scholarly journals Swine Atrioventricular Node Ablation Using Stereotactic Radiosurgery: Methods and In Vivo Feasibility Investigation for Catheter‐Free Ablation of Cardiac Arrhythmias

2017 ◽  
Vol 6 (11) ◽  
Author(s):  
Marwan M. Refaat ◽  
Jad A. Ballout ◽  
Patrick Zakka ◽  
Mostafa Hotait ◽  
Karine A. Al Feghali ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Cardiac Arrhythmias ◽  
Atrioventricular Node

The effect of destruction of the bundle of His or the atrioventricular node on cyclopropane–adrenaline cardiac arrhythmias

1970 ◽  
Vol 48 (4) ◽  
pp. 207-215 ◽  
Author(s):  
Betty I. Sasyniuk ◽  
Peter E. Dresel
Keyword(s):  
Coronary Artery ◽  
Cardiac Arrhythmias ◽  
Atrioventricular Node ◽  
Circumflex Coronary Artery ◽  
Selective Destruction ◽  
Anesthetized Dogs ◽  
Bundle Of His

Destruction of the bundle of His abolished bigeminal rhythms produced by adrenaline in thiopentone–cyclopropane anesthetized dogs. Bigeminal rhythms were still elicited, however, after selective destruction of the A–V node. Destruction of the bundle of His did not prevent multifocal arrhythmias but did increase the dose of adrenaline required to induce them. Multifocal arrhythmias produced after destruction of the bundle of His were abolished by injections of acetylcholine into the left anterior descending, but not the circumflex coronary artery, results opposite to those obtained in normal hearts.

scholarly journals Modeling Human Cardiac Arrhythmias: Insights from Zebrafish

2022 ◽  
Vol 9 (1) ◽  
pp. 13
Author(s):  
Sébastien Gauvrit ◽  
Jaclyn Bossaer ◽  
Joyce Lee ◽  
Michelle M. Collins
Keyword(s):  
Public Health ◽  
Cardiac Arrhythmia ◽  
Cardiac Arrhythmias ◽  
Heart Rhythm ◽  
Therapeutic Strategies ◽  
Adult Zebrafish ◽  
Disease Mechanisms ◽  
New Models ◽  
Public Health Challenges

Cardiac arrhythmia, or irregular heart rhythm, is associated with morbidity and mortality and is described as one of the most important future public health challenges. Therefore, developing new models of cardiac arrhythmia is critical for understanding disease mechanisms, determining genetic underpinnings, and developing new therapeutic strategies. In the last few decades, the zebrafish has emerged as an attractive model to reproduce in vivo human cardiac pathologies, including arrhythmias. Here, we highlight the contribution of zebrafish to the field and discuss the available cardiac arrhythmia models. Further, we outline techniques to assess potential heart rhythm defects in larval and adult zebrafish. As genetic tools in zebrafish continue to bloom, this model will be crucial for functional genomics studies and to develop personalized anti-arrhythmic therapies.

scholarly journals The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0166041 ◽  
Author(s):  
Zsófia Kohajda ◽  
Nikolett Farkas-Morvay ◽  
Norbert Jost ◽  
Norbert Nagy ◽  
Amir Geramipour ◽  
...  
Keyword(s):  
Cardiac Arrhythmias ◽  
Selective Inhibitor ◽  
Sodium Calcium Exchanger ◽  
In Vivo Experiments ◽  
Sodium Calcium

scholarly journals Catheter Cryoablation of the Atrioventricular Node in Patients with Atrial Fibrillation: A Novel Technology for Ablation of Cardiac Arrhythmias

2001 ◽  
Vol 12 (4) ◽  
pp. 439-444 ◽  
Author(s):  
MARC DUBUC ◽  
PAUL KHAIRY ◽  
ANGEL RODRIGUEZ-SANTIAGO ◽  
MARIO TALAJIC ◽  
JEAN-CLAUDE TARDIF ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Arrhythmias ◽  
Atrioventricular Node ◽  
Novel Technology

scholarly journals Redox-Active Drug, MnTE-2-PyP5+, Prevents and Treats Cardiac Arrhythmias Preserving Heart Contractile Function

