The Statewide Epidemiology of Mucormycosis Among Trauma Patients in Florida

Objectives Mucormycosis is a rare angioinvasive infection caused by filamentous fungi with a high lethality among the immunocompromised. In healthy people, the innate immune system is sufficient to prevent infection. The exception to this is deep tissue exposure seen during trauma. The purpose of this study is to evaluate the epidemiology of mucormycosis using a statewide population-based data set. Methods This is a retrospective cohort study of all hospital admissions for mucormycosis within the state of Florida from 1997 through the beginning of 2020. A distribution map was created to evaluate for geographic variation. Botanical growth zones, based on plant hardiness, used by state environmental agencies and landscapers were also used to detect possible patterns based on climate conditions throughout Florida. A multivariable regression analysis was performed to account for confounders and limit bias. Results A total of 1190 patients were identified for mucormycosis infection. Only 86 of these patients were admitted for trauma. Cutaneous infections were more prevalent among trauma patients while non-trauma patients had more pulmonary infections ( P = .04). Trauma patients with infection tended to be younger and less likely to suffer from comorbidities such as immunosuppression (36% vs 46%, P = .07) and diabetes (22.1% vs 47.1%, P ≤ .0001) as compared to their non-trauma counterparts. Mortality was similar with 17.8% for non-trauma patients and 15.1% for traumatized patients (AOR .80 [.42, 1.52]). Length of stay was longer for trauma patients (37.3 vs 23.0, P < .0001). Infections were less prominent in plant hardiness Zone 9 and Zone 10 as compared to Zone 8 (AOR .71 [.61, .82]; AOR .54 [.46, .64], respectively). Conclusion Trauma patients who develop infection from mucormycosis are at high risk of death despite being a younger and healthier population. Mucormycosis infections were primarily soft tissue based among trauma patients. These infections are more prevalent in colder regions within Florida.

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Prognostic value of weight loss in patients with amyotrophic lateral sclerosis: a population-based study

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2020-322909 ◽

2020 ◽

Vol 91 (8) ◽

pp. 867-875 ◽

Cited By ~ 1

Author(s):

Mark R Janse van Mantgem ◽

Ruben P A van Eijk ◽

Hannelore K van der Burgh ◽

Harold H G Tan ◽

Henk-Jan Westeneng ◽

...

Keyword(s):

Weight Loss ◽

Amyotrophic Lateral Sclerosis ◽

Body Weight ◽

Prognostic Value ◽

Population Based ◽

Data Set ◽

Population Based Study ◽

Risk Of Death ◽

Lateral Sclerosis

ObjectiveTo determine the prevalence and prognostic value of weight loss (WL) prior to diagnosis in patients with amyotrophic lateral sclerosis (ALS).MethodsWe enrolled patients diagnosed with ALS between 2010 and 2018 in a population-based setting. At diagnosis, detailed information was obtained regarding the patient’s disease characteristics, anthropological changes, ALS-related genotypes and cognitive functioning. Complete survival data were obtained. Cox proportional hazard models were used to assess the association between WL and the risk of death during follow-up.ResultsThe data set comprised 2420 patients of whom 67.5% reported WL at diagnosis. WL occurred in 71.8% of the bulbar-onset and in 64.2% of the spinal-onset patients; the mean loss of body weight was 6.9% (95% CI 6.8 to 6.9) and 5.5% (95% CI 5.5 to 5.6), respectively (p<0.001). WL occurred in 35.1% of the patients without any symptom of dysphagia. WL is a strong independent predictor of survival, with a dose response relationship between the amount of WL and the risk of death: the risk of death during follow-up increased by 23% for every 10% increase in WL relative to body weight (HR 1.23, 95% CI 1.13 to 1.51, p<0.001).ConclusionsThis population-based study shows that two-thirds of the patients with ALS have WL at diagnosis, which also occurs independent of dysphagia, and is related to survival. Our results suggest that WL is a multifactorial process that may differ from patient to patient. Gaining further insight in its underlying factors could prove essential for future therapeutic measures.

