scholarly journals The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study Protocol

Stroke ◽  
2013 ◽  
Vol 44 (10) ◽  
Author(s):  
Daniel Woo ◽  
Jonathan Rosand ◽  
Chelsea Kidwell ◽  
Jacob L. McCauley ◽  
Jennifer Osborne ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Case Control ◽  
Metropolitan Region ◽  
Sample Collection ◽  
Racial Variations ◽  
Epidemiological Risk ◽  
Control Study ◽  
Hispanic White

Background and Purpose— Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case–control study of ICH. Methods— The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case–control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (±5 years), race, ethnicity, sex, and metropolitan region. Results— As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5% of the target for that date, and 851 controls had been recruited, which is 67.2% of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5% of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white, and 554 (34%) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation. Conclusions— The ERICH study is a large, case–control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.

Abstract WP369: Long Sleep Duration as a Risk Factor for Intracerebral Hemorrhage: a Nationwide, Multicenter Case-control Study

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Tae Jung Kim ◽  
Chi Kyung Kim ◽  
Yerim Kim ◽  
Han-Gil Jeong ◽  
Kiwoong Nam ◽  
...  
Keyword(s):  
Risk Factor ◽  
Confidence Interval ◽  
Intracerebral Hemorrhage ◽  
Sleep Duration ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Stroke Incidence ◽  
Long Sleep ◽  
Control Study

Introduction: Sleep duration has been regarded as a potential risk factor for cardiovascular disease and stroke. Short sleep duration is linked with higher stroke incidence, and mortality. Moreover, and paradoxically, long sleep duration is also reported to be positively associated with stroke incidence. However, the impact of sleep duration on the intracerebral hemorrhage (ICH) risk remains unclear. Hypothesis: We assessed the relationship between sleep duration and the risk of ICH. Methods: We performed a nationwide, multicenter matched case-control study to investigate the risk factors for hemorrhagic stroke, using patients from 33 hospitals in Korea. We enrolled a total of 490 patients with ICH and 980 age- and sex-matched controls. We obtained information regarding sleep, sociodemographic factors, lifestyle, and medical history before ICH onset, using qualified structured questionnaires. Sleep duration was categorized as ≤5, 6, 7, 8, and ≥9 hours. We chose sleep duration of 7 h as the reference duration. Results: The included patients were mostly male (58.2%) with a mean age of 57 years. The number of subjects with long sleep duration, more than 8 h, was significantly greater in the ICH group than in the control group (≥8 h, 30.4% vs. 22.6%, P = 0.002). Compared to 7 h, long sleep duration participants tended to be older, be more hypertensive, and be more likely to have blue collar jobs, lower education levels, and poorer marital status (i.e., unmarried or divorced/separated). After controlling for confounding factors, we found that longer sleep duration was independently associated with the risk of ICH in a dose-response manner (8 h: Odds ratio, 1.44; confidence interval, 1.01-2.07; ≥9 h: Odds ratio, 2.60; confidence interval, 1.50–4.49). Conclusions: In conclusion, our study suggested that long sleep duration is positively related to ICH risk in a dose-dependent manner. In this context, our data might suggest that sleep duration is a modifiable risk factor for ICH.

Epidemiological risk factors for adrenocortical carcinoma: A hospital‐based case–control study

2019 ◽  
Vol 146 (7) ◽  
pp. 1836-1840 ◽  
Author(s):  
Mouhammed A. Habra ◽  
Mohamad A. Sukkari ◽  
Ansam Hasan ◽  
Youssef Albousen ◽  
Mohamed A. Elsheshtawi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adrenocortical Carcinoma ◽  
Case Control Study ◽  
Case Control ◽  
Epidemiological Risk ◽  
Control Study

scholarly journals Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma

2020 ◽  
Vol 17 (17) ◽  
pp. 6146
Author(s):  
Chiara Airoldi ◽  
Daniela Ferrante ◽  
Dario Mirabelli ◽  
Danila Azzolina ◽  
Corrado Magnani
Keyword(s):  
Case Control Study ◽  
Hospital Admissions ◽  
Reference Group ◽  
Epidemiological Studies ◽  
Case Control ◽  
Education Level ◽  
Nonresponse Bias ◽  
Cumulative Exposure ◽  
The Status ◽  
Control Study

