Abstract P232: Psoriasis is Associated with Increased Arterial Stiffness: a Systematic Review and Meta-analysis

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Sikarin Upala ◽  
Anawin Sanguankeo
Keyword(s):  
Systematic Review ◽  
Arterial Stiffness ◽  
Observational Studies ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Aortic Pulse Wave Velocity ◽  
P Value ◽  
Original Research ◽  
Cvd Risk ◽  
Non Invasive

Background: Studies have shown that patients with psoriasis have higher risk of CVD, independent of traditional CVD risk factors. However, pathophysiology of the development of CVD in psoriasis is not well known. Arterial stiffness has been recognized as an independent predictor of cardiovascular risk. It is controversial whether psoriasis and arterial stiffness is associated. In this systematic review and meta-analysis, we sought to assess the hypothesis that patients with psoriasis have increased arterial stiffness compared with controls. Methods: Systematic literature search was performed using MEDLINE and EMBASE databases from inception to May 2016. We included original research publications that contained data on arterial stiffness and psoriasis. Aortic pulse wave velocity (aPWV) is the non-invasive marker for assessment of arterial stiffness. We compared aPWV between patients with psoriasis and controls and estimated the pooled mean difference (MD) and 95% confidence interval (CI) of aPWV using a random-effects model meta-analysis. Results: Data from five observational studies involving 438 participants (233 with psoriasis) were extracted and included in the meta-analysis. Pooled MD of aPWV was 1.17 m/sec higher in patients with psoriasis compared with controls (95% CI: 0.78-1.55, P-value<0.01, I 2 = 69%). There is no change in the direction or statistical significance of MD of aPWV after removing each study at a time in the sensitivity analysis. Conclusion: Psoriasis is associated with increased arterial stiffness. Assessment of arterial stiffness parameters may be important for early detection of cardiovascular deterioration in psoriasis patients.

scholarly journals Determinants of Perinatal birth Asphyxia among Newborns in Ethiopia: A Systematic Review and Meta-analysis of Observational Studies Protocol

2020 ◽  
Author(s):  
Abay Woday ◽  
Muluken Dessalegn ◽  
Setognal Birara ◽  
Kusse Urmale ◽  
Gebeyaw Biset ◽  
...  
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Associated Factors ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Birth Asphyxia ◽  
Cochrane Library ◽  
P Value ◽  
African Countries ◽  
Significance Level

Abstract Background: Birth asphyxia among newborns accounted for nearly fifty percent of neonatal mortality in sub-Saharan African countries. This scenario has been worst in Ethiopia where every two out of three deaths attributed to birth asphyxia among these babies. Moreover, studies conducted in Ethiopia are highly variable and inconclusive to estimate the pooled prevalence and risk factors of birth asphyxia. Objective: This study aims to analyses collectively and systematically the prevalence of birth asphyxia and associated factors among newborns in Ethiopia.Methods: The protocol for this review is registered at PROSPERO with registration number CRD42020158224. A comprehensive online databases (PubMed, HINARI, Scopus, EMBASE, Science direct, and Cochrane library database), Google Scholar, African Journals online, other gray and online repository accessed studies will be searched using different search engines. In addition, maternity & infant care databases uploaded at Ethiopian Health Development Journal and Ethiopian Journal of Health Sciences will be searched until June 30, 2020. Newcastle-Ottawa Quality Assessment Scale (NOS) will be used for critical appraisal of studies.. Three reviewers will screen all retrieved articles, conduct data extraction, and then critically appraise all identified studies. All identified observational studies reporting the prevalence of birth asphyxia and associated factors among neonates in Ethiopia will be considered. The analysis of data will be done using STATA 11.0 statistical software. We will demonstrate pooled estimates and determinants of birth asphyxia with effect size and 95% confidence interval. Heterogeneity among the included studies will be assessed through the Cochrane Q-test statistics and I2 test. Publication bias will be checked using funnel plot and egger’s test. Finally, statistical significance level will be declared at a p-value of less than 0.05. Discussion: the result from this systematic review will inform and guide health policy planners to invest limited resources on maternal and neonatal health. Furthermore, it will be a stimulus for future cumulative meta-analysis researchers in developing nations.

