scholarly journals Association Between Blood Lead Level and Uncontrolled Hypertension in the US Population (NHANES 1999–2016)

2020 ◽  
Vol 9 (13) ◽  
Author(s):  
Hui Miao ◽  
Yan Liu ◽  
Thomas C. Tsai ◽  
Joel Schwartz ◽  
John S. Ji
Keyword(s):  
Blood Pressure ◽  
Smoking Status ◽  
Lead Level ◽  
Blood Lead ◽  
Uncontrolled Hypertension ◽  
Serum Cotinine ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
The Us ◽  
Lead Levels

Background This study aims to explore whether higher blood lead levels ( BLL ) may be associated with failure to control blood pressure and subsequent uncontrolled hypertension. Methods and Results We used serial cross‐sectional waves of the US National Health and Nutrition Examination Survey (NHANES) from 1999 to 2016. 30 762 subjects aged 20 years and above were included. Uncontrolled hypertension was defined as systolic blood pressure ≥130 mm Hg or diastolic blood pressure ≥80 mm Hg. We estimated odds ratios ( OR s) of quartiles of BLL for any hypertension and uncontrolled hypertension by sex using logistic regression, adjusted for demographics, smoking status, serum cotinine, alcohol intake, body mass index, and menopause status in women. The weighted prevalence of hypertension was 46.7%, of which 80.1% were uncontrolled. Men, younger ages, ethnic minorities, people with lower income, never and current smokers, and people with higher BLL were less likely to have their hypertension controlled. In men, compared with the lowest quartile of BLL (<0.94 μg/dL), the highest 2 quartiles (0.94–1.50 μg/dL, 1.50–2.30 μg/dL) were associated with hypertension (Q2: OR , 1.12; 95% CI , 0.96–1.30; Q3: OR , 1.16; 95% CI , 1.01–1.34; Q4: OR , 1.25; 95% CI , 1.08–1.45), but not in women. In hypertensive men, higher BLL was related to uncontrolled hypertension compared with the lowest quartile (Q2: OR , 1.34; 95% CI , 0.98–1.85; Q3: OR , 1.70; 95% CI , 1.26–2.30; Q4: OR , 1.96; 95% CI , 1.45–2.65). In women, the relationship was similar (Q2: OR , 1.26; 95% CI , 0.95–1.67; Q3: OR , 1.48; 95% CI , 1.10–2.00; Q4: 1.70; 95% CI , 1.26–2.30). Conclusions BLL is associated with higher prevalence of hypertension and uncontrolled hypertension, with more pronounced association in men.

scholarly journals Blood lead level and risk of hypertension in the United States National Health and Nutrition Examination Survey 1999–2016

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Man Fung Tsoi ◽  
Chris Wai Hang Lo ◽  
Tommy Tsang Cheung ◽  
Bernard Man Yung Cheung
Keyword(s):  
Blood Pressure ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
The United States ◽  
Study Data ◽  
Blood Lead Levels ◽  
Environmental Lead ◽  
Lead Levels

AbstractLead is a heavy metal without a biological role. High level of lead exposure is known to be associated with hypertension, but the risk at low levels of exposure is uncertain. In this study, data from US NHANES 1999–2016 were analyzed. Adults with blood lead and blood pressure measurements, or self-reported hypertension diagnosis, were included. If not already diagnosed, hypertension was defined according to the AHA/ACC 2017 hypertension guideline. Results were analyzed using R statistics version 3.5.1 with sample weight adjustment. Logistic regression was used to study the association between blood lead level and hypertension. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated. Altogether, 39,477 participants were included. Every doubling in blood lead level was associated with hypertension (OR [95%CI] 1.45 [1.40–1.50]), which remained significant after adjusting for demographics. Using quartile 1 as reference, higher blood lead levels were associated with increased adjusted odds of hypertension (Quartile 4 vs. Quartile 1: 1.22 [1.09–1.36]; Quartile 3 vs. Quartile 1: 1.15 [1.04–1.28]; Quartile 2 vs. Quartile 1: 1.14 [1.05–1.25]). In conclusion, blood lead level is associated with hypertension in the general population with blood lead levels below 5 µg/dL. Our findings suggest that reducing present levels of environmental lead exposure may bring cardiovascular benefits by reducing blood pressure.

