Primary Squamous Cell Carcinomas of Major Salivary Glands

1983 ◽  
Vol 92 (1) ◽  
pp. 97-98 ◽  
Author(s):  
John G. Batsakis
Keyword(s):  
Parotid Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Major Salivary Glands ◽  
Submandibular Salivary Glands ◽  
True Frequency

Primary squamous cell carcinomas of the major (parotid and submandibular) salivary glands are uncommon neoplasms. Statistics contrary to that statement are tainted by the inclusion of mucoepidermoid carcinomas and, in the instance of the parotid gland, by metastatic carcinomas. The true frequency is less than 1% of all tumors in the parotid gland and approximately 4% for the submandibular gland.

scholarly journals Unilateral submandibular gland aplasia with ipsilateral parotid gland hypertrophy presenting as infra-auricular swelling

2020 ◽  
Vol 7 (1) ◽  
pp. 186
Author(s):  
Rupali Jain ◽  
Chirag Kamal Ahuja ◽  
Ramandeep Virk ◽  
Paramjeet Singh
Keyword(s):  
Computed Tomography ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Rare Case ◽  
Clinical Findings ◽  
Congenital Absence ◽  
Major Salivary Glands ◽  
Facial Swelling ◽  
Per Se

<p class="abstract">Congenital absence of any one of the major salivary glands is usually asymptomatic per se but may come to the fore during evaluation of a relatively insignificant consequence it may lead to. We report a rare case of unilateral submandibular gland aplasia presenting with a long-standing ipsilateral infra-auricular facial swelling due to compensatory secondary hypertrophy of the parotid gland, which was mistaken as recurrent parotitis. This was evident on computed tomography as an absent right submandibular gland with smooth bulky ipsilateral parotid having no ductal dilatation or periglandular inflammation. An awareness of this etiology, though rare, would be helpful to both the radiologist and the referring physician as it would prevent an unnecessary biopsy of the enlarged parotid and mitigate the scare arising out of the clinical findings of an infra-auricular swelling.</p>

scholarly journals Autoradiographic localization of dihydrotestosterone binding in the major salivary glands and other androgen-responsive organs of the mouse.

1987 ◽  
Vol 35 (10) ◽  
pp. 1053-1058 ◽  
Author(s):  
J I Morrell ◽  
E W Gresik ◽  
T Barka
Keyword(s):  
Growth Factor ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Cellular Localization ◽  
Incidental Finding ◽  
Acinar Cells ◽  
Unexpected Finding ◽  
Cervical Lymph Nodes ◽  
Major Salivary Glands ◽  
Duct Cells

Mouse submandibular glands show an androgen-dependent sexual dimorphism, reflected in higher concentrations in males than in females of bioactive peptides, such as epidermal growth factor (EGF), nerve growth factor, and renin in the cells of the granular convoluted tubules (GCT). Biochemical studies have demonstrated androgen receptors in submandibular gland and other androgen-responsive organs in mouse. We have determined the cellular localization of these receptors using steroid autoradiography. Fifteen adult gonadectomized male mice were injected intravenously with 0.13 microgram or 0.26 microgram [3H]-dihydrotestosterone (SA 135 Ci/mM); some animals were pre-treated with cyclocytidine to stimulate secretion by GCT cells. Animals were killed 15 min, 1, 2, or 3 hr after isotope injection. Steroid autoradiographs were prepared, and some were stained immunocytochemically for EGF. Of the different cell types of submandibular gland, the acinar cells most frequently and intensely concentrated [3H]-DHT; GCT cells also concentrated the hormone, as did a small number of striated duct cells. In the other major salivary glands, the only cells that concentrated the androgen were interlobular striated duct cells in sublingual gland. In prostate, anterior pituitary, and brain a large number of cells concentrated androgen, as has been previously reported. Androgen binding by the GCT cells was a predictable finding, since androgen-induced alterations in composition and form of these cells are well documented. The intense androgen concentration by the acinar cells was an unexpected finding and suggests a hitherto unknown androgen regulation of these cells. An incidental finding was intense concentration of [3H]-DHT in the nuclei of the endothelial cells of the post-capillary venules of the cervical lymph nodes.

Cysts of the parotid gland

1975 ◽  
Vol 89 (4) ◽  
pp. 435-444 ◽  
Author(s):  
N. A. Shaheen ◽  
G. T. Harboyan ◽  
R. I. Nassif
Keyword(s):  
Parotid Gland ◽  
Salivary Glands ◽  
Diagnosis And Treatment ◽  
Cystic Lesions ◽  
Definite Diagnosis ◽  
Radical Mastoidectomy ◽  
Major Salivary Glands ◽  
Congenital Origin ◽  
Benign Tumours ◽  
Extensive Surgery

SummaryCYSTS of the major salivary glands are most frequent in the parotid where they form a small percentage of its benign tumours. They can be congenital or acquired and of parotid or extraparotid origin. Two unusual cysts are reported: a cholesteatoma arising from the ipsilateral mastoid, twenty years after successful radical mastoidectomy, and a deeply located cyst of probable congenital origin. The literature is reviewed and the management discussed. Parotidectomy, often with extensive dissection, remains in general the treatment of choice.Cysts in the parotid gland represent a small percentage of benign parotid masses. They usually arise within the gland from salivary or non-salivary parotid tissue, and may be congenital or acquired. Some, however, may arise from surrounding structures.Unless the cyst is superficial and therefore readily amenable to proper examination, it usually escapes a definite diagnosis even with the help of sialography or more sophisticated procedures. Exploration is eventually resorted to for diagnosis and treatment. That is why the surgeon should be ready to perform extensive surgery if the findings at exploration necessitate it.The purpose of this article is to present two cystic lesions of the parotid. The first is a rarity, a cholesteatoma originating from the ipsilateral mastoid; and the second an unusually deeply located cyst. These cases illustrate well the problems met with in the management of preauricular masses.

