Overtime Work—Related to Increased Risk of Incident Coronary Heart Disease?

Background Circulating galectin‐3 levels provide prognostic information in patients with established heart failure (HF), but the associations between galectin‐3 levels and other incident cardiovascular events in asymptomatic individuals at midlife and when remeasured ≈15 years later are largely uncharacterized. Methods and Results Using multivariable Cox proportional hazards models, we identified associations between plasma galectin‐3 levels (hazard ratio [HR] per 1 SD increase in natural log galectin‐3) and incident coronary heart disease, ischemic stroke, HF hospitalization, and total mortality in ARIC (Atherosclerosis Risk in Communities) participants free of cardiovascular disease at ARIC visit 4 (1996–1998; n=9247) and at ARIC visit 5 (2011–2013; n=4829). Higher galectin‐3 level at visit 4 (median age 62) was independently associated with incident coronary heart disease (adjusted HR, 1.30; 95% CI, 1.06–1.60), ischemic stroke (HR, 1.42; 95% CI, 1.01–2.00), HF (HR, 1.44; 95% CI, 1.17–1.76), and mortality (HR, 1.56; 95% CI, 1.35–1.80). At visit 5 (median age, 74), higher galectin‐3 level was associated with incident HF (HR, 1.93; 95% CI, 1.15–3.24) and total mortality (HR, 1.70; 95% CI, 1.15–2.52), but not coronary heart disease or stoke. Individuals with the greatest increase in galectin‐3 levels from visit 4 to visit 5 were also at increased risk of incident HF and total mortality. Conclusions In a large, biracial community‐based cohort, galectin‐3 measured at midlife and older age was associated with increased risk of cardiovascular events. An increase in galectin‐3 levels over this period was also associated with increased risk.

Download Full-text

Abstract 054: Diet Beverage Intake is Positively Associated With Incident Coronary Heart Disease in People With Type 2 Diabetes

Circulation ◽

10.1161/circ.137.suppl_1.054 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Andrew O Odegaard ◽

Lyn M Steffen ◽

David R Jacobs ◽

Katherine L Tucker ◽

Kenneth J Mukamal ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Heart Disease ◽

Meta Analysis ◽

Health Concern ◽

Cardiovascular Health Study ◽

High Risk Population ◽

Incident Coronary Heart Disease ◽

Increased Risk

Introduction: Diet beverages are calorie free beverages sweetened with non-nutritive sweeteners. People with diabetes are the highest per-capita consumers of diet beverages, tending to consume them as a replacement for dietary sources of sugar, especially in place of sugar sweetened beverages. This behavior is endorsed by dietetic and scientific organizations and diet beverages are marketed synonymously with better health, weight loss, and thus, are considered advantageous for diabetes control. The underlying public health concern is the lack of data to support or refute this concept. Hypothesis: Higher diet beverage intake is positively associated with incident Coronary Heart Disease (CHD) Methods: We pooled the data sets of the Atherosclerosis Risk in Communities (ARIC) study (1987-2014), Cardiovascular Health Study (CHS) (1989-2014), Framingham Offspring Study (FOS) (1995-2014), Jackson Heart Study (JHS) (2000-2012), and Multi-Ethnic Study of Atherosclerosis (MESA (2000-2013) to conduct a prospective examination of the association of diet beverage intake with the incidence of CHD among participants with clinically ascertained type 2 diabetes (T2D) without prevalent CHD and with valid dietary data (N=3,947). We carried out a 2-step meta-analysis using individual level, cohort-specific Cox regression analyses with identical adjustment for demographic, lifestyle, overall diet quality and clinical risk factors to generate effect estimates that were pooled together using fixed and random effects meta-analysis. Results: 1,046 participants developed adjudicated CHD during follow-up. There was a positive, graded association between diet beverage intake and risk of incident CHD (Table). Results were consistent by sex, race and age. Conclusions: Diet beverage intake is associated with increased risk of developing CHD in a population with T2D. These results suggest the need to further evaluate dietary recommendations related to diet beverages and consider their role in this high risk population.

