Blood Cell Parameters and Predicting Coronary In-Stent Restenosis

Angiology ◽  
2019 ◽  
Vol 70 (8) ◽  
pp. 711-718 ◽  
Author(s):  
Zhichao Wang ◽  
Chi Liu ◽  
Hong Fang
Keyword(s):  
Blood Cell ◽  
Platelet Activation ◽  
Blood Cells ◽  
Inflammatory Marker ◽  
Distribution Width ◽  
Cell Parameters ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Stent Restenosis ◽  
In Stent Restenosis

Major advances in coronary interventional techniques and pharmacotherapy as well as the use of drug-eluting stents (DESs) have considerably reduced the risk of in-stent restenosis (ISR). However, ISR remains a major clinical challenge. Inflammation and platelet activation are important processes that underlie the pathophysiology of ISR. Parameters related to blood cells, entailing both cell count and morphology, are useful markers of the inflammatory response and platelet activation in clinical practice. Recent studies have highlighted several new combined or derived parameters related to blood cells that independently predict ISR after DES implantation. The neutrophil/lymphocyte ratio, an inflammatory marker, is regarded as a predictor of the risk of ISR and the stability of atherosclerotic plaques. The mean platelet volume, a widely used platelet activation parameter, has been shown to be a predictor of the risk of ISR and the efficacy of antiplatelet therapy. Other markers considered include the platelet/lymphocyte ratio, red blood cell distribution width, and platelet distribution width. This review provides an overview of these parameters that may help stratify the risk of coronary angiographic and clinical outcomes related to ISR.

scholarly journals The Association between Peripheral Blood Cells and the Frailty Syndrome in Patients with Cardiovascular Diseases

2020 ◽  
Vol 20 (9) ◽  
pp. 1419-1433
Author(s):  
Constantin Bodolea ◽  
Elisabeta I. Hiriscau ◽  
Elena-Cristina Buzdugan ◽  
Alin I. Grosu ◽  
Laurențiu Stoicescu ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Blood Cell ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cell ◽  
Neutrophil To Lymphocyte Ratio ◽  
Frailty Syndrome ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Frail Patients

Background: Frailty syndrome is characterized by multisystem dysregulation frequently found in older individuals or even in younger patients with chronic disabling diseases such as cardiovascular diseases. Objective: To determine whether peripheral blood cell count, and its subpopulations, red blood cell and platelets, morphology and different ratios (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and red blood distribution width-to-platelet ratio) are associated with cardiac frail patients, and through this to improve the prediction of frailty status in patients with cardiovascular diseases. Methods: An observational, retrospective, cohort study enrolling 179 patients with cardiovascular disease divided into two groups: non-frail group (100 pts) and frail group (79 pts), a cohort detached from the Frail.RO study. The frailty was evaluated based on the Fried criteria; haematological markers, sociodemographic data, and variables related to cardiovascular diseases and comorbidities were also recorded. Results: Lower lymphocytes, platelet count, and neutrophil-to-lymphocyte ratio were significantly associated with a more severe frailty syndrome. Regarding red blood cells, haemoglobin concentration and red cell distribution width significantly correlated with the severity of the frailty syndrome. Receiver operating characteristic curve analysis for these markers associated with the frailty syndrome revealed an acceptable sensitivity of 66 % and specificity of 65% to identify frail individuals. Malnutrition and hypercholesterolemia are relevant predictors for identifying frailty in hospitalized cardiovascular patients. Conclusion: The evaluation of peripheral blood cell composition routinely measured in clinical practice can represent a valuable, but limited indicator, to diagnose frailty syndrome and eventually, the effects of interventions in frail patients with cardiovascular diseases.

scholarly journals Diagnostic value of the blood monocyte–lymphocyte ratio in knee osteoarthritis

2019 ◽  
Vol 47 (9) ◽  
pp. 4413-4421 ◽  
Author(s):  
Kun Gao ◽  
Wenxiu Zhu ◽  
Weidong Liu ◽  
Dujun Ma ◽  
Heng Li ◽  
...  
Keyword(s):  
Blood Cell ◽  
Knee Osteoarthritis ◽  
Multiple Logistic Regression Analysis ◽  
Diagnostic Value ◽  
Chronic Inflammatory Disease ◽  
Cross Sectional ◽  
Distribution Width ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Cell Counts