High Lead Exposure Associated With Higher Blood Pressure in Haiti: a Warning Sign for Low-Income Countries

Hypertension ◽  
2021 ◽  
Author(s):  
Lily D. Yan ◽  
Vanessa Rouzier ◽  
Jean Lookens Pierre ◽  
Myung Hee Lee ◽  
Paul Muntner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Lead Exposure ◽  
Lead Level ◽  
Blood Lead ◽  
Lower Income ◽  
Environmental Lead ◽  
Lead Levels ◽  
Environmental Lead Exposure ◽  
Lower Income Countries

Cardiovascular disease is the leading cause of death in lower-income countries including Haiti. Environmental lead exposure is associated with high blood pressure and cardiovascular mortality in high-income countries but has not been systematically measured and evaluated as a potential modifiable cardiovascular risk factor in lower-income countries where 6.5 billion people reside. We hypothesized lead exposure is high in urban Haiti and associated with higher blood pressure levels. Blood lead levels were measured in 2504 participants ≥18 years enrolled in a longitudinal population-based cohort study in Port-au-Prince. Lead screening was conducted using LeadCare II (detection limit ≥3.3 µg/dL). Levels below detection were imputed by dividing the level of detection by √2. Associations between lead (quartiles) and systolic blood pressure and diastolic blood pressure were assessed, adjusting for age, sex, obesity, smoking, alcohol, physical activity, income, and antihypertensive medication use. The median age of participants was 40 years and 60.1% were female. The geometric mean blood lead level was 4.73µg/dL, 71.1% had a detectable lead level and 42.3% had a blood lead level ≥5 µg/dL. After multivariable adjustment, lead levels in quartile four (≥6.5 µg/dL) compared with quartile 1 (<3.4 µg/dL) were associated with 2.42 mm Hg (95% CI, 0.36–4.49) higher systolic blood pressure and 1.96 mm Hg (95% CI, 0.56–3.37) higher diastolic blood pressure. In conclusion, widespread environmental lead exposure is evident in urban Haiti, with higher lead levels associated with higher systolic and diastolic blood pressure. Lead is a current and potentially modifiable pollutant in lower-income countries that warrants urgent public health remediation. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03892265.

scholarly journals Proximity of residence to an old mineral storage site in Chile and blood lead levels in children

2016 ◽  
Vol 32 (4) ◽  
Author(s):  
Loreto Lisboa ◽  
José Klarián ◽  
Rosario Toro Campos ◽  
Verónica Iglesias
Keyword(s):  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Outcome Variable ◽  
Blood Lead Levels ◽  
Storage Site ◽  
Inverse Association ◽  
Cross Sectional ◽  
Exposure Variable ◽  
Lead Levels

Evidence suggests that an old mineral storage site removed in 1998 due to high lead content, remains as a source of exposure in the city of Antofagasta, Chile. The aim was to determine the association between blood lead levels in children and the residential proximity to the old mineral storage site. A cross sectional study was conducted with 185 children aged 7 to 16 years. The outcome variable was blood lead levels measured in 2005. The exposure variable was the distance between the current residence and the old mineral storage site. The distance was measured in meters by Geographic Information System (GIS). The median blood lead level in 2005 was 3.3μg/dL (interquartile range ‒ IQR: 2.0-4.3). A significant inverse association was found between the residential distance to the old mineral storage site and the blood lead levels in children, after adjusting by confounders (β: -0.04; 95%CI: -0.09; -0.01). This result suggests that the old mineral storage site continues to be a source of lead exposure for the children living nearby.

scholarly journals Pengaruh Jenis Kelamin dan Kebiasaan Merokok terhadap Kadar Timbal Darah

