Abstract P228: Lower Serum 25-hydroxyvitamin D Concentration is Associated With Greater Risk of Non-alcoholic Fatty Liver Disease Among Caucasians but Not Other Racial-ethnic Groups in the Multi Ethnic Study of Atherosclerosis

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Samar R El Khoudary ◽  
Saad Samargandy ◽  
Irfan Zeb ◽  
Temitope Foster ◽  
Ian De Boer ◽  
...  
Keyword(s):  
Risk Factors ◽  
African American ◽  
Liver Disease ◽  
Ethnic Groups ◽  
Alcoholic Fatty Liver ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Race Ethnicity ◽  
Racial Ethnic ◽  
Alcoholic Fatty Liver Disease

Objective: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in developed nations and is independently associated with increased overall morality from all causes as well as from CVD. Growing evidence support that low serum 25-hydroxyvitamin D ((25OH)D) is associated with NAFLD. However, significant racial/ethnic differences exist in serum 25(OH)D and the prevalence of NAFLD: African Americans have lower 25(OH)D than Caucasians, and NAFLD prevalence is higher in Caucasians. We tested whether the association between 25(OH)D and NAFLD vary by race/ethnicity, adjusting for common risk factors for low 25(OH)D and NAFLD. Methods: Participants were from the MESA study, who were free from CVD and liver conditions, were not taking oral corticosteroids, did not report heavy alcohol intake (>7 drinks/week for women and > 14 drinks/week for men), and had serum 25(OH)D and upper abdominal non-contrast CT images available at baseline. 25(OH)D was adjusted for season. NAFLD was defined if liver-to-spleen Hounsfield units ratio was <1. Logistic regression was used for statistical analyses. Final models were adjusted for study site, age, gender, education, income, BMI, triglycerides, high-density lipoproteins, systolic blood pressure, smoking, diabetes, interlukine-6 and C-reactive protein. Results: The study included3,484 participants (mean age (SD): 62.7(10.4) Yr; 44% of participants were male; 38.4% Caucasian, 27.8% African American, 23.5% Hispanic, and 10.3% Chinese American). Serum 25(OH)D significantly varied by race/ethnicity; with Caucasian have the highest levels and African American have the lowest levels (mean(SD): 29.5(10.4)ng/ml vs. 19.6(9.1)ng/ml, respectively, p<0.0001). NAFLD was present among 17.5% (n=611) of the participants; with Hispanic showing the highest prevalence rate (26.2%) followed by Chinese American (19.8%), Caucasian (15.8%) and African American (11.7%), P=<0.0001. In unadjusted and final models, the association of 25(OH)D with NAFLD differed significantly by race/ethnicity (P<0.01). Stratification analyses showed significant negative association only in Causations; such that lower 25(OH)D was significantly associated with higher risk of NAFLD (adjusted OR (95% CI):1.23(1.03, 1.47) per 1 SD decrease in serum 25(OH)D). For other racial/ethnic groups, BMI, triglycerides, diabetic status and/or smoking, but not serum 25(OH)D, were common independent risk factors for NAFLD. Conclusions: The association of 25(OH)D with NAFLD varies by race/ethnicity. Future studies should assess if targeting vitamin D deficiency in Caucasians may reduce their higher risk of NAFLD above and beyond controlling other modifiable risk factors, whereas, controlling modifiable risk factors, excluding vitamin D, may be more important in reducing NAFLD risk in other racial/ethnic groups.

scholarly journals Inverse Association between Serum 25-hydroxyvitamin D Levels and Risk of Suspected Non-Alcoholic Fatty Liver Disease in Obese Population

2021 ◽  
Vol 18 (16) ◽  
pp. 8682
Author(s):  
Eunjung Park ◽  
Eun Young Park
Keyword(s):  
Public Health ◽  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Hydroxyvitamin D ◽  
Obese Population ◽  
25 Hydroxyvitamin D ◽  
Alcoholic Fatty Liver Disease

