Prevention of Capsular Contracture with Montelukast After Insertion of Silicone Implants in Rabbits

2016 ◽  
Vol 13 (10) ◽  
pp. 7623-7627
Author(s):  
Zhenyu Jin ◽  
Ki Yong Hong ◽  
Kyung Won Minn ◽  
Hak Chang ◽  
Ung Sik Jin
Keyword(s):  
Breast Implant ◽  
Capsular Contracture ◽  
White Female ◽  
Silicone Implants ◽  
Control Group ◽  
Tissue Samples ◽  
Significant Difference ◽  
Group A ◽  
The Right ◽  
Experimental Group

Capsular contracture is the most common complication after insertion of silicone implants during breast implant surgery. The discovery that myofibroblasts play an important role in the formation of hypertrophic scars led to the development of pharmacological drugs such as zafirlukast, which prevents capsular contracture by resisting the above mechanism. As a result, the author sought to investigate the effect of the anti-leukotriene montelukast on capsular contracture. Ten white female New Zealand rabbits, each weighing approximately 3 kg, were used as subjects. Through bilateral incision of the midback area, the prostheses were inserted on the subpanniculus carnosus plane. Once the silicone prostheses had been inserted, the right implant was injected with 10 mL of montelukast (10 µg/mL), and the left implant was injected with 10 mL of normal saline. Eight weeks after the procedure, the capsular pressure was measured via tonometry using a circular glass piece weighing 42.7 g. The tissue samples were then extracted, and their thicknesses were measured using hematoxylin-eosin stain and Masson trichrome stain. The average pressure was 4.23±0.99 mmHg in the control group and 3.71±0.51 mmHg in the experimental group, a statistically significant difference (p = 0.02). The average capsular thickness was 947.938±300 µm in the control group and 709.672±274 µm in the experimental group, a statistically significant difference (p = 0.028). The author confirmed that montelukast injections during silicone prosthesis insertion decreased the formation of capsular contracture.

scholarly journals Parenting Stress and Need Assessment of Families with Disabled Children across Himachal Himalaya

2015 ◽  
Vol 3 (2) ◽  
pp. 38 ◽  
Author(s):  
Randhir S. Ranta ◽  
Vijay Kumar Sharma ◽  
Pankaj Gupta
Keyword(s):  
Parenting Stress ◽  
Assessment Scale ◽  
Control Group ◽  
Disabled Children ◽  
Normal Children ◽  
Need Assessment ◽  
Significant Difference ◽  
Group A ◽  
And Control ◽  
Experimental Group

The study pertains to the parenting stress, which is believed to be the resultant of child disability and further assesses the needs of the families across selected pockets of Himachal Himalaya. Perceived Stress Questionnaire (PSQ) and Need Assessment Scale were used for the purpose. For assessing the stress level among the parents, PQS was administered among two hundred parents having disabled children, herein called experimental group and two hundred parents with normal children, herein called control group. A three point Need assessment scale was used to measure the needs of 200 families on five different parameters. The result of t-test shows the significant difference between experimental and control groups indicating that the parents of disabled children experience more stress than their control counterpart. The study indicates that people need proper guidance and information regarding a child’s disability, nutritional requirements of a child, vocational training and child management. There is a need for proper counselling for parents suffering from stress and creating consciousness among parents of children with disabilities and in the society.

Different selective dry cow therapy concepts compared to blanket antibiotic dry cow treatment

2017 ◽  
Vol 45 (06) ◽  
pp. 343-349 ◽  
Author(s):  
Nicole Wente ◽  
Jan-Hendrik Paduch ◽  
Doris Klocke ◽  
Elisabeth Mansion-de Vries ◽  
Martina Hoedemaker ◽  
...  
Keyword(s):  
Rapid Test ◽  
Study Groups ◽  
Test Methods ◽  
Farm Animals ◽  
Control Group ◽  
Dry Period ◽  
Udder Health ◽  
Significant Difference ◽  
Group A ◽  
The Right

