Abstract 182: Thermal Imaging as a Diagnostic Biomarker in Acute Ischemic Stroke

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Linda F Aulmann ◽  
Kira Busch ◽  
Andrea Zegelin ◽  
Thomas Eckey ◽  
Alexander Neumann ◽  
...  
Keyword(s):  
Thermal Imaging ◽  
Arterial Occlusion ◽  
Current Method ◽  
Contralateral Side ◽  
Temperature Pattern ◽  
Ipsilateral Side ◽  
Anterior Circulation ◽  
Vessel Occlusion ◽  
Clear Trend ◽  
Infrared Thermal Imaging

Purpose: With highly portable mobile infrared cameras thermal imaging during acute stroke triage has become possible. The purpose of this pilot study was to evaluate the pattern of superficial facial skin temperature in patients with acute proximal arterial occlusion of the anterior circulation compared to non-ischemic controls. We hypothesize, that temperature dysregulation in stroke with associated thermal pattern may be used to predict presence of proximal vessel occlusion. Methods: In 46 patients suffering from acute occlusion in the anterior circulation (ICA: 17, M1-MCA: 13, M2-MCA: 16) infrared thermal imaging of the face was performed before endovascular treatment. Asymmetric temperature patterns were evaluated visually. Quantitative temperature values were obtained from regions of interest (ROIs) placed symmetrically on the left and right half of on the facial thermal image. Presence and side of vessel occlusion was correlated with temperature measurements. Results: Regional facial asymmetric temperature was readily visible at 0.5°C. Temperature differences ranged from 0.5 to 1.5° C in stroke patients, and <0.5°C in controls. In 16 of 17 patients with ICA occlusion, facial asymmetric temperature was detected (in 13 lower temperatures on ipsilateral side, in 3 on the contralateral side). In 11 of 13 patients with M1-MCA occlusion, facial asymmetric temperature was detected (in 8 lower temperatures on the contralateral side, 3 on the ipsilateral side). In 15 of 16 patients with an occlusion of M2-segment, asymmetric temperature pattern was apparent, however no clear trend with regard. In 16 of 20 controls, no asymmetric temperature pattern >0.5°C was observed. Conclusion: Thermal imaging could serve as a fast point-of-care test to detect asymmetrical pattern in facial temperature as a predictor of proximal vessel occlusion in stroke. However, the current method is prone to imaging artifacts and reliability of detected asymmetry is moderate.

Internal cerebral vein asymmetry is an independent predictor of poor functional outcome in endovascular thrombectomy

2021 ◽  
pp. neurintsurg-2021-017684
Author(s):  
May Zin Myint ◽  
Leonard LL Yeo ◽  
Benjamin Y Q Tan ◽  
Ei Zune The ◽  
Mei Chin Lim ◽  
...  
Keyword(s):  
Functional Outcomes ◽  
Intravenous Thrombolysis ◽  
Contralateral Side ◽  
Cerebral Vein ◽  
Cerebral Veins ◽  
Anterior Circulation ◽  
Vessel Occlusion ◽  
Endovascular Thrombectomy ◽  
Ct Angiogram ◽  
Venous Phase

BackgroundEndovascular thrombectomy (EVT) in large vessel occlusion (LVO) in anterior circulation acute ischaemic stroke (AIS) results in good functional outcomes in only approximately 60% of the patients. Internal cerebral veins (ICVs) are easily visible, with a consistent midline location, and are linked to stroke outcomes. We hypothesize that ICV asymmetry on multiphasic CT angiogram (mCTA) can be an adjunctive predictor for poor functional outcomes.MethodsWe studied consecutive AIS patients from 2017 to 2019 with anterior circulation LVO treated with EVT regardless of intravenous thrombolysis. Asymmetrical ICV was defined as the presence of hypodensity (less opacification) on the ipsilateral occlusion side as compared with the contralateral side. The primary outcome was modified Rankin Score (mRS) score at 3 months. Secondary outcomes were good recanalization (modified Thrombolysis In Cerebral Infarction (mTICI) 2b-3), symptomatic hemorrhage, and mortality.ResultsA total of 185 patients were included with a median age of 70 years (IQR 59–77); 87 patients (47%) were female. 82 patients (44.3%) achieved good functional outcomes (mRS 0–2) at 3 months. On multivariate analysis, National Institutes of Health Stroke Scale (NIHSS) (OR 1.076, 95% CI 1.015 to 1.140; p<0.013), poor collateral score (OR 0.285, 95% CI 0.162 to 0.501; p<0.001), asymmetrical ICV on the peak venous phase (OR 2.47, 95% CI 1.115 to 5.471; p<0.026), and late venous phase of the mCTA (OR 2.642, 95% CI 1.161 to 6.016; p<0.021) were independent risks factors of poor outcomes.ConclusionICV asymmetry is a novel radiological sign which is independently associated with poor functional outcomes in EVT, even after correction for collateral circulation. Further studies are needed to validate this finding.