2013 ◽  
pp. 164
Author(s):  
Wirsal Hasan ◽  
Abdul Rahim Matondang ◽  
Alvi Syahrin ◽  
Chatarina Umbul Wahyuni
Keyword(s):  
Blood Pressure ◽  
Pearson Correlation ◽  
Lead Level ◽  
Blood Lead ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Blood Lead Levels ◽  
Drinking Habits ◽  
Consecutive Sampling ◽  
Lead Levels

Penarik becak dayung dan becak bermesin, pengatur lalu lintas, pedagang asongan, dan pedagang kaki lima banyak terpapar dengan polusi timbal dari udara ambien yang merupakan ancaman terhadap para pekerja pinggir jalan. Penelitian ini bertujuan mengetahui hubungan karakteristik responden dengan kadar timbal dalam darah. Sampel dalam penelitian ini berjumlah 109 orang terdiri dari 58 orang penarik becak dayung, 30 orang penarik becak bermesin dan 21 orang pedagang kaki lima yang ditarik secara consecutive sampling. Hasil penelitian menunjukkan bahwa tidak ada korelasi yang signifikan antara variabel usia, tekanan darah sistolik dan tekanan darah diastolik terhadap kadar timbal dalam darah (p>0,05). Rerata kadar timbal dalam darah berbeda bermakna menurut jenis kelamin (p=0,047) dan kebiasaan merokok (p=0,003). Rerata kadar timbal dalam darah berdasarkan jenis pekerjaan, lama bekerja, tingkat pendidikan, tempat beristirahat, lokasi tempat tinggal, kebiasaan minum susu, dan kebiasaan minum alkohol tidak ada perbedaan bermakna. Uji korelasi Pearson dan korelasi Spearman menemukan tidak ada korelasi antara variabel usia dan tekanan darah terhadap kadar timbal dalam darah (p>0,05).Paddle rickshaw puller, motorized rickshaw pullers, traffic police, street vendors and roadside vendors is that many workers are exposed to lead from ambient air pollution. Lead pollution is a threat to roadside workers. This study is observational. The purpose of the study was to determine the association between respondent characteristic with blood lead levels. The 109 samples in this study was the 58 paddle rickshaw puller, 30 motorized rickshaw pullers and 21 hawkers, drawn with consecutive sampling. The results showed that there were no significant correlation between age, blood pressure and blood lead level (p>0.005), there were differences in mean blood lead levels by sex (p = 0.047) and smoking (p = 0.003), there was no difference in mean blood lead levels based on the type of work, length of work, level of education, place of rest, the location shelter, drinking milk, and alcohol drinking habits. Pearson correlation test and Spearman correlation found no correlation between the variables of age, and blood pressure on blood lead levels (p> 0.05).

scholarly journals The Correlation between Blood Lead Level with Hypertension of Painting Cars Worker in Surabaya

2018 ◽  
Vol 9 (1) ◽  
pp. 66
Author(s):  
Hendra Eka
Keyword(s):  
Blood Pressure ◽  
Blood Lead Level ◽  
Lead Concentration ◽  
Health Workers ◽  
Smoking Habit ◽  
Lead Level ◽  
Blood Lead ◽  
Blood Lead Concentration ◽  
Cross Sectional ◽  
High Calcium

Lead (Pb) is a metal that used as a color pigment in paint material. Lead has an acute effect on blood pressure and caused hypertension in chronic poisoning because it accumulated in blood. The objective of this research was to identify the correlation between aerial lead level and blood lead level with hypertension of workers in car painting workshop Surabaya. This research was an observational with cross-sectional study and to know the correlation analyzed by using phi correlation. Sample of this research were 16 respondents taken from population compatible from defi ned criteria. Blood lead level and blood pressure examined by the health workers then analyzed in the laboratory and using questionnaires to determine the characteristic of respondents. The results of this research is 83.33% respondents were exposed have blood lead concentration exceeds the limit that is > 10 μg/dL and 66.67% respondents were exposed have hypertension. Blood lead concentration have a strong correlation with hypertension (r = 0.618). The workers need to do a routine blood lead concentration check up once every 6 months and use personal protective equipment at work, consume foods and beverages that contain high calcium often nevertheless decrease smoking habit to inhibit absorption of lead in blood.