Objective Knee osteoarthritis (KOA) is a chronic inflammatory disease. The monocyte–lymphocyte ratio (MLR) was reported to be a non-invasive, cost-effective marker in various systemic diseases, but it has not yet been investigated in KOA. This cross-sectional study evaluated the diagnostic value of MLR in KOA. Methods Two hundred and five KOA patients and 120 healthy control subjects were enrolled. Patient data, including age, sex, blood cell counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, red blood cell distribution width, and the Kellgren–Lawrence (KL) score were recorded. Results One hundred nineteen patients (55 men, 64 women) were included, with a mean age of 55.47 ± 9.23 years. KOA patients showed a significantly higher MLR, neutrophil–lymphocyte ratio (NLR), and platelet–lymphocyte ratio (PLR) than controls. The MLR area under the curve was 0.81, which was higher than that of NLR and PLR. Multiple logistic regression analysis revealed blood MLR as an independent predictor of KOA. Correlation analysis showed that MLR was positively correlated with ESR and CRP levels. MLR and NLR were significantly higher in KL4 patients than in KL1–3 patients. Conclusions MLR has a high diagnostic value for KOA, so could be a reliable disease marker.

Correlation of Red Blood Cells and Platelets Parameters.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3764-3764
Author(s):  
Zoi Saouli ◽  
Georgia Kaiafa ◽  
Fotios Girtovitis ◽  
Zisis Kontoninas ◽  
George Ntaios ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Red Cell ◽  
Blood Cell Count ◽  
Distribution Width ◽  
Mean Values ◽  
Cell Parameters ◽  
The Mean

Abstract INTRODUCTION: Platelet along with red blood cell count is a part of complete blood cell count, one of the most frequent laboratory tests in medicine. Platelet distribution width, plateletcrit and mean platelet volume are three indices provided by hematological analyzers. There are few reports in literature regarding the correlation of these three parameters with red blood cell parameters. AIM: Aim of this study is to investigate the correlation between these platelets parameters and red cell parameters: hematocrit, mean corpuscular volume and red blood cell distribution width. METHODS: Three hundred and three healthy blood donor volunteers (176 men and 127 women, mean age 37,3 years) were included. None of them had any known hematological disease in the past. The parameters mentioned above were measured by the automated hematological analyzer Coulter®LH780. RESULTS: The mean values for platelets were: PCT: 0,25±0,11%, MPV: 8,11±1,94 fL and PDW: 15,89±2,74%. The mean values for their parallel red blood cell parameters were: HCT: 40,55±2,63%), MCV: 91±4,17 fL, RDW: 13,3±1,35% Statistical and regression analysis including the correlation coefficient between platelet and red cell parameters as well as Student’s t-test was carried out. CONCLUSIONS: There seems to be no significant correlation between HCT and PCT. MCV and MPV were not correlated significantly as well, indicating that red blood cell and platelet sizes are independent. But there is a statistically significant correlation between RDW and PDW (r: 0,68, p<0,01) demostrating that anisocytosis of red blood cells and platelets might occur simultaneously. Based on these observations, further more studies should be carried out for the correlation between platelets and red blood cell indices in certain disorders.

scholarly journals The relationship between neutrophil–lymphocyte ratio and in-stent restenosis in superficial femoral artery

2020 ◽  
Vol 40 (7) ◽  
Author(s):  
Yaobo Yang ◽  
Fangfang Ge ◽  
Jing Shen ◽  
Jianbo Song ◽  
Jiapei Xie ◽  
...  
Keyword(s):  
Femoral Artery ◽  
Superficial Femoral Artery ◽  
Odds Ratio ◽  
Multivariate Logistic Regression Analysis ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Stent Restenosis ◽  
The Relationship ◽  
In Stent Restenosis ◽  
Group 1

Abstract The present study aimed to investigate the relationship between an increase in the pre- and post-operative neutrophil–lymphocyte ratio (NLR) and superficial femoral artery in-stent restenosis (ISR) rate. We recruited 199 patients that underwent superficial femoral artery stenting for lower extremity arteriosclerosis obliterans at our hospital from March 2015 to July 2018. Patients were divided into two groups according to the occurrence of ISR within 1 year (group 1, ISR and group 2, Non-ISR). The after NLR (NLRafter) and NLR change ratio (NLRratio) (P&lt;0.001) were significantly higher in group 1. A NLRafter &gt; 4.3 was associated with an odds ratio of 1.946 (95% CI [1.51–2.50]; P&lt;0.001) for the presence of ISR. A NLRratio &gt; 37.5% was associated with an odds ratio of 3.6 (95% CI [2.03–6.36]; P&lt;0.001) for occurrence of ISR. A NLRafter level &gt; 4.3 had 75% sensitivity and 76% specificity for the prediction of ISR, as identified by the ROC curve. A NLRratio level &gt; 37.5% predicted ISR with 77% sensitivity and 60% specificity. Multivariate logistic regression analysis demonstrated that NLRratio was the strongest independent predictor of ISR (P&lt;0.001). In conclusions, NLRratio could be used as a prognostic marker in superficial femoral artery stents.

