Abstract P195: Assessing the Validity of Predicting Resting Metabolic Rate in Chronic Stroke Patients

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Maria Novitskaya ◽  
Alice Ryan
Keyword(s):  
Metabolic Rate ◽  
Lean Mass ◽  
Resting Metabolic Rate ◽  
Chronic Stroke ◽  
Healthy Adults ◽  
Stroke Patients ◽  
Estimation Equations ◽  
Stroke Population ◽  
History Of ◽  
Total Body

Chronic stroke patients may have lower resting metabolic rate (RMR) due to disability and ensuing loss of skeletal muscle. Established equations used to estimate RMR based on weight, height, age, or lean body mass in healthy non-stroke individuals may not be accurate for a hemiparetic patient population. The purpose of this study is to determine resting metabolic rate in chronic stroke survivors and compare to RMR calculated with established equations in healthy adults. Adults (n=71; 56 males, 15 females; 40 African American, 27 Caucasian, 4 other / not reported) aged 44-76 years (61 ± 7.5 yrs) who had a history of chronic stroke (> 3 months prior) underwent a 30 minute test after a 12-hour fast to measure RMR by indirect calorimetry, total body DXA scan, and treadmill test (VO2 peak). Estimated RMR was calculated using nine established equations. RMR measured in the total group (1552 ± 319 kcal/day) was significantly different from all nine estimated RMR values (Katch-McArdle 1664 ± 242 kcal/day, P=0.05; Livingston 1671 ± 239 kcal/day, P<0.001; Mifflin 1703 ± 254 kcal/day, P<0.001; Owen 1761 ± 269 kcal/day, P<0.001; Harris Benedict 1782 ± 308 kcal/day, P<0.001; revised Harris-Benedict 1795 ± 306 kcal/day, P<0.001; Cunningham 1818 ± 247 kcal/day, P<0.001; Schofield 2147 ± 301 kcal/day, P<0.001; IMNA 2428 ± 405 kcal/day, P<0.001). Calculated RMR was between 9% and 60% greater than measured RMR, regardless of race. Appendicular lean mass (r=0.65, P<0.001), total lean mass (r=0.65, P<0.001), and VO2 peak (r=0.50, P<0.001) were associated with measured RMR. RMR estimation equations established in healthy adults are not reliable for the chronic stroke population, indicating the need for a more accurate predictive equation to better assist nutritional status in patients with conditions of muscle atrophy.

Relationship of resting metabolic rate to body composition and protein turnover

1990 ◽  
Vol 258 (6) ◽  
pp. E990-E998 ◽  
Author(s):  
S. Welle ◽  
K. S. Nair
Keyword(s):  
Protein Synthesis ◽  
Metabolic Rate ◽  
Protein Turnover ◽  
Resting Metabolic Rate ◽  
Whole Body ◽  
Simultaneous Estimation ◽  
Total Body Potassium ◽  
Average Value ◽  
Total Body ◽  
Relationship Of

This study examined whether variability among healthy young adults in resting metabolic rate, normalized for the amount of metabolically active tissue (assessed by total body potassium), is related to protein turnover. Resting metabolic rate was measured by indirect calorimetry for 2 h in 26 men and 21 women, 19-33 yr old, with simultaneous estimation of protein turnover during a 4-h infusion of L-[1-13C]leucine. After adjusting metabolic rate for total body potassium, the standard deviation was only 89 kcal/day, or 5.5% of the average value. There was a high correlation between leucine flux (an index of proteolysis) and metabolic rate (r = 0.84) and between the nonoxidized portion of leucine flux (an index of protein synthesis) and metabolic rate (r = 0.83). This relationship was weaker, but still significant, after adjusting leucine metabolism and metabolic rate for total body potassium (r = 0.36 for leucine flux vs. metabolic rate, r = 0.33 for nonoxidized portion of leucine flux vs. metabolic rate, P less than 0.05). The regression analysis suggested that the contribution of protein turnover to resting metabolic rate was approximately 20% in an average subject. Metabolic rate and protein turnover were highest in the subjects with the greatest amount of body fat, even after accounting for differences in whole body potassium. Neither resting metabolic rate nor protein turnover was related to total or free concentrations of thyroxine or triiodothyronine, within the euthyroid range.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Metabolic reduction after long-duration flight is not related to fat-free mass loss or flight duration in a migratory passerine