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Residential status and health in middle and late life: a population-based study with new data from Spain

BMJ Open ◽

10.1136/bmjopen-2019-033330 ◽

2020 ◽

Vol 10 (1) ◽

pp. e033330 ◽

Cited By ~ 2

Author(s):

Miguel Requena ◽

David Reher

Keyword(s):

Excess Mortality ◽

Population Based ◽

Living Alone ◽

Spanish Population ◽

Differential Mortality ◽

Elderly Persons ◽

Data Set ◽

Population Based Study ◽

Residential Status ◽

Risk Of Death

ObjectivesTo address how different residential situations impact the likelihood of death among mature adults and elderly persons.DesignPopulation-based study with administrative data linked to census data.SettingSpain.ParticipantsSpanish population alive on 1 January 2012, observed between 1 January 2012 and 31 December 2012. A 10% random sample of the Spanish population, including 2 054 427 person years and 28 736 deaths, is used.Main outcome measureRegistered deaths in the 2012 Spanish vital statistics.MethodsUsing a new data set based on linked administrative registers, we estimate unadjusted and adjusted mortality rates by coresidential situation. Differential mortality is measured by rate ratios (RR) estimated with Poisson regression. Cause of death data are used to explore the mechanisms involved in excess mortality by residential status.ResultsCompared with men 45–54 living with partners, the risk of death is much higher for those without partners living with others (RR 2.0, 95% CI 1.7 to 2.4) or for those living alone (RR 1.9, 95% CI 1.5 to 2.4). After 84, excess mortality among men living with others persists (RR 1.4, 95% CI 1.3 to 1.5), but disappears for those living alone (RR 1.0, 95% CI 0.9 to 1.1). Both among women 45–64 living with others but without partner (RR 1.8, 95% CI 1.5 to 2.3) and among those living alone (RR 2.2, 95% CI 1.5 to 3.1) the pattern is similar to men. At higher ages, however, excess mortality for women living alone decreases (RR 1.2, 95% CI 1.1 to 1.2), though it persists for women living with others (RR 1.9, 95% CI 1.7 to 2.0).ConclusionsThese findings indicate direct effects of living arrangements on mortality and health-related selection effects influencing residential choices. These effects may be partially affected by age and prevailing societal and cultural contexts.

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Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England

BMJ ◽

10.1136/bmj.n628 ◽

2021 ◽

pp. n628 ◽

Cited By ~ 1

Author(s):

Harriet Forbes ◽

Caroline E Morton ◽

Seb Bacon ◽

Helen I McDonald ◽

Caroline Minassian ◽

...

Keyword(s):

Cohort Study ◽

Intensive Care ◽

Hospital Admissions ◽

Absolute Risk ◽

Population Based ◽

Intensive Care Admission ◽

Risk Of Death ◽

Hazard Ratios ◽

Increased Risk ◽

The Uk

Abstract Objective To investigate whether risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and outcomes of coronavirus disease 2019 (covid-19) differed between adults living with and without children during the first two waves of the UK pandemic. Design Population based cohort study, on behalf of NHS England. Setting Primary care data and pseudonymously linked hospital and intensive care admissions and death records from England, during wave 1 (1 February to 31 August 2020) and wave 2 (1 September to 18 December 2020). Participants Two cohorts of adults (18 years and over) registered at a general practice on 1 February 2020 and 1 September 2020. Main outcome measures Adjusted hazard ratios for SARS-CoV-2 infection, covid-19 related admission to hospital or intensive care, or death from covid-19, by presence of children in the household. Results Among 9 334 392 adults aged 65 years and under, during wave 1, living with children was not associated with materially increased risks of recorded SARS-CoV-2 infection, covid-19 related hospital or intensive care admission, or death from covid-19. In wave 2, among adults aged 65 years and under, living with children of any age was associated with an increased risk of recorded SARS-CoV-2 infection (hazard ratio 1.06 (95% confidence interval 1.05 to 1.08) for living with children aged 0-11 years; 1.22 (1.20 to 1.24) for living with children aged 12-18 years) and covid-19 related hospital admission (1.18 (1.06 to 1.31) for living with children aged 0-11; 1.26 (1.12 to 1.40) for living with children aged 12-18). Living with children aged 0-11 was associated with reduced risk of death from both covid-19 and non-covid-19 causes in both waves; living with children of any age was also associated with lower risk of dying from non-covid-19 causes. For adults 65 years and under during wave 2, living with children aged 0-11 years was associated with an increased absolute risk of having SARS-CoV-2 infection recorded of 40-60 per 10 000 people, from 810 to between 850 and 870, and an increase in the number of hospital admissions of 1-5 per 10 000 people, from 160 to between 161 and 165. Living with children aged 12-18 years was associated with an increase of 160-190 per 10 000 in the number of SARS-CoV-2 infections and an increase of 2-6 per 10 000 in the number of hospital admissions. Conclusions In contrast to wave 1, evidence existed of increased risk of reported SARS-CoV-2 infection and covid-19 outcomes among adults living with children during wave 2. However, this did not translate into a materially increased risk of covid-19 mortality, and absolute increases in risk were small.

