scholarly journals The Functional Role of Response Suppression during an Urge to Relieve Pain

2019 ◽  
Vol 31 (9) ◽  
pp. 1404-1421
Author(s):  
Kelsey K. Sundby ◽  
Johanna Wagner ◽  
Adam R. Aron
Keyword(s):  
Short Interval ◽  
Intracortical Inhibition ◽  
Gabaergic Interneuron ◽  
Response Suppression ◽  
Active Response ◽  
Relieve Pain ◽  
Clinical Disorders ◽  
Functional Relevance ◽  
Interneuron Activity

Being in the state of having both a strong impulse to act and a simultaneous need to withhold is commonly described as an “urge.” Although urges are part of everyday life and also important to several clinical disorders, the components of urge are poorly understood. It has been conjectured that withholding an action during urge involves active response suppression. We tested that idea by designing an urge paradigm that required participants to resist an impulse to press a button and gain relief from heat (one hand was poised to press while the other arm had heat stimulation). We first used paired-pulse TMS over motor cortex (M1) to measure corticospinal excitability of the hand that could press for relief, while participants withheld movement. We observed increased short-interval intracortical inhibition, an index of M1 GABAergic interneuron activity that was maintained across seconds and specific to the task-relevant finger. A second experiment replicated this. We next used EEG to better “image” putative cortical signatures of motor suppression and pain. We found increased sensorimotor beta contralateral to the task-relevant hand while participants withheld the movement during heat. We interpret this as further evidence of a motor suppressive process. Additionally, there was beta desynchronization contralateral to the arm with heat, which could reflect a pain signature. Strikingly, participants who “suppressed” more exhibited less of a putative “pain” response. We speculate that, during urge, a suppressive state may have functional relevance for both resisting a prohibited action and for mitigating discomfort.

scholarly journals Short interval intracortical inhibition as measured by TMS-EEG

2019 ◽  
Author(s):  
Vishal Rawji ◽  
Isabella Kaczmarczyk ◽  
Lorenzo Rocchi ◽  
John C. Rothwell ◽  
Nikhil Sharma
Keyword(s):  
Early Diagnosis ◽  
Motor Neurons ◽  
Short Interval ◽  
Single Pulse ◽  
Significant Negative Correlation ◽  
Intracortical Inhibition ◽  
Cortical Inhibition ◽  
Independent Marker ◽  
Lateral Sclerosis

AbstractThe diagnosis of amyotrophic lateral sclerosis (ALS) relies on involvement of both upper (UMN) lower motor neurons (LMN). Yet, there remains no objective marker of UMN involvement, limiting early diagnosis of ALS. This study establishes whether TMS combined with EEG can be used to measure short-interval intracortical inhibition (SICI) via TMS evoked potentials (TEP) in healthy volunteers - an essential first step in developing an independent marker of UMN involvement in ALS.We hypothesised that a SICI paradigm would result in characteristic changes in the TMS-evoked EEG potentials that directly mirror the changes in MEP.TMS was delivered to the left motor cortex using single-pulse and three inhibitory stimulation paradigms. SICI was present in all three conditions. TEP peaks were reduced predominantly under the SICI 70 protocol but less so for SICI 80 and not at all for SICI 90. There was a significant negative correlation between MEPs and N45 TEP peak for SICI 70 (rho = −0.54, p = 0.04). In other words, as MEPs becomes inhibited the N45 increases. The same trend was maintained across SICI 80 and 90 (SICI 80, rho = −0.5, p = 0.06; SICI 90, rho = −0.48, p = 0.07). Additional experiments suggest these results cannot be explained by artefact.We establish that motor cortical inhibition can be measured during a SICI 70 protocol expanding on previous work. We have carefully considered the role of artefact in TEPs and have taken a number of steps to show that artefact cannot explain these results and we suggesting the differences are cortical in origin. TMS-EEG has potential to aid early diagnosis and to further understand central and peripheral pathophysiology in MND.

TESTING GOAL-DRIVEN CAPTURE BY THREAT

2019 ◽  
Author(s):  
Chris Robert Harrison Brown
Keyword(s):  
Experimental Evidence ◽  
Attentional Capture ◽  
Critical Role ◽  
Experimental Manipulation ◽  
Contingent Capture ◽  
Top Down ◽  
Affective Stimuli ◽  
Clinical Disorders ◽  
Positive Stimuli

Attention has long been characterised within prominent models as reflecting a competition between goal-driven and stimulus-driven processes. It remains unclear, however, how involuntary attentional capture by affective stimuli, such as threat-laden content, fits into such models. While such effects were traditionally held to reflect stimulus-driven processes, recent research has increasingly implicated a critical role of goal-driven processes. Here we test an alternative goal-driven account of involuntary attentional capture by threat, using an experimental manipulation of goal-driven attention. To this end we combined the classic ‘contingent capture’ and ‘emotion-induced blink’ (EIB) paradigms in an RSVP task with both positive or threatening target search goals. Across six experiments, positive and threat distractors were presented in peripheral, parafoveal, and central locations. Across all distractor locations, we found that involuntary attentional capture by irrelevant threatening distractors could be induced via the adoption of a search goal for a threatening category; adopting a goal for a positive category conversely led to capture only by positive stimuli. Our findings provide direct experimental evidence for a causal role of voluntary goals in involuntary capture by irrelevant threat stimuli, and hence demonstrate the plausibility of a top-down account of this phenomenon. We discuss the implications of these findings in relation to current cognitive models of attention and clinical disorders.