Background: Worldwide, vitamin D deficiency is a public health issue and the prevalence of obesity and non-alcoholic fatty liver disease (NAFLD) are rapidly increasing. There are a limited number of studies assessing the association between serum levels of 25-hydroxyvitamin D (25(OH)D) and NAFLD risk in obese population. Objective: We evaluated the associations between serum 25(OH)D levels and risk of suspected NAFLD after stratification by obesity using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2014. Methods: This study included 25,755 subjects without significant alcohol consumption for the serum alanine aminotransferase (ALT) and hepatic steatosis index (HSI) analyses (8922 subjects for the serum gamma-glutamyl transferase (GGT) and fatty liver index (FLI) analyses), based on a cross-sectional study design. Serum 25(OH)D levels were measured using a Gamma counter with radioimmunoassay. A survey logistic regression model was applied to estimate ORs and 95% CIs. Restricted cubic smoothing splines were applied to evaluate nonlinear associations. Results: The risk of suspected NAFLD was reduced per unit of natural log-transformed serum 25(OH)D concentration in obese individuals (OR [95% (CI)]; for ALT, 0.80 [0.67, 0.96]; for GGT, 0.70 [0.49, 0.99; for FLI, 0.68 [0.47, 1.01]; for HSI, 0.70 [0.56, 0.87]). The ORs [95% CI] of suspected NAFLD changed across the quartiles: for serum ALT, from 1.02 [0.85, 1.23] to 0.72 [0.59, 0.87]; for serum GGT, from 0.79 [0.56, 1.13] to 0.64 [0.44, 0.92]; for FLI, from 0.98 [0.67, 1.44] to 0.70 [0.48, 1.02]; and for HSI, from 0.91 [0.73, 1.14] to 0.65 [0.52, 0.81] with dose–response relationships (all p for trend < 0.01). Conclusions: This study suggests that vitamin D sufficiency for public health should be emphasized in order to prevent adverse health effects in obese populations.

Low 25-hydroxyvitamin D level is not an independent risk factor for hepatosteatosis in obese children

2016 ◽  
Vol 29 (7) ◽  
Author(s):  
Oya Balcı Sezer ◽  
Derya Buluş ◽  
Şamil Hızlı ◽  
Nesibe Andıran ◽  
Deniz Yılmaz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Density Lipoprotein ◽  
Obese Children ◽  
Alcoholic Fatty Liver ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Alcoholic Fatty Liver Disease

AbstractObesity is an important risk factor for non-alcoholic fatty liver disease. Few studies have evaluated the association between vitamin D and non-alcoholic fatty liver disease in obese children. Therefore, we conducted a study to examine the relationship of vitamin D levels and hepatosteatosis in obese children.One hundred and eleven children with obesity participated in this study. Hepatosteatosis was diagnosed and graded using ultrasonography in all patients. Study participants were divided based on the presence of hepatosteatosis into two subgroups (hepatosteatosis and non-hepatosteatosis). Serum levels of 25-hydroxyvitamin D, calcium, phosphate, alkaline phosphatase, parathormone, and lipids were measured and compared.Hepatosteatosis existed in 52% of obese children without chronic diseases. There was no statistically significant difference in the vitamin D level between the hepatosteatosis and non-hepatosteatosis groups. Alanine aminotransferase levels and the triglycerides-to-high density lipoprotein ratio were significantly higher, and the high density lipoprotein levels were significantly lower in the hepatosteatosis group compared to the non-hepatosteatosis group.Vitamin D deficiency is not directly related with hepatosteatosis. A high ALT level and a high triglycerides-to-HDL ratio and low HDL levels are more significant in hepatic steatosis in obese children.

scholarly journals Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity

2014 ◽  
Vol 29 (6) ◽  
pp. 1215-1222 ◽  
Author(s):  
Lucinda J Black ◽  
Peter Jacoby ◽  
Wendy Chan She Ping-Delfos ◽  
Trevor A Mori ◽  
Lawrence J Beilin ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Alcoholic Fatty Liver Disease ◽  
Low Serum

scholarly journals Non-alcoholic fatty liver disease in polycystic ovary syndrome women

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Young Bin Won ◽  
Seok Kyo Seo ◽  
Bo Hyon Yun ◽  
SiHyun Cho ◽  
Young Sik Choi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Liver Enzyme ◽  
Fatty Liver Disease ◽  
Polycystic Ovary ◽  
Insulin Level ◽  
University Hospital ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

AbstractTo evaluate risk factors leading to non-alcoholic fatty liver disease (NAFLD) occurrence in polycystic ovarian syndrome (PCOS) women. A retrospective cohort study of a total of 586 women diagnosed with PCOS aged 13–35 years at the gynecology department at a university hospital was done to evaluate PCOS phenotype, metabolic syndrome (MetS) diagnosis, body composition, insulin sensitivity, sex hormones, lipid profile, liver function, and transient elastography (TE). In PCOS women with NAFLD compared to those without, MetS diagnosis (Hazard ratio [HR] 5.6, 95% Confidence interval [CI] 2.2–14.4, p < 0.01) and hyperandrogenism (HA) (HR 4.4, 95% CI 1.4–13.4, p = 0.01) were risk factors significantly associated with subsequent NAFLD occurrence, whereas 2-h insulin level in 75 g glucose tolerance test (GTT) (HR 1.2, 95% CI 0.5–2.5, p = 0.70) and body mass index (BMI) > 25 kg/m2 (HR 2.2, 95% CI 0.6–8.0, p = 0.24) was not. Among NAFLD patients who underwent TE, a higher number of MetS components indicated a worse degree of fibrosis and steatosis. MetS diagnosis and HA at PCOS diagnosis were risk factors associated with NAFLD, while 2-h insulin level in 75 g GTT and obesity were not. Although elevated aspartate aminotransferase levels were significant for NAFLD risk, liver enzyme elevations may not be present until late liver damage. Further prospective studies of PCOS women with MetS or HA are warranted to determine whether patients without liver enzyme elevations should undergo preemptive liver examinations.

