Telerehabilitation for Chronic Respiratory Disease: A Cochrane Systematic Review

IntroductionChronic disease in children is increasing, including the prevalence of chronic respiratory diseases such as asthma, cystic fibrosis (CF), bronchiectasis and bronchopulmonary dysplasia (BPD). The aim of this systematic review and meta-analysis was to evaluate the effects of exercise training on health outcomes in children with chronic respiratory disease.MethodFive databases were searched for randomised controlled trials investigating the effects of exercise training on children with chronic respiratory disease. Following the PRISMA guidelines, eligible studies were identified and data were extracted. A meta-analysis was conducted for the outcomes cardiovascular fitness, lung function and quality of life (QoL).ResultsThe initial search returned 3688 papers. Twenty-seven (17 in children with asthma, 10 in children with CF) were included in the systematic review and 24 of these were included in the meta-analysis. No studies were identified in children with bronchiectasis or BPD. Included papers had a total of 1009 participants aged 8–20 years. In addition to cardiovascular fitness, lung function and QoL, studies also assessed pulmonary function, respiratory muscle strength, muscular strength and inflammation. Meta-analysis showed a large significant effect size in favour of exercise for cardiovascular fitness (peak VO2) (standard mean difference (SMD)=1.16, 95% CI 0.61 to 1.70) and QoL (SMD=1.27, 95% CI 0.72 to 1.82) as well as a small, non-significant effect size for lung function (FEV1) (SMD=0.02, 95% CI -0.38 to 0.42).ConclusionExercise training significantly improves cardiovascular fitness and QoL in children with asthma and CF. Further research is needed, particularly in children with bronchiectasis and BPD.

Download Full-text

Non-communicable respiratory disease in Malawi: a systematic review and meta-analysis

Malawi Medical Journal ◽

10.4314/mmj.v32i2.3 ◽

2020 ◽

Vol 32 (2) ◽

pp. 64-73

Author(s):

Rebecca Nightingale

Keyword(s):

Systematic Review ◽

Respiratory Disease ◽

Meta Analysis ◽

Airflow Obstruction ◽

Secondary Data ◽

Chronic Respiratory Disease ◽

African Countries ◽

History Of ◽

Sub Saharan ◽

The Life Course

BackgroundNon-communicable respiratory diseases are important contributors to morbidity and mortality in sub-Saharan African countries such as Malawi. AimTo conduct a systematic review of the available literature relating to chronic respiratory disease in Malawi. MethodsWe conducted a systematic protocol-driven literature search of key scientific databases including Scopus and Medline. Papers were independently assessed for eligibility by two authors and included if they reported objective measures (including self-reported standard symptoms) of chronic respiratory disease and were conducted in Malawi. A meta-analysis of available estimates was then conducted. We re-analysed data from three of these studies in a secondary data analysis to allow for between-study comparisons. ResultsOur search identified 393 papers of which 17 (5 involving children and 12 involving adults) met the inclusion criteria. Wheeze was the symptom most frequently reported in children in the community (12.1%), hospital (11.2%) and HIV clinic (8.1%) settings. Cough was the symptom most frequently reported by adults in the community (3–18%). Spirometric abnormalities varied substantially between studies. For example, in adults, airflow obstruction varied between 2.3% and 20% and low forced vital capacity (FVC) varied between 2.7% and 52.8%. ConclusionWe identified a high burden of chronic respiratory symptoms and abnormal spirometry (particularly low FVC) within paediatric and adult populations in Malawi. The estimates for country-wide burden related to this disease were limited by the heterogeneity of the methods used to assess symptoms and spirometry. There is an urgent need to develop a better understanding of the determinants and natural history of non-communicable respiratory disease across the life-course in Malawi.

Download Full-text

Characteristics and Role of Neutrophil Extracellular Traps in Asthma

Inflammation ◽

10.1007/s10753-021-01526-8 ◽

2021 ◽

Author(s):

Fei Chen ◽

Min Yu ◽

Yonghong Zhong ◽

Lina Wang ◽

Huaqiong Huang

Keyword(s):

Systematic Review ◽

Protective Effect ◽

Allergic Asthma ◽

Respiratory Disease ◽

Bronchial Asthma ◽

Inflammatory Cells ◽

Neutrophil Extracellular Traps ◽

Chronic Respiratory Disease ◽

Extracellular Traps

Abstract Asthma is a common chronic respiratory disease that affects millions of people worldwide. The incidence of asthma has continued to increase every year. Bronchial asthma involves a variety of cells, including airway inflammatory cells, structural cells, and neutrophils, which have gained more attention because they secrete substances that play an important role in the occurrence and development of asthma. Neutrophil extracellular traps (NETs) are mesh-like structures composed of DNA, histones, and non-histone molecules that can be secreted from neutrophils. NETs can enrich anti-bacterial substances and limit pathogen migration, thus having a protective effect in case of inflammation. However, despite of their anti-inflammatory properties, NETs have been shown to trigger allergic asthma and worsen asthma progression. Here, we provide a systematic review of the roles of NETs in asthma.

