scholarly journals Association of elevated serum aminotransferase levels with chronic kidney disease measures: hispanic community health study/study of latinos

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Celestin Missikpode ◽  
Holly Kramer ◽  
Scott J. Cotler ◽  
Ramon Durazo-Arvizu ◽  
James P. Lash ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Community Health ◽  
Elevated Serum ◽  
Demographic Characteristics ◽  
Health Study ◽  
Serum Aminotransferase ◽  
Alcoholic Fatty Liver ◽  
Hispanic Community

Abstract Background Previous studies have shown an association between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD), but it is unclear whether the association is independent of metabolic syndrome. Methods Data from 13,006 participants aged 18 to 74 years in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) without viral hepatitis, excessive alcohol consumption, or high transferrin saturation levels were analyzed. Suspected NAFLD was defined as presence of sex-specific elevations in serum aminotransferase levels (aspartate aminotransferase (AST) > 37 U/L or alanine aminotransferase (ALT) > 40 U/L for men and AST or ALT > 31 U/L for women). Logistic regression was used to examine cross-sectional associations of elevated serum aminotransferase levels with low estimated glomerular filtration rate (eGFR < 60 ml/min/1.73 m2 based on cystatin C), and with high urinary albumin-to-creatinine ratio (UACR) (> 17 mg/g in men and > 25 mg/ g in women) in separate models adjusting for demographic characteristics and metabolic syndrome. Results Mean (SD) age was 41 (0.27) years, and 45 % were male. Elevated serum aminotransferase levels were noted in 18.8 % of the population and were associated with greater odds of high UACR (OR = 1.31; 95 % CI = 1.10, 1.56) after adjusting for demographic characteristics; this association became non-significant after adjustment for metabolic syndrome (OR = 1.11, 95 % CI = 0.92, 1.33). In contrast, elevated serum aminotransferase levels were not associated with low eGFR (odds ratio (OR) = 0.73; 95 % confidence interval (CI) = 0.45, 1.18) after adjusting for covariates. Conclusions In this sample of diverse U.S. Hispanic Latino adults, elevated serum aminotransferase levels were not independently associated with measures of CKD.

scholarly journals Acculturation and chronic kidney disease in the Hispanic community health study/study of Latinos (HCHS/SOL)

2018 ◽  
Vol 10 ◽  
pp. 285-291 ◽  
Author(s):  
Claudia M. Lora ◽  
Ana C. Ricardo ◽  
Jinsong Chen ◽  
Jianwen Cai ◽  
Michael Flessner ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Community Health ◽  
Health Study ◽  
Hispanic Community

Abstract P313: Association of Positive Emotion and Cardiovascular Health in Hispanics/Latinos With Chronic Kidney Disease: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Rosalba Hernandez ◽  
James P Lash ◽  
Brett Burrows ◽  
Holly J Mattix-Kramer ◽  
Ramon A Durazo-Arvizu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Community Health ◽  
Positive Emotion ◽  
Cardiovascular Health ◽  
Smoking Status ◽  
Depression Scale ◽  
Heart Association ◽  
Health Study ◽  
Hispanic Community

Introduction: Mounting evidence exists, linking positive emotion (e.g., joy) to favorable health outcomes. Little is known of the relationship between positive emotion and the American Heart Association defined concept of cardiovascular health ( CVH ), particularly in Hispanics/Latinos with chronic kidney disease ( CKD ), a group at high risk of cardiovascular mortality. Hypothesis: In Hispanics/Latinos with CKD, those with greater positive emotion will display more favorable CVH profiles. Methods: We analyzed data from adults ages 18-74 with stage 1-5 non-dialysis dependent CKD enrolled in the Hispanic Community Health Study/Study of Latinos in 2008-11. Positively worded items of the Center for Epidemiologic Studies Depression Scale were used to create a composite positive emotion score (range, 0-6; higher scores indicative of greater positive emotion). A composite overall CVH score was calculated using metrics of diet, body mass index, physical activity, cholesterol, blood pressure, fasting glucose, and smoking status. Each metric was defined as ideal, intermediate, or poor to compute an additive score ranging from 0-14; ideal metrics were also enumerated to compute an ideal CVH score, ranging from 0-7. Linear and logistic regression analyses were used to examine associations of positive emotion with CVH, after adjusting for relevant covariates. Results: Overall, 1,716 participants screened positive for CKD † . In multivariable-adjusted models, a higher positive emotion score was associated with higher overall and ideal CVH scores when modeling CVH as a continuous outcome, (overall CVH: β=0.11, 95% CI=0.01, 0.20; ideal CVH: β=0.06, 95% CI=0.01, 0.11) ( Table 1 ). A 1-unit increase in positive emotion was associated with 1.14 times higher odds of having > 4 (vs. <4) ideal CVH indicators. Conclusions: These findings provide preliminary evidence for an association between positive emotion and CVH in Hispanics/Latinos with CKD. Future studies should explore the mechanism through which emotion influence heart health.

scholarly journals Smoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos

2016 ◽  
Vol 31 (10) ◽  
pp. 1670-1676 ◽  
Author(s):  
Nora Franceschini ◽  
Yu Deng ◽  
Michael F. Flessner ◽  
John H. Eckfeldt ◽  
Holly J. Kramer ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Community Health ◽  
Health Study ◽  
Hispanic Community ◽  
Smoking Patterns

scholarly journals Infertility and Pregnancy Loss in Hispanic/Latino Women with Chronic Kidney Disease: Results from the Hispanic Community Health Study/ Study of Latinos (HCHS/SOL)

