scholarly journals Correlation of Blood Lead Levels and Elevated Blood Pressure in Newly Detected Hypertensive Patients

2021 ◽  
Vol 10 (13) ◽  
pp. 941-946
Author(s):  
Shuaib Ahmed M. A ◽  
Raghav Sharma ◽  
Shama Prakash K
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Lead Level ◽  
Blood Lead ◽  
Health Concern ◽  
Blood Lead Levels ◽  
P Value ◽  
Hypertensive Patients ◽  
Lead Levels

BACKGROUND Hypertension is one of the most common diseases all over the world. Lead is a common environmental and industrial pollutant with no beneficial biological role. The contribution of environmental lead exposure to hypertension is an important public health concern. The objective of this study was to determine the blood lead levels in hypertensive patients and to investigate the correlation between blood lead (B-Pb) levels and the values of blood pressure in hypertensive patients. METHODS This is a hospital based analytical cross-sectional study conducted over a period of one and half years. Subjects included 50 newly detected hypertensive and 50 healthy subjects recruited who were both age and sex matched. Mean of age, blood lead levels, systolic blood pressure (SBP), diastolic blood pressure (DBP) with standard deviation were assessed. Linear regression was used to estimate the predicted systolic blood pressure (BP) and diastolic BP with lead levels. Pearson correlation was used to estimate the correlation between blood lead and blood pressure levels. RESULTS In this study, 52 % of cases and controls were in the age group of 41 - 60 years. 22 % of the subjects were more than 61 years of age. 45 % of the total subjects were females and 55 % were males. 46 % of the controls and 44 % of the cases were females. Comparison of the serum lead levels (mcg / dl) between cases and controls showed that serum lead levels (mcg / dl) were higher in Cases group with a t-value of -7.38 and was statistically significant with a P-value of < 0.001. Comparison of the serum lead levels (mcg / dl) between the males and females showed that serum lead levels (mcg / dl) were higher in female group with a t-value of - 0.151 and was statistically non-significant with a P-value of 0.881. This study showed that there is an increase in blood lead levels in hypertensive patients compared to the control group. Stage 2 hypertension has higher serum lead level value of 21.228 compared to stage 1. Serum lead levels were higher in females compared to males. CONCLUSIONS Our study indicated that blood lead level is significantly and positively correlated to blood pressure among newly detected hypertensive patients. Increase in blood lead levels causes increase in both systolic and diastolic blood pressures. KEY WORDS Hypertension, Lead, Systolic Blood Pressure, Diastolic Blood Pressure

scholarly journals Missile-related Lead Exposure and Blood Pressure in Patients with Retained Pellets in the Craniomaxillofacial Region

2018 ◽  
Vol 12 (6) ◽  
pp. 7-12
Author(s):  
Ekaniyere Benlance Edetanlen ◽  
◽  
Ozoemene Ndubuisi Obuekwe ◽  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Lead Exposure ◽  
Predictor Variable ◽  
Positive Association ◽  
Blood Lead ◽  
Outcome Variable ◽  
Blood Lead Levels ◽  
P Value ◽  
Lead Levels

Background: Environmental and occupational lead exposures are known to cause an elevated blood pressure but can this concept be applied to missile-related lead exposure? Methods: We implemented a controlled, cohort study design to examine study samples with long-standing missiles in craniomaxillofacial region using atomic absorption spectrophotometry and standard sphygmomanometry to measure the blood lead levels and blood pressure respectively. The predictor variable was blood lead levels and the outcome variable were blood pressure. Other variables were age, number of pellets, and duration of retention. Descriptive, bivariate and multivariate statistics were computed and the P-value was set at 0.05. Results: There was a significant, strong and positive association seen between diastolic blood pressure (r = 0.34;P< 0.001) unlike systolic blood pressure that showed an insignificant, weak and negative associations with blood lead levels(r = - 0.01, P = 0.82). Binary logistic regression showed that blood lead levels, though less significant, (OR= 1.24, P = 0.01, 95%CI = 1.04-1.42) had a higher likelihood to cause hypertension than the age of the patients (OR = 1.03, 95%CI=1.01-1.04, 0.003). Conclusion: The results of this study suggest an association between missiles-related lead exposure and the diastolic blood pressure.

scholarly journals Blood lead level and risk of hypertension in the United States National Health and Nutrition Examination Survey 1999–2016

