Hypercaloric high-lipid diet and brain development: Effects on cortical spreading depression in adult rats

2013 ◽  
Vol 16 (6) ◽  
pp. 275-281 ◽  
Author(s):  
Paula Catirina Pereira da Silva Germano ◽  
Débora de Lima e Silva ◽  
Geórgia de Sousa Ferreira Soares ◽  
Ângela Amâncio dos Santos ◽  
Rubem Carlos Araújo Guedes
Keyword(s):  
Brain Development ◽  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Adult Rats ◽  
High Lipid ◽  
High Lipid Diet ◽  
Lipid Diet

Altered composition of high-lipid diet may generate reactive oxygen species by disturbing the balance of antioxidant and free radicals

2020 ◽  
Vol 31 (3) ◽  
Author(s):  
Arnab Banerjee ◽  
Debasmita Das ◽  
Rajarshi Paul ◽  
Sandipan Roy ◽  
Ankita Bhattacharjee ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Risk Factor ◽  
Reactive Oxygen ◽  
Control Group ◽  
Preliminary Evaluation ◽  
Oxygen Species ◽  
High Lipid ◽  
Tnf Α ◽  
High Lipid Diet ◽  
Lipid Diet

AbstractBackgroundIn the present era, obesity is increasing rapidly, and high dietary intake of lipid could be a noteworthy risk factor for the occasion of obesity, as well as nonalcoholic fatty liver disease, which is the independent risk factor for type 2 diabetes and cardiovascular disease. For a long time, high-lipid diet (HLD) in “fast food” is turning into part of our everyday life. So, we were interested in fulfilling the paucity of studies by means of preliminary evaluation of these three alternative doses of HLD on a rat model and elucidating the possible mechanism of these effects and divulging the most alarming dose.MethodsThirty-two rats were taken, and of these, 24 were fed with HLD in three distinctive compositions of edible coconut oil and vanaspati ghee in a ratio of 2:3, 3:2 and 1:1 (n = 8), orally through gavage at a dose of 10 mL/kg body weight for a period of 28 days, whereas the other eight were selected to comprise the control group.ResultsAfter completion of the experiment, followed by analysis of data it was revealed that hyperlipidemia with increased liver and cardiac marker enzymes, are associated with hepatocellular injury and cardiac damage. The data also supported increased proinflammatory cytokines such as interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α). As oxidative stress parameter increased in both liver and heart, there is also an increased in TNF-α due to an increased expression of inducible nitric oxide (NO) synthase, which led to a high production of NO. Moreover, HLD treatment explicitly weakens reasonability of hepatocytes and cardiomyocytes conceivably through G0/G1 or S stage capture or perhaps by means of enlistment of sub-G0/G1 DNA fragmentation and a sign of apoptosis.ConclusionsBased on the outcomes, it tends to be inferred that consequences of the present examination uncovered HLD in combination of 2:3 applies most encouraging systemic damage by reactive oxygen species generation and hyperlipidemia and necroapoptosis of the liver and heart. Hence, outcome of this study may help to formulate health care strategy and warns about the food habit in universal population regarding the use of hydrogenated and saturated fats (vanaspati ghee) in diet.

scholarly journals Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats.

2009 ◽  
Vol 2 (2) ◽  
pp. 235-241 ◽  
Author(s):  
Euclides Mauricio Trindade-Filho ◽  
Carlos Augusto Carvalho de Vasconcelos ◽  
Rubem Carlos Araújo Guedes
Keyword(s):  
Rem Sleep ◽  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Adult Rats

scholarly journals Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma

2021 ◽  
Author(s):  
Daniel J. Silver ◽  
Gustavo A. Roversi ◽  
Nazmin Bithi ◽  
Sabrina Z. Wang ◽  
Katie M. Troike ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
High Lipid ◽  
High Lipid Diet ◽  
Lipid Diet

scholarly journals Cerebral cortex does not modulate “regulated” decrease in core temperature during hypoxemia in rats

1998 ◽  
Vol 274 (4) ◽  
pp. R1158-R1161
Author(s):  
Evvi-Lynn M. Rollins ◽  
James E. Fewell
Keyword(s):  
Cerebral Cortex ◽  
Core Temperature ◽  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Temperature Response ◽  
Sprague Dawley ◽  
Adult Rats ◽  
The Core ◽  
Sprague Dawley Rats ◽  
Before And After

In newborns and adults of a number of species including humans, exposure to acute hypoxemia produces a “regulated” decease in core temperature, the mechanism of which is unknown. Considering that various cortical areas participate in autonomic regulation including thermoregulation, the present experiments were carried out to test the hypothesis that the cerebral cortex plays a role in modulating the regulated decrease in core temperature during acute hypoxemia. This hypothesis was tested by determining the core temperature response to acute hypoxemia in chronically instrumented adult Sprague-Dawley rats before and after cortical spreading depression (i.e., functional decortication) was produced by the local application of potassium chloride to the dura overlying the cerebral hemispheres. There was no effect of cortical spreading depression on baseline core temperature. Core temperature decreased during acute hypoxemia in a similar fashion when the cerebral cortex was intact as well as during functional decortication. Thus our data do not support the hypothesis that the cerebral cortex modulates the regulated decrease in core temperature that occurs in adult rats during acute hypoxemia.