Abstract P269: Cardio-Ankle Vascular Index and the Risk of Cardiovascular Outcomes and All-cause Mortality: A Systematic Review

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Kunihiro Matsushita ◽  
Ning Ding ◽  
Esther Kim
Keyword(s):  
Systematic Review ◽  
Arterial Stiffness ◽  
Cohort Studies ◽  
Statistical Significance ◽  
Risk Of Bias ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Stiffness Evaluation ◽  
All Cause Mortality ◽  
Cross Sectional Studies

Introduction: Arterial stiffness is widely used as an index of arteriosclerosis and is associated with cardiovascular disease (CVD). Recently, cardio-ankle vascular index (CAVI) was developed as a measurement of arterial stiffness that is independent of blood pressure at the time of arterial stiffness evaluation. The associations of CAVI with CVD events and all-cause mortality have not been extensively assessed. We therefore systematically reviewed the studies reporting CAVI and relevant outcomes. Methods: We searched for both prospective and cross-sectional studies using MEDLINE, Embase, and Cochrane from inception to April 11, 2017. Two independent reviewers screened the retrieved papers, extracted relevant data and assessed the risk of bias. Any discrepancy was solved by discussion or a third reviewer. Heterogeneity among studies was assessed using the I 2 statistic. We pooled the results of studies that were sufficiently homogeneous. Results: Among 1,519 records, we identified 9 cohort studies (n=5,292) and 17 cross-sectional eligible studies (n=7,309). All 9 cohort studies reported the outcome of composited CVD (498 cases), but the categorization/modeling of CAVI was not consistent across those studies. The pooled hazard ratio (HR) of CVD for the highest vs. lowest CAVI category in 3 studies was borderline significant (pooled HR=1.34 [0.95, 1.87], p=0.092) (I 2 = 25.2%, p=0.263). For 3 studies examining the continuous association between CAVI and CVD, 1standard deviation (SD) increment of CAVI was significantly associated with CVD risk (pooled HR=1.22 [1.03, 1.45], p=0.023) (I 2 = 27.1%, p=0.253). Only 3 cohort studies investigated CAVI and all-cause mortality, and none of them reported a significant association. All 17 cross-sectional studies reported higher CAVI values in patients with CVD compared to those without CVD, with statistical significance in most studies. Conclusions: CAVI was generally higher in patients with CVD compared to their counterparts. In terms of the prospective prognostic value of CAVI, we found a limited number of studies, but they indicated a modest association between CAVI and CVD risk. Our systematic review highlighted the need for large prospective studies to assess the usefulness of CAVI as a predictor of CVD and mortality.

Relationship between circulating leptin levels and arterial stiffness: a systematic review and meta-analysis of observational studies

2020 ◽  
Vol 27 (6) ◽  
pp. 505-513
Author(s):  
Lanfranco D’Elia ◽  
Alfonso Giaquinto ◽  
Francesca De Luca ◽  
Pasquale Strazzullo ◽  
Ferruccio Galletti
Keyword(s):  
Systematic Review ◽  
Arterial Stiffness ◽  
Observational Studies ◽  
Meta Analysis

scholarly journals Evidence on the effect of gender of newborn, antenatal care and postnatal care on breastfeeding practices in Ethiopia: a meta-analysis andmeta-regression analysis of observational studies

BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e023956 ◽  
Author(s):  
Tesfa Dejenie Habtewold ◽  
Nigussie Tadesse Sharew ◽  
Sisay Mulugeta Alemu
Keyword(s):  
Systematic Review ◽  
Regression Analysis ◽  
Antenatal Care ◽  
Breast Feeding ◽  
Postnatal Care ◽  
Observational Studies ◽  
Meta Analysis ◽  
P Value ◽  
Timely Initiation ◽  
Breastfeeding Practices