2020 ◽  
Vol 223 (19) ◽  
pp. jeb215384
Author(s):  
Alexander R. Gerson ◽  
Joely G. DeSimone ◽  
Elizabeth C. Black ◽  
Morag F. Dick ◽  
Derrick J. Groom
Keyword(s):  
Metabolic Rate ◽  
Mass Loss ◽  
Body Mass ◽  
Lean Mass ◽  
Migratory Birds ◽  
Resting Metabolic Rate ◽  
Fat Free Mass ◽  
Flight Duration ◽  
Long Duration ◽  
Resting Metabolism

ABSTRACTMigratory birds catabolize large quantities of protein during long flights, resulting in dramatic reductions in organ and muscle mass. One of the many hypotheses to explain this phenomenon is that decrease in lean mass is associated with reduced resting metabolism, saving energy after flight during refueling. However, the relationship between lean body mass and resting metabolic rate remains unclear. Furthermore, the coupling of lean mass with resting metabolic rate and with peak metabolic rate before and after long-duration flight have not previously been explored. We flew migratory yellow-rumped warblers (Setophaga coronata) in a wind tunnel under one of two humidity regimes to manipulate the rate of lean mass loss in flight, decoupling flight duration from total lean mass loss. Before and after long-duration flights, we measured resting and peak metabolism, and also measured fat mass and lean body mass using quantitative magnetic resonance. Flight duration ranged from 28 min to 600 min, and birds flying under dehydrating conditions lost more fat-free mass than those flying under humid conditions. After flight, there was a 14% reduction in resting metabolism but no change in peak metabolism. Interestingly, the reduction in resting metabolism was unrelated to flight duration or to change in fat-free body mass, indicating that protein metabolism in flight is unlikely to have evolved as an energy-saving measure to aid stopover refueling, but metabolic reduction itself is likely to be beneficial to migratory birds arriving in novel habitats.

Energy Conservation in Amenorrheic Ballet Dancers

2006 ◽  
Vol 21 (3) ◽  
pp. 97-104
Author(s):  
Beth Glace ◽  
Ian Kremenic ◽  
Marijeanne Liederbach
Keyword(s):  
Eating Disorders ◽  
Energy Conservation ◽  
Metabolic Rate ◽  
Body Fat ◽  
Lean Mass ◽  
Resting Metabolic Rate ◽  
Ballet Dancers ◽  
Thermic Effect Of Food ◽  
Effect Of Food ◽  
Thermic Effect

Ballet dancers may be at risk of eating disorders, and women with eating disorders are at increased risk for menstrual dysfunction. Caloric intakes of amenorrheic dancers have been reported to be less than those of eumenorrheic dancers, indicating a possible conservation of energy. We evaluated resting metabolic rate and the thermic effect of food following ingestion of a 500-kcal liquid supplement in 8 amenorrheic dancers and 10 eumenorrheic dancers. Body fat was higher for the eumenorrheic group (20%) than the amenorrheic group (15%). Resting metabolic rate did not differ between groups when corrected for body mass (24.2 ± 1.1 kcal/kg/day for amennorheic dancers vs. 25.0 ± 0.9 kcal/kg/day for eumennorheic dancers), nor did resting metabolic rate differ when adjusted for lean mass. However, amennorheic dancers expended significantly less energy post-prandially once adjusted for lean mass (ANOVA, effect of group p = 0.035). Dancers were asked to complete the Eating Disorder Inventory, a self-report scale that measures symptoms of disordered eating; 9 of 10 eumennorheic but only 4 of 8 amennorheic women were willing to complete the questionnaire. Eumennorheic dancers had profiles similar to or less pathologic than those of non-eating-disordered populations. Greater dissatisfaction was expressed by eumennorheic women as body fat increased. Contrary to the findings in previous studies, amennorheic ballet dancers did not exhibit energy conservation via reductions in resting metabolic rate but did expend slightly less energy in thermic effect of food compared to normally menstruating women.