Download Full-text

Tuberculosis and chronic respiratory disease: a systematic review

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2014.12.016 ◽

2015 ◽

Vol 32 ◽

pp. 138-146 ◽

Cited By ~ 90

Author(s):

Anthony L. Byrne ◽

Ben J. Marais ◽

Carole D. Mitnick ◽

Leonid Lecca ◽

Guy B. Marks

Keyword(s):

Systematic Review ◽

Respiratory Disease ◽

Chronic Respiratory Disease

Download Full-text

An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease

European Respiratory Journal ◽

10.1183/09031936.00150414 ◽

2014 ◽

Vol 44 (6) ◽

pp. 1447-1478 ◽

Cited By ~ 276

Author(s):

Sally J. Singh ◽

Milo A. Puhan ◽

Vasileios Andrianopoulos ◽

Nidia A. Hernandes ◽

Katy E. Mitchell ◽

...

Keyword(s):

Systematic Review ◽

Respiratory Disease ◽

Learning Effect ◽

Supplemental Oxygen ◽

Chronic Respiratory Disease ◽

Track Length ◽

Measurement Properties ◽

Walking Distance ◽

Walk Test ◽

European Respiratory Society

This systematic review examined the measurement properties of the 6-min walk test (6MWT), incremental shuttle walk test (ISWT) and endurance shuttle walk test (ESWT) in adults with chronic respiratory disease.Studies that report the evaluation or use of the 6MWT, ISWT or ESWT were included. We searched electronic databases for studies published between January 2000 and September 2013.The 6-min walking distance (6MWD) is a reliable measure (intra-class correlation coefficients ranged from 0.82 to 0.99 in seven studies). There is a learning effect, with greater distance walked on the second test (pooled mean improvement of 26 m in 13 studies). Reliability was similar for ISWT and ESWT, with a learning effect also evident for ISWT (pooled mean improvement of 20 m in six studies). The 6MWD correlates more strongly with peak work capacity (r=0.59–0.93) and physical activity (r=0.40–0.85) than with respiratory function (r=0.10–0.59). Methodological factors affecting 6MWD include track length, encouragement, supplemental oxygen and walking aids. Supplemental oxygen also affects ISWT and ESWT performance. Responsiveness was moderate to high for all tests, with greater responsiveness to interventions that included exercise training.The findings of this review demonstrate that the 6MWT, ISWT and ESWT are robust tests of functional exercise capacity in adults with chronic respiratory disease.

Download Full-text

Specialist to non-specialist teleconsultations in chronic respiratory disease management: A systematic review

Journal of Global Health ◽

10.7189/jogh.11.04019 ◽

2021 ◽

Vol 11 ◽

Author(s):

Rutuja Patil ◽

Rahul Shrivastava ◽

Sanjay Juvekar ◽

Brian McKinstry ◽

Karen Fairhurst

Keyword(s):

Systematic Review ◽

Disease Management ◽

Respiratory Disease ◽

Chronic Respiratory Disease

Download Full-text

Identifying and Describing Impact of Disasters on Non-Communicable Diseases: A Systematic Review

Iranian Journal of Public Health ◽

10.18502/ijph.v50i6.6413 ◽

2021 ◽

Author(s):

Elham Ghazanchaei ◽

Davoud Khorasani-Zavareh ◽

Javad Aghazadeh-Attari ◽

Iraj Mohebbi

Keyword(s):

Mental Health ◽

Systematic Review ◽

Cardiovascular Disease ◽

Natural Disasters ◽

Respiratory Disease ◽

Communicable Disease ◽

Chronic Respiratory Disease ◽

Communicable Diseases ◽

Non Communicable Diseases ◽

The Impact

Background: Patients with non-communicable diseases are vulnerable to disasters. This is a systematic review describing the impact of disasters on non-communicable diseases. Methods: A systematic review was conducted using PRISMA standards. Relevant articles published from 1997 to 2019 collected by searching the Scopus, PubMed, Science Direct, databases. We specifically examined reports describing NCDs and including the key words “non-communicable disease and Disasters”. NCDs included cardiovascular, respiratory, diabetes, cancer and mental health diseases. Results: Of the 663 studies identified, only 48 articles met all the eligibility criteria. Most studies have shown the impact of all natural disasters on non-communicable diseases (39.8% n=19). The largest study was the effect of earthquakes on non-communicable diseases (29.2% n=14). For the NCDs targeted by this research, most of the included studies were a combination of four diseases: cardiovascular disease, respiratory disease, diabetes and cancer (44% n=21). Followed by cardiovascular disease (14.6% n=7), chronic respiratory disease (12.5% n=6), diabetes and cancer (6.2% n=3) and mental health (12.5% n=6). Conclusion: The incidence of disasters affects the management of treatment and care for patients with NCDs. Specific measures include a multi-part approach to ensuring that patients with non-communicable diseases have access to life-saving services during and after disasters. The approach of the health system should be expanded from traditional approaches to disasters and requires comprehensive planning of health care by policy makers and health professionals to develop effective strategies to enable patients to access medical, therapeutic and diagnostic services in natural disasters.

