scholarly journals 5-HT7 receptorsare over-expressed in patients with nasal polyps

2017 ◽  
Vol 96 (12) ◽  
pp. E14-E18 ◽  
Author(s):  
Muhammed Yayla ◽  
Zekai Halici ◽  
Duygu Kose ◽  
Arzu Tatar ◽  
Mustafa SitkiGozeler
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyp ◽  
Paranasal Sinuses ◽  
Nasal Polyps ◽  
Inferior Turbinate ◽  
Healthy Tissue ◽  
Receptor Expression ◽  
Pcr Analysis ◽  
And Control ◽  
First Time

Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose of our study is to determine the expression of 5-HT7 receptors both in nasal polyps and in healthy tissue in the nasal cavity. The subsequent aim is to compare the expression of 5-HT7 receptors in patients with NP and in inferior turbinate tissue (control).The study included 60 participants (40 with NP and 20 controls) aged 35 to 62 years. Nasal polyp samples were collected from all patients and relative 5-HT7 receptor expression analyses were performed. RT-PCR analysis of nasal polyps and control tissue identified 5-HT7 receptor expression in the nasal cavities of controls. This expression was approximately 67 times higher in nasal polyp tissue than in healthy tissue. Our study identifies the expression of 5-HT7 receptors in the nasal cavity for the first time. It is also the first demonstration of increased 5-HT7 receptor expression in tissue from nasal polyps, which occur in the paranasal sinuses and nasal cavity.

scholarly journals The Role of CD68 (+) Histiocytic Macrophages in Nasal Polyp Development

2020 ◽  
Author(s):  
Nuray Bayar Muluk ◽  
Osman Kürşat Arikan ◽  
Pınar Atasoy ◽  
Rahmi Kiliç ◽  
Eda Tuna Yalçinozan
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyp ◽  
Nasal Polyps ◽  
Deep Layer ◽  
Ethmoid Sinus ◽  
Adult Patients ◽  
Control Group ◽  
Study Group ◽  
Deep Layers

Abstract Objectives The aim of this study was to investigate the role of CD68 (+) histiocytic macrophages (H-M) in the nasal polyp pathogenesis. Materials and Methods The study group consisted of 24 adult patients with nasal polyposis. The control group consisted of 11 adult patients without nasal polyps. A total of 36 nasal polyp samples (10-nasal cavity, 10-maxillary sinus, and 16-ethmoid sinus) from the study group and 11 inferior turbinate samples from the control group were analyzed by immunohistochemical staining, with monoclonal antibodies against CD68 (+) H-M. Results CD68 positivity was significantly higher than the control group in the subepithelial (SE) layer of the ethmoid sinus, and deep layers of nasal cavity, maxillary, and ethmoid sinuses. In SE and deep layers of ethmoid and maxillary sinuses, CD68 positivity was significantly higher than that of the epithelial layer. In the deep layer, histiocytic macrophages tended to gather around eosinophils. Conclusion The high numbers of CD68 (+) histiocytic macrophages mainly located in deep layer of lamina propria may be responsible for the phagocytosis of eosinophils within the polyp tissue. Therefore, it may be concluded that increased macrophages in nasal polyps do not trigger the growth of nasal polyps. Instead, they may serve to reduce the number of eosinophils in already-developed nasal polyps.

scholarly journals Association between methylation in nasal epithelial TSLP gene and chronic rhinosinusitis with nasal polyps

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Jingyun Li ◽  
Jian Jiao ◽  
Yunbo Gao ◽  
Yuan Zhang ◽  
Luo Zhang
Keyword(s):  
Dna Methylation ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Inferior Turbinate ◽  
Nasal Resistance ◽  
Total Ige ◽  
Control Subjects ◽  
Human Nasal Epithelial Cells ◽  
Serum Total Ige ◽  
And Control