scholarly journals Correlation of Blood Lead Levels and Elevated Blood Pressure in Newly Detected Hypertensive Patients

2021 ◽  
Vol 10 (13) ◽  
pp. 941-946
Author(s):  
Shuaib Ahmed M. A ◽  
Raghav Sharma ◽  
Shama Prakash K
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Lead Level ◽  
Blood Lead ◽  
Health Concern ◽  
Blood Lead Levels ◽  
P Value ◽  
Hypertensive Patients ◽  
Lead Levels

BACKGROUND Hypertension is one of the most common diseases all over the world. Lead is a common environmental and industrial pollutant with no beneficial biological role. The contribution of environmental lead exposure to hypertension is an important public health concern. The objective of this study was to determine the blood lead levels in hypertensive patients and to investigate the correlation between blood lead (B-Pb) levels and the values of blood pressure in hypertensive patients. METHODS This is a hospital based analytical cross-sectional study conducted over a period of one and half years. Subjects included 50 newly detected hypertensive and 50 healthy subjects recruited who were both age and sex matched. Mean of age, blood lead levels, systolic blood pressure (SBP), diastolic blood pressure (DBP) with standard deviation were assessed. Linear regression was used to estimate the predicted systolic blood pressure (BP) and diastolic BP with lead levels. Pearson correlation was used to estimate the correlation between blood lead and blood pressure levels. RESULTS In this study, 52 % of cases and controls were in the age group of 41 - 60 years. 22 % of the subjects were more than 61 years of age. 45 % of the total subjects were females and 55 % were males. 46 % of the controls and 44 % of the cases were females. Comparison of the serum lead levels (mcg / dl) between cases and controls showed that serum lead levels (mcg / dl) were higher in Cases group with a t-value of -7.38 and was statistically significant with a P-value of < 0.001. Comparison of the serum lead levels (mcg / dl) between the males and females showed that serum lead levels (mcg / dl) were higher in female group with a t-value of - 0.151 and was statistically non-significant with a P-value of 0.881. This study showed that there is an increase in blood lead levels in hypertensive patients compared to the control group. Stage 2 hypertension has higher serum lead level value of 21.228 compared to stage 1. Serum lead levels were higher in females compared to males. CONCLUSIONS Our study indicated that blood lead level is significantly and positively correlated to blood pressure among newly detected hypertensive patients. Increase in blood lead levels causes increase in both systolic and diastolic blood pressures. KEY WORDS Hypertension, Lead, Systolic Blood Pressure, Diastolic Blood Pressure

Are Blood Lead Levels in the United States Still Declining? The US National Health Nutrition and Examination Survey (NHANES) 1999-2016

2020 ◽  
Author(s):  
Kelvin KW Lui ◽  
Man-Fung Tsoi ◽  
Tommy Tsang Cheung ◽  
Ching-Lung Cheung ◽  
Bernard MY Cheung
Keyword(s):  
Low Income ◽  
Lead Level ◽  
Blood Lead ◽  
The United States ◽  
Reference Level ◽  
The Us ◽  
Low Income Groups ◽  
Lead Levels ◽  
Safe Limit ◽  
The Mean

