis on the Association Between Alcohol Consumption and Incidence of Atrial Fibrillation

10.21203/rs.3.rs-89496/v1 ◽

2020 ◽

Author(s):

Haifu Zhang ◽

Qinxia Zhang ◽

Dong Yang ◽

Zhao Xu ◽

Xingwei Zhang

Keyword(s):

Atrial Fibrillation ◽

Alcohol Consumption ◽

Dose Response ◽

Meta Analysis ◽

Cochrane Library ◽

Response Curves ◽

Female Population ◽

Men And Women ◽

Heavy Alcohol ◽

Heavy Alcohol Consumption

Abstract Background: Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice. Alcohol consumption has been linked to the occurrence of AF.Methods: A comprehensive search of electronic databases (PubMed, Cochrane Library, OVID, Google scholar, and Web of Science) was performed. The search yielded a total of 1177 articles, and 12 cohort studies from the total were included in the meta-analysis. The effects of different doses of alcohol consumption on the risk of AF in men and women were compared using hierarchical analysis. Dose-response curves of alcohol consumption and risk of AF were plotted for the two groups according to sex.Results: The risk of AF increased with increased alcohol consumption in both men and women. In the male population, light-moderate alcohol consumption did not increase the risk of AF (HR: 1.07, 95%CI: 0.92-1.23, P=0.38), while heavy alcohol consumption significantly increased the risk of AF (HR: 1.38, 95%CI: 1.23-1.54, P<0.01). In the female population, the risk of AF was not significantly increased by either light-moderate or heavy alcohol consumption (light- moderate drink: HR: 1.00, 95%CI: 0.92-1.10, P=0.95; heavy drink: HR: 1.05, 95%CI: 0.90-1.23, P=0.55).Conclusions: In women, the risk of AF was not associated with any degree of alcohol consumption while high levels of alcohol consumption significantly increased the risk of AF in men.

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Alcohol Abstinence and the Risk of Atrial Fibrillation in Patients With Newly Diagnosed Type 2 Diabetes Mellitus: A Nationwide Population-Based Study

10.2337/figshare.13956677 ◽

2021 ◽

Author(s):

You-jung Choi ◽

Kyung-Do Han ◽

Eue-Keun Choi ◽

Jin-Hyeung Jung ◽

So-Ryoung Lee ◽

...

Keyword(s):

Diabetes Mellitus ◽

Atrial Fibrillation ◽

Alcohol Consumption ◽

Alcohol Intake ◽

Newly Diagnosed ◽

Heavy Alcohol ◽

Alcohol Abstinence ◽

Heavy Alcohol Consumption ◽

New Onset

Objectives: To investigate the effects of alcohol abstinence in preventing new-onset atrial fibrillation (AF) in patients with type 2 diabetes mellitus (T2DM). Research Design and Methods: A total of 1,112,682 patients newly diagnosed with T2DM between 2011–2014, were identified from the Korean National Health Insurance Service database. After excluding a previous history of AF, 175,100 subjects were included. The primary outcome was new-onset AF. Results: During a mean follow-up of 4.0 years, AF occurred in 4,174 patients. Heavy alcohol consumption (alcohol intake ≥40 g/day) before a T2DM diagnosis had a higher risk of AF (adjusted hazard ratio [aHR] 1.22, 95% confidence interval [CI] 1.06–1.41) compared to no alcohol consumption. After a T2DM diagnosis, moderate-to-heavy alcohol consumption (alcohol intake ≥20 g/day) who abstained from alcohol had a lower risk of AF (aHR 0.81, 95% CI 0.68–0.97) than did constant drinkers. Alcohol abstinence showed consistent trends toward lower incident AF in all subgroups and was statistically significant in men (aHR 0.80, 95% CI 0.67–0.96), those aged >65 years (aHR 0.69, 95% CI 0.52–0.91), those with CHA2DS2-VASc score <3 points (aHR 0.71, 95% CI 0.59–0.86), non-insulin users (aHR 0.77, 95% CI 0.63–0.94), and body mass index < 25 mg/k2 (aHR 0.68, 95% CI 0.53–0.88). Conclusions: In patients with newly diagnosed T2DM, alcohol abstinence was associated with a low risk of AF development. Lifestyle modifications, such as alcohol abstinence, in patients newly diagnosed with T2DM should be recommended to reduce the risk of AF.