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Man Fung Tsoi ◽  
Chris Wai Hang Lo ◽  
Tommy Tsang Cheung ◽  
Bernard Man Yung Cheung
Keyword(s):  
Blood Pressure ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
The United States ◽  
Study Data ◽  
Blood Lead Levels ◽  
Environmental Lead ◽  
Lead Levels

AbstractLead is a heavy metal without a biological role. High level of lead exposure is known to be associated with hypertension, but the risk at low levels of exposure is uncertain. In this study, data from US NHANES 1999–2016 were analyzed. Adults with blood lead and blood pressure measurements, or self-reported hypertension diagnosis, were included. If not already diagnosed, hypertension was defined according to the AHA/ACC 2017 hypertension guideline. Results were analyzed using R statistics version 3.5.1 with sample weight adjustment. Logistic regression was used to study the association between blood lead level and hypertension. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated. Altogether, 39,477 participants were included. Every doubling in blood lead level was associated with hypertension (OR [95%CI] 1.45 [1.40–1.50]), which remained significant after adjusting for demographics. Using quartile 1 as reference, higher blood lead levels were associated with increased adjusted odds of hypertension (Quartile 4 vs. Quartile 1: 1.22 [1.09–1.36]; Quartile 3 vs. Quartile 1: 1.15 [1.04–1.28]; Quartile 2 vs. Quartile 1: 1.14 [1.05–1.25]). In conclusion, blood lead level is associated with hypertension in the general population with blood lead levels below 5 µg/dL. Our findings suggest that reducing present levels of environmental lead exposure may bring cardiovascular benefits by reducing blood pressure.

High Lead Exposure Associated With Higher Blood Pressure in Haiti: a Warning Sign for Low-Income Countries

Hypertension ◽  
2021 ◽  
Author(s):  
Lily D. Yan ◽  
Vanessa Rouzier ◽  
Jean Lookens Pierre ◽  
Myung Hee Lee ◽  
Paul Muntner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Lead Exposure ◽  
Lead Level ◽  
Blood Lead ◽  
Lower Income ◽  
Environmental Lead ◽  
Lead Levels ◽  
Environmental Lead Exposure ◽  
Lower Income Countries

Cardiovascular disease is the leading cause of death in lower-income countries including Haiti. Environmental lead exposure is associated with high blood pressure and cardiovascular mortality in high-income countries but has not been systematically measured and evaluated as a potential modifiable cardiovascular risk factor in lower-income countries where 6.5 billion people reside. We hypothesized lead exposure is high in urban Haiti and associated with higher blood pressure levels. Blood lead levels were measured in 2504 participants ≥18 years enrolled in a longitudinal population-based cohort study in Port-au-Prince. Lead screening was conducted using LeadCare II (detection limit ≥3.3 µg/dL). Levels below detection were imputed by dividing the level of detection by √2. Associations between lead (quartiles) and systolic blood pressure and diastolic blood pressure were assessed, adjusting for age, sex, obesity, smoking, alcohol, physical activity, income, and antihypertensive medication use. The median age of participants was 40 years and 60.1% were female. The geometric mean blood lead level was 4.73µg/dL, 71.1% had a detectable lead level and 42.3% had a blood lead level ≥5 µg/dL. After multivariable adjustment, lead levels in quartile four (≥6.5 µg/dL) compared with quartile 1 (<3.4 µg/dL) were associated with 2.42 mm Hg (95% CI, 0.36–4.49) higher systolic blood pressure and 1.96 mm Hg (95% CI, 0.56–3.37) higher diastolic blood pressure. In conclusion, widespread environmental lead exposure is evident in urban Haiti, with higher lead levels associated with higher systolic and diastolic blood pressure. Lead is a current and potentially modifiable pollutant in lower-income countries that warrants urgent public health remediation. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03892265.

scholarly journals Pengaruh Jenis Kelamin dan Kebiasaan Merokok terhadap Kadar Timbal Darah

2013 ◽  
pp. 164
Author(s):  
Wirsal Hasan ◽  
Abdul Rahim Matondang ◽  
Alvi Syahrin ◽  
Chatarina Umbul Wahyuni
Keyword(s):  
Blood Pressure ◽  
Pearson Correlation ◽  
Lead Level ◽  
Blood Lead ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Blood Lead Levels ◽  
Drinking Habits ◽  
Consecutive Sampling ◽  
Lead Levels