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Harmonising data from different sources to conduct research using linked survey and routine datasets

International Journal for Population Data Science ◽

10.23889/ijpds.v3i4.750 ◽

2018 ◽

Vol 3 (4) ◽

Cited By ~ 1

Author(s):

Amrita Bandyopadhyay ◽

Karen Tingay ◽

Mario Cortina Borja ◽

Lucy Griffiths ◽

Ashley Akbari ◽

...

Keyword(s):

Emergency Department ◽

Hospital Admissions ◽

Routine Data ◽

Population Based ◽

Data Sources ◽

Effective Sample Size ◽

Hospital Inpatient ◽

Data Set ◽

Health Records ◽

Heterogeneous Variables

IntroductionHarmonization of different data sources from various electronic health records across systems enhances the potential scope and granularity of data available to health data research, providing more opportunities for research by improving the generalizability and effective sample size of a range of outcome metrics. Objectives and ApproachThis study describes data harmonisation for a UK longitudinal birth cohort, the Millennium Cohort Study (MCS) which was linked to routine inpatient and emergency department, and, where available, general practice and child health records for 1838 Welsh and 1431 Scottish consenting MCS participants. Datasets requiring harmonisation were: from Wales, Patient Episode Dataset for Wales (PEDW) and Emergency Department Data Set (EDDS) data and from Scotland, Scottish Medical Record 01 (SMR01) and Accident and Emergency dataset (A&E2). Heterogeneous variables were created by transforming variable names, concepts, codes to improve scope for analysis. ResultsA harmonized dataset of 2166 participants and 5747 hospital admissions were derived of cohort members who had at least 1 hospital inpatient or A&E event before their 14th birthday. Harmonisation included: dealing with date granularity by generating random dates of birth; standardising periods of data collection; identifying inconsistencies and then mapping and bridging differences in definitions of periods of care and levels of diagnostic and operational coding across countries and datasets. Conclusion/ImplicationsHeterogeneous variables from different data sources were pooled and converted into standardised data for research, extending existing harmonisation work, including curation of a population based anonymously linkable longitudinal cohort. [AA1] These methods are reproducible and can be utilised by other researchers and projects applying to use these routine data sources.

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Association of socioeconomic deprivation with asthma care, outcomes, and deaths in Wales: A 5-year national linked primary and secondary care cohort study

PLoS Medicine ◽

10.1371/journal.pmed.1003497 ◽

2021 ◽

Vol 18 (2) ◽

pp. e1003497

Author(s):

Mohammad A. Alsallakh ◽

Sarah E. Rodgers ◽

Ronan A. Lyons ◽

Aziz Sheikh ◽

Gwyneth A. Davies

Keyword(s):