SummaryObjective: The aim of the study was to investigate the use of somatic cell count (SCC) and aerobic bacterial counts as possible tools to choose animals for selective dry cow treatment (DCT) on cow level. Blanket antibiotic DCT is an approved and common method in Germany aimed at increasing the cure rate of existing intramammary infections (IMI) at the time of drying off and decreasing the risk of new infections during the dry period. However, not all animals benefit equally from an antibiotic DCT. Moreover, dairies, consumers and politicians demand a reduction in the use of antibiotics in farm animals. Several criteria for identifying animals which would benefit from antibiotic DCT have been described in the literature. Material and methods: Animals chosen for this investigation were divided into three study groups: Aerobic Count Petrifilm® group A (153 cows), SCC group S (160 cows) and control group C (169 cows). All quarters were treated with an internal teat sealant (ITS) no matter which group the cows belonged to. Results: Group C, in which all cows received an antibiotic DCT, achieved the best results referred to udder health, particularly regarding bacteriological dry period cure. However, the results of the two study groups A and S, in which the animals were dried off selectively, were only marginally worse. A significant difference regarding bacterial dry period cure was revealed between group S and group C (p = 0.039), whereas no significant difference concerning new IMI risk could be detected between the three study groups. Compared to a blanket antibiotic DCT of all cows in the corresponding study group, a reduction of the usage of antibiotics of 23.5 % (A) and 55 % (S) was noticed, respectively. Furthermore, it could be shown that the lactation number as well as the microorganisms present at the time of drying off influence udder health. Conclusion: Selective DCT is an alternative method to the widespread blanket antibiotic DCT. However, it has to be mentioned that selective DCT involves the described marginal decline in udder health and the additional amount of time, which might arise from the procedure of choosing the right animals and performing the applied rapid test methods.

EFFECT OF YOGA ON CARDIOVASCULAR EFFICIENCY

2019 ◽  
pp. 12-16
Author(s):  
Brij Bhushan Singh ◽  
Shubi Mirja ◽  
Samiya Husain
Keyword(s):  
Statistical Technique ◽  
Step Test ◽  
Control Group ◽  
Significant Difference ◽  
Post Test ◽  
Group A ◽  
Cardio Vascular ◽  
Level Of Significance ◽  
Group B ◽  
Experimental Group

The purpose of this study was to investigate the effects of yogic practices on cardio-vascular efficiency. Material and methods: Total Forty (40) subject’s boys/girls were selected as the sample of the study through the random sampling and their age ranged between 20 to 25 years from the Department of Physical Education, Aligarh Muslim University, Aligarh. The subjects were divided into two groups comprising 20 subjects in each group, namely group “A” (the experimental group) performs yogic practices (Asanas, Pranayamas and Kriyas) and group “B” (the control group) served as control. Statistical technique: for the assessment of the cardiovascular efficiency through Harvard step test pre and post-test was conducted and t-test was applied for the analysis. Result: revealed that there exist a significant difference between group A and group B, at .05 level of significance. On the basis of the pre and post-test among experimental and control group, experimental group found better than the control group on cardiovascular efficiency and significant result were found in this study.

scholarly journals Comparison of a novel herbal skin care ointment with regular ointments to treat skin around the abdominal stoma: A clinical trial study

2019 ◽  
Author(s):  
Maryam Hajikari ◽  
Soheila Mojdeh ◽  
Mohsen Shariari
Keyword(s):  
Data Collection ◽  
Herbal Product ◽  
Gastric Ulcers ◽  
Control Group ◽  
Skin Ulcers ◽  
Significant Difference ◽  
Group A ◽  
The Mean ◽  
Experimental Group

