Efficacy of Periodontal Tissue Regeneration Combined with Orthodontic Therapy on Periodontitis and Its Influences on Inflammatory Factors in Patients

2020 ◽  
Vol 10 (5) ◽  
pp. 737-742
Author(s):  
Jianxing Han ◽  
Junping Dong ◽  
Hua Zhao ◽  
Yuan Ma ◽  
Shuoran Yang ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Tissue Regeneration ◽  
Orthodontic Treatment ◽  
Inflammatory Factors ◽  
Control Group ◽  
Inflammatory Factor ◽  
Observation Group ◽  
Periodontal Tissue ◽  
Clinical Attachment Loss ◽  
Periodontal Tissue Regeneration

Objective: To assess the effect of periodontal tissue regeneration combined with orthodontic treatment on periodontitis and inflammatory factors. Methods : 100 patients with periodontitis were randomly separated into observation group and control group. Patients were treated with periodontal tissue regeneration in control group and received orthodontic treatment in observation group. The periodontal indexes, X-ray cephalometric indexes, serum inflammatory factor levels, tooth mobility, the postoperative complications, efficacy and life quality were measured. Results: After treatment, levels of clinical attachment loss (CAL), probing depth (PD), sulcus bleeding index (SBI), gingival index (GI), plaque index (PLI), SNB angle, SNA angle, IL-8, IL-5, TNF-α and hs-CRP of patients in observation group were significantly decreased, while ANB angle was significantly elevated (p < 0 05). Meanwhile, the treatment effective rate and quality of life score was significantly improved after treatment in observation group (p < 0 05). Conclusion: Periodontal tissue regeneration combined with orthodontic treatment can significantly improve periodontitis symptoms, promote the recovery of tooth function, reduce inflammation and postoperative complications, and improve the uniformity and appearance of teeth in patients with periodontitis.

Influences of Periodontal Tissue Regeneration Combined with Orthodontics on Inflammatory Microenvironment, Osteocalcin Level, and Stability and Outcome of Offending Teeth in Periodontitis

2020 ◽  
Vol 10 (7) ◽  
pp. 1059-1064
Author(s):  
Liwen Zhang ◽  
Jing Li ◽  
Xuan Yang ◽  
Baohua Xu
Keyword(s):  
Therapeutic Effect ◽  
Tissue Regeneration ◽  
Control Group ◽  
Observation Group ◽  
Periodontal Tissue ◽  
Inflammatory Microenvironment ◽  
Osteocalcin Level ◽  
Masticatory Function ◽  
Orthodontic Therapy ◽  
Periodontal Tissue Regeneration

Objective: To assess periodontal tissue regeneration combined with orthodontics' effect on the inflammatory microenvironment, osteocalcin level, and masticatory function and stability of offending teeth in periodontitis as well as its overall clinical therapeutic effect. Methods: 80 patients with periodontitis treated in our hospital were enrolled and separated into observation group (n = 40) (periodontal tissue regeneration combined with orthodontic therapy) and control group (n = 40) (orthodontic therapy). All patients were followed up for 12 weeks. Inflammatory cytokines in the culture supernatant of periodontal cells and masticatory function of offending teeth in both groups after treatment were measured, and osteocalcin level and stability of offending teeth in both groups were evaluated before treatment, and at 2, 4, 8 and 12 weeks after treatment. Moreover, the overall therapeutic effects were recorded, such as tooth loosening, subjective symptoms and performing function. Results: At 12 weeks after treatment, the levels of TNF-α , IL-6 and IL-1 in observation group were significantly reduced compared to control group (p < 0 05), and the masticatory function of offending teeth was superior to control (p < 0 05). At 2, 4, 8 and 12 weeks after treatment, the osteocalcin level and stability of offending teeth in observation group were better (p < 0 05). In terms of overall therapeutic effect, observation group presented significantly lower proportion of tooth loosening and superior scores of subjective symptoms and performing function of offending teeth (p < 0 05). Conclusion: Periodontal tissue regeneration combined with orthodontic therapy can effectively reduce the local inflammation and improve the masticatory function of patients with periodontitis. At 2 weeks after treatment, the osteocalcin level and stability of offending teeth are significantly improved, with a satisfactory clinical therapeutic effect.