Download Full-text

A systematic review to assess the components of clinical decision support systems (CDSS) in chronic respiratory disease (CRD) and their relevance to physiotherapy management

10.1183/13993003.congress-2021.pa3449 ◽

2021 ◽

Author(s):

Katherine O'Neill ◽

Helen Parrott ◽

Rebecca Mc Grath ◽

Curtis Neilly ◽

Judy. M. Bradley

Keyword(s):

Systematic Review ◽

Decision Support ◽

Decision Support Systems ◽

Respiratory Disease ◽

Clinical Decision Support ◽

Support Systems ◽

Clinical Decision Support Systems ◽

Clinical Decision ◽

Chronic Respiratory Disease

Download Full-text

Behavior change theory, content and delivery of interventions to enhance adherence in chronic respiratory disease: A systematic review

Respiratory Medicine ◽

10.1016/j.rmed.2016.05.021 ◽

2016 ◽

Vol 116 ◽

pp. 78-84 ◽

Cited By ~ 10

Author(s):

Amanda R. McCullough ◽

Crístín Ryan ◽

Christopher Macindoe ◽

Nathan Yii ◽

Judy M. Bradley ◽

...

Keyword(s):

Systematic Review ◽

Behavior Change ◽

Respiratory Disease ◽

Change Theory ◽

Chronic Respiratory Disease ◽

Behavior Change Theory

Download Full-text

Risk Factors for Severe Illness and Death in COVID-19: A Systematic Review and Meta-analysis

10.21203/rs.3.rs-133791/v1 ◽

2021 ◽

Author(s):

Abraham Degarege ◽

Zaeema Naveed ◽

Josiane Kabayundo ◽

David Brett-Major

Keyword(s):

Systematic Review ◽

Cardiovascular Diseases ◽

Respiratory Disease ◽

Meta Analysis ◽

Chronic Respiratory Disease ◽

Cerebrovascular Diseases ◽

Cochrane Library ◽

Severe Illness ◽

Male Sex ◽

The Impact

Abstract Objectives This systematic review and meta-analysis synthesized the evidence on the impact of demographics and comorbidities with clinical outcomes of COVID-19, including severe illness, admission to the intensive care unit (ICU), and death.MethodsThe PRISMA guidelines were followed to conduct and report this meta-analysis. The protocol is registered in PROSPERO International prospective register of systematic reviews (ID=CRD42020184440). Two authors independently searched literature from PubMed, Embase, Cochrane library and CINHAL on May 6, 2020; removed duplicates; screened titles, abstracts and full text using criteria; and extracted data from eligible articles. A random-effects model was used to estimate the summary odds ratio (OR). Variations among studies were examined using Cochrane Q and I2.ResultsOut of 4,275 articles obtained from the databases and screened, 71 studies that involved 216,843 patients were abstracted and then, where appropriate, analyzed by meta-analysis. The COVID-19 related outcomes reported were death in 26 studies, severe illness in 41 studies, and admission to ICU in 11 studies. Death was significantly correlated with hypertension (OR 2.60, 95% CI 1.95–3.25, I2 = 52.6%, n= 13 studies), cardiovascular disease (5.16, 4.10–6.22, 0.0%, 6), diabetes (2.11, 1.35–2.87, 67.4%, 12), chronic respiratory disease (2.83, 2.14–3.51, 0.0%, 9), cerebrovascular diseases (5.14, 1.08–9.19, 0.0%, 2), male sex (1.34, 1.18 – 1.50, 38.7%, 16), age older than 60 (6.09, 3.53 – 8.66, 95.5%, 6) or 65 years (3.56, 1.21 – 5.90, 18.2%, 6). Severe illness was also significantly associated with hypertension (1.70, 1.30 –2.10, 47.8%, 21), cardiovascular diseases (2.04, 1.01–3.08, 30.6%, 10), diabetes (1.65, 1.23–2.08, 24.9%, 18), male sex (1.35, 1.23 – 1.47, 0.0%, 32) and age at least 60 (4.91, 1.35 – 8.47, 0.0%, 4) or 65 (2.55,1.94 – 3.17, 24.5%, 9) years. Among hospitalized patients, the odds of admission to ICU was greater in individuals who had cardiovascular diseases (1.36,1.04–1.69, 0.0%, 4), diabetes (1.55, 1.20–1.90, 0.0%, 5) and chronic respiratory disease (1.52, 1.09–1.94, 0.0%, 5) than those who were not having these comorbidities. ConclusionsOlder age and chronic diseases increase the risk of developing severe illness, admission to ICU and death among COVID-19 patients. Special strategies are warranted to prevent SARS-CoV-2 infection and manage COVID-19 cases in those with vulnerabilities.

Download Full-text