Abstract 15796: The Inverse Correlation Between Lifetime Occupational Radiation Exposure Duration and Prevalence of Atrial Arrhythmia

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Rithika Thirumal ◽  
Catherine Vanchiere ◽  
Ruchi Bhandari ◽  
Sania Jiwani ◽  
Ronald Horswell ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Radiation Exposure ◽  
Large Scale ◽  
Inverse Correlation ◽  
Cardiovascular Complications ◽  
Occupational Radiation Exposure ◽  
Electronic Survey ◽  
Increased Risk ◽  
Traditional Risk Factors ◽  
Occupational Radiation

Introduction: Fluoroscopy assisted procedures have increased occupational radiation exposure among Cardiologists. Radiation has been linked to cardiovascular complications but its effects on cardiac rhythm has not been extensively explored. Hypothesis: We hypothesized that radiation exposure is associated with increased risk of atrial arrhythmias (AA) despite appropriate leaded body coverage. Methods: Demographic, social, occupational, and medical history was collected from board-certified cardiologists via an electronic survey. Bivariate and multivariable logistic regression analyses were performed. Results: We received 1478 responses from cardiologists; 85.4% were males, 79% were White and 66.1% were ≤65 yrs of age. 35.6% of respondents were interventional cardiologists and 16.4% were electrophysiologists, and of those, 92.2% wore lead apparel during all times of radiation exposure. Cardiologists >50 yrs of age, with >10,000 hours of occupational radiation exposure, had a significantly lower prevalence of AA compared to those with ≤10,000 hours of radiation exposure (11.1% vs 16.7%, p =0.019). A multivariate logistic regression was performed and among cardiologists >50 years of age, exposure to >10,000 radiation hours was significantly associated with lower likelihood of AA, after adjusting for age, sex, DM, HTN and OSA (adjusted OR 0.57; 95% CI 0.38 - 0.85, p =0.007). Traditional risk factors such as age, sex, HTN, DM and OSA were more prevalent in those with AA and cataracts, a well-established complication of radiation exposure in cardiologists, was more prevalent in those exposed to >10,000 radiation hours compared to those exposed to ≤10,000 radiation hours, validating the dependent (AA) and independent variables (radiation exposure), respectively. Conclusions: Radiation exposure in Cardiologists with appropriate lead apparel is inversely related to AA. Large scale prospective studies are needed to validate our findings.

scholarly journals Analysis of lncRNA and mRNA Transcriptomes Expression in Thyroid Cancer Tissues Among Patients With Exposure of Medical Occupational Radiation

Dose-Response ◽  
2019 ◽  
Vol 17 (3) ◽  
pp. 155932581986422 ◽  
Author(s):  
Feng Shi ◽  
Ying Liu ◽  
Min Li ◽  
Peng Wen ◽  
Qiu Qin Qian ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Radiation Exposure ◽  
Messenger Rna ◽  
Cancer Biology ◽  
Differentially Expressed ◽  
Occupational Radiation Exposure ◽  
Lncrna Expression ◽  
Increased Risk ◽  
Cancer Tissues ◽  
Occupational Radiation

Background: Occupational exposure of radiation among medical radiation workers contributes to the subsequent increased risk of thyroid cancer. Long noncoding RNAs (lncRNAs) are emerging as important regulators of cancer biology. However, little is known about lncRNA expression in thyroid cancer tissues from patients who are exposed to medical occupational radiation. The purpose of this study is to reveal the transcriptomes difference between thyroid cancer tissues and adjacent nonneoplastic thyroid tissues. Methods: Microarray technology was used in this study. Quantitative reverse transcription polymerase chain reaction was adopted to verify 6 differentially expressed lncRNAs. Gene ontology and pathway analyses were performed using standard enrichment computational methods. Potential target genes of the differentially expressed lncRNAs were predicted with 2 independent algorithms. Results: A total of 23 lncRNA and messenger RNA transcripts were found differentially expressed in the thyroid cancer tissues (fold change ≥2.0, P < .05). This differential lncRNA expression may affect many pathways, including those involved in cysteine and methionine metabolism, Huntington disease, propanoate metabolism, and carcinogenesis. Conclusions: Our study provides a transcriptome-wide screening and analysis of the lncRNA expression profile in thyroid cancer tissues from patients with medical occupational radiation exposure and lays the foundation for further investigation of lncRNAs related to thyroid cancer development and carcinogenic risk of medical occupational radiation exposure.

scholarly journals Non-Hodgkin lymphoma and occupational radiation exposure assessed using local data

2009 ◽  
Vol 59 (6) ◽  
pp. 437-439 ◽  
Author(s):  
K. K. Karipidis ◽  
G. Benke ◽  
M. R. Sim ◽  
L. Fritschi ◽  
C. Vajdic ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Hodgkin Lymphoma ◽  
Local Data ◽  
Occupational Radiation Exposure ◽  
Non Hodgkin Lymphoma ◽  
Occupational Radiation

scholarly journals Occupational Radiation Exposure During Endovascular Aortic Procedures