Penarik becak dayung dan becak bermesin, pengatur lalu lintas, pedagang asongan, dan pedagang kaki lima banyak terpapar dengan polusi timbal dari udara ambien yang merupakan ancaman terhadap para pekerja pinggir jalan. Penelitian ini bertujuan mengetahui hubungan karakteristik responden dengan kadar timbal dalam darah. Sampel dalam penelitian ini berjumlah 109 orang terdiri dari 58 orang penarik becak dayung, 30 orang penarik becak bermesin dan 21 orang pedagang kaki lima yang ditarik secara consecutive sampling. Hasil penelitian menunjukkan bahwa tidak ada korelasi yang signifikan antara variabel usia, tekanan darah sistolik dan tekanan darah diastolik terhadap kadar timbal dalam darah (p>0,05). Rerata kadar timbal dalam darah berbeda bermakna menurut jenis kelamin (p=0,047) dan kebiasaan merokok (p=0,003). Rerata kadar timbal dalam darah berdasarkan jenis pekerjaan, lama bekerja, tingkat pendidikan, tempat beristirahat, lokasi tempat tinggal, kebiasaan minum susu, dan kebiasaan minum alkohol tidak ada perbedaan bermakna. Uji korelasi Pearson dan korelasi Spearman menemukan tidak ada korelasi antara variabel usia dan tekanan darah terhadap kadar timbal dalam darah (p>0,05).Paddle rickshaw puller, motorized rickshaw pullers, traffic police, street vendors and roadside vendors is that many workers are exposed to lead from ambient air pollution. Lead pollution is a threat to roadside workers. This study is observational. The purpose of the study was to determine the association between respondent characteristic with blood lead levels. The 109 samples in this study was the 58 paddle rickshaw puller, 30 motorized rickshaw pullers and 21 hawkers, drawn with consecutive sampling. The results showed that there were no significant correlation between age, blood pressure and blood lead level (p>0.005), there were differences in mean blood lead levels by sex (p = 0.047) and smoking (p = 0.003), there was no difference in mean blood lead levels based on the type of work, length of work, level of education, place of rest, the location shelter, drinking milk, and alcohol drinking habits. Pearson correlation test and Spearman correlation found no correlation between the variables of age, and blood pressure on blood lead levels (p> 0.05).

scholarly journals PENGARUH PEMBERIAN PUDING PISANG MELON DAN AIR KELAPA MUDA TERHADAP PENURUNAN TEKANAN DARAH PENDERITA HIPERTENSI

2021 ◽  
Vol 9 (1) ◽  
pp. 28-32
Author(s):  
Eliza Eliza ◽  
Ayu Lestari ◽  
Sumarman Sumarman ◽  
Andi Eka Yunianto
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Coconut Water ◽  
Control Group ◽  
P Value ◽  
High Potassium ◽  
Control Group Design ◽  
Hypertensive Patients ◽  
Average Decrease

Background : Hypertension is a condition when systolic blood pressure ≥ 140 mmHg and diastolic blood pressure  ≥ 90 mmHg blood. One of herbal therapies to help lowering blood pressure is by utilizing foods which contain high potassium, such as bananas, melons, and young coconut water.Objective : To analyze the effect of banana melon and young coconut water pudding on lowering blood pressure levels of hypertensive patients at the Palembang Public Health Center.Method : A quasi-experimental study with pre and pos test control group design. The subjects were 60 hypertensive patients at Palembah PHC who were eagerly fulfilled inclusion and exclusion criteria. Data analysis were used t-dependent and t-independent tests to analyze the effect of melon banana pudding and young coconut water with blood pressure.Results : The results showed there was an average decrease in systolic and diastolic blood pressure in the treatment group of 13.07 mmHg (p= 0.000) and 6.93 mmHg (p= 0,000). Consumption of banana melon pudding and young coconut water showed a significant effect on reducing 6.1 mmHg systolic blood pressure (p=0.003) and 4.56 mmHg diastolic blood pressure (p=0,000). T-independent test showed that systolic blood pressure in the treatment and control groups obtained p-0.005 and diastolic blood pressure obtained p-value 0.048.Conclusion : Consumption of banana melon pudding and young coconut water could lower blood pressure levels f hypertensive patients

scholarly journals Blood Lead Levels and Cardiovascular Disease Risk: Results from the Korean National Health and Nutrition Examination Survey

2021 ◽  
Vol 18 (19) ◽  
pp. 10315
Author(s):  
Yoonjin Park ◽  
Jungjin Han
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Systolic Blood Pressure ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Hdl Cholesterol ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Lead Levels