2020 ◽  
Author(s):  
Monica Reynolds ◽  
Laura R Loehr ◽  
Susan L Hogan ◽  
Yichun Hu ◽  
Carmen R Isasi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Community Health ◽  
Pregnancy Loss ◽  
Reproductive Age ◽  
Health Study ◽  
Women Of Reproductive Age ◽  
Hispanic Community ◽  
Increase Risk ◽  
To Receive

Abstract Background: Hispanic/Latino individuals are less likely to receive optimal treatment for chronic kidney disease (CKD) than non-Hispanic whites. This may be particularly detrimental for women of reproductive age as CKD may increase risk for infertility, menstrual irregularities, and pregnancy loss. While these maternal outcomes have been associated with advanced CKD, their occurrence in mild to moderate CKD is unclear. Methods: Using baseline (2008-2011) and second study visit (2014-2017) data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we assessed the association between CKD and self-reported infertility, cessation of menses, hysterectomy, and nonviable pregnancy loss (experienced at less than 24 weeks gestation) in women of reproductive age (18-45 years). Multivariable survey logistic regression analyses were used to compute prevalence odds ratios with 95% confidence intervals (OR, 95% CI). Results: Of the 2,589 women included (mean age 31.4 years), 4.6% were considered to have CKD. In adjusted analyses, women with CKD did not have a significantly increased odds of infertility (OR 1.02, 95% CI 0.42 - 2.49), cessation of menses (OR 1.25, 95% CI 0.52 - 3.04) or hysterectomy (OR 1.17, 95% CI 0.61 - 2.25) compared to those without CKD. In those with CKD, the adjusted odds of a nonviable pregnancy loss was increased when considering pregnancies occurring after baseline visit (OR 2.11, 95% CI 0.63 - 7.02) but not statistically significance. Conclusion: In our Hispanic/Latino cohort, the presence of mild to moderate CKD did not confer an additional risk of our outcomes of interest. Examining nonviable pregnancy loss after CKD diagnosis in a larger sample warrants further study.

scholarly journals Prevalence of Metabolic Syndrome Among Hispanics/Latinos of Diverse Background: The Hispanic Community Health Study/Study of Latinos

Diabetes Care ◽  
2014 ◽  
Vol 37 (8) ◽  
pp. 2391-2399 ◽  
Author(s):  
Gerardo Heiss ◽  
Michelle L. Snyder ◽  
Yanping Teng ◽  
Neil Schneiderman ◽  
Maria M. Llabre ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Community Health ◽  
Health Study ◽  
Diverse Background ◽  
Hispanic Community

scholarly journals Do all components of the metabolic syndrome cluster together in U.S. Hispanics/Latinos? Results from the Hispanic Community Health study/Study of Latinos

2015 ◽  
Vol 25 (7) ◽  
pp. 480-485 ◽  
Author(s):  
Maria M. Llabre ◽  
William Arguelles ◽  
Neil Schneiderman ◽  
Linda C. Gallo ◽  
Martha L. Daviglus ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Community Health ◽  
Health Study ◽  
The Metabolic Syndrome ◽  
Hispanic Community

scholarly journals Defining abdominal obesity as a risk factor for coronary heart disease in the US: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

2020 ◽  
Author(s):  
Diana A. Chirinos ◽  
Maria M. Llabre ◽  
Ronald Goldberg ◽  
Marc Gellman ◽  
Armando Mendez ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Waist Circumference ◽  
Community Health ◽  
Abdominal Obesity ◽  
Health Study ◽  
Cut Points ◽  
Hispanic Community

<b>Objective: </b>Various organizations have highlighted the need to examine whether abdominal obesity cut-points are appropriate for identification of cardiovascular risk among ethnic minority adults, particularly Hispanic/Latino living in western societies. This study aimed (1) to establish optimal definitions for abdominal obesity among Hispanic/Latinos, and (2) determine the level of agreement between the presence of metabolic syndrome diagnosed by the current Joint Interim Statement (IJS) definition and an updated definition with optimal abdominal obesity cut points. <p><b>Research Design and Methods:</b> The sample included 16,289 adults who self-identified as Hispanic/Latino ages 18-74 years enrolled in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Receiving operating characteristic (ROC) curves were used to derive sensitivity and specificity values. The largest sum of sensitivity plus specificity was used to determine appropriate cut-points. </p> <p><b>Results:</b> Among US Hispanic/Latino adults, waist circumference cut points of >102 cm in men (in line with current IJS criteria) and >97 cm (9 points higher than IJS criteria) in women provide optimal discrimination for cardiovascular risk as judged by the presence of coronary heart disease. When using these cut points to create an updated metabolic syndrome definition among women, we found disagreement between our updated definition and the current IJS criteria. The prevalence of the metabolic syndrome was overestimated by about 5% points among women based on IJS criteria when compared to our definition. </p> <p><b>Conclusions: </b>Our results suggest that the current recommendations for waist circumference cut-points may not be appropriate for US Hispanic/Latino women. </p>

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