Abstract 17426: Pulmonary Vein Isolation ‘Rewires’ Electrical Communications to Enhance Small-world Network Topology During Atrial Fibrillation

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Hiroshi Ashikaga ◽  
Jonathan Chrispin ◽  
Degang Wu ◽  
Joshua Garland

Recent evidence suggests that pulmonary vein isolation (PVI) may perturb the electrophysiological substrate for maintenance of atrial fibrillation (AF). Our previous work indicates that information theory metrics can quantify electrical communications during arrhythmia. We hypothesized that PVI ‘rewires’ the electrical communication network during AF such that the topology exhibits higher levels of small-world network properties, with higher clustering coefficient and lower path length, than would be expected by chance. Thirteen consecutive patients (n=6 with prior PVI and n=7 without) underwent AF ablation using a 64-electrode basket catheter in the left atrium. Multielectrode recording was performed during AF for 60 seconds, followed by PVI. Mutual information was calculated from the time series between each pair of electrodes using the Kraskov-Stögbauer-Grassberger estimator. The all-to-all mutual information matrix (64x64; Figure, upper panels) was thresholded by the median and standard deviations of mutual information to build a binary adjacency matrix for electrical communication networks. The properties of small-world network ( swn ; ‘small-world-ness’) were quantified by the ratio of the observed average clustering coefficient to that of a random network over the ratio of the observed average path length to that of a random network. swn was expressed in normal Z standard deviation units. As the binarizing threshold increased, the Z-score of swn decreased (Figure, lower panel). However, the Z-score at each threshold value was consistently higher with prior PVI than those without (p<0.05). In conclusion, electrical communication network during AF with prior PVI is associated with higher levels of small-world network properties than those without. This finding supports the concept that PVI perturbs the underlying substrate. In addition, swn of electrical communication network may be a promising metric to quantify substrate modification.

2018 ◽  
Vol 7 (4) ◽  
pp. 564-584
Author(s):  
Jeff Alstott ◽  
Christine Klymko ◽  
Pamela B Pyzza ◽  
Mary Radcliffe

Abstract Many real-world networks have high clustering among vertices: vertices that share neighbours are often also directly connected to each other. A network’s clustering can be a useful indicator of its connectedness and community structure. Algorithms for generating networks with high clustering have been developed, but typically rely on adding or removing edges and nodes, sometimes from a completely empty network. Here, we introduce algorithms that create a highly clustered network by starting with an existing network and rearranging edges, without adding or removing them; these algorithms can preserve other network properties even as the clustering increases. They rely on local rewiring rules, in which a single edge changes one of its vertices in a way that is guaranteed to increase clustering. This greedy step can be applied iteratively to transform a random network into a form with much higher clustering. Additionally, the algorithms presented grow a network’s clustering faster than they increase its path length, meaning that network enters a regime of comparatively high clustering and low path length: a small world. These algorithms may be a basis for how real-world networks rearrange themselves organically to achieve or maintain high clustering and small-world structure.


2013 ◽  
Vol 443 ◽  
pp. 509-512
Author(s):  
Yan Zhu ◽  
Yun Yu

Based on the complex network property of wireless sensor networks, this study focus on the topology of wireless sensor network and carry out series simulation according to complex network research methods. The characteristic of topology for the wireless sensor network is probed in the experiment. The degree distribution, clustering coefficient and average path length are analyzed during the experimental process. Our results verify that the topology of wireless sensor network is neither regular nor random. It is between random network and small-world network which has comparatively smaller average path length and bigger cluster coefficient. In order to form a network that is similar to the property of small-world network, which can reduce network energy consumption by decrease the average hops, our experiment constructs a network model which has significant small-world network characteristic. The results indicate that the added small sum of long range edges in the network will not increase the network load while it can reduce the energy consumption of the network effectively.