Secondary Care ◽

Hospital Admissions ◽

Population Based ◽

Socioeconomic Deprivation ◽

Prescribing Patterns ◽

Service Utilisation ◽

Risk Of Death ◽

Asthma Patients ◽

National Cohort ◽

Care Outcomes

Background Socioeconomic deprivation is known to be associated with worse outcomes in asthma, but there is a lack of population-based evidence of its impact across all stages of patient care. We investigated the association of socioeconomic deprivation with asthma-related care and outcomes across primary and secondary care and with asthma-related death in Wales. Methods and findings We constructed a national cohort, identified from 76% (2.4 million) of the Welsh population, of continuously treated asthma patients between 2013 and 2017 using anonymised, person-level, linked, routinely collected primary and secondary care data in the Secure Anonymised Information Linkage (SAIL) Databank. We investigated the association between asthma-related health service utilisation, prescribing, and deaths with the 2011 Welsh Index of Multiple Deprivation (WIMD) and its domains. We studied 106,926 patients (534,630 person-years), 56.3% were female, with mean age of 47.5 years (SD = 20.3). Compared to the least deprived patients, the most deprived patients had slightly fewer total asthma-related primary care consultations per patient (incidence rate ratio [IRR] = 0.98, 95% CI 0.97–0.99, p-value < 0.001), slightly fewer routine asthma reviews (IRR = 0.98, 0.97–0.99, p-value < 0.001), lower controller-to-total asthma medication ratios (AMRs; 0.50 versus 0.56, p-value < 0.001), more asthma-related accident and emergency (A&E) attendances (IRR = 1.27, 1.10–1.46, p-value = 0.001), more asthma emergency admissions (IRR = 1.56, 1.39–1.76, p-value < 0.001), longer asthma-related hospital stay (IRR = 1.64, 1.39–1.94, p-value < 0.001), and were at higher risk of asthma-related death (risk ratio of deaths with any mention of asthma 1.56, 1.18–2.07, p-value = 0.002). Study limitations include the deprivation index being area based and the potential for residual confounders and mediators. Conclusions In this study, we observed that the most deprived asthma patients in Wales had different prescribing patterns, more A&E attendances, more emergency hospital admissions, and substantially higher risk of death. Interventions specifically designed to improve treatment and outcomes for these disadvantaged groups are urgently needed.

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Incidence, mortality and survival in children and young people aged 11-25 in Wales with co-occurring mental disorders and problem, hazardous or harmful substance use: estimates derived from linked routine data

10.21203/rs.3.rs-50077/v1 ◽

2020 ◽

Author(s):

Sarah Rees ◽

Alan Watkins ◽

Janet Keauffling ◽

Ann John

Keyword(s):

Substance Use ◽

Young People ◽

Hospital Admissions ◽

Cox Regression ◽

Routine Data ◽

Population Based ◽

Older Age ◽

Harmful Substance ◽

Risk Of Death ◽

Male Sex

Abstract Background Mental disorder (MD) and problem, hazardous or harmful substance use (SUD) are associated with poorer than average health and greater mortality. We analysed routine data to estimate incidence of co-occurring (CC) MD and SUD, and to estimate all-cause mortality and survival with CC, a single MD or SUD diagnosis or neither condition (NC), in young people aged 11-25 in Wales, UK. Methods A retrospective population-based electronic cohort study using data from the Secure Anonymised Information Linkage (SAIL) Databank. Participants were 958,603 individuals aged 11-25 between 2008 and 2017, with a subset for mortality and survival analysis of 465,242 individuals born between 1983 and 1997 and present in the data on 1st January 2008. Incidence was defined as date of first recorded occurrence of a CC code. Incidence and observed unadjusted mortality were reported as rates per 1,000 person-years at risk (PYAR). We plotted Kaplan-Meier survival curves and carried out Cox regression to estimate hazard ratios for risk of death by condition group (CC; MD or SUD only; NC). Results CC incidence in primary care significantly decreased, from 2.5/1,000 PYAR (95% CI 2.3-2.6) in 2008 to 2.1/1,000 (95% CI 2.0-2.2) in 2017 (Incidence rate ratio (IRR) = 0.9, 95% CI 0.8-1.0, p=0.01), and in hospital admissions remained stable, from 2.3/1,000 (95% CI 2.1-2.4) in 2008 to 2.2/1,000 (95% CI 2.0-2.3) in 2017 (IRR = 1.0, 95% CI 0.9-1.1). Higher incidence was associated with male sex, older age and greater deprivation.Observed unadjusted mortality rates for CC (1.4/1,000 PYAR, 95% CI 1.2-1.5) and SUD only (1.1/1,000, 95% CI 0.9-1.4) were significantly higher than for MD only (0.4/1,000, 95% CI 0.3-0.4) and no condition (NC) (0.3/1,000, 95% CI 0.2-0.3). Risk of death was significantly higher for CC (HR = 8.7, 95% CI 7.5-10.0, p<0.001), SUD only (HR = 4.5, 95% CI 3.4-5.9, p<0.001) and MD only (HR = 2.7, 95% CI 2.4-3.1, p<0.001), compared with NC.Conclusions Male sex, older age and greater deprivation were associated with significantly higher CC incidence. CC, and also SUD or MD only, were associated with greater risk of death, compared with individuals with NC.