ObjectivesThe aim of this systematic review and meta-analysis was to investigate the association of gender of newborn, antenatal care (ANC) and postnatal care (PNC) with timely initiation of breast feeding (TIBF) and exclusive breastfeeding (EBF) practices in Ethiopia.DesignSystematic review and meta-analysis.Data sourcesTo retrieve all available literature, PubMed, EMBASE, CINAHL, WHO Global Health Library, Web of Science and SCOPUS databases were systematically searched and complemented by manual searches. The search was done from August 2017 to September 2018.Eligibility criteriaAll observational studies including cross-sectional, case-control, cohort studies conducted in Ethiopia from 2000 to 2018 were included. Newcastle-Ottawa Scale was used for quality assessment of included studies.Data extraction and synthesisStudy area, design, population, number of mothers (calculated sample size and participated in the study) and observed frequency data were extracted using Joanna Briggs Institute tool. To obtain the pooled effect size, a meta-analysis using weighted inverse variance random-effects model was performed. Cochran’s Q X2test, τ2and I2statistics were used to test heterogeneity, estimate amount of total/residual heterogeneity and measure variability attributed to heterogeneity, respectively. Mixed-effects meta-regression analysis was done to identify possible sources of heterogeneity. Egger’s regression test at p value threshold ≤0.01 was used to examine publication bias. Furthermore, the trend of evidence over time was examined by performing a cumulative meta-analysis.ResultsOf 523 articles retrieved, 17 studies (n=26 146 mothers) on TIBF and 24 studies (n=17 819 mothers) on EBF were included in the final analysis. ANC (OR=2.24, 95% CI 1.65 to 3.04, p<0.001, I2=90.9%), PNC (OR=1.86, 95% CI 1.41 to 2.47, p<0.001, I2=63.4%) and gender of newborn (OR=1.31, 95% CI 1.01 to 1.68, p=0.04, I2=81.7%) significantly associated with EBF. ANC (OR=1.70, 95% CI 1.10 to 2.65, p=0.02, I2=93.1%) was also significantly associated with TIBF but not with gender of newborn (OR=1.02, 95% CI 0.86 to 1.21, p=0.82, I2=66.2%).ConclusionsIn line with our hypothesis, gender of newborn, ANC and PNC were significantly associated with EBF. Likewise, ANC was significantly associated with TIBF. Optimal care during pregnancy and after birth is important to ensure adequate breast feeding. This meta-analysis study provided up-to-date evidence on breastfeeding practices and its associated factors, which could be useful for breastfeeding improvement initiative in Ethiopia and cross-country and cross-cultural comparison.Trial registration numberCRD42017056768

Helmet non-invasive ventilation compared to facemask non-invasive ventilation and high flow nasal cannula in acute respiratory failure: a systematic review and meta-analysis

2021 ◽  
pp. 2101269
Author(s):  
Dipayan Chaudhuri ◽  
Rehman Jinah ◽  
Karen E.A. Burns ◽  
Federico Angriman ◽  
Bruno Ferreyro ◽  
...  
Keyword(s):  
Systematic Review ◽  
Respiratory Failure ◽  
Observational Studies ◽  
Meta Analysis ◽  
High Flow ◽  
Invasive Ventilation ◽  
High Flow Nasal Cannula ◽  
Non Invasive ◽  
Icu Length Of Stay ◽  
Non Invasive Ventilation

