Soft Drink Consumption and Risk of Developing Cardiometabolic Risk Factors and the Metabolic Syndrome in Middle-Aged Adults in the Community

This cross-sectional study aimed to examine the association of basal metabolic rate (BMR) and basal fat and carbohydrate oxidation (BFox and BCHox, respectively) with cardiometabolic risk factors and insulin sensitivity in sedentary middle-aged adults. A total of 71 healthy sedentary adults (37 women) aged 40–65 years participated in the current study. Data were collected during the baseline assessments of the FIT-AGEING randomized controlled trial. BMR was measured via indirect calorimetry, and BFox and BCHox estimated by stoichiometric equations. Blood pressure, glucose, insulin, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides plasma levels were selected as cardiometabolic risk factors and assessed following standard procedures. We observed positive associations of BMR with plasma insulin and the homeostatic model assessment of insulin resistance index (HOMA; all p < 0.05) which were attenuated or disappeared after controlling by sex, age, and/or lean mass. There were positive associations between BFox and the quantitative insulin sensitivity check index (QUICKI; p < 0.015), while negative associations were noted between BFox and plasma insulin and HOMA (p < 0.015). There was a significant negative association between BCHox with QUICKI (p < 0.01), whereas significant positive relationships were obtained when BCHox was associated with plasma insulin and HOMA (p < 0.01). These associations persisted in almost all cases when controlling by sex, age and/or lean mass. No further relationships were found when BMR, BFox, and BCHox were associated with other cardiometabolic risk factors. In conclusion, our study findings support that greater BFox and lower BCHox are related to improved insulin sensitivity, whereas BMR seems to be not associated with neither cardiometabolic risk nor insulin sensitivity in sedentary middle-aged adults. Further intervention studies are necessary to well-understand the physiological mechanism implied in this relationship.

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Serum Uric Acid Levels are Associated with Cardiometabolic Risk Factors in Healthy Young and Middle-Aged Adults

Arquivos Brasileiros de Cardiologia ◽

10.5935/abc.20180197 ◽

2018 ◽

Cited By ~ 5

Author(s):

Thaís da Silva Ferreira ◽

Julia Freitas Rodrigues Fernandes ◽

Luciene da Silva Araújo ◽

Lívia de Paula Nogueira ◽

Priscila Mansur Leal ◽

...

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Serum Uric Acid ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

Middle Aged ◽

Middle Aged Adults

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Irregularity of energy intake at meals: prospective associations with the metabolic syndrome in adults of the 1946 British birth cohort

British Journal Of Nutrition ◽

10.1017/s0007114515004407 ◽

2015 ◽

Vol 115 (2) ◽

pp. 315-323 ◽

Cited By ~ 8

Author(s):

Gerda K. Pot ◽

Rebecca Hardy ◽

Alison M. Stephen

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Energy Intake ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

Logistic Regression Models ◽

The Metabolic Syndrome ◽

Increased Risk ◽

Health And Development

AbstractIrregularity in eating patterns could be a potential cardiometabolic risk factor. We aimed to study the associations of irregular intake of energy at meals in relation to cardiometabolic risk factors 10 and 17 years later. Variability of energy intake data – derived from 5-d estimated diet diaries of cohort members of the National Survey for Health and Development collected at ages 36 (n1416), 43 (n1505) and 53 years (n1381) – was used as a measure for irregularity. Associations between meal irregularity scores with cardiometabolic risk factors measured 10 and 17 years later were investigated using linear mixed models and logistic regression models. The results showed that irregularity scores changed significantly over the years (P<0·05). At age 36 years, subjects with a more irregular intake of energy at lunch (OR 1·42; 95 % CI 1·05, 1·91) and between meals (OR 1·35; 95 % CI 1·01, 1·82) had an increased risk for the metabolic syndrome 17 years later; at lunch was also associated with an increased waist circumference (OR 1·58; 95 % 1·27, 1·96) and TAG levels (OR 1·33; 95 % CI 1·02, 1·72). At age 43 years, subjects with a more irregular intake at breakfast had an increased risk of the metabolic syndrome 10 years later (OR 1·53; 95 % CI 1·15, 2·04), as well as an increased BMI (OR 1·66; 95 % CI 1·31, 2·10), waist circumference (OR 1·53; 95 % CI 1·23, 1·90) and diastolic blood pressure (OR 1·42; 95 % CI 1·13, 1·78). In conclusion, subjects with a more irregular intake of energy, mostly at breakfast and lunch, appeared to have an increased cardiometabolic risk 10 and 17 years later.

