Study on the Application of 1.5T Magnetic Resonance Imaging Image Fusion in the Staging of Rectal Cancer

2021 ◽  
Vol 11 (6) ◽  
pp. 1678-1685
Author(s):  
Jiexia Lv ◽  
Huajun Yu

Rectal cancer is a common gastric testicular malignancy, and surgical resection is the most effective treatment. The depth of local tumour filtration, lymph node metastasis and distant metastasis are all factors that influence the prognosis of rectal cancer surgery. MRI has the advantages of high-resolution, multidirectional, multi-angle, multiparameter imaging and zero radiation in soft tissue, so you can estimate the depth of tumour filtration and lymph node metastasis more accurately than ultrasound or CT. Today, it is a standard method for pre-operative imaging of rectal cancer. In this study, patients with rectal cancer have been studied from May 2020 to May 2021. 75 Patients were scanned at an arrow-shaped position and cross-sectional images, which are strictly vertical to the rectal wall, were designed after improvement at tumour level. The position of the coronal image is strictly vertical to the horizontal position. In this way, partial volume effects can be avoided and the depth of tumour filtration accurately evaluated. This helps surgeons determine the horizontal position of the tumor based on MRI images. To avoid the volume effect, the cross-section line must be vertical to the tumour axis. This study shows that in T3 tumours it is particularly important to measure the minimum level between the tumour and the rectal mesioma phase. The histology of the resected samples showed that if the distance between the tumor and the rectal mestrincular fascia exceeds 1 mm, the frequency of local recurrence is greatly reduced. If the distance between the tumor and the rectal mesiole fascia is less than 1 mm, the risk of local recurrence is greatly increased. Therefore, tumours with a straight mesosis of 1 mm or less margin-positive are called.

1992 ◽  
Vol 35 (12) ◽  
pp. 1130-1134 ◽  
Author(s):  
Osamu Kimura ◽  
Toshihisa Kijima ◽  
Seiji Moriwaki ◽  
Kazuyoshi Hoshino ◽  
Masao Yonekawa ◽  
...  

2012 ◽  
Vol 15 (1) ◽  
pp. e13-e20 ◽  
Author(s):  
J. Peng ◽  
H. Wu ◽  
X. Li ◽  
W. Sheng ◽  
D. Huang ◽  
...  

2017 ◽  
Vol 7 (1) ◽  
pp. 1078-1083
Author(s):  
A Pradhan ◽  
P Paudyal ◽  
AK Sinha ◽  
CS Agrawal

Background: Breast carcinoma is the most frequent malignant tumor in women accounting for approximately 15% of female cancer deaths. It is the second most common malignancy among women in Nepal. Our objectives were to study the extent and spread of different histological types breast carcinoma in the eastern region of Nepal, to grade and stage the tumors, score the prognosis.Materials and Methods: A cross-sectional descriptive study of mastectomy specimens with axillary lymph node sampling was done for a period of two years. Diagnosis was done using WHO classification. Modified Bloom Richardson score and TNM system was used to grade and stage the tumors. Nottingham Prognostic index was applied to score the prognosis.Results: Out of 31 total cases, the most common histologic type was Invasive Carcinoma of No Special Type (67.74%). The largest tumor size was of 12cm which had poor NPI score. Most tumors were of grade II and T2. Out of 30 cases with lymph nodes, 13 were negative for metastasis pN0, 10 were pN1 and 7 were pN2. Extranodal spread was observed in 6 out of 17 cases with lymph node metastasis and was associated with higher grades and poor prognosis.Conclusion: Higher grade tumors, lymph node metastasis and extranodal extension are associated with higher Nottingham Prognostic Index score. 


2021 ◽  
Author(s):  
Thérèse Rachell Theodoro ◽  
Rodrigo Lorenzetti Serrano ◽  
Karine Corcione Turke ◽  
Sarhan Sydney Saad ◽  
Marcelo Augusto Fontenelle Ribeiro Junior ◽  
...  

AbstractThe process of proliferation and invasion of tumor cells depends on changes in the extracellular matrix (ECM) through the activation of enzymes and alterations in the profile of ECM components. We aimed to investigate the mRNA and protein expression of ECM components such as heparanase (HPSE), heparanase-2 (HPSE2), matrix metalloproteinase-9 (MMP-9), and syndecan-1 (SYND1) in neoplastic and non-neoplastic tissues of patients with colorectal carcinoma (CRC). It is a cross-sectional study in which twenty-four adult patients that had CRC were submitted to resection surgery. We analyzed the expression of HPSE, HPSE2, MMP-9, and SYND1 by quantitative RT-PCR and immunohistochemistry. Differing from most of the studies that compare the mRNA expression between tumor samples and non-neoplastic tissues, we decided to investigate whether variations exist in the expression of the ECM components between the affected tissue and nontumoral tissue collected from the same patient with CRC. We removed both tissue samples immediately after the surgical resection of CRC. The data showed higher mRNA and protein expression of HPSE2 (P = 0.0058), MMP-9 (P = 0.0268), and SYND1 (P = 0.0002) in tumor samples compared to the non-neoplastic tissues, while there was only an increase in the level of HPSE protein in tumor tissues. A greater expression of HPSE2 was observed in patients with lymph node metastasis (P = 0.048), suggesting that such protein can be a marker of lymph node metastasis in CRC.


2019 ◽  
Vol 29 (12) ◽  
pp. 6469-6476 ◽  
Author(s):  
Lanqing Yang ◽  
Dan Liu ◽  
Xin Fang ◽  
Ziqiang Wang ◽  
Yue Xing ◽  
...  

2016 ◽  
Vol 46 (1) ◽  
pp. 194-206 ◽  
Author(s):  
Endre Grøvik ◽  
Kathrine Røe Redalen ◽  
Tryggve Holck Storås ◽  
Anne Negård ◽  
Stein Harald Holmedal ◽  
...  

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