Abstract 3253: The Predictability of C-reactive Protein, Lipoprotein-Associated Phospholipase A2, and Depression on Later Health Outcomes in Patients Experiencing a First-Time Stroke

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
mary K brethour ◽  
Karen C Albright ◽  
David E Vance ◽  
Andrei V Alexandrov ◽  
Anne W Alexandrov
Keyword(s):  
Quality Of Life ◽  
Health Outcomes ◽  
Tissue Injury ◽  
Beck Depression Inventory Score ◽  
Significant Independent Predictor ◽  
Post Stroke ◽  
Reactive Protein ◽  
Post Stroke Depression ◽  
The Impact

Background: Strokes trigger an acute inflammatory response prompted by brain tissue injury at the infarct site and the surrounding ischemic penumbra. CRP and Lp-PLA2 have been significantly correlated in some studies with infarct size and post-stroke complications, and up to 60% of stroke survivors experience depression which may contribute to poor health outcomes. We sought to examine interaction effects between baseline CRP and Lp-PLA2 levels with depression in patients with a first-ever ischemic stroke. Methods: Baseline levels of CRP, Lp-PLA2 and depression were measured in 24 consecutive stroke patients presenting to the ED within 24 hours of symptoms onset. Depression levels, NIHSS, mRS, and quality of life (SF-36) were re-measured at 3 months post-stroke. Hierarchial multiple regression models were used to assess each outcome measure; Spearman correlations were used to reduce the number of predictor variables. Results: The median age of the participants was 62 (range 45 - 85); 62% were male, 25% African American, and 75% Caucasian. Stroke subtypes were 62% lacunar, 4% large vessel; and 33% cardioembolic; 45% were taking a statin prior to admission and mean baseline LDL was 108.6 + 33.8mg/dL (range 66-189). Of the 24 participants enrolled, 20 completed the study. At 3 months post-stroke, 92% were taking a statin; mean LDL was 89.71. The median admission NIHSS score was 3.1 (range 0-15), and 17% were treated with IV t-PA Baseline CRP values ranged from <0.1 to 34.9 with a median of 0.3. Baseline Lp-PLA 2 values ranged from 85 to 617 with a median of 194. The mean Beck Depression Inventory score on admission was 5.9 + 4.6. Neither the biological markers of CRP and Lp-PLA 2 nor the interaction between CRP and Lp-PLA2 and depression were significant independent predictors of health outcomes at 3 months post-stroke. Depression, however, was a significant independent predictor of functionality (p=.009) and quality of life (p=.02) at 3 months post-stroke. Discussion: The impact of depression on 3 month outcomes is significant. While these 2 biomarkers were unreliable at predicting health outcomes, providers should standardize their assessment of depression to ensure proper detection and treatment that may improve health outcomes post-stroke.

scholarly journals Early screening for post-stroke depression, and the effect on functional outcomes, quality of life and mortality: a protocol for a systematic review and meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e050451
Author(s):  
Sudhakar Selvaraj ◽  
Teresa Arora ◽  
Tahani Casameni Montiel ◽  
Ian Grey ◽  
Hind Alfraih ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Functional Outcomes ◽  
Meta Analysis ◽  
Stroke Survivors ◽  
Early Screening ◽  
Post Stroke ◽  
Post Stroke Depression ◽  
The Impact

IntroductionPost-stroke depression (PSD) is a severe complication of cerebrovascular stroke affecting about one-third of stroke survivors. Moreover, PSD is associated with functional recovery and quality of life (QOL) in stroke survivors. Screening for PSD is recommended. There are, however, differences in the literature on the impact of early screening on functional outcomes. In this systematic review, we synthesise the currently available literature regarding the associations between timing and setting of PSD screening and mortality, QOL and functional outcomes in stroke survivors.Methods and analysisWe will systematically search electronic databases including PubMed, Embase, APA PsycINFO, Web of Science, Scopus and CINAHL from inception to August 2021. Four reviewers will screen the title and abstract and full-text level records identified in the search in a blinded fashion to determine the study eligibility. Any selection disagreements between the reviewers will be resolved by the study investigator. Data extraction of eligible studies will be conducted by two reviewers using a predefined template. We will complete the quality assessment of included articles independently by two reviewers using the Newcastle Ottawa Scale. Eventual discrepancies will be resolved by the principal investigator.Ethics and disseminationDue to the nature of the study design, ethical approval is not required. The systematic review and meta-analysis findings will be published and disseminated in a peer-reviewed journal. Our results will also be disseminated through posters and presentations at appropriate scientific conferences.PROSPERO registration numberCRD42021235993.