Abstract Background: Lead is toxic without a safe limit. The current upper reference blood lead level (BLL), 5 μg/dL, came from the 97.5th percentile in children aged 1-5 years in NHANES 2007-2010.Objectives: We studied the latest trend in BLL in US NHANES and estimated the proportion of children with BLL ≥5 μg/dL, which would inform the setting of an upper reference level.Methods: We analyzed 68877 participants (aged 1 to 85 years) with BLL measurements in NHANES 1999-2016 using SPSS complex sample module v25.0.Results: In NHANES 2011-2012, 2013-2014, and 2015-2016, the mean and 95% confidence intervals (CIs) of BLLs (μg/dL) were 0.97 (0.96, 0.99), 0.86 (0.85, 0.87), and 0.82 (0.81, 0.83), respectively (P <0.0001). The estimated proportion (95% CI) of children aged 1-5 years with elevated BLL (EBLL) in 2011-2012, 2013-2014, and 2015-2016 were 2.0% (1.3, 3.0), 0.5% (0.4, 0.7), and 1.3% (0.8, 2.3), respectively (P=0.267). In 2015-2016, the proportion of children with EBLL was similar in high- and low-income groups (P = 0.9979). The estimated 97.5th percentile of BLL in children was 3.71 μg/dL in NHANES 2015-2016.Conclusions: BLL continued to decline in the overall US population. The disparity in BLL in children from higher and lower income families has decreased. Our findings support a reduction in the reference BLL, continual monitoring of population BLL and continual efforts to reduce environmental exposure to lead.

scholarly journals Childhood Lead Exposure from Battery Recycling in Vietnam

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
William E. Daniell ◽  
Lo Van Tung ◽  
Ryan M. Wallace ◽  
Deborah J. Havens ◽  
Catherine J. Karr ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Soil Lead ◽  
Effective Strategies ◽  
Battery Recycling ◽  
Home Based ◽  
Lead Levels

Background. Battery recycling facilities in developing countries can cause community lead exposure.Objective. To evaluate child lead exposure in a Vietnam battery recycling craft village after efforts to shift home-based recycling outside the village.Methods. This cross-sectional study evaluated 109 children in Dong Mai village, using blood lead level (BLL) measurement, parent interview, and household observation. Blood samples were analyzed with a LeadCare II field instrument; highest BLLs (≥45 μg/dL) were retested by laboratory analysis. Surface and soil lead were measured at 11 households and a school with X-ray fluorescence analyzer.Results. All children had high BLLs; 28% had BLL ≥45 μg/dL. Younger age, family recycling, and outside brick surfaces were associated with higher BLL. Surface and soil lead levels were high at all tested homes, even with no recycling history. Laboratory BLLs were lower than LeadCare BLLs, in 24 retested children.Discussion. In spite of improvements, lead exposure was still substantial and probably associated with continued home-based recycling, legacy contamination, and workplace take-home exposure pathways. There is a need for effective strategies to manage lead exposure from battery recycling in craft villages. These reported BLL values should be interpreted cautiously, although the observed field-laboratory discordance may reflect bias in laboratory results.

scholarly journals Serum Cotinine Levels and Prehypertension in Never Smokers

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Omayma Alshaarawy ◽  
Jie Xiao ◽  
Michael E. Andrew ◽  
Cecil Burchfiel ◽  
Anoop Shankar
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Secondhand Smoke ◽  
Positive Association ◽  
Smoke Exposure ◽  
Secondhand Smoke Exposure ◽  
Serum Cotinine ◽  
Health And Nutrition ◽  
The Us ◽  
Never Smokers

Background. Few studies have shown that self-reported secondhand smoke exposure in never smokers is associated with high blood pressure. However, there are no studies investigating the relationship between secondhand smoke exposure, measured objectively by serum cotinine levels, and high blood pressure in never smokers.Methods. We examined never smokers (n=2027) from the National Health and Nutrition Examination Survey 2005–2008. Our exposure of interest was the secondhand smoke exposure estimated by serum cotinine level and our outcome was prehypertension (n=734), defined as a systolic blood pressure of 120–139 mmHg or diastolic blood pressure of 80–89 mmHg.Results. We found that, in never smokers, serum cotinine levels were positively associated with prehypertension. Compared to those with cotinine levels in the lowest quartile (≤0.024 ng/mL), the multivariable odds ratio (95% confidence interval) of prehypertension among those with cotinine levels in the highest quartile (≥0.224 ng/mL) was 1.45(1.00, 2.11);Ptrend=0.0451. In subsequent subgroup analyses, the positive association was found to be stronger among men, non-Whites, and non-obese subjects.Conclusion. Higher secondhand smoke exposure measured objectively by serum cotinine levels was found to be associated with prehypertension in certain subgroups of a representative sample of the US population.

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