2021 ◽  
Author(s):  
Mayuri Gadhawe ◽  
Ravi Kumar Guntu ◽  
Ankit Agarwal

&lt;p&gt;Complex network is a relatively young, multidisciplinary field with an objective to unravel the spatiotemporal interaction in natural processes. Though network theory has become a very important paradigm in many fields, the applications in the hydrology field are still at an emerging stage.&amp;#160; In this study, we employed the Pearson correlation coefficient and Spearman correlation coefficient as a similarity measure with varying threshold ranges to construct the precipitation network of the Ganga River Basin (GRB). Ground-based observed dataset (IMD) and satellite precipitation product (TRMM) are used. Different network properties such as node degree, degree distribution, clustering coefficient, and architecture were computed on each resultant precipitation network of GRB. We also ranked influential grid points in the precipitation network by using weighted degree betweenness to identify the importance of each grid station in the network Our results reveal that the choice of correlation method does not significantly affect the network measures and reconfirm that the thresholds significantly influence network construction and network properties in the case of both datasets. The spatial distribution of the clustering coefficient value is high to low from center to boundary and inverse in the case of degree.&amp;#160; In addition, there is a positive correlation between the average neighbor degree and node degree. Again, we analyzed the architecture of precipitation networks and found that the network has a small world with random network behavior. &amp;#160;&amp;#160;Our results also indicated that both products have similar network measures and showed similar kinds of spatial patterns.&lt;/p&gt;


Fractals ◽  
2019 ◽  
Vol 27 (02) ◽  
pp. 1950010
Author(s):  
DAOHUA WANG ◽  
YUMEI XUE ◽  
QIAN ZHANG ◽  
MIN NIU

Many real systems behave similarly with scale-free and small-world structures. In this paper, we generate a special hierarchical network and based on the particular construction of the graph, we aim to present a study on some properties, such as the clustering coefficient, average path length and degree distribution of it, which shows the scale-free and small-world effects of this network.


2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Alexander P. Christensen ◽  

The nature of associations between variables is important for constructing theory about psychological phenomena. In the last decade, this topic has received renewed interest with the introduction of psychometric network models. In psychology, network models are often contrasted with latent variable (e.g., factor) models. Recent research has shown that differences between the two tend to be more substantive than statistical. One recently developed algorithm called the Loadings Comparison Test (LCT) was developed to predict whether data were generated from a factor or small-world network model. A significant limitation of the current LCT implementation is that it's based on heuristics that were derived from descriptive statistics. In the present study, we used artificial neural networks to replace these heuristics and develop a more robust and generalizable algorithm. We performed a Monte Carlo simulation study that compared neural networks to the original LCT algorithm as well as logistic regression models that were trained on the same data. We found that the neural networks performed as well as or better than both methods for predicting whether data were generated from a factor, small-world network, or random network model. Although the neural networks were trained on small-world networks, we show that they can reliably predict the data-generating model of random networks, demonstrating generalizability beyond the trained data. We echo the call for more formal theories about the relations between variables and discuss the role of the LCT in this process.


2020 ◽  
Vol 132 (3) ◽  
pp. 504-524 ◽  
Author(s):  
Zhenhu Liang ◽  
Lei Cheng ◽  
Shuai Shao ◽  
Xing Jin ◽  
Tao Yu ◽  
...  

Abstract Background The neurophysiologic mechanisms of propofol-induced loss of consciousness have been studied in detail at the macro (scalp electroencephalogram) and micro (spiking or local field potential) scales. However, the changes in information integration and cortical connectivity during propofol anesthesia at the mesoscopic level (the cortical scale) are less clear. Methods The authors analyzed electrocorticogram data recorded from surgical patients during propofol-induced unconsciousness (n = 9). A new information measure, genuine permutation cross mutual information, was used to analyze how electrocorticogram cross-electrode coupling changed with electrode-distances in different brain areas (within the frontal, parietal, and temporal regions, as well as between the temporal and parietal regions). The changes in cortical networks during anesthesia—at nodal and global levels—were investigated using clustering coefficient, path length, and nodal efficiency measures. Results In all cortical regions, and in both wakeful and unconscious states (early and late), the genuine permutation cross mutual information and the percentage of genuine connections decreased with increasing distance, especially up to about 3 cm. The nodal cortical network metrics (the nodal clustering coefficients and nodal efficiency) decreased from wakefulness to unconscious state in the cortical regions we analyzed. In contrast, the global cortical network metrics slightly increased in the early unconscious state (the time span from loss of consciousness to 200 s after loss of consciousness), as compared with wakefulness (normalized average clustering coefficient: 1.05 ± 0.01 vs. 1.06 ± 0.03, P = 0.037; normalized average path length: 1.02 ± 0.01 vs. 1.04 ± 0.01, P = 0.021). Conclusions The genuine permutation cross mutual information reflected propofol-induced coupling changes measured at a cortical scale. Loss of consciousness was associated with a redistribution of the pattern of information integration; losing efficient global information transmission capacity but increasing local functional segregation in the cortical network. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New