Download Full-text

Hemoglobin A1cIs Associated With Increased Risk of Incident Coronary Heart Disease Among Apparently Healthy, Nondiabetic Men and Women

Journal of the American Heart Association ◽

10.1161/jaha.112.000077 ◽

2013 ◽

Vol 2 (2) ◽

Cited By ~ 28

Author(s):

Jennifer K. Pai ◽

Leah E. Cahill ◽

Frank B. Hu ◽

Kathryn M. Rexrode ◽

JoAnn E. Manson ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Incident Coronary Heart Disease ◽

Men And Women ◽

Increased Risk ◽

Apparently Healthy

Download Full-text

Overtime work and incident coronary heart disease: the Whitehall II prospective cohort study

European Heart Journal ◽

10.1093/eurheartj/ehq124 ◽

2010 ◽

Vol 31 (14) ◽

pp. 1737-1744 ◽

Cited By ~ 106

Author(s):

M. Virtanen ◽

J. E. Ferrie ◽

A. Singh-Manoux ◽

M. J. Shipley ◽

J. Vahtera ◽

...

Keyword(s):

Coronary Heart Disease ◽

Cohort Study ◽

Heart Disease ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Incident Coronary Heart Disease ◽

Overtime Work

Download Full-text

Abstract 17237: Physical Inactivity, Mortality and Incident Coronary Heart Disease in Blacks: The Jackson Heart Study

Circulation ◽

10.1161/circ.138.suppl_1.17237 ◽

2018 ◽

Vol 138 (Suppl_1) ◽

Author(s):

Daisuke Kamimura ◽

Loretta Cain ◽

Donald T Clark ◽

Cameron S Guild ◽

Paul D Loprinzi ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Sex Education ◽

Physical Inactivity ◽

Jackson Heart Study ◽

Incident Coronary Heart Disease ◽

Heart Study ◽

Increased Risk ◽

Significant Difference ◽

Overall Mortality

Introduction: Despite reductions in overall mortality in recent decades, blacks continue to have higher death rates compared to whites. According to a recent CDC report, blacks were more likely to have a higher prevalence of unhealthy behaviors such as physical inactivity/sedentariness compared to whites. We assessed the associations between physical activity (PA) and incident coronary heart disease (CHD) and overall mortality in blacks in the Jackson Heart Study (JHS). Methods: Among the 5306 participants enrolled in JHS at baseline (2000-2004), we examined overall mortality through 2016, and among 3507 participants without prevalent CHD at baseline, clinically adjudicated incident CHD events (CHD hospitalizations and fatal myocardial infarction). Based on participant responses and the American Heart Association’s Life’s Simple 7 metrics, participants were classified as having poor (0 minutes/week), intermediate (&rt;0 and <75 minutes/week) or ideal (<=150 minutes/week) PA based on number of minutes of moderate of vigorous PA per week. Cox proportional hazard ratios (HR) were used to assess the relationships between PA categories and incident CHD and overall mortality. Results: Through 2016, there were 992 deaths (18.7% mortality rate) with higher rates in men (21.5%) compared with women (17.1%, p<0.0001). After adjustment for age, sex, education, systolic blood pressure, hypertension medications, diabetes, cholesterol, alcohol use and current smoking at baseline, poor PA was associated with increased mortality (HR 1.53, 95% CI 1.18, 1.98) compared to those with ideal PA. However, there was no significant difference in incident CHD events between those with ideal and poor PA (HR 1.05, 95% CI 0.66, 1.67). Compared with ideal PA, there was no significant difference in mortality in those with intermediate PA (HR 1.23, 95% CI 0.93, 1.62). Conclusions: In a large community-based cohort of blacks, lower PA was associated with higher overall mortality but was not associated with increased risk of incident CHD events.

Download Full-text