scholarly journals Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Rui Huang ◽  
Jian-Gao Fan ◽  
Jun-Ping Shi ◽  
Yi-Min Mao ◽  
Bing-Yuan Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Related Quality ◽  
Health Related ◽  
Independent Risk Factors ◽  
Alcoholic Fatty Liver Disease

Abstract Background Health Related Quality of Life (HRQL) is a multi-dimensional construct that can comprehensively evaluate the patient’s health status, including physical, emotional, mental and social well-being. In this study, we aimed to evaluate the impact of non-alcoholic fatty liver disease (NAFLD) on HRQL in a Chinese population. Methods In this national multicenter cross-sectional survey, patients with NAFLD were enrolled. Chronic Liver Disease Questionnaire (CLDQ)-NAFLD was used to qualify HRQL. Univariate and multivariate analysis were used to identify independent risk factors of HRQL. Results A total of 5181 patients with NAFLD from 90 centers were enrolled in this study (mean age, 43.8 ± 13.3 years; male, 65.8%). The overall CLDQ score was 5.66 ± 0.89. Multivariate logistic regression analysis showed that body mass index (BMI: HR, 1.642; 95% CI, 1.330–2.026), alanine transaminase (ALT: HR, 1.006; 95% CI, 1.001–1.011), triglyceride (HR, 1.184; 95% CI, 1.074–1.305), disease severity (HR, 3.203; 95% CI, 1.418–7.232) and cardiovascular disease (HR, 4.305; 95% CI, 2.074–8.939) were independent risk factors for overall CLDQ score. In the logistic analyses of individual domain, BMI and triglyceride were independent risk factors of all domains. ALT, disease severity, diabetes, depression and cardiovascular disease were influencing factors for the CLDQ score of several domains. Conclusions This national multicenter cross-sectional survey in China indicated that the HRQL in patients with NAFLD was impaired. HRQL was found to be significantly associated with sociodemographic and clinical factors. Attention should be paid to the optimally managing care of patients with NAFLD to improve their HRQL.

scholarly journals Implementation of a care bundle improves the management of patients with non-alcoholic fatty liver disease

2021 ◽  
pp. flgastro-2020-101480
Author(s):  
Laura Jane Neilson ◽  
Louise Macdougall ◽  
Phey Shen Lee ◽  
Timothy Hardy ◽  
David Beaton ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Metabolic Risk Factors ◽  
Care Bundle ◽  
Metabolic Risk ◽  
Lifestyle Advice ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

BackgroundNon-alcoholic fatty liver disease (NAFLD) is common and is associated with liver-related and cardiovascular-related morbidity. Our aims were: (1) to review the current management of patients with NAFLD attending hospital clinics in North East England (NEE) and assess the variability in care; (2) develop a NAFLD ‘care bundle’ to standardise care; (3) to assess the impact of implementation of the NAFLD care bundle.MethodsA retrospective review was conducted to determine baseline management of patients with NAFLD attending seven hospitals in NEE. A care bundle for the management of NAFLD was developed including important recommendations from international guidelines. Impact of implementation of the bundle was evaluated prospectively in a single centre.ResultsBaseline management was assessed in 147 patients attending gastroenterology, hepatology and a specialist NAFLD clinic. Overall, there was significant variability in the lifestyle advice given and management of metabolic risk factors, with patients attending an NAFLD clinic significantly more likely to achieve >10% body weight loss and have metabolic risk factors addressed. Following introduction of the NAFLD bundle 50 patients were evaluated. Use of the bundle was associated with significantly better documentation and implementation of most aspects of patient management including management of metabolic risk factors, documented lifestyle advice and provision of NAFLD-specific patient advice booklets.ConclusionThe introduction of an outpatient ‘care bundle’ led to significant improvements in the assessment and management of patients with NAFLD in the NEE and could help improve and standardise care if used more widely.

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