BackgroundAlthough small randomised controlled trials (RCTs) and observational studies have examined helmet non-invasive ventilation (NIV), uncertainty remains regarding its role. We conducted a systematic review and meta-analysis to examine the effect of helmet NIV compared to facemask NIV or high flow nasal cannula (HFNC) in acute respiratory failure.MethodsWe searched multiple databases to identify RCTs and observational studies reporting on at least one of mortality, intubation, ICU length of stay, NIV duration, complications, or comfort with NIV therapy. We assessed study risk of bias (ROB) using the Cochrane ROB tool for RCTs and the Ottawa-Newcastle scale for observational studies and rated certainty of pooled evidence using GRADE.ResultsWe separately pooled data from 16 RCTs (n=949) and 8 observational studies (n=396). Compared to facemask NIV, based on low certainty evidence, helmet NIV may reduce mortality (relative risk (RR) 0.56, 95% confidence interval (CI) (0.33 to 0.95)), and intubation (RR 0.35, 95% CI (0.22 to 0.56)) in both hypoxic and hypercapnic respiratory failure but may have no effect on duration of NIV. There was an uncertain effect of helmet on ICU length of stay and development of pressure sores. Data from observational studies was consistent with the foregoing findings but of lower certainty. Based on low and very low certainty data, helmet NIV may reduce intubation compared to HFNC, but its effect on mortality is uncertain.ConclusionCompared to facemask NIV, helmet NIV may reduce mortality and intubation; however, the effect of helmet compared to HFNC remains uncertain.

scholarly journals A systematic review and meta-analysis protocol of observational studies to assess the association between sleep and mental resilience in healthy individuals

2020 ◽  
Author(s):  
Teresa Arora ◽  
Asma Alamoodi ◽  
Ian Grey ◽  
Linda Östlundh ◽  
Omar M. Omar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sleep Quality ◽  
Sleep Duration ◽  
Observational Studies ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Original Research ◽  
Psychological Resilience ◽  
Healthy Children ◽  
Mental Resilience

Abstract Background: Mental resilience has emerged as a recent focus within the context of positive psychology. Resilience is a potentially modifiable construct. Some preliminary evidence from experimental studies as well as clinical populations has indicated that sleep may be related to mental resilience, but little is known about this relationship in healthy populations. Sleep is a complex with multi-factorial outcome, although the majority of research effort has focused on sleep duration and sleep quality. Our systematic review and meta-analysis will identify original research data from observational studies to assess if sleep duration and/or sleep quality is associated with levels of psychological resilience amongst healthy children, adolescents and adults. We hypothesize that there will be a positive association between sleep duration/quality and mental resilience across all age groups. Methods: A comprehensive, systematic search for literature will be conducted in June 2020 (LÖ), covering a total of eight academic databases (PubMed, Embase, PsycInfo, PsycArticles, CINAHL, Scopus, Web of Science and Academic Search Complete). Sources for grey materials will also be included and experts in the field will also be contacted for inclusion of unpublished data. PubMed and PubMed’s MeSH terms were used to develop the search strategy and systematically identify relevant search terms. Two authors (IG & AA) will screen the articles independently, and a third researcher (TA) will resolve discrepancies. The primary outcome is mental/psychological resilience. The systematic review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Discussion: The results of our systematic review and meta-analysis are intended to be published in an appropriate scientific peer-reviewed journal and will be made publicly available. The findings from our project are envisioned to inform and educate the public as well as healthcare and education systems, globally. Our systematic review protocol has been peer-reviewed and is currently registered in the international database, PROSPERO.Systematic review registration: CRD42020191119 (submitted on 2 July 2020).

scholarly journals Effectiveness of COVID-19 Vaccines and Post-vaccination SARS-COV 2 Infection, Hospitalization, and Mortality: a Systematic Review and Meta-analysis of Observational Studies

2021 ◽  
Author(s):  
Kazem Rahmani ◽  
Rasoul Shavaleh ◽  
Mahtab Forouhi ◽  
Hamideh Feiz Disfani ◽  
Mostafa Kamandi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Booster Dose ◽  
Meta Analysis ◽  
The Other ◽  
P Value ◽  
Post Vaccination ◽  
Analysis Study ◽  
Dose Injection ◽  
Related Mortality