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Death and readmissions after hospital discharge during the December holiday period: cohort study

BMJ ◽

10.1136/bmj.k4481 ◽

2018 ◽

pp. k4481 ◽

Cited By ~ 4

Author(s):

Lauren Lapointe-Shaw ◽

Peter C Austin ◽

Noah M Ivers ◽

Jin Luo ◽

Donald A Redelmeier ◽

...

Keyword(s):

Emergency Department ◽

Cohort Study ◽

Hospital Discharge ◽

Hospital Admissions ◽

Healthcare Utilisation ◽

Population Based ◽

Emergency Department Visits ◽

Risk Of Death ◽

Holiday Period

Abstract Objective To determine whether patients discharged from hospital during the December holiday period have fewer outpatient follow-ups and higher rates of death or readmission than patients discharged at other times. Design Population based retrospective cohort study. Setting Acute care hospitals in Ontario, Canada, 1 April 2002 to 31 January 2016. Participants 217 305 children and adults discharged home after an urgent admission, during the two week December holiday period, compared with 453 641 children and adults discharged during two control periods in late November and January. Main outcome measures The primary outcome was death or readmission, defined as a visit to an emergency department or urgent rehospitalisation, within 30 days. Secondary outcomes were death or readmission and outpatient follow-up with a physician within seven and 14 days after discharge. Multivariable logistic regression with generalised estimating equations was used to adjust for characteristics of patients, admissions, and hospital. Results 217 305 (32.4%) patients discharged during the holiday period and 453 641 (67.6%) discharged during control periods had similar baseline characteristics and previous healthcare utilisation. Patients who were discharged during the holiday period were less likely to have follow-up with a physician within seven days (36.3% v 47.8%, adjusted odds ratio 0.61, 95% confidence interval 0.60 to 0.62) and 14 days (59.5% v 68.7%, 0.65, 0.64 to 0.66) after discharge. Patients discharged during the holiday period were also at higher risk of 30 day death or readmission (25.9% v 24.7%, 1.09, 1.07 to 1.10). This relative increase was also seen at seven days (13.2% v 11.7%, 1.16, 1.14 to 1.18) and 14 days (18.6% v 17.0%, 1.14, 1.12 to 1.15). Per 100 000 patients, there were 2999 fewer follow-up appointments within 14 days, 26 excess deaths, 188 excess hospital admissions, and 483 excess emergency department visits attributable to hospital discharge during the holiday period. Conclusions Patients discharged from hospital during the December holiday period are less likely to have prompt outpatient follow-up and are at higher risk of death or readmission within 30 days.

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National Temporal Trend Analysis of Infective Endocarditis among Patients Infected with HIV in Spain (1997–2014): A Retrospective Study

Journal of Clinical Medicine ◽

10.3390/jcm8081167 ◽

2019 ◽

Vol 8 (8) ◽

pp. 1167 ◽

Cited By ~ 2

Author(s):

Maria Fe Muñoz-Moreno ◽

Pablo Ryan ◽

Alejandro Alvaro-Meca ◽

Jorge Valencia ◽

Eduardo Tamayo ◽

...