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Genetically determined tobacco and alcohol use and risk of atrial fibrillation

BMC Medical Genomics ◽

10.1186/s12920-021-00915-0 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Yunlong Lu ◽

Yan Guo ◽

Hefeng Lin ◽

Zhen Wang ◽

Liangrong Zheng

Keyword(s):

Atrial Fibrillation ◽

Smoking Cessation ◽

Alcohol Consumption ◽

Alcohol Use ◽

Smoking Initiation ◽

Genome Wide Association Studies ◽

Heavy Alcohol ◽

A Genome ◽

Heavy Alcohol Consumption ◽

Mr Study

Abstract Background The causality between the use of alcohol and cigarettes and atrial fibrillation (AF) remains controversial. We conducted a Mendelian randomization (MR) study to evaluate the association of genetic variants related to tobacco and alcohol use with AF. Methods Single nucleotide polymorphisms (SNPs) related to smoking initiation (N = 374), age at initiation of regular smoking (N = 10), cigarettes per day (N = 55), and smoking cessation (N = 24) were derived from a genome-wide association studies (GWAS) of tobacco use (N = 1.2 million individuals). SNPs related to heavy alcohol use (N = 6) were derived from a GWAS of UK biobank (N = 125,249 individuals). The genetically matching instrumented variables were obtained from the GWAS of AF (N = 588,190 individuals). The estimates between tobacco and alcohol use and AF were combined by inverse-variance weighted (IVW), simple median, weighted median, MR-robust adjusted profile score method, MR-PRESSO, and multivariable MR. Results A total of 65,446 AF patients and 522,744 referents were included. In the IVW analysis, the odds ratio per one-unit increase of smoking initiation was 1.11 (95% CI, 1.06–1.16; P = 3.35 × 10−6) for AF. Genetically predicted age at initiation of regular smoking, cigarettes per day and smoking cessation were not associated with AF. The IVW estimate showed that heavy alcohol consumption increased AF risk (OR, 1.11; 95% CI, 1.04–1.18; P = 0.001). The results were consistent in complementary analyses and multivariable MR. Conclusion Our MR study indicated that regular smoking was associated with increased risk of AF, no matter the age at initiation of regular smoking, or the number of cigarettes smoked per day. Genetically predicted heavy alcohol consumption increased the risk of AF.

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Coronary deaths during Midsummer festival in Finland: miseries of long, light nights

European Journal of Epidemiology ◽

10.1007/s10654-021-00744-6 ◽

2021 ◽

Author(s):

Simo Näyhä

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Alcohol Consumption ◽

Negative Binomial ◽

Negative Binomial Regression ◽

Adverse Consequence ◽

Heavy Alcohol ◽

Summer Peak ◽

Binomial Regression ◽

Heavy Alcohol Consumption

AbstractThis paper examines whether the anomalous summer peak in deaths from coronary heart disease (CHD) in Finland could be attributed to adverse effects of the Midsummer festival and alcohol consumption during the festival. Daily deaths from CHD and alcohol poisoning in Finland, 1961–2014, that occurred during the 7 days centering on Midsummer Day were analysed in relation to deaths during 14 to 4 days before and 4 to 14 after Midsummer Day. Daily counts of deaths from CHD among persons aged 35–64 years were regressed on days around the Midsummer period by negative binomial regression. Mortality from CHD was highest on Midsummer Day (RR 1.25 (95% confidence interval 1.12–1.31), one day after the peak in deaths from alcohol poisonings. RR for CHD on Midsummer Day was particulary high (RR = 1.43; 1.09–1.86) in the 2000s, 30% of deaths being attributable to that day. In conclusion, the anomalous and prominent summer peak in deaths from CHD in Finland is an adverse consequence of the Midsummer festival. The most likely underlying reason is heavy alcohol consumption during the festival period, especially on Midsummer Eve. In the 2000s, one third of deaths from CHD on Midsummer Day are preventable.

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