Introduction & Objective: Vaccination is one of the most important and effective ways of preventing infectious diseases, and has recently been used in the COVID-19 epidemic and pandemic. The present meta-analysis study aimed to evaluate the effectiveness of COVID-19 vaccines in reducing the incidence of infection, hospitalization, and mortality in observational studies. Materials and Methods: A systematic search was performed independently in Scopus, PubMed, ProQuest, and Google Scholar electronic databases as well as Preprint servers using the keywords under study. The heterogeneity of the studies was assessed using I2 and χ2 statistics, according to which the I2 of > 50% and P-value <0.1 was reported as heterogeneity of the studies. In addition, the Pooled Vaccine Effectiveness (PVE) obtained from the studies was calculated by converting (1- Pooled estimate * 100%) based on the type of outcome. Results: A total of 54 records were included in this meta-analysis. The rate of PVE against SARS-COV 2 infection was about 71% (OR = 0.29, 95% CI: 0.23-0.36) in the first dose and 87% (OR = 0.13, 95% CI: 0.08-0.21) in the second, and the highest effectiveness in the first and second doses was that of BNT162b2 mRNA and combined studies. The PVE versus COVID-19-associated hospitalization was 73% (OR = 0.27, 95% CI: 0.18-0.41) in the first dose and 89% (OR = 0.11, 95% CI: 0.07-0.17) in the second. mRNA-1273 and combined studies in the first dose and ChAdOx1 and mRNA-1273 in the second dose had the highest effectiveness. Regarding the COVID-19-related mortality, PVE was about 28% (HR = 0.39, 95% CI: 0.23-0.45) in the first dose and 89% (HR = 0.11, 95% CI: 0.03-0.43) in the second. Conclusion: The evidence obtained from this study showed that the effectiveness of BNT162b2 mRNA, mRNA-1273, and ChAdOx1 in the first and second doses, and even combined studies were associated with increased effectiveness against SARS-COV2 infection, hospitalization, and death from COVID-19. In addition, considering that the second dose was significantly more efficient than the first one, a booster dose injection could be effective in high-risk individuals. On the other hand, it was important to observe other prevention considerations in the first days after taking the first dose.

Abstract P216: Association Between White-coat Hypertension and Arterial Stiffness: a Systematic Review and Meta-analysis

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Sikarin Upala ◽  
Anawin Sanguankeo
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Observational Studies ◽  
Pulse Wave ◽  
Meta Analysis ◽  
White Coat ◽  
White Coat Hypertension ◽  
P Value ◽  
Sustained Hypertension

Background: Previous studies have shown inconclusive effects of target organ damage from white-coat hypertension (WCHT). Arterial stiffness is involved in the atherosclerotic processes in the setting of sustained hypertension. This meta-analysis aimed to compare arterial stiffness in subjects with diagnosis of WCHT to subjects with normotension (NT) and SHT. Methods: A comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through May 2016. The inclusion criterion was the observational studies’ assessment of the association between WCHT and NT or SHT in adult subjects. European Society of Hypertension practice guidelines for ambulatory blood pressure (BP) monitoring was used to define WCHT (office BP≥140/90mmHg and daytime BP <135/85mmHg), and SHT (office BP≥140/90mmHg and daytime BP≥135/85mmHg). Aortic stiffness was assessed using Carotid-femoral pulse wave velocity (PWV) measurements. Pooled mean difference (MD) of PWV and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Data were extracted from 4 observational studies involving 2,413 subjects. PWV is not different in patients with WCHT compared with SHT (pooled MD= -0.25 m/sec; 95% CI, -0.81 to 0.30; P-value=0.37, I 2 =74%). PWV in WCHT is also not different when compared with PWV in NT (MD= 0.86 m/sec; 95% CI, -0.30 to 2.03; P-value=0.15, I 2 =97%). Conclusion: In a meta-analysis, we observe that arterial stiffness measured by pulse wave velocity is not different in patients with white-coat hypertension when compared with sustained hypertension or normotension.

scholarly journals A Systematic Review And Meta-Analysis Protocol Of Observational Studies To Assess The Association Between Sleep And Mental Resilience In Healthy Individuals

2020 ◽  
Author(s):  
Teresa Arora ◽  
Asma Alamoodi ◽  
Ian Grey ◽  
Linda Östlundh ◽  
Omar M. Omar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sleep Quality ◽  
Sleep Duration ◽  
Observational Studies ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Original Research ◽  
Psychological Resilience ◽  
Healthy Children ◽  
Mental Resilience