scholarly journals Anesthetics management strategy for endovascular treatment of acute ischemic stroke. A proposal for anesthetic approach

2021 ◽  
Keyword(s):  
Ischemic Stroke ◽  
General Anesthesia ◽  
Acute Ischemic Stroke ◽  
Medical Emergency Team ◽  
Arterial Occlusion ◽  
Anaesthetic Management ◽  
Medical Emergency ◽  
Anterior Circulation ◽  
Vessel Occlusion ◽  
Emergency Team

GEAcute ischemic stroke is one of the leading causes of death and long-term disability for adults. Endovascular therapy is the standard of care for severe acute ischemic stroke, caused by large-vessel occlusion in the anterior circulation; however, the optimal anaesthetic management during the procedure is still a matter of debate. The best anesthetic treatment should mainly be related to patients’ clinical conditions and the site of arterial occlusion. With this article, we share our experience based on the use of ketamine as the choosen hypnotic drug for general anesthesia, in order to avoid a sudden drop in blood pressure. The core of our proposal approach is the general anesthesia management by the medical emergency team with skills on both time-dependent diseases and neurocritical care.

Abstract TMP12: Aspiration Thrombectomy Works Better Wn Time from Stroke Onset to Clot Contact is Shorter

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Raphael Blanc ◽  
Hocine Redjem ◽  
Gabriele Ciccio ◽  
Stanislas Smadja ◽  
Jean Philippe Desilles ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Arterial Occlusion ◽  
Stroke Onset ◽  
Anterior Circulation ◽  
Vessel Occlusion ◽  
Aspiration Thrombectomy ◽  
Two Factors ◽  
Procedural Complications ◽  
Stent Retrievers ◽  
Large Retrospective Study

Background and Purpose: The technique of A Direct Aspiration, First Pass for the Endovascular Treatment of Stroke (ADAPT) has been reported to be fast, safe and effective for the treatment of acute ischemic stroke(AIS). The aim of this study is to determine the preoperative factors that affect success of the aspiration component of the technique in ischemic stroke patients with large vessel occlusion in the anterior circulation. Methods: We enrolled all 347 consecutive patients with anterior circulation AIS admitted for mechanical thrombectomy (MT) at our institution from August 2013 to October 2015 and treated by ADAPT. Baseline and procedural characteristics, mTICI scores and 3-month mRS were captured and analyzed. Results: Among the 347 patients (occlusion sites: MCA=200, 58%; ICA Siphon=89, 25%; Tandem=58, 17%), aspiration component led to successful reperfusion (mTICI 2b/3 scores) in 56% (193/347 patients), stent retrievers were required in 40 % and a total successful final reperfusion rate of 83% (288/345) was achieved. Overall mRS 0-2 at 90 days was reported in 45% (144/323). Only two factors positively influenced the success of the aspiration component: an isolated MCA occlusion ( p< 0.001) and a shorter time from stroke onset to clot contact ( p= 0.018). Overall procedural complications occurred in 13.3% of patients (48/345). Conclusion: In this large retrospective study, ADAPT technique was shown to be safe and effective for anterior circulation AIS with a final successful reperfusion achieved in 83%. Delay from onset to clot contact and the site of arterial occlusion were predictors for reperfusion.