2020 ◽  
Vol 2020 ◽  
pp. 1-15 ◽  
Author(s):  
Andrezza M. Barbosa ◽  
José F. Sarmento-Neto ◽  
José E. R. Menezes Filho ◽  
Itamar C. G. Jesus ◽  
Diego S. Souza ◽  
...  
Keyword(s):  
Cardiac Arrhythmias ◽  
Contractile Function ◽  
Antiarrhythmic Effect ◽  
Cardiac Contractile Function ◽  
Rat Cardiomyocytes ◽  
Cell Contractility ◽  
Redox Active ◽  
Intracellular Ca

Background. Cardiomyopathies remain among the leading causes of death worldwide, despite all efforts and important advances in the development of cardiovascular therapeutics, demonstrating the need for new solutions. Herein, we describe the effects of the redox-active therapeutic Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, AEOL10113, BMX-010 (MnTE-2-PyP5+), on rat heart as an entry to new strategies to circumvent cardiomyopathies. Methods. Wistar rats weighing 250-300 g were used in both in vitro and in vivo experiments, to analyze intracellular Ca2+ dynamics, L-type Ca2+ currents, Ca2+ spark frequency, intracellular reactive oxygen species (ROS) levels, and cardiomyocyte and cardiac contractility, in control and MnTE-2-PyP5+-treated cells, hearts, or animals. Cells and hearts were treated with 20 μM MnTE-2-PyP5+ and animals with 1 mg/kg, i.p. daily. Additionally, we performed electrocardiographic and echocardiographic analysis. Results. Using isolated rat cardiomyocytes, we observed that MnTE-2-PyP5+ reduced intracellular Ca2+ transient amplitude, without altering cell contractility. Whereas MnTE-2-PyP5+ did not alter basal ROS levels, it was efficient in modulating cardiomyocyte redox state under stress conditions; MnTE-2-PyP5+ reduced Ca2+ spark frequency and increased sarcoplasmic reticulum (SR) Ca2+ load. Accordingly, analysis of isolated perfused rat hearts showed that MnTE-2-PyP5+ preserves cardiac function, increases SR Ca2+ load, and reduces arrhythmia index, indicating an antiarrhythmic effect. In vivo experiments showed that MnTE-2-PyP5+ treatment increased Ca2+ transient, preserved cardiac ejection fraction, and reduced arrhythmia index and duration. MnTE-2-PyP5+ was effective both to prevent and to treat cardiac arrhythmias. Conclusion. MnTE-2-PyP5+ prevents and treats cardiac arrhythmias in rats. In contrast to most antiarrhythmic drugs, MnTE-2-PyP5+ preserves cardiac contractile function, arising, thus, as a prospective therapeutic for improvement of cardiac arrhythmia treatment.

Radiofrequency catheter ablation for supraventricular tachycardias: Part II

1994 ◽  
Vol 3 (1) ◽  
pp. 77-80
Author(s):  
LG Futterman ◽  
L Lemberg
Keyword(s):  
Catheter Ablation ◽  
Cardiac Arrhythmias ◽  
Radiofrequency Catheter Ablation ◽  
Standard Treatment ◽  
Atrioventricular Node ◽  
Complication Rates ◽  
Efficacy And Safety ◽  
Percutaneous Catheter ◽  
Radiofrequency Current ◽  
Supraventricular Tachycardias

Use of percutaneous catheter ablation with radiofrequency current for cardiac arrhythmias is expanding rapidly. Technical ease, high success and low complication rates have allowed RFCA to become standard treatment for accessory AV connections and is the therapeutic procedure of choice for patients with atrioventricular node reentry tachycardias. Techniques still being investigated and evaluated for the treatment of supraventricular tachycardias include laser catheter ablation, cryocatheter ablation and microwave catheter ablation. With further clinical experience, the efficacy and safety of these and other procedures can be determined.

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