Introduction The incidence of gastric ulcers in patients with abdominal stoma is high and affects the quality of patients’ life. Aim To evaluate the effect of Adib herbal ointment containing chamomile rose, black nightshade origin versus Comfeel and Conveen ointments on the skin of abdominal stoma. Material and methods This is a clinical study in which the volunteers were stoma patients. Study group consisted of 52 qualified subjects, 26 were included in the experimental group and 26 in the control group. A 2-part questionnaire was used for the data collection. The 1st part was demographic information. The 2nd part of the data collection was evaluated according to the pressure ulcer scale for healing (PUSH) tool, which used for examining skin ulcers around the stoma. P ≤ 0.05 was considered as a significant. Results and discussion The results of the Mann–Whitney test showed that between the mean score of the total score of the wound before intervention (P = 0.92) and on the 3rd day (P = 0.476), 6th (P = 0.222), 9th (P = 0.11) and 12th (P = 0.418), there was no significant difference between the control and test groups. Also, the Friedman test (intra-group) also showed that between the mean score of the total score of the wound before the intervention and the 3rd, 6th, 9th and 12th days in the control group (P = 0.0001) and in the experimental group (P = 0.0001) There was a significant statistical difference. Conclusions Based on the study, Adib herbal ointment could be recommended for the treatment of stoma to the skin as an herbal product as other common treatments.

Effectiveness of Peer Tutoring Program on Students’ Academic Performance for Engineering Course

2021 ◽  
Vol 6 (1) ◽  
pp. 71
Author(s):  
Fei Ha Chiew ◽  
Clotilda Petrus ◽  
Siti Zaidah Othman ◽  
Joe Davylyn Nyuin ◽  
Ung Hua Lau
Keyword(s):  
Peer Tutoring ◽  
Intervention Program ◽  
Solid Mechanics ◽  
Practical Significance ◽  
Control Group ◽  
Tutoring Program ◽  
Significant Difference ◽  
Group A ◽  
And Control ◽  
Experimental Group

This study investigated the effectiveness of a peer tutoring program that was implemented for Basic Solid Mechanics course, as an intervention program to improve students’ performance in the course. Ten tutors were chosen to provide tutoring services to an experimental group of 36 tutees. Tutees were required to answer an entry test before the intervention program, and another exit test after the program. A control group which shared the same instructor in their lecture classes was included in the study. Comparison between the performances for entry and exit tests of both experimental and control groups were made. Analyses showed an increase in the percentage of students that passed the exit test from the experimental group. The average marks for the experimental group in the exit test also increased, compared to their marks in the entry test. A Mann- Whitney U test conducted indicated a significant difference between the gain scores of the experimental group and control group. A further metaanalysis revealed a large effect size, signaling the practical significance of the results. The findings demonstrated the effectiveness of the peer tutoring intervention program on students’ performance of the course.

scholarly journals Healing of abdominal wall aponeurosis of rats after incision with either cold scalpel or electrocautery

2007 ◽  
Vol 22 (suppl 1) ◽  
pp. 12-15 ◽  
Author(s):  
Ademar Garcia ◽  
José Eduardo Aguilar-Nascimento ◽  
Eduardo Mulinari Darold ◽  
Rodolfo Edson de Franco Pimentel ◽  
Eloísa Almeida Curvo ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Histological Study ◽  
Control Group ◽  
Hydroxyproline Content ◽  
Tissue Samples ◽  
Significant Difference ◽  
Experimental Group

PURPOSE: To compare the healing of abdominal wall aponeurosis of rats after incision with either cold scalpel or electrocautery. METHODS: Twelve male adults Wistar inbreed rats weightin 258-362g entered the experiment. They were randomly divided in two groups, control group (N= 6) and experimental group (N= 6). All animals underwent anesthesia followed abdominal wall incision with either cold scalpel (controls) or electrocautery (experimental group). The animals were killed on the 10th day and necropsied. Tissue samples containig the abdominal wall aponeurosis were sent for both histological study and hydroxyproline content assay. RESULTS: The histological study showed no significant difference between the two groups. Hydroxiproline content in experimenral group (128,56 [78,98-198,92] µg /100m) was not significantly different from control group (140,27 [116,20-166,59] mg /100ml; p = 0.53). CONCLUSION: Healing of abdominal wall after dieresis with either cold scalpel or electrocautery are equivalent and do not differ.

scholarly journals Effect of Pilates exercise on the level of fatigue, cognition and knee proprioception in the elderly population of 60-80 years

2021 ◽  
Vol 9 (2) ◽  
pp. 3774-3779
Author(s):  
Shradha Santosh Shah ◽  
◽  
Sandhya Wasnik ◽  
Keyword(s):  
Elderly Population ◽  
The Elderly ◽  
Exercise Group ◽  
Control Group ◽  
Significant Difference ◽  
Strengthening Exercises ◽  
Group A ◽  
Randomized Control ◽  
Group B ◽  
Experimental Group

