Abstract 15034: Exposure to Secondhand Smoke is Associated With Increased Left Ventricular Mass

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Travis M Skipina ◽  
Bharathi Upadhya ◽  
Elsayed Z Soliman
Keyword(s):  
Secondhand Smoke ◽  
Left Ventricular ◽  
Nhanes Iii ◽  
P Value ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Serum Cotinine ◽  
Lv Mass ◽  
Shs Exposure ◽  
Exposure To Secondhand Smoke

Background: Exposure to secondhand smoke (SHS), or passive smoking, has been associated with chronic hypertension. However, little is known about the relationship between SHS and left ventricular (LV) hypertrophy, the most common complication of hypertension and a manifestation of cardiac end-organ damage. Hypothesis: SHS exposure is independently associated with LV mass. Methods: This analysis included 4,982 non-smoker participants (age 60.8±13.6 years, 57.8% women, 77.7% whites) from the Third National Health and Nutrition Examination (NHANES-III). Non-smoking was defined by self-report and serum cotinine ≤ 10 ng/dL, a biomarker for tobacco exposure. SHS was defined as serum cotinine level >1 ng/dL. LV mass was estimated using an electrocardiographic model developed and applied in NHANES-III then validated in the Cardiovascular Health Study. Multivariable linear regression was used to examine the cross-sectional association between SHS exposure (vs. no exposure) with estimated LV mass. In similar models, we also examined the associations of LV mass across quartiles of serum cotinine (reference group, 1 st quartile) and in subgroups stratified by race, sex, and hypertension status. Results: About 9.8% (n=489) of the participants were exposed to SHS. Exposure to SHS was associated with an estimated 2.9 gram increase in LV mass, with a dose-response relationship between higher serum cotinine and LV mass ( Table ). These results were consistent in men and women (interaction p-value= 0.31), whites and non-whites (interaction p-value= 0.21), and those with and without hypertension (interaction p-value= 0.88) Conclusion: In a racially diverse sample of non-smokers, SHS is associated with increased LV mass with a dose-response relationship between level of exposure and LV mass. These findings underscore the harmful effect of passive smoking on the cardiovascular system and highlight the need for more restrictions on smoking in public areas.

scholarly journals Setting-Specific and Symptom-Specific Association between Secondhand Smoke Exposure and Depressive Symptoms

2019 ◽  
Vol 16 (7) ◽  
pp. 1249
Author(s):  
Xiaohua Ye ◽  
Jingya Huang ◽  
Liang Xia ◽  
Xiaojun Xu ◽  
Xiao Gong ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Dose Response ◽  
Secondhand Smoke ◽  
Negative Binomial ◽  
Negative Binomial Regression ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Cross Sectional ◽  
Shs Exposure ◽  
The Impact

Few studies have focused on the potential relationship between secondhand smoke (SHS) exposure and depressive symptoms. This study aimed to explore the potential association between SHS exposure and depressive symptoms and differentiate this association in setting-specific exposure and symptom-specific outcomes. A cross-sectional study was conducted in Guangdong province of China from September to December 2010 using a multistage sampling method to randomly sample adults aged 18 years and older. SHS exposure was defined as inhalation by non-smokers of the smoke exhaled from smokers for at least 1 day a week in the past 30 days. Depressive symptoms were measured using the nine-item Patient Health Questionnaire. The zero-inflate negative binomial regression models were used to explore the associations between SHS exposure and depressive symptoms. A total of 2771 non-smokers were included in this study, with mean age of 49.6 ± 14.0 years and 70.3% of females. The prevalence of depressive symptoms was significantly higher in participants with SHS exposure than in those without exposure (incidence rate ratio (IRR) = 1.32, 95% confidence interval (CI) 1.16–1.51), and there were similar positive associations for SHS exposure in medical facilities (IRR = 1.37, 95% CI 1.17–1.61) and in schools (IRR = 1.46, 95% CI 1.20–1.77). Notably, there was a monotonically increasing dose-response relationship between frequency of SHS exposure and depressive symptoms. When differentiating this relationship by the dimensions of depressive symptoms, there were similar dose-response relationships for cognitive-affective and somatic symptoms. When differentiating this relationship by sex, only females showed a significant dose-response relationship. Our findings suggest dose-response relationships between SHS exposure and depressive symptoms in sex-specific and symptom-specific manners. Future longitudinal studies are needed to establish the biological mechanisms of the impact of SHS exposure.