Infrared thermal imaging denoising method based on second-order channel attention mechanism

2021 ◽  
pp. 103789
Author(s):  
Zhuo Li ◽  
Shaojuan Luo ◽  
Meiyun Chen ◽  
Heng Wu ◽  
Tao Wang ◽  
...  
Keyword(s):  
Thermal Imaging ◽  
Second Order ◽  
Attention Mechanism ◽  
Denoising Method ◽  
Infrared Thermal Imaging

EXPRESS: Stent Retriever Alone vs. Aspiration and Stent-Retriever Combination in Large Vessel Occlusion Stroke: A Matched Analysis

2021 ◽  
pp. 174749302110192
Author(s):  
Mahmoud H Mohammaden ◽  
Diogo C. Haussen ◽  
Leonardo Pisani ◽  
Alhamza Al-Bayati ◽  
Aaron Anderson ◽  
...  
Keyword(s):  
Randomized Clinical Trials ◽  
Functional Independence ◽  
Stent Retriever ◽  
Sensitivity Analyses ◽  
First Line ◽  
Anterior Circulation ◽  
Vessel Occlusion ◽  
Guide Catheter ◽  
First Pass ◽  
Combined Technique

Background Three randomized clinical trials have reported similar safety and efficacy for contact aspiration (CA) and Stent-retriever (SR) thrombectomy. Aim We aimed to determine whether the Combined Technique (SR+CA) was superior to SR alone as first-line thrombectomy strategy in a patient cohort where balloon-guide catheter was universally used. Methods A prospectively maintained mechanical thrombectomy database from January 2018-December 2019 was reviewed. Patients were included if they had anterior circulation proximal occlusion ischemic stroke (intracranial ICA or MCA-M1/M2 segments) and underwent SR alone thrombectomy or SR+CA as first-line therapy. The primary outcome was the first-pass effect (FPE) (mTICI2c-3). Secondary outcomes included modified FPE (mTICI2b-3), successful reperfusion (mTICI2b-3) prior to and after any rescue strategy, and 90-day functional independence (mRS ≤2). Safety outcomes included rate of parenchymal hematoma (PH) type-2 and 90-day mortality. Sensitivity analyses were performed after dividing the overall cohort according to first-line modality into two matched groups. Results A total of 420 patients were included in the analysis (mean age 64.4 years; median baseline NIHSS 16[11-21]). As compared to first-line SR alone, first-line SR+CA resulted in similar rates of FPE (53% vs. 51%,aOR 1.122, 95%CI[0.745-1.691],p=0.58), mFPE (63% vs. 60.4%,aOR1.250, 95%CI[0.782-2.00],p=0.35), final successful reperfusion (97.6% vs. 98%,p=0.75) and higher chances of successful reperfusion prior to any rescue strategy (81.8% vs. 72.5%,aOR 2.033, 95%CI[1.209-3.419],p=0.007). Functional outcome and safety measures were comparable between both groups. Likewise, the matched analysis (148 patient-pairs) demonstrated comparable results for all clinical and angiographic outcomes except for significantly higher rates of successful reperfusion prior to any rescue strategies with the first-line SR+CA treatment (81.8% vs. 73.6%,aOR 1.881, 95%CI[1.039-3.405],p=0.037). Conclusions Our findings reinforce the findings of ASTER-2 trial in that the first-line thrombectomy with a Combined Technique did not result in increased rates of first-pass reperfusion or better clinical outcomes. However, addition of contact aspiration after initial SR failure might be beneficial in achieving earlier reperfusion.

scholarly journals Outcome of endovascular treatment within and beyond 6 h without perfusion software

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhen Jing ◽  
Hao Li ◽  
Shengming Huang ◽  
Min Guan ◽  
Yongxin Li ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Endovascular Treatment ◽  
General Anesthesia ◽  
Acute Ischemic Stroke ◽  
Clinical Outcomes ◽  
Symptom Onset ◽  
Anterior Circulation ◽  
Vessel Occlusion ◽  
Group A ◽  
Group B

AbstractEndovascular treatment (EVT) has been accepted as the standard of care for patients with acute ischemic stroke. The aim of the present study was to compare clinical outcomes of patients who received EVT within and beyond 6 h from symptom onset to groin puncture without perfusion software in Guangdong district, China. Between March 2017 and May 2018, acute ischemic stroke patients who received EVT from 6 comprehensive stroke centers, were enrolled into the registry study. In this subgroup study, we included all patients who had acute proximal large vessel occlusion in the anterior circulation. The demographic, clinical and neuroimaging data were collected from each center. A total of 192 patients were included in this subgroup study. They were divided into two groups: group A (n = 125), within 6 h; group B (n = 67), 6–24 h from symptom onset to groin puncture. There were no substantial differences between these two groups in terms of 90 days favorable outcome (modified Rankin scale [mRS] ≤ 2, P = 0.051) and mortality (P = 0.083), and the risk of symptomatic intracranial hemorrhage at 24 h (P = 0.425). The NIHSS (median 16, IQR12-20, group A; median 12, IQR8-18, group B; P = 0.009) and ASPECTS (median 10, IQR8-10, group A; median 9, IQR8-10, group B; P = 0.034) at baseline were higher in group A. The anesthesia method (general anesthesia, 21.3%, group A vs. 1.5% group B, P = 0.001) were also statistically different between the two groups. The NIHSS and ASPECTS were higher, and general anesthesia was also more widely used in group A. Clinical outcomes were not significantly different within 6 h versus 6–24 h from symptom onset to groin puncture in this real world study.

