Cyclooxygenase-2 in Cancer and Angiogenesis

Angiology ◽  
2008 ◽  
Vol 60 (2) ◽  
pp. 242-253 ◽  
Author(s):  
Mehmet ßahin ◽  
Emel ßahin ◽  
Saadet Gümüşlü
Keyword(s):  
Arachidonic Acid ◽  
Endometrial Cancer ◽  
Blood Vessels ◽  
Solid Tumors ◽  
Tumor Angiogenesis ◽  
Cyclooxygenase 2 ◽  
Tumor Proliferation ◽  
Cancer Types ◽  
Cyclooxygenase 2 Inhibitors

Tumor angiogenesis is a process where new blood vessels are formed from preexisting ones, resulting in several pathologies. Solid tumors induce angiogenesis to obtain the required nutrients and oxygen. Otherwise, tumors do not grow beyond 2 to 3 mm in diameter. Cyclooxygenase-2, an inducible enzyme important in inflammation, catalyzes the production of prostanoids from arachidonic acid. Cyclooxygenase-2 plays an important role in several cancer types, including colorectal, gastric, prostate, breast, lung, and endometrial cancer. Besides, cyclooxygenase-2 has been implicated in the progression and angiogenesis of cancers. Cyclooxygenase-2 inhibitors have been used to block angiogenesis and tumor proliferation. In this review, the recent studies related to the role of cyclooxygenase-2 in several cancer types and tumor-induced angiogenesis were compiled.

scholarly journals Non-Coding RNAs as Prognostic Markers for Endometrial Cancer

2021 ◽  
Vol 22 (6) ◽  
pp. 3151 ◽  
Author(s):  
Roberto Piergentili ◽  
Simona Zaami ◽  
Anna Franca Cavaliere ◽  
Fabrizio Signore ◽  
Giovanni Scambia ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Prognostic Markers ◽  
Classification Systems ◽  
Prognostic Role ◽  
Protein Coding ◽  
Pathological Characteristics ◽  
Epigenetic Events ◽  
Cancer Types ◽  
Non Coding Rnas

Endometrial cancer (EC) has been classified over the years, for prognostic and therapeutic purposes. In recent years, classification systems have been emerging not only based on EC clinical and pathological characteristics but also on its genetic and epigenetic features. Noncoding RNAs (ncRNAs) are emerging as promising markers in several cancer types, including EC, for which their prognostic value is currently under investigation and will likely integrate the present prognostic tools based on protein coding genes. This review aims to underline the importance of the genetic and epigenetic events in the EC tumorigenesis, by expounding upon the prognostic role of ncRNAs.

Renal Tissue Damage After Experimental Pyelonephritis: Role of Anti-Oxidants and Selective Cyclooxygenase-2 Inhibitors

2009 ◽  
Vol 5 ◽  
pp. S22
Author(s):  
Serhat Gurocak ◽  
Iyimser Ure ◽  
Ahmet Cumaoglu ◽  
Ipek Isik Gonul ◽  
Ilker Sen ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Renal Tissue ◽  
Cyclooxygenase 2 ◽  
Experimental Pyelonephritis ◽  
Cyclooxygenase 2 Inhibitors

scholarly journals gamma-H2AX: Can it be established as a classical cancer prognostic factor?

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769593 ◽  
Author(s):  
Viktoria-Varvara Palla ◽  
Georgios Karaolanis ◽  
Ioannis Katafigiotis ◽  
Ioannis Anastasiou ◽  
Paul Patapis ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Endometrial Cancer ◽  
Prognostic Factors ◽  
Prognostic Factor ◽  
Normal Tissue ◽  
Prognostic Value ◽  
Double Strand Breaks ◽  
Strand Breaks ◽  
Cancer Types

Double-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to double-strand breaks, and the gamma-H2AX is formatted as a result of genomic instability. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. gamma-H2AX has already been investigated in a variety of cancer types, including breast, lung, colon, cervix, and ovary cancers. The prognostic value of gamma-H2AX is indicated in certain cancer types, such as breast or endometrial cancer, but further investigation is needed to establish gamma-H2AX as a prognostic marker. This review outlines the role of gamma-H2AX in cell cycle, and its formation as a result of DNA damage. We investigate the role of gamma-H2AX formation in several cancer types and its correlation with other prognostic factors, and we try to find out whether it fulfills the requirements for its establishment as a classical cancer prognostic factor.

Renal Tissue Damage After Experimental Pyelonephritis: Role of Antioxidants and Selective Cyclooxygenase-2 Inhibitors

Urology ◽  
2010 ◽  
Vol 76 (2) ◽  
pp. 508.e1-508.e5 ◽  
Author(s):  
Serhat Gurocak ◽  
Iyimser Ure ◽  
Ahmet Cumaoglu ◽  
Ipek Isik Gonul ◽  
Ilker Sen ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Renal Tissue ◽  
Cyclooxygenase 2 ◽  
Experimental Pyelonephritis ◽  
Cyclooxygenase 2 Inhibitors
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