Abstract Background: Mental resilience has emerged as a recent focus within the context of positive psychology. Resilience is a potentially modifiable construct. Some preliminary evidence from experimental studies as well as clinical populations has indicated that sleep may be related to mental resilience, but little is known about this relationship in healthy populations. Sleep is a complex with multi-factorial outcome, although the majority of research effort has focused on sleep duration and sleep quality. Our systematic review and meta-analysis will identify original research data from observational studies to assess if sleep duration and/or sleep quality is associated with levels of psychological resilience amongst healthy children, adolescents and adults. We hypothesize that there will be a positive association between sleep duration/quality and mental resilience across all age groups. Methods: A comprehensive, systematic search for literature will be conducted in June 2020 (LÖ), covering a total of eight academic databases (PubMed, Embase, PsycInfo, PsycArticles, CINAHL, Scopus, Web of Science and Academic Search Complete). Sources for grey materials will also be included and experts in the field will also be contacted for inclusion of unpublished data. PubMed and PubMed’s MeSH terms were used to develop the search strategy and systematically identify relevant search terms. Two authors (IG & AA) will screen the articles independently, and a third researcher (TA) will resolve discrepancies. The primary outcome is mental/psychological resilience. The systematic review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Discussion: The results of our systematic review and meta-analysis are intended to be published in an appropriate scientific peer-reviewed journal and will be made publicly available. The findings from our project are envisioned to inform and educate the public as well as healthcare and education systems, globally. Our systematic review is currently undergoing peer-review in the international database, PROSPERO.Systematic review registration: 191119 (submitted on 2 July 2020).

scholarly journals Determinants of Perinatal Birth Asphyxia Among Preterm Babies in Ethiopia: A Systematic Review and Meta-Analysis of Observational Studies Protocol

2020 ◽  
Author(s):  
Abay woday Tadesse ◽  
Muluken Dessalegn ◽  
Setognal Birara ◽  
Kusse Urmale ◽  
Gebeyaw Biset ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neonatal Mortality ◽  
Observational Studies ◽  
Associated Factors ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Grey Literature ◽  
Birth Asphyxia ◽  
Cochrane Library ◽  
Preterm Babies

Abstract Background: Birth asphyxia among preterm babies accounted for nearly fifty percent of neonatal mortality in sub-Saharan African countries. This scenario has been worst in Ethiopia where every two out of three deaths attributed to birth asphyxia. Moreover, studies conducted in Ethiopia lack consistency in the prevalence and risk factors of birth asphyxia. Objective: This study aims to analyses collectively and systematically prevalence of birth asphyxia and associated factors among preterm neonates in Ethiopia. Methods: The protocol for this review is registered at PROSPERO with registration number CRD42020158224. A comprehensive search of the following electronic databases were made using: MEDLINE, EMBASE, CINAHL, Scopus, web science, HINARI, Cochrane library, Google Scholar and maternity & infant care databases as well as grey literature uploaded at Ethiopian Health Development Journal will be searched until June 30, 2020. The quality of studies will be assessed using Joanna Briggs Institute (JBI) checklist. Three reviewers will screen all retrieved articles, conduct data extraction, and then critically appraise all identified studies. All identified observational studies reporting the prevalence of birth asphyxia and associated factors among neonates in Ethiopia will be considered. The analysis of data will be done using STATA 14.0 statistical software. We will demonstrate pooled estimates and determinants of neonatal mortality with effect size and 95% confidence interval. Heterogeneity among the included studies will be assessed through the Cochrane Q-test statistics and I2 test. Furthermore, publication bias will be checked using funnel plot and egger’s test. Finally, statistical significance level will be declared at a p-value less than 0.05. Discussion: the result from this systematic review will inform and guide health policy planners to invest limited resources on maternal and neonatal health. Furthermore, it will be a stimulus for future cumulative meta-analysis researchers in developing nations.

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