2013 ◽  
Vol 46 (4) ◽  
pp. 424-430 ◽  
Author(s):  
A.P. Patel ◽  
D. Gallacher ◽  
R. Dourado ◽  
O. Lyons ◽  
A. Smith ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Occupational Radiation Exposure ◽  
Occupational Radiation

scholarly journals Comparative occupational radiation exposure between fixed and mobile imaging systems

2016 ◽  
Vol 63 (1) ◽  
pp. 190-197 ◽  
Author(s):  
Daniel E. Kendrick ◽  
Claire P. Miller ◽  
Pamela A. Moorehead ◽  
Ann H. Kim ◽  
Henry R. Baele ◽  
...  
Keyword(s):  
Radiation Exposure ◽  
Imaging Systems ◽  
Occupational Radiation Exposure ◽  
Mobile Imaging ◽  
Occupational Radiation

Impact of considering non-occupational radiation exposure on the association between occupational dose and solid cancer among French nuclear workers

2017 ◽  
Vol 75 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Lucie Fournier ◽  
Enora Cléro ◽  
Eric Samson ◽  
Sylvaine Caër-Lorho ◽  
Dominique Laurier ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Cancer Risk ◽  
Radiation Exposure ◽  
Cancer Mortality ◽  
Environmental Radiation ◽  
Occupational Radiation Exposure ◽  
X Ray ◽  
Work Related ◽  
The Mean ◽  
Occupational Radiation

ObjectivesThe French nuclear worker cohort allows for the assessment of cancer risk associated with occupational radiation exposure, but workers are also exposed to medical and environmental radiation which can be of the same order of magnitude. This study aims to examine the impact of non-occupational radiation exposures on the dose-risk analysis between occupational radiation exposure and cancer mortality.MethodsThe cohort included workers employed before 1995 for at least one year by CEA, AREVA NC or EDF and badge-monitored for external radiation exposure. Monitoring results were used to calculate occupational individual doses. Scenarios of work-related X-ray and environmental exposures were simulated. Poisson regression was used to quantify associations between occupational exposure and cancer mortality adjusting for non-occupational radiation exposure.ResultsThe mean cumulative dose of external occupational radiation was 18.4 mSv among 59 004 workers. Depending on the hypotheses made, the mean cumulative work-related X-ray dose varied between 3.1 and 9.2 mSv and the mean cumulative environmental dose was around 130 mSv. The unadjusted excess relative rate of cancer per Sievert (ERR/Sv) was 0.34 (90% CI −0.44 to 1.24). Adjusting for environmental radiation exposure did not substantially modify this risk coefficient, but it was attenuated by medical exposure (ERR/Sv point estimate between 0.15 and 0.23).ConclusionsOccupational radiation risk estimates were lower when adjusted for work-related X-ray exposures. Environmental exposures had a very slight impact on the occupational exposure risk estimates. In any scenario of non-occupational exposure considered, a positive but insignificant excess cancer risk associated with occupational exposure was observed.

scholarly journals Assessing the health effects associated with occupational radiation exposure in Korean radiation workers: protocol for a prospective cohort study

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e017359 ◽  
Author(s):  
Songwon Seo ◽  
Wan Young Lim ◽  
Dal Nim Lee ◽  
Jung Un Kim ◽  
Eun Shil Cha ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Risk ◽  
Radiation Exposure ◽  
Health Effects ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Low Dose ◽  
Occupational Radiation Exposure ◽  
Radiation Workers ◽  
Occupational Radiation

IntroductionThe cancer risk of radiation exposure in the moderate-to-high dose range has been well established. However, the risk remains unclear at low-dose ranges with protracted low-dose rate exposure, which is typical of occupational exposure. Several epidemiological studies of Korean radiation workers have been conducted, but the data were analysed retrospectively in most cases. Moreover, groups with relatively high exposure, such as industrial radiographers, have been neglected. Therefore, we have launched a prospective cohort study of all Korean radiation workers to assess the health effects associated with occupational radiation exposure.Methods and analysisApproximately 42 000 Korean radiation workers registered with the Nuclear Safety and Security Commission from 2016 to 2017 are the initial target population of this study. Cohort participants are to be enrolled through a nationwide self-administered questionnaire survey between 24 May 2016 and 30 June 2017. As of 31 March 2017, 22 982 workers are enrolled in the study corresponding to a response rate of 75%. This enrolment will be continued at 5-year intervals to update information on existing study participants and recruit newly hired workers. Survey data will be linked with the national dose registry, the national cancer registry, the national vital statistics registry and national health insurance data via personal identification numbers. Age-specific and sex-specific standardised incidence and mortality ratios will be calculated for overall comparisons of cancer risk. For dose–response assessment, excess relative risk (per Gy) and excess absolute risk (per Gy) will be estimated with adjustments for birth year and potential confounders, such as lifestyle factors and socioeconomic status.Ethics and disseminationThis study has received ethical approval from the institutional review board of the Korea Institute of Radiological and Medical Sciences (IRB No. K-1603-002-034). All participants provided written informed consent prior to enrolment. The findings of the study will be disseminated through scientific peer-reviewed journals and be provided to the public, including radiation workers, via the study website (http://www.rhs.kr/) and onsite radiation safety education.

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