Effect of high lipid diet on circadian rhythms of tissue glycogen

1980 ◽  
Vol 36 (9) ◽  
pp. 1085-1086 ◽  
Author(s):  
Susan M. Garthwaite ◽  
D. K. Meyer
Keyword(s):  
Circadian Rhythms ◽  
High Lipid ◽  
High Lipid Diet ◽  
Lipid Diet

scholarly journals Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Arnab Banerjee ◽  
Debasmita Das ◽  
Rajarshi Paul ◽  
Sandipan Roy ◽  
Ujjal Das ◽  
...  
Keyword(s):  
Monosodium Glutamate ◽  
Ethanol Extract ◽  
Inflammatory Factors ◽  
Mechanistic Study ◽  
Metabolic Disturbances ◽  
Alcoholic Fatty Liver ◽  
Coccinia Grandis ◽  
High Lipid ◽  
High Lipid Diet ◽  
Lipid Diet

Abstract In the context of failure of treatment for non alcoholic fatty liver disease (NAFLD)-mediated systemic damages, recognition of novel and successful characteristic drug to combat these anomalous situations is earnestly required. The present study is aimed to evaluate protective value of ethanol extract of Coccinia grandis leaves (EECGL), naturally occurring medicinal plant, on NAFLD-mediated systemic damage induced by high lipid diet along with monosodium glutamate (HM)-fed rats. Our study uncovered that EECGL significantly ameliorates HM-induced hyperlipidemia, increased lipogenesis and metabolic disturbances (via up regulation of PPAR-α and PPAR-γ), oxidative stress (via reducing the generation of reactive oxygen species and regulating the redox-homeostasis) and inflammatory response (via regulating the pro-inflammatory and anti-inflammatory factors with concomitant down regulation of NF-kB, iNOS, TNF-α and up regulation of eNOS). Furthermore, EECGL significantly inhibited HM-induced increased population of cells in sub G0/G1 phase, decreased Bcl2 expression and thereby loss of mitochondrial membrane potential with over expression of Bax, p53, p21, activation of caspase 3 and 9 indicated the apoptosis and suppression of cell survival. It is perhaps the first comprehensive study with a mechanistic approach which provides a strong unique strategy for the management of HM-induced systemic damage with effective dose of EECGL.

Citalopram has an Antagonistic Action on Cortical Spreading Depression in Well-nourished and Early-malnourished Adult Rats

2002 ◽  
Vol 5 (2) ◽  
pp. 115-123 ◽  
Author(s):  
R.C.A. Guedes ◽  
A. Amâncio-Dos-Santos ◽  
R. Manhães-De-Castro ◽  
R.R.G. Costa-Cruz
Keyword(s):  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Adult Rats ◽  
Antagonistic Action

scholarly journals Noradrenergic Agonists and Antagonists Influence Migration of Cortical Spreading Depression in Rat—a Possible Mechanism of Migraine Prophylaxis and Prevention of Postischemic Neuronal Damage

2005 ◽  
Vol 25 (9) ◽  
pp. 1225-1235 ◽  
Author(s):  
Frank Richter ◽  
Oskar Mikulik ◽  
Andrea Ebersberger ◽  
Hans-Georg Schaible
Keyword(s):  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Neuronal Damage ◽  
Regional Cerebral Blood ◽  
Adrenergic Agonist ◽  
Adult Rats ◽  
Arterial Blood ◽  
Β Blocker ◽  
Β Receptor ◽  
Focal Brain Ischemia

Cortical spreading depression (CSD) is thought to be a neuronal mechanism that expands the penumbra zone after focal brain ischemia and that causes migraine aura. Both adrenergic agonists and antagonists significantly influence the size of the penumbra zone and decline the frequency of migraine. To study whether these compounds act by influencing CSD, we applied different drugs topically to an area of the exposed cortex of anesthetized adult rats and observed the migration of CSD-related DC potential deflections across the treated area. The adrenergic agonist norepinephrine (1 mmol/L) and the α2-agonist clonidine (0.56 mmol/L) blocked reversibly the migration of CSD. The β-blocker propranolol (250 μmol/L to 1 mmol/L) dose-dependently diminished migration velocity or even blocked migration of CSD. The CSD blockade by the α2-antagonist yohimbine (1.75 mmol/L) was because of its action on inhibitory 5-HT1A receptors. None of the substances in the concentrations used had influence on regional cerebral blood flow or on systemic arterial blood pressure. The data suggest that the interference of these compounds with CSD may contribute to their beneficial therapeutic effect. The effect of β-receptor antagonists in human migraine needs further exploration, since these drugs also work in migraine without aura.

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