Physiological Effects of Weight Cycling in Female Lightweight Rowers

1993 ◽  
Vol 18 (3) ◽  
pp. 291-303 ◽  
Author(s):  
Linda J. McCargar ◽  
Deanna Simmons ◽  
Neil Craton ◽  
Jack E. Taunton ◽  
C. Laird Birmingham
Keyword(s):  
Body Weight ◽  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Metabolic Changes ◽  
Fat Free Mass ◽  
Control Group ◽  
Weight Cycling ◽  
Weight Fluctuation ◽  
Healthy Female ◽  
History Of

Repeated cycles of weight loss and regain are referred to as weight cycling. It is a practice of many athletes who must achieve a low body weight. The purpose of this study was to determine whether a history of weight cycling results in sustained metabolic changes. Healthy female rowers with a history of dieting and weight fluctuation (n = 7) were compared to a control group of rowers who had never dieted (n = 7). Anthropometric and metabolic measurements were done at pre-, peak, and off-season during a 1-year period. At peak season the weight cyclers restricted their food intake and lost 4.2 ± 1.8 kg, and subsequently regained 4.0 ± 2.1 kg in the off-season. This was different from the controls (p =.003), who maintained a stable body weight at all times. No other group differences were observed. Resting metabolic rate (RMR) and triiodothyronine (T3) changed with time (p =.001, p =.000, respectively) in both groups, which appeared to reflect changes in fat free mass (FFM), not body weight. Long-term metabolic changes were not observed in these athletes. Key words: weight cycling, metabolic rate, body composition, rowers

scholarly journals Direct evidence for tonic sympathetic support of resting metabolic rate in healthy adult humans

2001 ◽  
Vol 280 (5) ◽  
pp. E740-E744 ◽  
Author(s):  
Mary Beth Monroe ◽  
Douglas R. Seals ◽  
Linda F. Shapiro ◽  
Christopher Bell ◽  
David Johnson ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Direct Evidence ◽  
Heart Rate Response ◽  
Healthy Adult ◽  
Resting Metabolic Rate ◽  
Healthy Adults ◽  
Saline Control ◽  
Adrenergic Blockade ◽  
Adult Humans ◽  
Control Infusion

The sympathetic nervous system (SNS) plays an important role in the regulation of energy expenditure. However, whether tonic SNS activity contributes to resting metabolic rate (RMR) in healthy adult humans is controversial, with the majority of studies showing no effect. We hypothesized that an intravenous propranolol infusion designed to achieve complete β-adrenergic blockade would result in a significant acute decrease in RMR in healthy adults. RMR (ventilated hood, indirect calorimetry) was measured in 29 healthy adults (15 males, 14 females) before and during complete β-adrenergic blockade documented by plasma propranolol concentrations ≥100 ng/ml, lack of heart rate response to isoproterenol, and a plateau in RMR with increased doses of propranolol. Propranolol infusion evoked an acute decrease in RMR (−71 ± 11 kcal/day; −5 ± 0.7%, P < 0.0001), whereas RMR was unchanged from baseline levels during a saline control infusion ( P > 0.05). The response to propranolol differed from the response to saline control ( P < 0.01). The absolute and percent decreases in RMR with propranolol were modestly related to baseline plasma concentration of norepinephrine ( r = 0.38, P = 0.05; r= 0.44, P = 0.02, respectively). These findings provide direct evidence for the concept of tonic sympathetic β-adrenergic support of RMR in healthy nonobese adults.

scholarly journals Performance of resting metabolic rate estimation equations in obese patients

2015 ◽  
Vol 7 (S1) ◽  
Author(s):  
Milene Moehlecke ◽  
Manoel Roberto Maciel Trindade ◽  
Ana Carolina Mazzuca ◽  
Carina Andriatta Blume ◽  
Jakeline Rheinheimer ◽  
...  
Keyword(s):  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Obese Patients ◽  
Rate Estimation ◽  
Estimation Equations

scholarly journals The Effect of Gender and Body Composition Method on the Apparent Decline in Lean Mass-Adjusted Resting Metabolic Rate With Age

2000 ◽  
Vol 55 (12) ◽  
pp. M757-M760 ◽  
Author(s):  
R. Roubenoff ◽  
V. A. Hughes ◽  
G. E. Dallal ◽  
M. E. Nelson ◽  
C. Morganti ◽  
...  
Keyword(s):  
Body Composition ◽  
Metabolic Rate ◽  
Lean Mass ◽  
Resting Metabolic Rate ◽  
Composition Method
Sign in / Sign up

Export Citation Format

Share Document