A Review of Off–On Fluorescent Nanoprobes: Mechanisms, Properties, and Applications

With the development of nanomaterials, fluorescent nanoprobes have attracted enormous attention in the fields of chemical sensing, optical materials, and biological detection. In this paper, the advantages of “off–on” fluorescent nanoprobes in disease detection, such as high sensitivity and short response time, are attentively highlighted. The characteristics, sensing mechanisms, and classifications of disease-related target substances, along with applications of these nanoprobes in cancer diagnosis and therapy are summarized systematically. In addition, the prospects of “off–on” fluorescent nanoprobe in disease detection are predicted. In this review, we presented information from all the papers published in the last 5 years discussing “off–on” fluorescent nanoprobes. This review was written in the hopes of being useful to researchers who are interested in further developing fluorescent nanoprobes. The characteristics of these nanoprobes are explained systematically, and data references and supports for biological analysis, clinical drug improvement, and disease detection have been provided appropriately.

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Capacitive touch sensor

Microelectronics International ◽

10.1108/mi-12-2017-0071 ◽

2018 ◽

Vol 35 (3) ◽

pp. 153-157 ◽

Cited By ~ 4

Author(s):

Samuel Zuk ◽

Alena Pietrikova ◽

Igor Vehec

Keyword(s):

Response Time ◽

Integrated Circuit ◽

High Reliability ◽

High Sensitivity ◽

Mechanical Resistance ◽

Content Type ◽

Short Response Time ◽

Sensing Range ◽

Touch Sensor ◽

Mechanical Switch

Purpose The purpose of this paper is to analyse the possibilities of mechanical switch replacement by capacitive film touch sensor in applications requiring high reliability and short response time. Advantage of replacing mechanical switch by capacitive touch sensor is no mechanical wear and possible implementation of sensor in application where the switch could not be used or where the flexibility of the sensor substrate is required. The aim of this work is to develop a capacitive touch sensor with the advantage of maximum mechanical resistance, short response time and high sensitivity. Design/methodology/approach Based on various possible sensors layouts, the authors realized 18 different (14 self-capacitance and four mutual capacitance) topologies of capacitive sensor for touch applications. Three different technologies – PCB, LTCC and polymer technology – were used to characterize sensor’s behaviour. For precise characterization of different layouts realized on various substrates, the authors used integrated circuit FDC2214 capacitance-to-digital converter. Findings Sensing range of the capacitive touch (proximity) sensor is affected by the per cent of area covered by the sensor, and it does not depend on topology of sensor. The highest sensing range offers PCB technology. Flexible substrates can be used as proper substituent to rigid PCB. Originality/value The novelty of this work lies in finding the touch capacitive sensors that allow shorter switching times compared to standard mechanical switches.

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Fe3O4/rGO nanocomposite: synthesis and enhanced NOxgas-sensing properties at room temperature

RSC Advances ◽

10.1039/c6ra02306a ◽

2016 ◽

Vol 6 (43) ◽

pp. 37085-37092 ◽

Cited By ~ 16

Author(s):

Ying Yang ◽

Li Sun ◽

Xiangting Dong ◽

Hui Yu ◽

Tingting Wang ◽

...

Keyword(s):

Graphene Oxide ◽

Detection Limit ◽

Response Time ◽

Reduced Graphene Oxide ◽

Room Temperature ◽

Gas Sensing ◽

High Sensitivity ◽

Short Response Time ◽

Reduced Graphene ◽

Sensing Performance

Fe3O4nanoparticles-decorated reduced graphene oxide nanocomposites have been successfully synthesized using solvothermal-pyrolytic method. They have superior gas sensing performance with low detection limit, high sensitivity and short response time.