Keyword(s):

Retrospective Study ◽

Infective Endocarditis ◽

Hospital Admissions ◽

Downward Trend ◽

Coagulase Negative Staphylococci ◽

Data Set ◽

Gram Negative ◽

Epidemiological Trend ◽

Incidence And Mortality ◽

Significant Downward Trend

Background: People living with human immunodeficiency virus (HIV) (PLWH) form a vulnerable population for the onset of infective endocarditis (IE). We aimed to analyze the epidemiological trend of IE, as well as its microbiological characteristics, in PLWH during the combined antiretroviral therapy era in Spain. Methods: We performed a retrospective study (1997–2014) in PLWH with data obtained from the Spanish Minimum Basic Data Set. We selected 1800 hospital admissions with an IE diagnosis, which corresponded to 1439 patients. Results: We found significant downward trends in the periods 1997–1999 and 2008–2014 in the rate of hospital admissions with an IE diagnosis (from 21.8 to 3.8 events per 10,000 patients/year; p < 0.001), IE incidence (from 18.2 to 2.9 events per 10,000 patients/year; p < 0.001), and IE mortality (from 23.9 to 5.5 deaths per 100,000 patient-years; p < 0.001). The most frequent microorganisms involved were staphylococci (50%; 42.7% Staphylococcus aureus and 7.3% coagulase-negative staphylococci (CoNS)), followed by streptococci (9.3%), Gram-negative bacilli (8.3%), enterococci (3%), and fungus (1.4%). During the study period, we found a downward trend in the rates of CoNS (p < 0.001) and an upward trends in streptococci (p = 0.001), Gram-negative bacilli (p < 0.001), enterococci (p = 0.003), and fungus (p < 0.001) related to IE, mainly in 2008–2014. The rate of community-acquired IE showed a significant upward trend (p = 0.001), while the rate of health care-associated IE showed a significant downward trend (p < 0.001). Conclusions: The rates of hospital admissions, incidence, and mortality related to IE diagnosis in PLWH in Spain decreased from 1997 to 2014, while other changes in clinical characteristics, mode of acquisition, and pathogens occurred over this time.

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Nonelective hospital admissions, discharge disposition, and health services utilization in epilepsy patients: A population‐based study

Epilepsia ◽

10.1111/epi.16642 ◽

2020 ◽

Vol 61 (9) ◽

pp. 1969-1978

Author(s):

Churl‐Su Kwon ◽

Bonnie Wong ◽

Parul Agarwal ◽

Jung‐Yi Lin ◽

Madhu Mazumdar ◽

...

Keyword(s):

Health Services ◽

Hospital Admissions ◽

Health Services Utilization ◽

Population Based ◽

Population Based Study ◽

Services Utilization ◽

Discharge Disposition

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Racial and Sex Disparities in Trauma Outcomes Based on Geographical Region

The American Surgeon ◽

10.1177/0003134820960063 ◽

2020 ◽

pp. 000313482096006

Author(s):

William Q. Duong ◽

Areg Grigorian ◽

Cyrus Farzaneh ◽

Jeffry Nahmias ◽

Theresa Chin ◽

...

Keyword(s):

United States ◽

The United States ◽

Trauma Patients ◽

Improvement Program ◽

Trauma Outcomes ◽

Risk Of Death ◽

Hospital Access ◽

Risk Of Mortality ◽

Sex Disparities ◽

Male Patients

Objectives Disparities in outcomes among trauma patients have been shown to be associated with race and sex. The purpose of this study was to analyze racial and sex mortality disparities in different regions of the United States, hypothesizing that the risk of mortality among black and Asian trauma patients, compared to white trauma patients, will be similar within all regions in the United States. Methods The Trauma Quality Improvement Program (2010-2016) was queried for adult trauma patients, separating by U.S. Census regions. Multivariable logistic regression analyses were performed for each region, controlling for known predictors of morbidity and mortality in trauma. Results Most trauma patients were treated in the South (n = 522 388, 40.7%). After risk adjustment, black trauma patients had a higher associated risk of death in all regions, except the Northeast, compared to white trauma patients. The highest associated risk of death for blacks (vs. whites) was in the Midwest (odds ratio [OR] 1.30, P < .001). Asian trauma patients only had a higher associated risk of death in the West (OR 1.39, P < .001). Male trauma patients, compared to women, had an increased associated risk of mortality in all four regions. Discussion This study found major differences in outcomes among different races within different regions of the United States. There was also both an increased rate and associated risk of mortality for male patients in all regions. Future prospective studies are needed to identify what regional differences in trauma systems including population density, transport times, hospital access, and other trauma resources explain these findings.

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