Abstract Background This study was performed to determine whether there was any association between abnormal DNA methylation of a thymic stromal lymphopoietin (TSLP) locus and pathogenesis of chronic rhinosinusitis (CRS). Methods A total of 48 CRS patients with nasal polyps (CRSwNP), 28 CRS patients without nasal polyps (CRSsNP) and 21 control subjects were enrolled into the study; and evaluated for serum total IgE level, olfactory score and nasal resistance. Samples were obtained from nasal polyps of CRSwNP patients, ethmoid mucosae of CRSsNP patients and inferior turbinate (IT) mucosa of control subjects during surgery, and used to isolate purified primary human nasal epithelial cells (HNECs). Genomic DNA was extracted from purified primary HNECs of each subject and DNA methylation ratios for a selected region of the TSLP gene were screened the using MassARRAY EpiTYPER. Results A total of 17 CpG units were analyzed; of which two CpG units (CpG3 and 22:23:24) had increased methylation ratios in the CRSwNP patients compared to the CRSsNP and control subjects after correction for false discovery rate (FDR) (Q < 0.1). The methylation ratios at both CpG3 and CpG22:23:24 units were positively correlated with olfactory score (r = 0.41, P = 0.0001; r = 0.25, P = 0.021) and unilateral nasal resistance at 75 Pa (r = 0.24, P = 0.04; r = 0.24, P = 0.036) and 150 Pa (r = 0.34, P = 0.004; r = 0.25, P = 0.031). Total nasal resistance at 75 Pa/150 Pa or serum total IgE levels were not correlated with the methylation ratios at either CpG unit. Conclusions Increased DNA methylation at the TSLP locus is likely to be associated with CRSwNP pathogenesis; however these findings need to be confirmed in larger multicentre group studies.

Roles of Free Radicals, Nitric Oxide, and Scavenging Enzymes in Nasal Polyp Development

2005 ◽  
Vol 114 (2) ◽  
pp. 122-126 ◽  
Author(s):  
Turgut Karlidaǧ ◽  
Erol Keles ◽  
Nevin İlhan ◽  
Sinasi Yakclin ◽  
İrfan Kaygusuz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nasal Polyp ◽  
Inferior Turbinate ◽  
Control Group ◽  
Free Oxygen Radicals ◽  
Control Groups ◽  
Free Radical Damage ◽  
Scavenging Enzymes ◽  
And Control

The aim of this study was to investigate the role of nitric oxide (NO), free oxygen radicals, and scavenging enzymes in the development of nasal polyp (NP) disease. This study included 41 patients who underwent endoscopic surgery because of NPs. Control specimens were taken from the inferior turbinate of 32 patients who underwent septoplasty. The levels of malondialdehyde (MDA), NO, and superoxide dismutase (SOD) were measured in intraoperative specimens of polyp tissue and turbinate mucosa. The levels of tissue NO were 191.06 ± 26.62 μmol/mg of protein in patients with NPs and 145.30 ± 19.19 μmol/mg of protein (p < .001) in the control group. The levels of MDA in the study and control groups were 12.47 ± 2.12 nmol/mg and 8.83 ± 1.08 nmol/mg (p < .01), respectively. The levels of SOD in the study and control groups were 50.77 ± 14.74 U/mg and 77.93 ± 15.31 U/mg (p < .001), respectively. It was determined that the levels of MDA in plasma and erythrocytes were higher in the patients with NPs than in the control group (p < .05). The levels of NO in plasma and erythrocytes in both groups were similar. The levels of SOD in plasma and erythrocytes were lower in patients with NPs than in the control group (p > .05). Increases in the levels of tissue MDA and NO and decreases in scavenging enzymes in patients with NPs as compared to control groups may indicate the presence of free radical damage in patients with nasal NPs. New studies are needed to clarify the efficacy of using antioxidants in the treatment of NPs.

scholarly journals PREVALENCE OF ENDONASAL PATHOLOGY IN PATIENTS WITH CHRONIC DACRYOCYSTITIS AND PECULIARITIES OF SURGICAL TREATMENT

2021 ◽  
Vol 19 (4) ◽  
Author(s):  
О.О. Minaiev
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Maxillary Sinusitis ◽  
Middle Turbinate ◽  
Postgraduate Education ◽  
Inferior Turbinate ◽  
Uncinate Process ◽  
National Medical ◽  
Chronic Dacryocystitis ◽  
Simultaneous Operations