Two malignant salivary gland tumours of different type in one patient

1994 ◽  
Vol 108 (9) ◽  
pp. 798-800 ◽  
Author(s):  
A. Hosni ◽  
C. Fisher ◽  
P. Rhŷ-Evans
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Histological Type ◽  
Salivary Gland Tumours ◽  
Adenoid Cystic ◽  
The Right ◽  
Left Parotid Gland

AbstractThe synchronous or metachronous occurrence of two tumours of the salivary glands in one patient is rare. These are mainly benign and of the same histological type. Here we report a 56-year-old man who developed a mucoepidermoid tumour of the left parotid gland four years after diagnosis of adenoid cystic carcinoma of the right submandibular gland. This combination of neoplasms has not to our knowledge been reported before.

scholarly journals Myeloid Sarcoma That Infiltrated a Preexisting Sebaceous Lymphadenoma in the Parotid Gland: Diagnostic Challenges and Literature Review

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Sunmi Jo ◽  
Hye-kyung Shim ◽  
Joo Yeon Kim ◽  
Sang Kyun Bae ◽  
Mi Ra Kim
Keyword(s):  
Salivary Gland ◽  
Literature Review ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Diagnostic Methods ◽  
Myeloid Sarcoma ◽  
Histopathologic Evaluation ◽  
High Index Of Suspicion ◽  
Sebaceous Lymphadenoma

Myeloid sarcoma (MS) is a rarely encountered extramedullary localized tumor that is composed of immature myeloid cells. We reported an extremely rare case of MS with concurrent bone marrow (BM) involvement that invaded into a preexisting sebaceous lymphadenoma in the parotid gland and neck lymph nodes. Prompted by this case, we also present a literature review of MS invasion into salivary glands. A 62-year-old man was initially diagnosed with carcinoma that arose in a sebaceous lymphadenoma in the parotid gland, through a total parotidectomy with neck dissection. After an extensive histopathological review that included immunohistochemistry, a pathologic diagnosis of MS with infiltration into the sebaceous lymphadenoma with concurrent BM involvement was confirmed. MS is difficult to diagnose accurately; herein, we analyzed the clinical presentations and effectiveness of the various diagnostic methods with a review of the literature. There are 17 cases, including our case, reported in 13 studies. Of the cases in which the salivary glands were affected, 10 involved the parotid gland, six involved the submandibular gland, and one involved both. Isolated invasion of the salivary gland was found in one case of parotid gland invasion and three cases of submandibular gland invasion. In 13 cases, the salivary glands were affected by various other lesions. Although there were no incidences of isolated MS, six patients were diagnosed with secondary MS and eight patients with MS with BM involvement, including this case. The diagnosis of MS is difficult given its rarity, and a high index of suspicion and integrated radiologic and careful histopathologic evaluation are required. Most cases of MS infiltrating the salivary gland might be indicated by the possibility of BM involvement. MS with BM involvement predicts poor prognosis and the need for intensive systemic treatment.

Angiomyoma in the submandibular gland: a rare location for a ubiquitous tumour

2003 ◽  
Vol 117 (12) ◽  
pp. 1001-1002 ◽  
Author(s):  
Fumio Ide ◽  
Kenji Mishima ◽  
Ichiro Saito
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
English Literature ◽  
Soft Tissue Tumour ◽  
Major Salivary Glands ◽  
Tissue Tumour ◽  
Rare Location

Angiomyoma is a common soft tissue tumour of the head and neck that sometimes presents to the otolaryngologist; however, it seldom occurs in the major salivary glands. We present a case of angiomyoma arising in the submandibular gland, a tumour not described previously in the English literature.

scholarly journals A proportion of primary squamous cell carcinomas of the parotid gland harbour high-risk human papillomavirus

2016 ◽  
Vol 69 (6) ◽  
pp. 921-929 ◽  
Author(s):  
Bin Xu ◽  
Lu Wang ◽  
Laetitia Borsu ◽  
Ronald Ghossein ◽  
Nora Katabi ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Parotid Gland ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas

Pathology Consultation Low-Grade and High-Grade Adenocarcinomas of the Salivary Duct System

1989 ◽  
Vol 98 (2) ◽  
pp. 162-163 ◽  
Author(s):  
John G. Batsakis ◽  
Mario A. Luna
Keyword(s):  
Oral Cavity ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Low Grade ◽  
High Grade ◽  
Duct System ◽  
Salivary Duct ◽  
Adenoid Cystic ◽  
Major Salivary Glands

Adenocarcinomas of salivary glands are encountered less frequently than adenoid cystic or mucoepidermoid carcinomas. They fall into two well-defined clinicopathologic groups: 1) those arising from intercalated ducts and 2) those from the excretory and interlobular ducts. The former, designated terminal duct adenocarcinomas, are low-grade malignancies found preponderantly in the oral cavity, especially the palate. The latter, designated salivary duct carcinomas, are high-grade neoplasms and arise almost exclusively in major salivary glands, especially the parotid gland.

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