Aim: To evaluate the effect of Pilates exercise on the level of fatigue, cognition and knee proprioception in elderly population (60-80 years). Study design: experimental study; randomized control trial. Method: 40 subjects both male and female of age ranging from 60-80 years (66.578 ± 4.857 in group A and 69.4 ± 5.442 in group B) were assigned in to two groups. The objective of the study was explained, and the subjects were screened based on the inclusion and exclusion criteria. Pre-interventional and post-interventional data analysis was done for FSS, 6MWT, MoCA and KJPS error angle. Group A (Experimental group) received Pilates exercise. Group B (control group) received aerobic and strengthening exercises. Both the groups underwent exercises 3 times a week on alternate days for 6 weeks. Duration of exercise for both groups was 45-60 minutes. Results: Both the groups showed clinically and statistically significant improvement in FSS (p<0.0001 in both groups) 6MWT (p<0.0001 in both groups), MoCA (p<0.001 in both groups) and KJPS scores (p<0.0002 in group A and p<0.0001 in group B) at the end of 6 weeks of treatment. There was no significant difference between the groups for FSS (p=0.7226), 6MWT (p=0.813), MoCA (p=0.416) and KJPS (p=0.6213). Conclusion: A significant improvement were observed in both the groups; which concluded that both the groups are equally effective in improvement of FSS, 6MWT, MoCA and KJPS scores. KEY WORDS: Pilates exercise, elderly population, fatigue, cognition, knee proprioception.

Effect of Hemiovariectomy on reproductive performance in Chinchila Rabbits.

2021 ◽  
Vol 36 (1) ◽  
pp. 167-174
Author(s):  
C. A. Eze ◽  
C. P. Nwodo ◽  
E. O. Ogbu
Keyword(s):  
Birth Weight ◽  
Litter Size ◽  
Conception Rate ◽  
Control Group ◽  
Significant Difference ◽  
Negative Effect ◽  
Group A ◽  
Group B ◽  
The Right ◽  
Reproductive Indices

This work evaluates the effects of hemiovariectomi (37 some reproductive indices such as conception rate, birth weight and birth litter size in Chinchilla breed of rabbits. Thirty females and six males were used for the experiment. The males were examined for breeding soundness before using them to cross the females. The experiment was replicated in two batches of three groups of five females and a male each at different periods. Hemi-ovariectomy was carried out in the right ovary of 10 does (Group A) and left ovary of another 10 does (Group B). Ten females in Group C were not ovariectomised and served as the control group. All groups were served at reproductive maturity by rotating the bucks. Pregnancy was diagnosed using a standard method. The reproductive indices evaluated included conception rate, birth weight and birth litter size. Data were analyzed using percentages, ratios, and analysis of variance (ANOVA) was computed where necessary. Results showed that hemi ovariectomy significantly (P<0.01) reduced the mean litter size, Group A (2.50+58), Group B (3.00+0.71), control (Group C) (6.20+0.84). However, there was increased mean litter birth weight which, differed significantly (P<0.01) from that of the control (27.06), Group A (33.64+1.86) and Group B (33.93=1.75). Also, the conception rate in the treated groups averaged 65% while the control was 80%. There was no significant difference (P>0.05) between the groups in the interval from the introduction of the huck to the does to the time of conception. It is concluded thai hemiovariectomy has negative effect on the conception rate and birth litter size but has positive effect on birth litter weight. The procedure has shown that in highly priced breed of animal with unilateral ovarian uilments such an animal can still be used for breeding using the healthy ovary: The procedure could also be a more reliable method of birth control in pet animals as well as a means of producing heavy weight offspring.

scholarly journals FEMORAL VASCULAR COMPLICATIONS

2018 ◽  
Vol 25 (07) ◽  
pp. 987-991
Author(s):  
Muhammad Yasir ◽  
Munir Ahmad ◽  
Liaqat Ali
Keyword(s):  
Coronary Angiography ◽  
Vascular Complications ◽  
Bed Rest ◽  
Control Group ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Experimental Group ◽  
Large Hematoma ◽  
Control Group Group