scholarly journals In-Hospital Intravenous Thrombolysis Offers No Benefit in Mechanical Thrombectomy in Optimized Tertiary Stroke Center Setting

2020 ◽  
Author(s):  
Juha-Pekka Pienimäki ◽  
Jyrki Ollikainen ◽  
Niko Sillanpää ◽  
Sara Protto
Keyword(s):  
Clinical Outcome ◽  
Acute Stroke ◽  
Mechanical Thrombectomy ◽  
Clinical Laboratory ◽  
Intravenous Thrombolysis ◽  
Stroke Patients ◽  
Anterior Circulation ◽  
Vessel Occlusion ◽  
Ordinal Logistic Regression Analysis ◽  
Stroke Center

Abstract Purpose Mechanical thrombectomy (MT) is the first-line treatment in acute stroke patients presenting with large vessel occlusion (LVO). The efficacy of intravenous thrombolysis (IVT) prior to MT is being contested. The objective of this study was to evaluate the efficacy of MT without IVT in patients with no contraindications to IVT presenting directly to a tertiary stroke center with acute anterior circulation LVO. Materials and Methods We collected the data of 106 acute stroke patients who underwent MT in a single high-volume stroke center. Patients with anterior circulation LVO eligible for IVT and directly admitted to our institution who subsequently underwent MT were included. We recorded baseline clinical, laboratory, procedural, and imaging variables and technical, imaging, and clinical outcomes. The effect of intravenous thrombolysis on 3-month clinical outcome (mRS) was analyzed with univariate tests and binary and ordinal logistic regression analysis. Results Fifty-eight out of the 106 patients received IVT + MT. These patients had 2.6-fold higher odds of poorer clinical outcome in mRS shift analysis (p = 0.01) compared to MT-only patients who had excellent 3-month clinical outcome (mRS 0–1) three times more often (p = 0.009). There were no significant differences between the groups in process times, mTICI, or number of hemorrhagic complications. A trend of less distal embolization and higher number of device passes was observed among the MT-only patients. Conclusions MT without prior IVT was associated with an improved overall three-month clinical outcome in acute anterior circulation LVO patients.

scholarly journals Factors associated with prominent vessel sign on susceptibility-weighted imaging in acute ischemic stroke

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hai-fei Jiang ◽  
Yi-qun Zhang ◽  
Jiang-xia Pang ◽  
Pei-ning Shao ◽  
Han-cheng Qiu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Large Vessel ◽  
Susceptibility Weighted Imaging ◽  
Regression Analyses ◽  
Large Vessel Occlusion ◽  
Stroke Patients ◽  
Anterior Circulation ◽  
Vessel Occlusion ◽  
Factors Associated ◽  
Univariate Analyses

AbstractThe prominent vessel sign (PVS) on susceptibility-weighted imaging (SWI) is not displayed in all cases of acute ischemia. We aimed to investigate the factors associated with the presence of PVS in stroke patients. Consecutive ischemic stroke patients admitted within 24 h from symptom onset underwent emergency multimodal MRI at admission. Associated factors for the presence of PVS were analyzed using univariate analyses and multivariable logistic regression analyses. A total of 218 patients were enrolled. The occurrence rate of PVS was 55.5%. Univariate analyses showed significant differences between PVS-positive group and PVS-negative group in age, history of coronary heart disease, baseline NIHSS scores, total cholesterol, hemoglobin, anterior circulation infarct, large vessel occlusion, and cardioembolism. Multivariable logistic regression analyses revealed that the independent factors associated with PVS were anterior circulation infarct (odds ratio [OR] 13.7; 95% confidence interval [CI] 3.5–53.3), large vessel occlusion (OR 123.3; 95% CI 33.7–451.5), and cardioembolism (OR 5.6; 95% CI 2.1–15.3). Anterior circulation infarct, large vessel occlusion, and cardioembolism are independently associated with the presence of PVS on SWI.

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