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The Application of Nucleic Acid Probe–Based Fluorescent Sensing and Imaging in Cancer Diagnosis and Therapy

Frontiers in Chemistry ◽

10.3389/fchem.2021.705458 ◽

2021 ◽

Vol 9 ◽

Author(s):

Ge Huang ◽

Chen Su ◽

Lijuan Wang ◽

Yanxia Fei ◽

Jinfeng Yang

Keyword(s):

Nucleic Acid ◽

Cancer Diagnosis ◽

High Sensitivity ◽

Good Tolerance ◽

Fast Detection ◽

Fluorescent Sensing ◽

Cancer Management ◽

Management Techniques ◽

Cancer Theranostics ◽

Cancer Diagnosis And Therapy

It is well known that cancer incidence and death rates have been growing, but the development of cancer theranostics and therapeutics has been a challenging work. Recently, nucleic acid probe–based fluorescent sensing and imaging have achieved remarkable improvements in a variety of cancer management techniques, credited to their high sensitivity, good tolerance to interference, fast detection, and high versatility. Herein, nucleic acid probe–based fluorescent sensing and imaging are labeled with advanced fluorophores, which are essential for fast and sensitive detection of aberrant nucleic acids and other cancer-relevant molecules, consequently performing cancer early diagnosis and targeted treatment. In this review, we introduce the characteristics of nucleic acid probes, summarize the development of nucleic acid probe–based fluorescent sensing and imaging, and prominently elaborate their applications in cancer diagnosis and treatment. In discussion, some challenges and perspectives are elaborated in the field of nucleic acid probe–based fluorescent sensing and imaging.

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Construction of anisotropic fluorescent nanofibers assisted by electro-spinning and its optical sensing applications

RSC Advances ◽

10.1039/c9ra00502a ◽

2019 ◽

Vol 9 (22) ◽

pp. 12585-12589 ◽

Cited By ~ 1

Author(s):

Fa-Heng Zhang ◽

Rui-Xue Jiang ◽

Wei Cao ◽

Bin Du ◽

Ding-Yuan Cao ◽

...

Keyword(s):

Response Time ◽

Vinylidene Fluoride ◽

Optical Sensing ◽

High Sensitivity ◽

The Self ◽

Short Response Time ◽

Perylene Bisimide ◽

Sensing Applications ◽

Poly Vinylidene Fluoride ◽

Self Assembled

Anisotropic fluorescent nanofibers constructed from the self-assembled perylene bisimide derivative and poly(vinylidene fluoride) show high sensitivity and short response time to aniline vapor.

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Hydrogel-based piezoresistive sensor for the detection of ethanol

Journal of Sensors and Sensor Systems ◽

10.5194/jsss-7-219-2018 ◽

2018 ◽

Vol 7 (1) ◽

pp. 219-226 ◽

Cited By ~ 11

Author(s):

Jan Erfkamp ◽

Margarita Guenther ◽

Gerald Gerlach

Keyword(s):

Response Time ◽

Low Cost ◽

High Sensitivity ◽

Alcoholic Beverages ◽

Swelling Kinetics ◽

Short Response Time ◽

Piezoresistive Sensors ◽

Piezoresistive Sensor ◽

Crosslinker Content ◽

Kinetics Of

Abstract. This article describes a low-cost sensor for the detection of ethanol in alcoholic beverages, which combines alcohol-sensitive hydrogels based on acrylamide and bisacrylamide and piezoresistive sensors. For reproducible measurements, the reversible swelling and deswelling of the hydrogel were shown via microscopy. The response time of the sensor depends on the swelling kinetics of the hydrogel. The selectivity of the hydrogel was tested in different alcohols. In order to understand the influence of monomer and crosslinker content on the swelling degree and on the sensitivity of the hydrogels, gels with variable concentrations of acrylamide and bisacrylamide were synthesized and characterized in different aqueous solutions with alcohol contents. The first measurements of such hydrogel-based piezoresistive ethanol sensors demonstrated a high sensitivity and a short response time over several measuring cycles.

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A rhodamine B-based lysosomal pH probe

Journal of Materials Chemistry B ◽

10.1039/c4tb01763c ◽

2015 ◽

Vol 3 (5) ◽

pp. 919-925 ◽

Cited By ~ 86

Author(s):

Shi-Li Shen ◽

Xin-Peng Chen ◽

Xiao-Fan Zhang ◽

Jun-Ying Miao ◽

Bao-Xiang Zhao

Keyword(s):

Response Time ◽

Rhodamine B ◽

High Selectivity ◽

High Sensitivity ◽

Living Cells ◽

Acidic Ph ◽

Ph Change ◽

Short Response Time ◽

Lysosomal Ph ◽

Ph Probe

A novel rhodamine B-based lysosomal pH probe RML was developed. RML responded to acidic pH with short response time, high selectivity and high sensitivity and could detect lysosomal pH change in living cells.

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