scholarly journals Early Pregnancy Atherogenic Profile in a First Pregnancy and Hypertension Risk 2 to 7 Years After Delivery

2021 ◽  
Author(s):  
Janet M. Catov ◽  
Rebecca B. McNeil ◽  
Derek J. Marsh ◽  
Brian M. Mercer ◽  
C. Noel Bairey Merz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
High Sensitivity ◽  
First Trimester ◽  
C Reactive Protein ◽  
Unique Identifier ◽  
Reactive Protein ◽  
Increased Risk

Background Cardiovascular risk in young adulthood is an important determinant of lifetime cardiovascular disease risk. Women with adverse pregnancy outcomes (APOs) have increased cardiovascular risk, but the relationship of other factors is unknown. Methods and Results Among 4471 primiparous women, we related first‐trimester atherogenic markers to risk of APO (hypertensive disorders of pregnancy, preterm birth, small for gestational age), gestational diabetes mellitus (GDM) and hypertension (130/80 mm Hg or antihypertensive use) 2 to 7 years after delivery. Women with an APO/GDM (n=1102) had more atherogenic characteristics (obesity [34.2 versus 19.5%], higher blood pressure [systolic blood pressure 112.2 versus 108.4, diastolic blood pressure 69.2 versus 66.6 mm Hg], glucose [5.0 versus 4.8 mmol/L], insulin [77.6 versus 60.1 pmol/L], triglycerides [1.4 versus 1.3 mmol/L], and high‐sensitivity C‐reactive protein [5.6 versus 4.0 nmol/L], and lower high‐density lipoprotein cholesterol [1.8 versus 1.9 mmol/L]; P <0.05) than women without an APO/GDM. They were also more likely to develop hypertension after delivery (32.8% versus 18.1%, P <0.05). Accounting for confounders and factors routinely assessed antepartum, higher glucose (relative risk [RR] 1.03 [95% CI, 1.00–1.06] per 0.6 mmol/L), high‐sensitivity C‐reactive protein (RR, 1.06 [95% CI, 1.02–1.11] per 2‐fold higher), and triglycerides (RR, 1.27 [95% CI, 1.14–1.41] per 2‐fold higher) were associated with later hypertension. Higher physical activity was protective (RR, 0.93 [95% CI, 0.87‐0.99] per 3 h/week). When evaluated as latent profiles, the nonobese group with higher lipids, high‐sensitivity C‐reactive protein, and insulin values (6.9% of the cohort) had increased risk of an APO/GDM and later hypertension. Among these factors, 7% to 15% of excess RR was related to APO/GDM. Conclusions Individual and combined first‐trimester atherogenic characteristics are associated with APO/GDM occurrence and hypertension 2 to 7 years later. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02231398.

scholarly journals Levels of high-sensitivity c-reactive protein in young and middle-aged working men

2021 ◽  
Vol 23 (1) ◽  
pp. 99-102
Author(s):  
Andrey A. Kirichenko ◽  
◽  
Olga A. Polyakova ◽  
Irina N. Dubovskaia ◽  
◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Screening Programs ◽  
Reactive Protein ◽  
Working Age ◽  
Hs Crp

Cardiovascular diseases remain the leading cause of death in the working age population. In recent decades, more and more attention has been attracted to a subacute chronic inflammatory process as the cause of the progression of atherosclerosis and the development of atherothrombosis. A high-sensitivity C-reactive protein (hs-CRP) is recognized as an independent marker of cardiovascular disease risk, comparable in value to cholesterol or blood pressure. Aim. Measurement of hs-CRP levels in the group of initially healthy young and middle-aged working men. Materials and methods. The study included 349 men aged 28 to 56 years, who undergo periodic medical examination at the Diagnostic and Rehabilitation Center of “Gazprom transgaz Moscow” OOO from November 2018 to February 2020.The examination was carried out according to an employee occupation by order of the Ministry of Health and Social Development of Russia No. 302n. dated 12.04.2011. Additionally, a blood test for hs-CRP was performed. Results. An increase in hs-CRP ≥2 mg/L was found in 26.7% of the men examined. In the majority of cases (89.2%), the increase in CRP ranged between 2 and 5 mg/L, in 7.5% of cases – between 5 and 10 mg/L, and only in 3,2% it exceeded 10 mg/L. All patients with elevated hs-CRP levels showed no signs of an acute inflammatory reaction. A direct correlation of hs-CRP levels with overweight and abdominal obesity, which increases with age, was revealed. In 151 men, hs-CRP levels were assessed in dynamics, of which baseline increase of ≥2 mg / l was noted in 28.5%, and after a year – in 23.2%. When assessing the absolute value of biomarker concentration, an increase in this indicator after a year was registered in 45.3% of men. Conclusion. The high incidence of increased baseline hs-CRP levels in the group of relatively healthy young and middle-aged working men, and the tendency for this indicator to increase after a year in 45.3% of men makes it appropriate to include routine measurement of the basal hs-CRP concentration in men over 40 years of age in screening programs and standards of medical examinations. Keywords: high-sensitivity C-reactive protein, atherosclerosis, cardiovascular diseases For citation: Kirichenko AA, Poliakova OA, Dubovskaia IN. Levels of high-sensitivity C-reactive protein in young and middle-aged working men. Consilium Medicum. 2021; 23 (1): 99–102. DOI: 10.26442/20751753.2021.1.200577

scholarly journals Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers

2017 ◽  
Vol 32 (2) ◽  
pp. 154-164 ◽  
Author(s):  
Christopher J. Morris ◽  
Taylor E. Purvis ◽  
Joseph Mistretta ◽  
Kun Hu ◽  
Frank A. J. L. Scheer
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
C Reactive Protein ◽  
Shift Workers ◽  
Circadian Misalignment ◽  
Reactive Protein ◽  
Hs Crp