(1) Objective: Lead, a heavy metal that exists commonly in air, soil and crops may cause chronic disease in the cardiovascular system. The purpose of this study is to investigate how blood lead levels affect cardiovascular disease in adults. (2) Study Design and Participants: It is a cross-sectional, descriptive study using data from the Korean National Health and Nutrition Examination Survey (KNHANES). Data from a total of 1929 participants, derived from the KNHANES, conducted by the Korea Centers for Disease Control and Prevention, in 2017, were analyzed using SPSS version 25.0. (3) Measurement: The cardiovascular disease risk was calculated using the Framingham risk score. There was a strong positive correlation between blood lead levels and the Framingham risk score. Furthermore, of the FRS sub-criteria, systolic blood pressure, HDL cholesterol level and total cholesterol level all also showed a significant correlation. (4) Results: We analyzed the correlation between PbB levels and the FRS sub-criteria, including systolic blood pressure, HDL cholesterol level, total cholesterol level and the FRS total. We found a significant positive correlation between PbB levels and systolic blood pressure, FRS total and total cholesterol level (p < 0.05), as well as a significant negative correlation with HDL cholesterol level (p < 0.05). (5) Conclusion: Based on the perception that there is no lower toxicological threshold for blood lead, it is necessary to restrict lead in product manufacturing for the purpose of public health. In addition, it is necessary to be aware of the dangers of exposure to even small amounts of lead in daily life.

scholarly journals Effects of lead poisoning in children- A narrative review

2021 ◽  
Vol 10 (7) ◽  
pp. e37410716616
Author(s):  
Kethilyn Cristhini de Oliveira Mota ◽  
Vitória Carolina Marques Pedroso ◽  
Gustavo Henrique Oliveira Rocha ◽  
Denise Grotto ◽  
Éric Diego Barioni ◽  
...  
Keyword(s):  
Public Health ◽  
Lead Poisoning ◽  
Lead Exposure ◽  
Lead Level ◽  
Blood Lead ◽  
Health Concern ◽  
Blood Lead Levels ◽  
Policy Makers ◽  
Health Agencies ◽  
Lead Levels

Objective: exposure of children to lead still poses a major health concern for public health agencies worldwide. This work aims to describe which are the symptoms most frequently associated with lead exposure in children, providing further basis to both researchers and policy makers to better guide future efforts aimed at addressing such issue. Methods: a systematized review of articles on the present topic published between June 2005 and February 2021 was carried out. Results: data described in the reviewed articles show a clear relationship between blood lead levels and hematopoietic and cognitive effects in children exposed to either low or high levels of lead. Concerning effects can be identified at blood lead levels above 4µg/dL, and the highest blood lead level reported was of 88.39 µg/dL. Conclusions: lead poisoning of children continues to be a serious public health issue worldwide, especially for those in South America, and health agencies and policy makers alike would benefit from more studies describing areas where lead exposure is high as well as describing how children have been responding to such exposure in the past years in order to better combat this issue.

scholarly journals Blood Lead Levels of Refugee Children in Rhode Island

2018 ◽  
Author(s):  
Tracey Ginaitt
Keyword(s):  
Disease Control ◽  
Rhode Island ◽  
Lead Level ◽  
Blood Lead ◽  
Health Concern ◽  
Refugee Children ◽  
Blood Lead Levels ◽  
Cdc Guidelines ◽  
Lead Levels ◽  
The U.S

Lead and its harmful effects on children have been known for over one hundred years. Yet exposure continues to be a public health concern within the U.S., specifically in the urban areas (Lidsky & Schneider, 2003). Blood lead levels (BLL) were found to be elevated in 11.3% of recent refugees children within the U.S. (Hebbar, Vanderslice, Simon, & Vallejo, 2010). Currently, the Center for Disease Control (CDC) estimates that approximately half a million children between the ages of one to five years have a blood lead level above 5μ/deciliter (CDC, 2017). Lead is neurotoxic and young children are at a particularly high risk of exposure. Many studies indicate that adverse outcomes in intellectual functioning and social-behavioral conduct. It is not clear if long-term effects develop at concentrations below 10 μg per deciliter (Canfield et al., 2003). Minimal research done to evaluate the implementation of the CDC guidelines on blood level screening of refugee children that are newly arrived into the U.S. (Raymond et al., 2012). This project analyzed the health records of refugee children who settled in Rhode Island and were receiving care in the refugee clinic within a large academic medical center. Records were reviewed for adherence to Center for Disease Control (CDC) guidelines regarding BLL in refugee children.

