Abstract P313: Association of Positive Emotion and Cardiovascular Health in Hispanics/Latinos With Chronic Kidney Disease: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Rosalba Hernandez ◽  
James P Lash ◽  
Brett Burrows ◽  
Holly J Mattix-Kramer ◽  
Ramon A Durazo-Arvizu ◽  
...  

Introduction: Mounting evidence exists, linking positive emotion (e.g., joy) to favorable health outcomes. Little is known of the relationship between positive emotion and the American Heart Association defined concept of cardiovascular health ( CVH ), particularly in Hispanics/Latinos with chronic kidney disease ( CKD ), a group at high risk of cardiovascular mortality. Hypothesis: In Hispanics/Latinos with CKD, those with greater positive emotion will display more favorable CVH profiles. Methods: We analyzed data from adults ages 18-74 with stage 1-5 non-dialysis dependent CKD enrolled in the Hispanic Community Health Study/Study of Latinos in 2008-11. Positively worded items of the Center for Epidemiologic Studies Depression Scale were used to create a composite positive emotion score (range, 0-6; higher scores indicative of greater positive emotion). A composite overall CVH score was calculated using metrics of diet, body mass index, physical activity, cholesterol, blood pressure, fasting glucose, and smoking status. Each metric was defined as ideal, intermediate, or poor to compute an additive score ranging from 0-14; ideal metrics were also enumerated to compute an ideal CVH score, ranging from 0-7. Linear and logistic regression analyses were used to examine associations of positive emotion with CVH, after adjusting for relevant covariates. Results: Overall, 1,716 participants screened positive for CKD † . In multivariable-adjusted models, a higher positive emotion score was associated with higher overall and ideal CVH scores when modeling CVH as a continuous outcome, (overall CVH: β=0.11, 95% CI=0.01, 0.20; ideal CVH: β=0.06, 95% CI=0.01, 0.11) ( Table 1 ). A 1-unit increase in positive emotion was associated with 1.14 times higher odds of having > 4 (vs. <4) ideal CVH indicators. Conclusions: These findings provide preliminary evidence for an association between positive emotion and CVH in Hispanics/Latinos with CKD. Future studies should explore the mechanism through which emotion influence heart health.

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Rosalba Hernandez ◽  
Hector Gonzalez ◽  
Wassim Tarraf ◽  
Mercedes Carnethon ◽  
Frank J Penedo ◽  
...  

Introduction: There is mounting evidence linking positive psychological functioning to restorative health processes and favorable medical outcomes. However, very little is known about the relationship between optimism--an indicator of psychological functioning--and the American Heart Association ( AHA ) defined concept of cardiovascular health ( CVH ), particularly in Hispanics/Latinos of diverse backgrounds. Hypothesis: Persons with greater optimism will have more favorable CVH profiles. Methods: We analyzed data from adults ages 18-75 that participated in the Hispanic Community Health Study/Study of Latinos ( HCHS/SOL ) Sociocultural Ancillary Study in 2010-11. Optimism was assessed using the Life-Orientation Test-Revised, with scores ranging from 6-24 and higher scores indicative of greater levels of optimism. AHA classification standards were used to derive a composite CVH score with subsequent grouping into categorizes of poor (0-7 points), intermediate (8-11 points), and ideal (12-14 points). Metrics considered when calculating the overall CVH score included diet, body mass index, physical activity, cholesterol, blood pressure, fasting glucose, and smoking status. Multinomial logistic regression was used to examine associations of optimism with ideal and intermediate CVH (poor CVH—ref. group), after adjusting for socio-demographic factors and depressive symptoms. Results: Among 4,960 participants with complete data, 9.2% were categorized as having ideal CVH. In multivariable-adjusted models, participants with moderate levels of optimism were more likely to have intermediate [OR = 1.37: 95%CI = 1.08, 1.74] and ideal [OR = 1.61: 95%CI = 1.04, 2.48] CVH when compared to the least optimistic group ( Table 1 ). Conclusions: The current study offers preliminary evidence for an association between optimism and CVH in a large heterogeneous group of Hispanic/Latino adults. Future studies should explore the concept of optimistic bias and whether exaggerated levels of optimism are detrimental to health.


2018 ◽  
Vol 10 ◽  
pp. 285-291 ◽  
Author(s):  
Claudia M. Lora ◽  
Ana C. Ricardo ◽  
Jinsong Chen ◽  
Jianwen Cai ◽  
Michael Flessner ◽  
...  

2016 ◽  
Vol 31 (10) ◽  
pp. 1670-1676 ◽  
Author(s):  
Nora Franceschini ◽  
Yu Deng ◽  
Michael F. Flessner ◽  
John H. Eckfeldt ◽  
Holly J. Kramer ◽  
...  

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Celestin Missikpode ◽  
Holly Kramer ◽  
Scott J. Cotler ◽  
Ramon Durazo-Arvizu ◽  
James P. Lash ◽  
...  