Nonparticipation limits the power of epidemiological studies, and can cause bias. In a case–control study on pleural malignant mesothelioma (MM), we found low participation in interviews (63%) among controls. Our goal was to characterize nonresponder controls and assess nonresponse bias in our study. We selected all nonresponder controls (204) and a random sample of responder controls (174). Data were obtained linking hospital admissions and town registrars, and concordance between sources was assessed. Nonresponse bias was evaluated using a logistic regression model applying the inverse probability weighting approach. The odds ratio (OR) for the status of the respondents was 0.61 (95% confidence interval (CI): 0.33–1.16) for controls aged 61–70, 0.37 (CI: 0.20–0.66) for those aged 71–80, and 0.40 (CI: 0.20–0.80) for those aged above 80 (reference group: ≤60 years). Controls with low education level had lower OR (0.47; CI: 0.26–0.84). After adjustment, the ORs for MM by categories of cumulative exposure to asbestos were similar to the unadjusted results, ranging from 4.6 (CI: 1.8–11.7) for cumulative exposures between 0.1 and 1 f/mL-y to 57.5 (CI: 20.2–163.9) above 10 f/mL-y. Responder controls were younger and had higher education level. Nevertheless, there was little evidence of bias from nonresponse in the risk estimates of MM.

scholarly journals Risk Factors of Intracerebral Hemorrhage: A Case-Control Study

2020 ◽  
Vol 29 (4) ◽  
pp. 104630
Author(s):  
Hanne Sallinen ◽  
Arto Pietilä ◽  
Veikko Salomaa ◽  
Daniel Strbian
Keyword(s):  
Risk Factors ◽  
Intracerebral Hemorrhage ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Case-control study about exposure to BPA and DEHP and risk of endometriosis

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
M Fiore ◽  
P Zuccarello ◽  
M Gulisano ◽  
M Monteleone ◽  
G Bonaccorso ◽  
...  
Keyword(s):  
Endocrine Disruptors ◽  
Food Packaging ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Case Control ◽  
Control Group ◽  
Reverse Correlation ◽  
Time Exposure ◽  
Urinary Analysis ◽  
Control Study

Abstract Background BPA and DEHP are endocrine disruptors. BPA-G and MEHP are their main metabolites. The main exposure route for human is the diet. Endometriosis is a pathology with uncertain etiopathogenesis, characterized by disturbances in sex hormones balance with a prevalence in women ranged from 1% to 7% in women aged 15-45 years. Methods A case-control study should highlight a possible relationship between exposure to DEHP and BPA and endometriosis. Patients (n = 40) with a surgical diagnosis of endometriosis will compose the group of cases; healthy women (n = 40) will compose the control group. Cases and controls will be studied by means of questionnaires and by means of urinary analysis of these endocrine disruptors concentration. Results BPA values ranged between 0.05-8.55 and 0.05-1.84 in cases and in controls, respectively; BPA-G values ranged between 0.05-16.1 and 0.05-7.38 in cases and in controls, respectively; total BPA values ranged between 0.05-3.26 and 0.05-3.51 in cases and in controls, respectively. DEHP values ranged between 13.63-57.78 and 16.66-61.93 in cases and in controls, respectively; MEHP values ranged between 1.74-6.16 and 4.26-14.16 in cases and in controls, respectively; total DEHP ranged between 15.27-63.93 and 21.72-72.73 in cases and in controls, respectively. A reverse correlation was found between endometriosis and phthalates, while a direct correlation was found between BPA and endometriosis. Conclusions The direct correlation between BPA and endometriosis suggests the decreasing the use of plasticizer in food packaging and the importance to implement interventions and strategy to minimize exposure. The reverse correlation between endometriosis and DEHP could be explained by the small size of sample and by the monitoring of urine that are representative of a short-time exposure. Key messages Improve epidemiological studies with analysis of alternative matrices that are more representative of long-time exposure. Implement interventions and strategy to minimize exposure to plasticizer.

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