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Abstract: P1304 THE RELEVANCE OF CARDIOMETABOLIC RISK FACTORS AS PREDICTORS OF THE METABOLIC SYNDROME

Atherosclerosis Supplements ◽

10.1016/s1567-5688(09)71321-2 ◽

2009 ◽

Vol 10 (2) ◽

pp. e1360

Author(s):

P Lindqvist ◽

V Sundh ◽

C Björkelund ◽

C Bengtsson

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

The Metabolic Syndrome

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Myokine–adipokine cross-talk: potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-019-0458-2 ◽

2019 ◽

Vol 11 (1) ◽

Cited By ~ 10

Author(s):

Adrian M. Gonzalez-Gil ◽

Mariana Peschard-Franco ◽

Elena C. Castillo ◽

Gustavo Gutierrez-DelBosque ◽

Victor Treviño ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Cross Talk ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

Mexican Children ◽

The Metabolic Syndrome

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A Unique Rodent Model of Cardiometabolic Risk Associated with the Metabolic Syndrome and Polycystic Ovary Syndrome

Endocrinology ◽

10.1210/en.2008-1612 ◽

2009 ◽

Vol 150 (9) ◽

pp. 4425-4436 ◽

Cited By ~ 33

Author(s):

Danni Shi ◽

Michael K. Dyck ◽

Richard R. E. Uwiera ◽

Jim C. Russell ◽

Spencer D. Proctor ◽

...

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Cardiometabolic Risk ◽

Polycystic Ovary ◽

Serum Testosterone ◽

Cardiometabolic Risk Factors ◽

Ovary Syndrome ◽

The Metabolic Syndrome ◽

Ovarian Morphology

Abstract Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-/anovulation, and polycystic ovarian morphology and is a complex endocrine disorder that also presents with features of the metabolic syndrome, including obesity, insulin resistance, and dyslipidemia. These latter symptoms form cardiometabolic risk factors predisposing individuals to the development of type 2 diabetes and cardiovascular disease (CVD). To date, animal models to study PCOS in the context of the metabolic syndrome and CVD risk have been lacking. The aim of this study was to investigate the JCR:LA-cp rodent as an animal model of PCOS associated with the metabolic syndrome. Metabolic indices were measured at 6 and 12 wk, and reproductive parameters including ovarian morphology and estrous cyclicity were assessed at 12 wk or adulthood. At 6 wk of age, the cp/cp genotype of the JCR:LA-cp strain developed visceral obesity, insulin resistance, and dyslipidemia (hypertriglyceridemia and hypercholesterolemia) compared with control animals. Serum testosterone concentrations were not significantly different between groups at 6 wk of age. However, at 12 wk, the cp/cp genotype had higher serum testosterone concentrations, compared with control animals, and presented with oligoovulation, a decreased number of corpora lutea, and an increased number of total follicles, in particular atretic and cystic follicles. The cardiometabolic risk factors in the cp/cp animals were exacerbated at 12 wk including obesity, insulin resistance, and dyslipidemia. The results of this study demonstrate that the JCR:LA-cp rodent may be a useful PCOS-like model to study early mechanisms involved in the etiology of cardiometabolic risk factors in the context of both PCOS and the metabolic syndrome.

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Associations Between CYP17A1 and SERPINA6/A1 Polymorphisms, and Cardiometabolic Risk Factors in Black South Africans

Frontiers in Genetics ◽

10.3389/fgene.2021.687335 ◽

2021 ◽

Vol 12 ◽

Author(s):

Siphiwe N. Dlamini ◽

Ananyo Choudhury ◽

Michèle Ramsay ◽

Lisa K. Micklesfield ◽

Shane A. Norris ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

South African ◽

Multiple Testing ◽

Cardiometabolic Risk ◽

Cardiometabolic Risk Factors ◽

Genetic Associations ◽

South Africans ◽

Black South African ◽

The Metabolic Syndrome

Research in European and Asian populations has reported associations between single nucleotide polymorphisms (SNPs) in CYP17A1 and SERPINA6/A1 and circulating glucocorticoid concentrations, and some key cardiometabolic risk factors. This study aimed to investigate these associations in black South African adults, who are disproportionally affected by the metabolic syndrome and its related cardiometabolic risk factors. The dataset included black South African adults (n = 4,431; 56.7% women) from the AWI-Gen study, genotyped on the H3A genotyping array and imputed using the African reference panel at the Sanger imputation service. From the imputed data, 31 CYP17A1 SNPs and 550 SERPINA6/A1 SNPs were extracted. The metabolic syndrome and its components were defined using the 2009 harmonized guidelines. Serum glucocorticoid concentrations were measured in a subset of 304 men and 573 women, using a liquid chromatography-mass spectrometry method. Genetic associations were detected using PLINK. Bonferroni correction was used to control for multiple testing. A SNP at SERPINA6/A1, rs17090691 (effect allele G), was associated with higher diastolic blood pressure (BP) in all adults combined (p = 9.47 × 10−6). Sex-stratified analyses demonstrated an association between rs1051052 (effect allele G), another SERPINA6/A1 SNP, and higher high-density lipoprotein (HDL) cholesterol concentrations in women (p = 1.23 × 10−5). No association was observed between these variants and glucocorticoids or between any of the CYP17A1 SNPs and metabolic outcomes after adjusting for multiple testing. Furthermore, there were no associations between any of the SNPs tested and the metabolic syndrome. This study reports novel genetic associations between two SNPs at SERPINA6/A1 and key cardiometabolic risk factors in black South Africans. Future replication and functional studies in larger populations are required to confirm the role of the identified SNPs in the metabolic syndrome and assess if these associations are mediated by circulating glucocorticoids.

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