Biomarker evaluation of Greek adolescents’ exposure to secondhand smoke

2009 ◽  
Vol 29 (6) ◽  
pp. 459-466 ◽  
Author(s):  
CI Vardavas ◽  
MN Tzatzarakis ◽  
M. Plada ◽  
AM Tsatsakis ◽  
A. Papadaki ◽  
...  
Keyword(s):  
Secondhand Smoke ◽  
Healthy Lifestyle ◽  
Gas Chromatography Mass Spectrometry ◽  
Serum Cotinine ◽  
Public Places ◽  
School Based ◽  
Shs Exposure ◽  
Almost All ◽  
Biomarker Evaluation ◽  
Exposure To Secondhand Smoke

Exposure to secondhand smoke (SHS) is a significant threat to public health, and represents a danger for both the development and health status of children and adolescents. Taking the above into account, our aim was to quantify Greek adolescents’ exposure to SHS using serum cotinine levels. During 2006, 341 adolescents aged 13-17 were randomly selected from high schools in Heraklion and agreed to participate as part of the European Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. Blood samples were drawn from a random sample of 106 adolescents, while serum cotinine/nicotine concentrations were measured by Gas Chromatography—Mass Spectrometry (GC-MS). The mean levels of serum cotinine and nicotine were calculated at 1.60 ± 2.18 ng/mL and 4.48 ± 4.00 ng/mL, respectively, while 97.7% of the non-smoker adolescents were found to have measureable levels of serum cotinine indicating exposure to SHS. The analysis revealed that their paternal (p = .001) and maternal smoking habits (p = .018) as also the existence of a younger brother or sister (p = .008) were the main modifiers of SHS exposure during adolescence. Conclusively, almost all of the measured Greek adolescents were exposed to SHS, even when their parents were non-smokers. This finding indicates the need for both community and school-based educational programmes as also the implementation of a comprehensive ban on smoking in public places.

scholarly journals Relationship Between Secondhand Smoke Exposure and Depressive Symptoms: A Systematic Review and Dose–Response Meta-Analysis

2019 ◽  
Vol 16 (8) ◽  
pp. 1356 ◽  
Author(s):  
Han ◽  
Liu ◽  
Gong ◽  
Ye ◽  
Zhou
Keyword(s):  
Depressive Symptoms ◽  
Dose Response ◽  
Secondhand Smoke ◽  
Meta Analysis ◽  
Random Effect ◽  
Continuous Variable ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Similar Dose ◽  
Shs Exposure

Previous studies have suggested an association between secondhand smoke (SHS) exposure and risk of depressive symptoms. However, it remains unclear whether there is a dose–response relationship. The effect estimates were pooled using fixed-effect or random-effect models based on homogeneity analysis. The dose–response meta-analysis was performed by linear and non-linear regression. Subgroup analyses were conducted to explore the possible sources of heterogeneity. Twenty-four studies were included in this meta-analysis. SHS exposure was significantly associated with increased odds of depressive symptoms (odds ratio (OR) = 1.32, 95% confidence interval (CI) 1.25–1.39). For SHS exposure expressed as an ordinal variable, the dose–response meta-analysis revealed a monotonically increasing relationship between SHS exposure and depressive symptoms. A similar dose–response relationship was observed for SHS exposure expressed as a continuous variable (OR = 1.57, 95% CI = 1.26–1.87). Our findings suggest that SHS exposure is associated with increasing odds of depressive symptoms in a dose–response manner.

Childhood Secondhand Smoke Exposure and Risk of Dementia in Adulthood

2021 ◽  
pp. 1-1
Author(s):  
T. Kawada
Keyword(s):  
Secondhand Smoke ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Follow Up Study ◽  
Hazard Ratios ◽  
Long Term Follow Up ◽  
Exposure To Secondhand Smoke ◽  
Subsequent Risk

I read the paper by Zhou et al. with great interest (1). The authors conducted a long-term follow-up study to investigate the associations between exposure to secondhand smoke and the subsequent risk of dementia, Alzheimer's disease (AD), and stroke (1). The adjusted hazard ratios (HRs; 95% confidence intervals [CIs]) of the highest exposure to secondhand smoke compared to individuals with no exposure for dementia, AD, and stroke were 2.86 (2.00–4.09), 3.13 (1.80–5.42), and 1.89 (1.37–2.61), respectively. In addition, a dose–response relationship was also observed in this study. I would like to present some information relevant to their study.