Shift work is a risk factor for inflammation, hypertension, and cardiovascular disease. This increased risk cannot be fully explained by classical risk factors. Shift workers’ behavioral and environmental cycles are typically misaligned relative to their endogenous circadian system. However, there is little information on the impact of acute circadian misalignment on cardiovascular disease risk in shift workers, independent of differences in work stress, food quality, and other factors that are likely to differ between night and day shifts. Thus, our objectives were to determine the independent effect of circadian misalignment on 24-h high-sensitivity C-reactive protein (hs-CRP; a marker of systemic inflammation) and blood pressure levels—cardiovascular disease risk factors—in chronic shift workers. Chronic shift workers undertook two 3-day laboratory protocols that simulated night work, comprising 12-hour inverted behavioral and environmental cycles (circadian misalignment) or simulated day work (circadian alignment), using a randomized, crossover design. Circadian misalignment increased 24-h hs-CRP by 11% ( p < 0.0001). Circadian misalignment increased 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP) by 1.4 mmHg and 0.8 mmHg, respectively (both p ≤ 0.038). The misalignment-mediated increase in 24-h SBP was primarily explained by an increase in SBP during the wake period (+1.7 mmHg; p = 0.017), whereas the misalignment-mediated increase in 24-h DBP was primarily explained by an increase in DBP during the sleep opportunity (+1.8 mmHg; p = 0.005). Circadian misalignment per se increases hs-CRP and blood pressure in shift workers. This may help explain the increased inflammation, hypertension, and cardiovascular disease risk in shift workers.

scholarly journals The Effects of Job Instability and Financial Strain on C-Reactive Protein in a Sample of Mexican Immigrants

2016 ◽  
Vol 26 (1) ◽  
pp. 37 ◽  
Author(s):  
Patrick R. Steffen ◽  
Jill Walker ◽  
Richard Meredith ◽  
Chris Anderson
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Job Stress ◽  
Mexican Immigrants ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Financial Strain ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Job Instability

<p><strong>Objective:</strong> Mexican immigrants have lower cardiovascular disease risk than US citizens, but risk increases with level of acculturation. Our study investigated whether job stress and financial strain would be related to inflammation (C-reactive protein), lipids, and blood pressure, and if they would play a role in the acculturation process in Mexican immigrants.  </p><p><strong>Method:</strong> A sample of 310 Mexican immigrants living in the United States were studied on measures of job stress, financial strain, acculturation, and cardiovascular disease risk factors (C-reactive protein, lipids, and blood pressure). </p><p><strong>Results:</strong> Job instability, financial strain, and acculturation, were related to inflammation, but psychological demands and decision latitude were not related. Lipids and clinic blood pressure were not related to the variables of interest. Body mass index was related to both increased acculturation and inflammation, and when controlling for BMI, acculturation was no longer a significant predictor of inflammation. Job instability and financial strain remained significant predictors of inflammation after controlling for BMI, gender, and age. Job instability and financial strain were not related to acculturation, suggesting that these factors are significant stressors for both newly arrived and more established immigrants.</p><p><strong>Conclusions:</strong> Job instability and financial strain predict increased inflammation in Mexican immigrants but they do not play a role in the relationship between acculturation and C-reactive protein. The effects of acculturation on inflammation in this study were mediated by BMI. <em>Ethn Dis.</em> 2016;26(1):37-44; doi: 10.18865/ed.26.1.37</p>

scholarly journals Association between Depression and C-Reactive Protein

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Yunsheng Ma ◽  
David E. Chiriboga ◽  
Sherry L. Pagoto ◽  
Milagros C. Rosal ◽  
Wenjun Li ◽  
...  
Keyword(s):  
Mixed Models ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Linear Mixed Models ◽  
High Sensitivity ◽  
Beck Depression Inventory Score ◽  
Depression Score ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Objective. Depression has been associated with increased cardiovascular disease risk, and a depression-related elevation of high sensitivity C-reactive protein (hs-CRP) has been proposed as a possible mechanism. The objective of this paper is to examine association between depression and high sensitivity C-reactive protein (hs-CRP).Methods. Subjects consisted of 508 healthy adults (mean age 48.5 years; 49% women, 88% white) residing in central Massachusetts. Data were collected at baseline and at quarterly intervals over a one-year period per individual. Multivariable linear mixed models were used to assess the association for the entire sample and by gender.Results. The mean Beck Depression Inventory score was 5.8 (standard deviation (SD) 5.4; median 4.3), and average serum hs-CRP was 1.8 mg/L (SD 1.7; median 1.2). Results from the multivariable linear mixed models show that individuals with higher depression scores have higher levels of hs-CRP. Analyses by gender show persistence of an independent association among women, but not among men. Body mass index (BMI = weight(kg)/height(m)2) appears to be a partial mediator of this relationship.Conclusion. Depression score was correlated to hs-CRP levels in women. Further studies are required to elucidate the biological mechanisms underlying these associations and their implications.

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