2016 ◽  
Vol 23 (4) ◽  
pp. 241-256 ◽  
Author(s):  
Eleni Daskalaki ◽  
Konstantinos Spiliotis ◽  
Constantinos Siettos ◽  
Georgios Minadakis ◽  
Gerassimos A. Papadopoulos

Abstract. The monitoring of statistical network properties could be useful for the short-term hazard assessment of the occurrence of mainshocks in the presence of foreshocks. Using successive connections between events acquired from the earthquake catalog of the Istituto Nazionale di Geofisica e Vulcanologia (INGV) for the case of the L'Aquila (Italy) mainshock (Mw = 6.3) of 6 April 2009, we provide evidence that network measures, both global (average clustering coefficient, small-world index) and local (betweenness centrality) ones, could potentially be exploited for forecasting purposes both in time and space. Our results reveal statistically significant increases in the topological measures and a nucleation of the betweenness centrality around the location of the epicenter about 2 months before the mainshock. The results of the analysis are robust even when considering either large or off-centered the main event space windows.


2008 ◽  
Vol 09 (03) ◽  
pp. 277-297 ◽  
Author(s):  
GREGOIRE DANOY ◽  
ENRIQUE ALBA ◽  
PASCAL BOUVRY

Multi-hop ad hoc networks allow establishing local groups of communicating devices in a self-organizing way. However, when considering realistic mobility patterns, such networks most often get divided in a set of disjoint partitions. This presence of partitions is an obstacle to communication within these networks. Ad hoc networks are generally composed of devices capable of communicating in a geographical neighborhood for free (e.g. using Wi-Fi or Bluetooth). In most cases a communication infrastructure is available. It can be a set of access point as well as a GSM/UMTS network. The use of such an infrastructure is billed, but it permits to interconnect distant nodes, through what we call “bypass links”. The objective of our work is to optimize the placement of these long-range links. To this end we rely on small-world network properties, which consist in a high clustering coefficient and a low characteristic path length. In this article we investigate the use of three genetic algorithms (generational, steady-state, and cooperative coevolutionary) to optimize three instances of this topology control problem and present initial evidence of their capacity to solve it.


2012 ◽  
Vol 263-266 ◽  
pp. 1096-1099
Author(s):  
Zhi Yong Jiang

Relationship between nodes in peer-to-peer overlay, currently becomes a hot topic in the field of complex network. In this paper a model of peer-to-peer overlay was purposed. And then the paper focused on figuring out the mean-shortest path length (MSPL), clustering coefficient (CC) and the degree of every node which allowed us to discover the degree distribution. The results show that the degree distribution function follows approximately power law distribution and the network possesses notable clustering and small-world properties.


2016 ◽  
Vol 20 (1) ◽  
pp. 149-173 ◽  
Author(s):  
Tore Opsahl ◽  
Antoine Vernet ◽  
Tufool Alnuaimi ◽  
Gerard George

Research has explored how embeddedness in small-world networks influences individual and firm outcomes. We show that there remains significant heterogeneity among networks classified as small-world networks. We develop measures of the efficiency of a network, which allow us to refine predictions associated with small-world networks. A network is classified as a small-world network if it exhibits a distance between nodes that is comparable to the distance found in random networks of similar sizes—with ties randomly allocated among nodes—in addition to containing dense clusters. To assess how efficient a network is, there are two questions worth asking: (a) What is a compelling random network for baseline levels of distance and clustering? and (b) How proximal should an observed value be to the baseline to be deemed comparable? Our framework tests properties of networks, using simulation, to further classify small-world networks according to their efficiency. Our results suggest that small-world networks exhibit significant variation in efficiency. We explore implications for the field of management and organization.


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