612 Assessing the Impact of Burns on Children Aged 5–18 Years: A Narrative Review of Health Outcomes Literature

2020 ◽  
Vol 41 (Supplement_1) ◽  
pp. S150-S150
Author(s):  
Amelia Austen ◽  
Carina Hou ◽  
Khushbu Patel ◽  
Keri Brady ◽  
Gabrielle G Grant ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Outcomes ◽  
Social Functioning ◽  
Physical Functioning ◽  
Psychological Functioning ◽  
Burn Injury ◽  
Health Domains ◽  
The Impact

Abstract Introduction Burn injuries can have major long-term effects on the health and quality of life for children and adolescents. This study narratively reviewed the health outcomes literature focusing on the impact of burn injury for children aged 5–18. Methods Literature targeting pediatric outcomes was reviewed to identify the effects of burns on children aged 5–18 (n=16). Inclusion criteria included studies that focused on the impact of burns on health and quality of life and were age-appropriate for this population. Articles were identified via PubMed, Web of Science, and manual reference checks. Data collected included the outcomes and health domains assessed in each article and the findings of the effects of the burn injury on those specific outcomes. The Preschool LIBRE Conceptual Model served as a ‘domains framework’ to guide the identification of outcomes and health domains. Results Long-term burn-specific outcomes and broad health domains identified were physical functioning (n=9), psychological functioning (n=12), social functioning (n=4), symptoms (n=8), and family (n=7). Some studies exclusively focused on one domain whereas others assessed two domains or more. Subdomains such as upper extremity functioning and functional independence were addressed in the physical functioning domain. Psychological functioning outcomes included subdomains such as emotional health and behavioral problems. Social functioning outcomes evaluated subdomains such as problems with peers and social participation. The symptoms domain addressed post-burn pain and itch. Family outcomes subdomains such as parental satisfaction with appearance and general family functioning were identified. Conclusions Burn-specific outcomes and health domains assessing the effects of burns on children aged 5–18 were identified among 16 studies. There is a need for a comprehensive assessment tool that more precisely measures the impact of burn injury across these domains. This work will inform the development of the School-Aged Life Impact Burn Recovery Evaluation (LIBRE) Computer Adaptive Test (CAT) Profile – a new outcome metric for children and adolescents with burns. Applicability of Research to Practice This review is relevant to researchers and clinicians assessing health outcomes and measuring burn recovery in children aged 5–18.

scholarly journals Association of Functional Outcome and Post Stroke Depression amongAssociation of Functional Outcome and Post Stroke Depression among Stroke Survivor after Three Months Onset: A Preliminary Study

2019 ◽  
Vol 14 (1) ◽  
pp. 31
Author(s):  
Fitria Handayani ◽  
Setyowati Setyowati ◽  
Dwi Pudjonarko ◽  
Dian Ratna Sawitri ◽  
Hastaning Sakti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Functional Outcome ◽  
Barthel Index ◽  
Rating Scale ◽  
Stroke Survivor ◽  
Nursing Intervention ◽  
Research Committee ◽  
Post Stroke ◽  
Post Stroke Depression

<p><span>Background </span></p><p><span>The Post Stroke Depression (PSD) prevalence of stroke survivor after three months onset was ranged from 17% to 37%. Depression led to fatigue, low quality of life, severe morbidity, and mortality.<span>  </span>Functional Outcome influence depression on stroke survivor. <span> </span>However, correlation between functional state level and depression among stroke survivor after three months onset has not been established. </span></p><p><span>Objective</span></p><p><span>This study was aimed to investigate the correlation of executive functional outcome and PSD among stroke survivor after three months onset. </span></p><p><span>Method</span></p><p><span>This study was a correlation study. The participants were 44 stroke ischemic patients after three months onset. Participants were recruited in an outpatient unit. PSD was measured using <span>The GRID-Hamilton Rating Scale for Depression 17 (GRID-HAMD 17) and </span>Functional Outcome was measured using <span>Barthel Index (BI). The reliability of GRID-HAMD 17 was .776. <span> </span>Both instruments were conducted on backward translation in to bahasa. Data was examined using </span>simple linier regression analyses. <span> </span>The ethical approval was obtained from the Ethical Research Committee of the Medical Faculty Diponegoro University and Tugurejo Semarang Hospital. </span></p><p><span>Results</span></p><p><span>The presence of PSD were 56.82. The median of HAMD-GRID-17 was 10.38 ± 7.58, and Barthel Index was 69.56 ± 21.69.<span>  </span>The Barthel Index showed positive correlation with HAMD-GRID-17 (?= -.41 ?=.006). The Functional Outcome determined PSD as much as 16.8 %. </span></p><p><span>Conclusion</span></p><p><span>Moderate association demonstrated the correlation between Functional Outcome and PSD. Nursing intervention should consider these two variables for an optimum quality of life among stroke survivors. </span></p><p> </p>

scholarly journals THE IMPACT OF COGNITIVE IMPAIRMENT AFTER STROKE ON QUALITY OF LIFE AND DAILY LIFE ACTIVITIES

2020 ◽  
Vol 7 (8) ◽  
pp. 6-11
Keyword(s):  
Quality Of Life ◽  
Cognitive Impairment ◽  
Daily Living ◽  
Daily Life ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Post Stroke ◽  
Daily Life Activities ◽  
The Impact

Stroke is a major cause of death and disability worldwide. Cognitive impairment is commonly seen after stroke and might significantly affect the functional outcome. The study aimed to investigate the impact of cognitive impairment after stroke on quality of life and daily life activities. This was a cross-sectional study involving 38 post stroke patients, consisted of 23 males (60.5%) and 15 females (39.5%). All patients underwent neuropsychology examination and assessment of quality of life and activity daily living. The proportion of post-stroke cognitive impairment was 44.7%. Cognitive impairment after stroke affects several domains, including attention, memory, executive function and visuospatial. Cognitive impairment was significantly associated with worse performance in daily life activities

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