scholarly journals P353 Structural, functional, and electromechanical alterations in patients with paroxysmal atrial fibrillation compared to healthy controls

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
S Trivedi ◽  
L Stefani ◽  
P Brown ◽  
E Kizana ◽  
S Kumar ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Paroxysmal Atrial Fibrillation ◽  
Inverse Correlation ◽  
Left Ventricular ◽  
P Value ◽  
Healthy Controls ◽  
Systolic Volume ◽  
Mechanical Dispersion ◽  
Lv Mass ◽  
Echocardiographic Parameters

Abstract Background and Methods We sought to evaluate the clinical and echocardiographic differences between healthy controls and paroxysmal atrial fibrillation (AF) patients. Clinical and echocardiographic parameters (performed in sinus rhythm) in 46 paroxysmal AF patients were compared with a departmental database of 83 health controls. Results AF patients were older and had increased body size (Table 1). 39/46 (84%) of AF patients had hypertension and 23/46 (50%) had diabetes mellitus. AF patients had increased left ventricular (LV) mass, and reduced diastolic function (lower e’ and increased E/e’ ratio) when compared to healthy controls. Left atrial (LA) volumes were significantly increased in the AF group. All strain parameters – reservoir, conduit, and contractile strain – were impaired in AF patients compared to controls. LA mechanical dispersion (MD) was significantly increased in AF patients. A ratio of indexed LA volume/LA reservoir strain was significantly higher in AF patients over controls. The duration of AF had an inverse correlation with LA reservoir strain (Fig 1) (r=–0.78; p < 0.001). Conclusions Compared to healthy controls, patients with paroxysmal AF have significant structural, functional and electromechanical alterations. LA strain is significantly impaired in paroxysmal AF and correlates with AF duration. Table 1. Echocardiographic parameters Parameter Controls (mean ± SD) AF patients (mean ± SD) P value Age (years) 48 ± 18 58 ± 14 0.001 Body surface area (m2) 1.9 ± 0.2 2 ± 0.2 0.014 LV mass (g) 178 ± 48 223 ± 68 <0.001 Average e’ velocity (cms-1) 10.3 ±2.7 8.1 ± 2.2 <0.001 E/e’ 7.4 ± 1.9 9.3 ± 3.4 0.001 Indexed LA end systolic volume (ml/m2) 27.2 ± 7.1 39.0 ± 11.6 <0.001 LA ejection fraction 55.2 ± 10.4 48.5 ± 14.0 0.007 LA functional index 43.7 ± 14.6 29.8 ± 14.3 <0.001 LA reservoir strain (%) 34.3 ± 6.8 27.9± 8.1 <0.001 LA conduit strain (%) 18.4 ± 6.2 13.5 ± 4.7 <0.001 LA contractile strain (%) 15.9 ± 3.9 14.4 ± 5.5 0.007 LA mechanical dispersion (ms) 25.8 ± 9.6 30.9 ± 11.6 0.018 Indexed LA volume / Reservoir strain ratio 0.8 ± 0.3 1.6 ± 0.9 <0.001 LV = left ventricular; LA = left atrium; SD = standard deviation Abstract P353 Figure. Fig 1. AF duration vs. Reservoir strain

scholarly journals Exposure to Secondhand Smoke: Inconsistency between Self-Response and Urine Cotinine Biomarker Based on Korean National Data during 2009–2018

2021 ◽  
Vol 18 (17) ◽  
pp. 9284
Author(s):  
Boram Sim ◽  
Myung-Bae Park
Keyword(s):  
Secondhand Smoke ◽  
Vulnerable Groups ◽  
Exposure Rate ◽  
Short Term ◽  
The Past ◽  
Health And Nutrition ◽  
Urine Cotinine ◽  
Short Term Exposure ◽  
Shs Exposure ◽  
Exposure To Secondhand Smoke