scholarly journals Paediatric Blood Lead Levels and its Correlation with Anaemia: A Study from Central India

2021 ◽  
Author(s):  
Usha Banga ◽  
Pawan Kumar Sharma ◽  
Jyoti Gupta ◽  
Ashok Banga ◽  
Puneet Agrawal ◽  
...  
Keyword(s):  
Public Awareness ◽  
Venous Blood ◽  
Tertiary Care ◽  
Lead Level ◽  
Blood Lead ◽  
Diagnostic Tools ◽  
Blood Lead Levels ◽  
P Value ◽  
Care Hospital ◽  
Lead Levels

Introduction: Lead is a toxic element used commonly in many products like lead-acid batteries, paints, toys etc. Young children are particularly vulnerable to lead poisoning because of higher absorption capacity in comparison of adults. Safe level of lead exposure has to be established yet. Literature suggests a threshold lead level of 20-40 μg/dL for a decrease in haemoglobin in children. Aim: To assess the correlation between Blood Lead Levels (BLL) and anaemia in children. Materials and Methods: This cross-sectional study was conducted in a Paediatric Tertiary Care Hospital of Gwalior, Madhya Pradesh, India, during the period of May 2019 to September 2020. A 81 children between one to five years of age were included in study. Information was collected regarding general profile of the children and other parameters like socio- economic status (Modified Kuppuswamy scale), history of pica, application of surma, type of toys used, scholastic performance and somatic symptoms. Routine blood investigations were done including Haemoglobin (Hb) and BLL through venous blood sampling. BLL were done at Defense Research and Development Establishment (DRDE) Gwalior. Data entry was done in Microsoft Office Excel 2010 and analysed using Statistical Package for the Social Sciences (SPSS) software version 21.0. Chi-square test with Yates correlation was applied and p-value <0.05 was considered statistically significant. Results: Among 81 study subjects, 53 were males and 28 were females. Total 48 (59.2%) children had Hb <11 gm/dL, 42 (51.8%) children had BLL <5 μg/dL and 32 (39.5%) had BLL between 5-10 μg/dL. There were 9% children (n=7) with BLL more than 10 μg/dL and none beyond 15 μg/dL. In the children it was found to have BLL ≥5 μg/dL, 20 children had Hb levels between 7-11 gm/dL whereas 19 had Hb levels above 11 gm/ dL. No statistically significant association was found between the BLL and childhood anaemia. Conclusion: This study did not show any relationship between BLL and Hb in children of age one to five years. Scarcity of diagnostic tools for detecting BLL and lack of public awareness regarding the probable sources of lead and its complications may result in missing the diagnosis.

EFEKTIVITAS PEMBERIAN HYDROTHERAPI RENDAM KAKI PADA PENDERITA HIPERTENSI DI BANJAR SRI MANDALA, KELURAHAN DAUHWARU KABUPATEN JEMBRANA

2019 ◽  
Vol 10 (01) ◽  
pp. 33-44
Author(s):  
N.L.G. Sudaryati ◽  
I P. Sudiartawan ◽  
Dwi Mertha Adnyana
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pressure Measurement ◽  
Blood Pressure Measurement ◽  
Reduce Blood Pressure ◽  
Second Grade ◽  
Control Group ◽  
Hypertensive Patients ◽  
First Category

The aim of the study was to determine the effectiveness of giving hydrotherapi foot soak in hypertensive patients. The study was conducted with one group pretestposttest design without a control group by measuring blood pressure (pretest) before being given an intervention in the form of foot soak hydrotherm against 15 people with hypertension in Banjar Sri Mandala, Dauhwaru Village, Jembrana Subregency. Then do the blood pressure measurement again (posttest) after finishing the intervention. After the study was completed, the results showed that before the hydrotherapi foot bath intervention, there were 0% of patients classified as normal, 13.32% in prehypertension category, 60.08% in hypertension category I and 26.60% in hypertension category II. After the intervention was given, there were 13.32% of the patients classified as normal, 66.68% in the prehypertension category, 20.00% in the first category of hypertension and no patients belonging to the second grade hypertension category. There is a decrease of 20-30 mmHg for systolic blood pressure and 0-10 mmHg for diastolic blood pressure after intervention. Based on the results of the study it can be concluded that the hydrotherapi foot bath is effectively used to reduce blood pressure in hypertensive patients in the Banjar Sri Mandala, Dauhwaru Village, Jembrana District.

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