Background: Coronary angiography is the most important and reliable test todiagnose coronary artery disease. Bed rest of few hours is advised after angiography to reducevascular complications but there is difference of opinion regarding duration of bed rest afterangiography. Objectives: To compare the frequency of vascular complications after 6 hoursof bed rest versus 3 hours of bed rest in patients undergoing femoral coronary angiography.Study Design: Experimental study. Place and Duration of Study: Angiography Department,Faisalabad Institute of Cardiology, Faisalabad from August, 2017 to January, 2018. Methods:A total of 100 patients were divided in two equal groups, group A (interventional group (n=50),3 hours rest) and group B (routine care (n=50), 6 hours rest). A 6 French sheath was insertedunder local anesthesia by seldinger technique in femoral artery. Coronary angiography wasdone using 6 F angiography catheters. At the end of procedure sheaths were immediatelyremoved and manual pressure was applied for 15 minutes. Puncture site was observed forhematoma formation or bleeding every 30 minutes for 2 hours in angiography ward, afterwardsthese observations were made every hour till time of discharge. Patients were called for checkupin outpatient department next day and after 1 week. Results: Out of 50 patients in group A therewere 35 (70%) male and 15 (30%) female and in group B out of 50 patients there were 40 (80%)male and 10 (20%) female patients. In group A mean age was (51.02 ±9.57) years while in groupB mean age was (51.50±10.19) years. There was no significant difference in patients betweenthe two groups regarding their age, gender, body mass index (BMI), coagulation profile and useof antiplatelets. There was no incidence of pre ambulation bleeding, small or large hematoma inboth groups. Post ambulation bleeding occurred in 1(2%) patient in experimental group (GroupA) and in 1 (2%) patient in the control group (Group B). Small hematoma occurred in 2 (4%)patients in experimental group (Group A) and in 1(2%) patient of control group (Group B).There was no incidence of post ambulation large hematoma in both groups. Conclusion: Shortbed rest of 3 hours after femoral angiography does not increase the frequency of puncture sitecomplications.

scholarly journals Morphological and radiological characteristics of experimental bone tissue regeneration

2021 ◽  
pp. 94-104
Author(s):  
E. A. Nadyrov ◽  
V. I. Nikolaev ◽  
S. I. Kirilenko ◽  
V. V. Rozhin ◽  
N. G. Maltseva ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Control Group ◽  
Experimental Animals ◽  
Male Wistar Rats ◽  
Group A ◽  
Bone Trabeculae ◽  
The Right ◽  
Experimental Group

Objective. To study the dynamics of reparative bone tissue regeneration in experimental animals using a native transplantation autosmix (NTA).Materials and methods. Male Wistar rats weighing 180–200 g and aged 6–7 months were used. Bone tissue defects were modelled using a cutter with a diameter of 2 mm (experimental group). A similar defect of the middle third of the right tibia was formed in the control group animals without flling the defects with bone tissue. The animals were removed from the experiment on days 3, 7, 14, 30 and 60 of the experiment (per 6 animals for each observation period). The indicators of defect occupancy, necrosis, the area of bone trabeculae, the area of granulation tissue were determined in the histological sections. All the indicators were presented as percentage of the tested area. Osteoblasts, osteocytes, and osteoclasts were calculated in absolute values on the tested area.Results. The study has showed a higher rate of bone tissue formation in the bone defects in the experimental animals after autotransplantation of the bone mixture. Bone recovery in the experimental group had a higher rate, which was manifested by faster flling of the bone tissue defect, a low percentage of the necrosis area, a higher area of bone trabeculae, its rapid transformation into lamellar bone tissue.Conclusion. Osteogenesis had practically completed by day 30 of the experiment. At the same time, in the control group it had completed by day 60. The results obtained are a theoretical precondition for further research in the feld of bone autoplasty. Advanced development of surgical and minimally invasive technologies of bone mixture application will increase the effciency of modern reconstructive surgery of bones and joints.

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