scholarly journals Modulation of intracortical inhibition during physically performed and mentally simulated balance tasks

2021 ◽  
Vol 121 (5) ◽  
pp. 1379-1388
Author(s):  
A. Mouthon ◽  
J. Ruffieux ◽  
W. Taube
Keyword(s):  
Motor Evoked Potentials ◽  
Action Observation ◽  
Short Interval ◽  
Intracortical Inhibition ◽  
Mental Simulation ◽  
Task Execution ◽  
Postural Tasks ◽  
Execution Condition ◽  
The One ◽  
Postural Task

Abstract Purpose Action observation (AO) during motor imagery (MI), so-called AO + MI, has been proposed as a new form of non-physical training, but the neural mechanisms involved remains largely unknown. Therefore, this study aimed to explore whether there were similarities in the modulation of short-interval intracortical inhibition (SICI) during execution and mental simulation of postural tasks, and if there was a difference in modulation of SICI between AO + MI and AO alone. Method 21 young adults (mean ± SD = 24 ± 6.3 years) were asked to either passively observe (AO) or imagine while observing (AO + MI) or physically perform a stable and an unstable standing task, while motor evoked potentials and SICI were assessed in the soleus muscle. Result SICI results showed a modulation by condition (F2,40 = 6.42, p = 0.009) with less SICI in the execution condition compared to the AO + MI (p = 0.009) and AO (p = 0.002) condition. Moreover, switching from the stable to the unstable stance condition reduced significantly SICI (F1,20 = 8.34, p = 0.009) during both, physically performed (− 38.5%; p = 0.03) and mentally simulated balance (− 10%, p < 0.001, AO + MI and AO taken together). Conclusion The data demonstrate that SICI is reduced when switching from a stable to a more unstable standing task during both real task execution and mental simulation. Therefore, our results strengthen and further support the existence of similarities between executed and mentally simulated actions by showing that not only corticospinal excitability is similarly modulated but also SICI. This proposes that the activity of the inhibitory cortical network during mental simulation of balance tasks resembles the one during physical postural task execution.

Role of intracortical inhibition in orientation tuning dynamics in the cat striate cortex neurons

1995 ◽  
Vol 27 (2) ◽  
pp. 77-84 ◽  
Author(s):  
I. A. Shevelev ◽  
U. T. Eysel ◽  
N. A. Lazareva ◽  
G. A. Sharaev
Keyword(s):  
Striate Cortex ◽  
Intracortical Inhibition ◽  
Orientation Tuning ◽  
Cat Striate Cortex

Effects of water immersion on short- and long-latency afferent inhibition, short-interval intracortical inhibition, and intracortical facilitation

2013 ◽  
Vol 124 (9) ◽  
pp. 1846-1852 ◽  
Author(s):  
Daisuke Sato ◽  
Koya Yamashiro ◽  
Takuya Yoshida ◽  
Hideaki Onishi ◽  
Yoshimitsu Shimoyama ◽  
...  
Keyword(s):  
Water Immersion ◽  
Short Interval ◽  
Intracortical Inhibition ◽  
Intracortical Facilitation ◽  
Afferent Inhibition ◽  
Long Latency

Intracortical Inhibition During Volitional Inhibition of Prepared Action

2006 ◽  
Vol 95 (6) ◽  
pp. 3371-3383 ◽  
Author(s):  
James P. Coxon ◽  
Cathy M. Stinear ◽  
Winston D. Byblow
Keyword(s):  
Primary Motor Cortex ◽  
Motor Evoked Potentials ◽  
Short Interval ◽  
Intracortical Inhibition ◽  
Corticomotor Excitability ◽  
Hand Muscles ◽  
Cortical Level ◽  
A Site ◽  
Intrinsic Hand Muscles ◽  
Inhibitory Networks

Volitional inhibition is the voluntary prevention of a prepared movement. Here we ask whether primary motor cortex (M1) is a site of convergence of cortical activity associated with movement preparation and volitional inhibition. Volitional inhibition was studied by presenting a stop signal before execution of an anticipated response that requires a key lift to intercept a revolving dial. Motor evoked potentials (MEPs) were elicited in intrinsic hand muscles by transcranial magnetic stimulation (TMS) to assess corticomotor excitability and short interval intracortical inhibition (sICI) during task performance. The closer the stop cue was presented to the anticipated response, the harder it was for subjects to inhibit their response. Corticomotor pathway excitability was temporally modulated during volitional inhibition. Using subthreshold TMS, corticomotor excitability was reduced for Stop trials relative to Go trials from 140 ms after the cue. sICI was significantly greater for Stop trials compared with Go trials at a time that preceded the onset of muscle activity associated with the anticipated response. These results provide evidence that volitional inhibition is exerted at a cortical level and that inhibitory networks within M1 contribute to volitional inhibition of prepared action.

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