Purpose – to study the prevalence of endonasal pathology in patients with chronicdacryocystitis (CD) and to justify the expediency of simultaneous operations in suchpatients.Material and methods. The study included 109 patients with CD, who were examinedand operated on in 2004-2014 at the Department of Otorhinolaryngology Faculty ofInternship and Postgraduate Education "Donetsk National Medical University of theMinistry of Health of Ukraine". Examination of patients included consultation with anophthalmologist, lavage of the lacrimal ducts, endoscopy of the nasal cavity, computedtomography. All patients underwent tearing by performing endonasal endoscopicdacryocystorhinostomy (EEDCR).Results. Endonasal pathology was detected in 85.3% of patients: curvature of the nasalseptum - in 71.6% of patients, hypertrophy of the inferior turbinate - in 59.6%, bulloushypertrophy of the middle turbinate - in 5.5%, hypertrophy of the uncinate process- in 6.4%, hyperpneumatization of Agger nasi cells - in 14.7% of patients. The mostcommon combination was curvature of the nasal septum and hypertrophy of the inferiorturbinates - in 56.0% of cases. Inflammatory pathology in the paranasal sinuses wasin 38.5% of cases: ethmoiditis - in 26.6% of patients, maxillary sinusitis - in 13.8%,sphenoiditis - in 1.8% of patients. In 94.6% of patients, the correction of intranasalpathology was performed simultaneously with EEDCR. In 6.4% of these patients therewere complications - nosebleeding after removal of tampons. Simultaneous operationsdid not significantly increase the percentage and variants of complications comparedwith isolated endonasal operations.Conclusion. The vast majority of patients with chronic dacryocystitis have pathologyof the nasal cavity and paranasal sinuses, which may contribute to the developmentof dacryocystitis and relapse of the disease after operation. Surgical correction ofconcomitant endonasal pathology in patients with chronic dacryocystitis should beperformed simultaneously with endonasal endoscopic dacryocystorhinostomy.

Nasal Polyps and Their Relation to Polyps/Hypertrophic Polypoid Mucosa in the Paranasal Sinuses: A Macro-, Endo-, and Microscopic Study of Autopsy Materials

1998 ◽  
Vol 12 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Per L. Larsen ◽  
Peter K. Tingsgaard ◽  
Jonathan Harcourt ◽  
Gitte Sofsrud ◽  
Mirko Tos
Keyword(s):  
Microscopic Study ◽  
Paranasal Sinuses ◽  
Microscopic Examination ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Endoscopic Screening ◽  
And Control

The present study comprised macro- and endoscopic screening of the nasosinusal complex in 56 autopsies, 24 with nasal polyps and 32 without. Seven had nasal polyposis (bilaterally more than two). Hypertrophic polypoid mucosa in the paranasal sinuses was not found in the cases with nasal polyposis and in only 2 (4%) of the total number (24) of cases with polyps. Microscopic examination of nine small polyps, the mucosa from which they originated, and control specimens showed accumulation of eosinophils in the mucosa from which the polyps originated, indicating localized inflammation.

scholarly journals An Unusual Presentation of Nasal Polyp Arising from Floor of Nasal Cavity

2011 ◽  
Vol 3 (2) ◽  
pp. 129-131 ◽  
Author(s):  
Mahendra S Naik ◽  
Sulabha M Naik
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyp ◽  
Paranasal Sinuses ◽  
Nasal Polyposis ◽  
Middle Meatus ◽  
Unusual Site ◽  
Polyp Formation ◽  
Ethmoid Sinuses ◽  
Airway Dynamics ◽  
Sinus Mucosa

ABSTRACT Introduction Nasal polyps are pedunculated, edematous, prolapsed mucosa of the paranasal sinuses. These polyps commonly arise around the ostia of the paranasal sinuses in the middle meatus. Discussion The commonest sites of polyp formation are the ethmoid sinuses and maxillary sinus. Rarely polyps may also arise from the other paranasal sinuses. Sites in the nasal mucosa other than the paranasal sinuses are very rare, though polyps arising from the septum have also been reported. The etiology of nasal polyposis is believed to be due to an inflammatory reaction of the nasal and paranasal sinus mucosa. Conclusion In addition to the theory of altered airway dynamics in the middle meatus, there also appears to be a link between polyp formation and preceding chronic inflammation. This is the most likely explanation for the origin of polyps in unusual sites. We present here a case of a nasal polyp arising from the floor of the nasal cavity. There are no previous records or reports in literature of this unusual site of origin of a nasal polyp.