scholarly journals Thoracoscope and thoracotomy in the treatment of thoracic trauma

2019 ◽  
Vol 35 (5) ◽  
Author(s):  
Juan Shi ◽  
Yucun Wang ◽  
Wenzhen Geng
Keyword(s):  
Postoperative Complications ◽  
Thoracic Trauma ◽  
Thoracoscopic Surgery ◽  
Statistical Significance ◽  
Control Group ◽  
Inflammatory Factor ◽  
Clinical Effects ◽  
Observation Group ◽  
Drainage Fluid ◽  
Significant Difference

Objective: To compare clinical effects of thoracoscopic surgery and thoracotomy in the treatment of thoracic trauma. Methods: Two hundred and fourteen patients with thoracic trauma were randomly divided into a control group and an observation group, 107 in each group. The control group was treated with conventional thoracotomy, while the observation group was treated with thoracoscopic surgery. The operation-related indications, hospitalization, postoperative complications and inflammatory factor level were observed and compared between the two groups. The study was conducted from April 2016 to February 2018. Results: The duration of operation of the observation group was shorter than that of the control group, the amount of bleeding during operation of the observation group was less than that of the control group, and the postoperative visual analogue score (VAS) of the observation group was lower than that of the control group; the difference were statistically significant (P<0.05). The hospitalization time, time of off-bed activity and time of resuming daily life of the observation group were shorter than those of the control group, and the amount of drainage fluid of the observation group within 24 hours after operation was less than that of the control group; the differences had statistical significance (P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups (P>0.05). The levels of C-reactive protein (CRP), tumor necrosis factor (TNF)-a and interleukin (IL)-6 in both groups after surgery were higher than those before surgery, but the indicators in the observation group were lower than those in the control group (P<0.05). Conclusion: Thoracoscopic surgery can reduce pains of patients, speed up recovery, and reduce incidence of surgical infection in the treatment of thoracic trauma. It is a safe and effective treatment method, which is worth clinical application. doi: https://doi.org/10.12669/pjms.35.5.514 How to cite this:Shi J, Wang Y, Geng W. Thoracoscope and thoracotomy in the treatment of thoracic trauma. Pak J Med Sci. 2019;35(5):---------.  doi: https://doi.org/10.12669/pjms.35.5.514 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Effects of combined use of atorvastatin and losartan in treating patients with diabetic nephropathy

2018 ◽  
Vol 16 ◽  
pp. 205873921879670
Author(s):  
Chao Ding ◽  
Xiaohua Hu
Keyword(s):  
Diabetic Nephropathy ◽  
Endothelial Function ◽  
Cardiovascular Events ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Inflammatory Factors ◽  
Control Group ◽  
Vascular Endothelial ◽  
Observation Group ◽  
Vascular Endothelial Function

This study is to investigate the effect of atorvastatin combined with losartan on inflammatory factors, vascular endothelial function, and cardiovascular events in patients with diabetic nephropathy. A total of 128 patients with diabetic nephropathy treated in our hospital from January 2014 to December 2015 were selected as the study subjects, and 64 cases were randomly divided into observation group and 64 cases in the control group. The control group was treated with losartan on the basis of routine treatment, and the observation group was treated with atorvastatin on the basis of the control group. The blood lipid, inflammatory factors, changes in vascular endothelial function and cardiovascular events were compared between the two groups. The levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were not significantly different between the two groups before treatment ( P > 0.05); after treatment, the levels of TC, TG, and LDL-C in the observation group were significantly lower than those of the control group, and the level of HDL-C was significantly higher than that of the control group ( P < 0.05). The levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) were not statistically different between the two groups before treatment ( P > 0.05); after treatment, the levels of hs-CRP, TNF-α, and IL-6 in the observation group were significantly lower than those of the control group ( P < 0.05), the level of HDL-C was significantly higher than that of the control group ( P < 0.05). There were no significant differences in the levels of endothelin-1 (ET-1) and nitric oxide (NO) between the two groups before treatment ( P > 0.05). After treatment, the level of ET-1 in the observation group was significantly lower than that of the control group ( P < 0.05), and the level of NO was significantly higher than that of the control group ( P < 0.05). After treatment, all patients were followed up for 2 years, and the incidence of secondary cardiovascular events in the observation group was 12.50% (8/64), which was significantly lower than 29.69% (19/64) of the control group ( P < 0.05). Combination of atorvastatin and losartan can significantly improve the levels of blood lipid, inflammatory factors, and vascular endothelial function in patients with diabetic nephropathy and can effectively reduce the incidence of cardiovascular events.