Abstract Background Previous studies have shown an association between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD), but it is unclear whether the association is independent of metabolic syndrome. Methods Data from 13,006 participants aged 18 to 74 years in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) without viral hepatitis, excessive alcohol consumption, or high transferrin saturation levels were analyzed. Suspected NAFLD was defined as presence of sex-specific elevations in serum aminotransferase levels (aspartate aminotransferase (AST) > 37 U/L or alanine aminotransferase (ALT) > 40 U/L for men and AST or ALT > 31 U/L for women). Logistic regression was used to examine cross-sectional associations of elevated serum aminotransferase levels with low estimated glomerular filtration rate (eGFR < 60 ml/min/1.73 m2 based on cystatin C), and with high urinary albumin-to-creatinine ratio (UACR) (> 17 mg/g in men and > 25 mg/ g in women) in separate models adjusting for demographic characteristics and metabolic syndrome. Results Mean (SD) age was 41 (0.27) years, and 45 % were male. Elevated serum aminotransferase levels were noted in 18.8 % of the population and were associated with greater odds of high UACR (OR = 1.31; 95 % CI = 1.10, 1.56) after adjusting for demographic characteristics; this association became non-significant after adjustment for metabolic syndrome (OR = 1.11, 95 % CI = 0.92, 1.33). In contrast, elevated serum aminotransferase levels were not associated with low eGFR (odds ratio (OR) = 0.73; 95 % confidence interval (CI) = 0.45, 1.18) after adjusting for covariates. Conclusions In this sample of diverse U.S. Hispanic Latino adults, elevated serum aminotransferase levels were not independently associated with measures of CKD.


2020 ◽  
Author(s):  
Monica Reynolds ◽  
Laura R Loehr ◽  
Susan L Hogan ◽  
Yichun Hu ◽  
Carmen R Isasi ◽  
...  

Abstract Background: Hispanic/Latino individuals are less likely to receive optimal treatment for chronic kidney disease (CKD) than non-Hispanic whites. This may be particularly detrimental for women of reproductive age as CKD may increase risk for infertility, menstrual irregularities, and pregnancy loss. While these maternal outcomes have been associated with advanced CKD, their occurrence in mild to moderate CKD is unclear. Methods: Using baseline (2008-2011) and second study visit (2014-2017) data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we assessed the association between CKD and self-reported infertility, cessation of menses, hysterectomy, and nonviable pregnancy loss (experienced at less than 24 weeks gestation) in women of reproductive age (18-45 years). Multivariable survey logistic regression analyses were used to compute prevalence odds ratios with 95% confidence intervals (OR, 95% CI). Results: Of the 2,589 women included (mean age 31.4 years), 4.6% were considered to have CKD. In adjusted analyses, women with CKD did not have a significantly increased odds of infertility (OR 1.02, 95% CI 0.42 - 2.49), cessation of menses (OR 1.25, 95% CI 0.52 - 3.04) or hysterectomy (OR 1.17, 95% CI 0.61 - 2.25) compared to those without CKD. In those with CKD, the adjusted odds of a nonviable pregnancy loss was increased when considering pregnancies occurring after baseline visit (OR 2.11, 95% CI 0.63 - 7.02) but not statistically significance. Conclusion: In our Hispanic/Latino cohort, the presence of mild to moderate CKD did not confer an additional risk of our outcomes of interest. Examining nonviable pregnancy loss after CKD diagnosis in a larger sample warrants further study.


2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1477-1477
Author(s):  
Caitlin Porter ◽  
Nicole Karazurna ◽  
Semra Aytur ◽  
Jesse Morrell ◽  
Yasmin Mossavar-Rahmani ◽  
...  

Abstract Objectives The literature on n-3 fatty acid (FA) intake and depressive symptoms is inconsistent, potentially due in part to the influence of psychosocial stress. Some evidence supports that n-3 intake may have greater benefit on depressive symptoms among those with high oxidative stress. We quantified the associations between dietary and plasma n-3 FA and 6-y depressive symptoms and measured the modifying effect of psychosocial stress. Methods Data are from the Hispanic Community Health Study/Study of Latinos (age 48 y, 63% female). At baseline (2008–11), EPA, DHA and n-3 very-long-chain FAs (n-3VLCFAs) were estimated using two 24-hr recalls and the NCI method. Plasma n-3 FAs were measured by mass spectrometry. Depressive symptoms were measured at baseline and 6-y follow-up with the 10-item Center for Epidemiological Studies Depression Scale (CESD). Approximately 9 months from baseline, the 10-item Perceived Stress (PSS) and Chronic Burden of Stress scales were obtained. Unstratified and psychosocial stress-stratified associations were analyzed using survey linear regression among those with dietary (n = 3537) and plasma (n = 718) FA data. Model covariates included, but were not limited to, baseline CESD score, ethnicity, study site, antidepressant use, total energy intake, and dietary or plasma n-6 FA. Results Baseline DHA and n-3VLCFA intake were inversely associated with 6-y CESD (P &lt; 0.05). All examined dietary n-3 FA exposures were inversely associated with CESD among those in the highest PSS quartile (Q4) (P &lt; 0.05), but this was attenuated after considering n-6 FA intake. DHA and n-3VLCFA intakes were associated with lower CESD among those with 2 chronic stressors, but not &lt;1 or &gt;2 stressors. Plasma n-3 FAs were not associated with CESD in PSS stratified and unstratified analyses. However, plasma n-3 FA were associated with lower CESD score among those with only 2 chronic stressors. Conclusions Dietary n-3VLCFAs, but not plasma, were inversely associated with 6-y CESD. Psychosocial stress did not clearly modify these associations. These results provide some evidence that greater n-3VLCFA intake may reduce depressive symptoms among Hispanic/Latino adults. However, considering the limitations of self-reported intake, further research is needed using biomarkers of long-term n-3 consumption and psychosocial stress to confirm our findings. Funding Sources None.


2016 ◽  
Vol 176 ◽  
pp. 134-144 ◽  
Author(s):  
Hector M. González ◽  
Wassim Tarraf ◽  
Carlos J. Rodríguez ◽  
Linda C. Gallo ◽  
Ralph L. Sacco ◽  
...  

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