Neutrophil to Lymphocyte Ratio as a Predictor of Restenosis After Angioplasty and Stenting for Asymptomatic Carotid Stenosis

Angiology ◽  
2018 ◽  
Vol 70 (2) ◽  
pp. 160-165 ◽  
Author(s):  
Zhengze Dai ◽  
Rongrong Li ◽  
Nan Zhao ◽  
Yunfei Han ◽  
Mengmeng Wang ◽  
...  
Keyword(s):  
Cox Regression ◽  
Inflammatory Marker ◽  
Vital Role ◽  
Neutrophil To Lymphocyte Ratio ◽  
Radiographic Evaluation ◽  
Lymphocyte Ratio ◽  
Stent Restenosis ◽  
Angioplasty And Stenting ◽  
Carotid Angioplasty And Stenting ◽  
In Stent Restenosis

The inflammatory response plays a vital role in the development of in-stent restenosis (ISR) after carotid angioplasty and stenting (CAS). The neutrophil to lymphocyte ratio (NLR) has been suggested as a sensitive inflammatory marker. We explored the association between NLR and ISR in CAS patients. A total of 427 patients who underwent CAS were enrolled. Neutrophil to lymphocyte ratio was measured before the procedure. Clinical examination and radiographic evaluation were performed at 6 months and annually after the procedure. In-stent restenosis was defined as ≥50% stenosis in the treated lesion. Cox regression was used to identify predictors of ISR after CAS. Of the 459 arteries (in 427 patients) with CAS, 72 (15.7%) were identified with ISR during a mean follow-up of 14.6 (19.1) months (range, 0.7-120.7 months). Increased NLR (≥2.13) was significantly related to ISR in patients with asymptomatic stenosis ( P = .001). However, significance was not observed in symptomatic stenosis. On multivariate analysis, baseline NLR ≥ 2.13 (hazard ratio [HR], 2.74; 95% confidence interval [CI], 1.46-5.14), smoking (HR, 1.99; 95% CI, 1.11-3.58), residual stenosis (HR, 1.12; 95% CI, 1.09-1.15), and baseline glucose level (HR, 1.01; 95% CI, 1.01-1.02) were associated with ISR. Elevated NLR may be a predictor of ISR after CAS for asymptomatic stenosis.

scholarly journals The Relationship Between Neutrophil–Lymphocyte Ratio and In-Stent Restenosis

Angiology ◽  
2018 ◽  
Vol 69 (7) ◽  
pp. 642-643 ◽  
Author(s):  
Guanglang Zhu ◽  
Zhenjiang Li ◽  
Liangxi Yuan ◽  
Jian Zhou ◽  
Zaiping Jing
Keyword(s):  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Stent Restenosis ◽  
The Relationship ◽  
In Stent Restenosis

scholarly journals Continuous changes in biological levels of complete blood count in a high altitude area of China

2020 ◽  
Vol 8 ◽  
pp. 205031212093133 ◽  
Author(s):  
Xuan Luo ◽  
Lei Feng ◽  
XueJing Bai ◽  
JiangXian Zhu ◽  
GuanCheng Zhao ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Complete Blood Count ◽  
White Blood Cells ◽  
Age Groups ◽  
Reference Interval ◽  
Distribution Width ◽  
Men And Women ◽  
Cell Parameters

Objectives: We aimed to establish a new reference interval of blood cell parameters by classifying and counting blood Cells of 16- to 85-year-old healthy volunteers and observing continuous changes with age. Methods: We analyzed the blood cell parameters of 42,678 cases (men, 24,406; women, 18,272), and compared the blood cell parameters of men and women in different age groups using an independent samples t-test. Using limits of 2.5%–97.5%, a 90% confidence interval was used to develop new reference intervals. Results: Counts of blood cell parameters, including white blood Cells, neutrophils, lymphocytes, monocytes, eosinophils, basophils, red blood Cells, hemoglobin, hematocrit, distribution width of red blood Cells and platelets, were found to differ between men and women in different age groups. These parameters were used to establish a new reference interval of blood Cells. Conclusion: The blood cell parameters of both men and women changed with increasing age. The reference interval that we established will provide more accurate basic evidence for clinical diagnosis and treatment of diseases.

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