Construction of Intelligent Nano-Drug Delivery System for Targeting Extranodal Nasal Natural Killer/Thymus Dependent Lymphocyte

2021 ◽  
Vol 17 (3) ◽  
pp. 487-500
Author(s):  
Xinyu Zhang ◽  
Jun Wu ◽  
Dongjun Lin
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Reticuloendothelial System ◽  
Treatment Programs ◽  
Multi Drug Resistance ◽  
Nano Drug Delivery ◽  
Further Development

Extranodal nasal NK/T-cell lymphoma is highly aggressive and malignant. Owing to the lack of multi-center prospective controlled studies, there is not a unified standard for the current clinical best treatment model. In recent years, new nano-drug delivery systems have made great progress in the field of tumor treatment. However, research on ENKTL is still in its infancy. The authors' previous research has proven that the dextran nano-drug delivery system can optimize and improve the in vivo pharmacokinetic behavior and anti-tumor effects of doxorubicin through interaction with the reticuloendothelial system and the complex tumor microenvironment. At the same time, gemcitabine, which is commonly used in the clinical treatment of ENKTL, and cisplatin, which is a radiosensitizer, both contain free amino groups, which can be successfully grafted to aldehyde-based natural polysaccharides. Therefore, based on the natural nano-drug carrier, we constructed a smart long-circulation drug delivery system that co-loaded gemcitabine and cisplatin and targeted ENKTL to achieve effective treatment of ENKTL under the dual treatment mode of chemotherapy and radiosensitization. This project improves the radiosensitivity of ENKTL and overcomes the multi-drug resistance of chemotherapeutics through the radiotherapy-cooperative natural nano-drug delivery system and provides a new idea for the further development and optimization of ENKTL treatment programs.

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

scholarly journals Targeted nano-drug delivery system for glioblastoma therapy: In vitro and in vivo study

2020 ◽  
Vol 60 ◽  
pp. 102039
Author(s):  
Majid Hassanzadeganroudsari ◽  
Majid Soltani ◽  
Amir Heydarinasab ◽  
Vasso Apostolopoulos ◽  
Azim Akbarzadehkhiyavi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vivo Study ◽  
Nano Drug Delivery

Construction of a tumor microenvironment pH-responsive cleavable PEGylated hyaluronic acid nano-drug delivery system for colorectal cancer treatment

2020 ◽  
Vol 8 (7) ◽  
pp. 1885-1896 ◽  
Author(s):  
Xinyu Zhang ◽  
Minyi Zhao ◽  
Nan Cao ◽  
Wei Qin ◽  
Meng Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Responsive ◽  
Nano Drug Delivery ◽  
Imine Bond ◽  
Microenvironment Ph ◽  
Colorectal Cancer Treatment

To improve the tumor cell active targeting, uptake efficiency and circulation time of doxorubicin (DOX) in vivo. Herein, we constructed a cleavable PEGylated hyaluronic acid nano-drug delivery system (HA–mPEG2k–DOX) based on pH-responsive imine bond.

Experimental study on nuclear-targeted plasmid-based short hairpin RNA (ShRNA) to hypoxia inducible factor-1α (PshHIF-1α) PshHIF-1α nano-drug carrier system for breast cancer treatment in rats

2021 ◽  
Vol 11 (7) ◽  
pp. 1045-1050
Author(s):  
Gang Sun ◽  
Jin Zhang ◽  
Shuai Wu ◽  
Yun Liu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Flow Cytometry ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Apoptosis ◽  
Drug Carrier ◽  
Carrier System ◽  
Nano Drug Delivery ◽  
Drug Carrier System

This study was aimed at exploring the regulatory mechanism of auclear-targeted pshHIF-1α nano-drug carrier system (NPNCS) in the treatment of breast cancer in rats. MDA-MB-231 cell was cultured and DJ-1 and PTEN mRNA level was detected by qRT-PCR along with analysis of cell viability by CCK-8 and apoptosis by means of flow cytometry. The rats were assigned into control group, nuclear-targeted pshHIF-1α nanopharmaceutical system treatment group, and nuclear-targeted pshHIF-1α nano-pharmaceutical system+PTEN inhibitor SF1670 group, followed by analysis of cell proliferation by EdU staining, cell apoptosis by flow cytometry, and the levels of DJ-1, PTEN, and p-AKT. Compared with MDA-MB-231 cells treated with NPNCS, cells without intervention showed decreased PTEN and increased DJ-1 level. NPNCS induced cell apoptosis. Administration of nuclear-targeted pshHIF-1α nano-drug delivery system down-regulated DJ-1 and up-regulated PTEN. Combined treatment with SF1670 promoted p-AKT level and decreased the inhibitory effect of NPNCS on p-AKT level. In conclusion, the nuclear-targeted pshHIF-1α nano-drug delivery system down-regulated DJ-1 and exerted a tumor suppressor and pro-apoptotic effect, which wasrelated to p-AKT phosphorylation and up-regulation of PTEN.

Development and Evaluation of Floating Pulsatile Drug Delivery System Using Meloxicam

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
ShirishaG. Suddala ◽  
S. K. Sahoo ◽  
M. R. Yamsani
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lag Time ◽  
Oral Dosage ◽  
Lag Phase ◽  
Pulsatile Drug Delivery

Objective: The objective of this research work was to develop and evaluate the floating– pulsatile drug delivery system (FPDDS) of meloxicam intended for Chrono pharmacotherapy of rheumatoid arthritis. Methods: The system consisting of drug containing core, coated with hydrophilic erodible polymer, which is responsible for a lag phase for pulsatile release, top cover buoyant layer was prepared with HPMC K4M and sodium bicarbonate, provides buoyancy to increase retention of the oral dosage form in the stomach. Meloxicam is a COX-2 inhibitor used to treat joint diseases such as osteoarthritis and rheumatoid arthritis. For rheumatoid arthritis Chrono pharmacotherapy has been recommended to ensure that the highest blood levels of the drug coincide with peak pain and stiffness. Result and discussion: The prepared tablets were characterized and found to exhibit satisfactory physico-chemical characteristics. Hence, the main objective of present work is to formulate FPDDS of meloxicam in order to achieve drug release after pre-determined lag phase. Developed formulations were evaluated for in vitro drug release studies, water uptake and erosion studies, floating behaviour and in vivo radiology studies. Results showed that a certain lag time before drug release which was due to the erosion of the hydrophilic erodible polymer. The lag time clearly depends on the type and amount of hydrophilic polymer which was applied on the inner cores. Floating time and floating lag time was controlled by quantity and composition of buoyant layer. In vivo radiology studies point out the capability of the system of longer residence time of the tablets in the gastric region and releasing the drug after a programmed lag time. Conclusion: The optimized formulation of the developed system provided a lag phase while showing the gastroretension followed by pulsatile drug release that would be beneficial for chronotherapy of rheumatoid arthritis and osteoarthritis.

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