scholarly journals Surgical Management of Horizontal Root Fracture with Platelet Rich Fibrin (PRF) Placement: Case Report of Two Cases

2013 ◽  
Vol 01 (02) ◽  
pp. 125-128
Author(s):  
Parul Bansal ◽  
Kalpana Kanyal ◽  
Vineeta Nikhil
Keyword(s):  
Case Report ◽  
Tissue Regeneration ◽  
Surgical Approach ◽  
Permanent Teeth ◽  
Periodontal Tissue ◽  
Root Fracture ◽  
Platelet Rich Fibrin ◽  
Periodontal Tissue Regeneration ◽  
Root Fractures ◽  
Horizontal Root Fracture

AbstractRadicular fractures in permanent teeth are uncommon injuries among dental traumas, being only 0.5 - 7% of the cases. Horizontal root fractures can be managed endodontically or combined endodontic and surgical approach. Treatment varies according to the displacement and vitality of the fragments. This paper presents a case report of two cases of horizontal root fracture, present between the middle and apical third of central incisors, which were managed by combined endodontic and surgical approach, while in second case it was followed by PRF placement to facilitate osteoinduction and periodontal tissue regeneration.

scholarly journals PO-052 Study on the Expression of Inflammatory Factor, chemotactic factor in the Repair of Skeletal Muscle Contusion in Mic

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Linlin Zhao ◽  
Weihua Xiao ◽  
Xin Xu
Keyword(s):  
Skeletal Muscle ◽  
Muscle Injury ◽  
Inflammatory Factors ◽  
Control Group ◽  
Inflammatory Factor ◽  
Post Injury ◽  
Skeletal Muscle Contusion ◽  
Chemotactic Factors ◽  
Polymerase Chain ◽  
Gastrocnemius Muscles

Objective To investigate the regulation of muscle inflammatory factors and chemotactic factors during the repair of skeletal muscle contusion in mice. Methods Forty C57 male mice were needed. Eight for control group (C, n=8) and thirty-tow for muscle contusion group (S, n=32). Subsequently, their gastrocnemius muscles were harvested at 0d, 1d, 3d, 7d, 14d after injury. Hematoxylinand eosin (HE) stain were used to assess the changes of muscle morphology. In addition, the gene expression of inflammatory factors and chemotactic factors was analyzed by real-time polymerase chain reaction. Results 1、Morphology of skeletal muscles showed signs of regeneration at 3d post injury. The maximumamount of regeneration muscle fibers appeared during one week post contusion. Two weeks post-injury morphology of myofibers nearly recovered to normal. 2、After skeletal muscle injury, macrophage markers (CD68, CD163, CD206), a variety of inflammatory factors (IL-1, IL-6, IL-10) were up-regulated. 3、chemotactic factors (CCL2, CCL3, CCL5, CCL8, CXCL9, CXCL10, CXCL12, mRNA) were up-regulated。 Conclusions After skeletal muscle contusion, the expression of a variety of chemotactic factors is up-regulated, which promotes macrophage infiltration and produces a variety of inflammatory factors. They may be involved in the inflammatory response and regeneration process after skeletal muscle contusion.

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