This study aimed to estimate the secondhand smoke (SHS) exposure using urinary cotinine (UCo) to prove that the SHS exposure could not be properly assessed by self-reporting (SR). In total, 28,574 nonsmokers aged >19 years were selected from the Korean National Health and Nutrition Examination Survey data (2009–2018). First, changes in the annual concentration of UCo were analyzed, and the annual SHS exposure rates were measured based on SR and UCo from 2009 to 2018. Then, the average UCo concentration and UCo-measured SHS exposure rate were confirmed according to the subjects’ characteristics. Finally, factors associated with the UCo-measured SHS exposure rate were identified based on multiple regression analysis. The findings showed that the annual UCo concentrations and self-reported SHS exposure rates dropped significantly over the past decade. In contrast, the UCo-measured SHS exposure rate indicated that >80% of nonsmokers are still exposed to SHS. Moreover, we found vulnerable groups using UCo-measured SHS exposure rate. In particular, the self-reported SHS exposure at home and in workplaces and house type was highly associated with SHS exposure. Thus, these findings indicate that the actual SHS exposure could not be properly assessed by SR and should be verified using a biomarker, such as UCo. Considering that even a short-term exposure can be harmful to health, the goal of the policy should be to keep cotinine concentration as low as possible.

scholarly journals Estimation of lifetime cumulative mortality risk of lung cancer by smoking status in Japan

2020 ◽  
Vol 50 (10) ◽  
pp. 1218-1224
Author(s):  
Megumi Hori ◽  
Eiko Saito ◽  
Kota Katanoda ◽  
Shoichiro Tsugane
Keyword(s):  
Lung Cancer ◽  
Life Table ◽  
Mortality Risk ◽  
Secondhand Smoke ◽  
Smoking Status ◽  
Cumulative Risk ◽  
Cumulative Mortality ◽  
Shs Exposure ◽  
Estimated Risk ◽  
Exposure To Secondhand Smoke

Abstract The main objective of this study was to estimate the cumulative mortality risk for lung cancer according to smoking status and exposure to secondhand smoke (SHS) in Japan. We applied a life-table method to estimate the cumulative risk. Estimated lifetime cumulative risk for 20-year-old non-smokers, former, and current smokers was 3.2%, 7.6%, and 14.9% for men and 1.9%, 5.6%, and 7.2% for women, respectively. For males, the estimated risk was 3.2% for non-smokers not exposed to SHS and 4.1% for non-smokers exposed to SHS. For females, the estimated risk was 1.9% for non-smokers not exposed to SHS and 2.4% for non-smokers exposed to SHS. Lifetime cumulative mortality risk differed greatly according to smoking status. Moreover, SHS exposure resulted in observable differences in lifetime mortality risk. This study may be useful for the development of tailored prevention programs.

scholarly journals Is exposure to secondhand smoke associated with current depression (PHQ-8) among never-smokers? Results from a survey among German adults

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Fabian Erdsiek ◽  
Patrick Brzoska
Keyword(s):  
Secondhand Smoke ◽  
Logistic Regression Model ◽  
German Health ◽  
Potential Association ◽  
Prevalence Of Depression ◽  
Patient Health ◽  
Shs Exposure ◽  
Interaction Term ◽  
Never Smokers ◽  
Exposure To Secondhand Smoke

Abstract Background Findings on the association between exposure to secondhand smoke (SHS) and depression are contradictory. Comparability of existing research is limited due to varied methods and measures. This study examines the potential association between exposure to SHS and depression and a potential moderation by sex using representative data from Germany. Methods For our study, we used data from the German Health Update (GEDA) 2014/2015 on n = 10,274 never-smokers. We calculated a logistic regression model with an interaction term for potential sex-exposure interactions. We used the self-reported duration of exposure to predict current depression of any type as defined by the Patient Health Questionnaire PHQ-8 (score ≥ 10), accounting for a large number of confounders. Results In our sample, prevalence of depression was 8.8% in women and 5.3% in men. 90.4% were never or almost never exposed to SHS, while 7.1% were exposed < 1 h per day and around 2.5% reported being exposed for ≥1 h per day. While SHS exposure for < 1 h per day was not associated with current depression (OR = 1.54; 95%-CI: 0.93–1.61), SHS exposure for at least 1 h per day was associated with increased odds for current depression (OR = 1.59; 95%-CI: 1.08–2.35). No sex-specific differences were found. Conclusions Higher levels of SHS exposure are associated with current depression, although the nature and direction of the association are still unclear. We identified no differences in the association between men and women. More studies, particularly using longitudinal data, are needed to determine the nature of the association.

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