scholarly journals Histopathological Profile of Nasal Cavity, Paranasal Sinuses, and Nasopharyngeal Masses in Hill State of Himachal Pradesh, India

2017 ◽  
Vol 10 (2) ◽  
pp. 93-98
Author(s):  
Trilok C Guleria ◽  
Shobha Mohindroo ◽  
Narender K Mohindroo ◽  
Ramesh K Azad
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyp ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Himachal Pradesh ◽  
Common Finding ◽  
Nasopharyngeal Angiofibroma ◽  
Neoplastic Lesion ◽  
Sinonasal Mass ◽  
Nasopharyngeal Masses

ABSTRACT Introduction: Nasal masses are common finding in the ear, nose, and throat outpatient department. Most patients present with complaints of nasal obstruction. A sinonasal mass can have various differential diagnoses. They may be congenital, inflammatory, neoplastic (benign or malignant), or traumatic in nature. A careful histopathological examination is necessary to decide the nature of any particular lesion. Materials and methods: The retrospective study was carried out between January 2011 and December 2013. A total of 185 cases diagnosed with masses of the nasal cavity, paranasal sinuses, and nasopharynx were included. Data from histopathological records were retrieved to confirm the diagnosis. Observations: Among 185 cases, 75% were non-neoplastic and 25% were neoplastic. Among neoplastic masses, 57% were benign and 43% were malignant. The age of presentation ranged from first to eighth decade of life (mean age 37.74 years). The lesions had a stronger predilection for males (1.68:1). Among non-neoplastic lesions, nasal polyp was the commonest lesion followed by ethmoidal mucocele (1.44%) and lupus vulgaris (0.72%). Among benign lesions, inverted papilloma (30.77%) and nasopharyngeal angiofibroma (30.77%) were the commonest followed by capillary hemangioma (15.38%), osteoma (7.68%), nasopharyngeal lymphoepithelioma (3.85%), chondroma (3.85%), pleomorphic adenoma (3.85%), and schwannoma (3.85%). Squamous cell carcinoma (40%) was the commonest malignant neoplastic lesion observed followed by adenoid cystic carcinoma (20%), malignant melanoma (15%), nasopharyngeal carcinoma (10%), esthesioneuroblastoma (10%), and non-Hodgkin lymphoma (5%). Conclusion: Among the noninflammatory lesion, nasal polyp is the commonest lesion. Nasal polyps are more common in hilly area may be due to exposure to pine pollens. There is no difference in the histopathological profile of benign and malignant lesions. How to cite this article: Guleria TC, Mohindroo S, Mohindroo NK, Azad RK, Kumar A. Histopathological Profile of Nasal Cavity, Paranasal Sinuses, and Nasopharyngeal Masses in Hill State of Himachal Pradesh, India. Clin Rhinol An Int J 2017;10(2):93-98.

scholarly journals Woakes syndrome

2014 ◽  
Vol 44 (1) ◽  
pp. 76
Author(s):  
Retno Sulistyo Wardani ◽  
Ika Dewi Mayangsari
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyp ◽  
Nasal Polyps ◽  
Bone Erosion ◽  
Aesthetic Surgery ◽  
Complete Information ◽  
Massive Bleeding ◽  
Sinus Surgery ◽  
Nasal Bridge ◽  
The Right

Background: Extensive nasal polyp growth in the paranasal sinuses can lead to bone erosion of the sinus walls and cause facial disfigurement due to continuous pressure or chronic inflammation. This extremely rare phenomenon is called Woakes syndrome. This syndrome consist of several symptoms include the destruction of ethmoid sinus that cause broadening of the bridge of the nose, frontal sinus aplasia and bronchiectasis. Purpose: To give complete information about the diagnosis and management of Woakes Syndrome. Case: A 16-year-old boy with deformity of the left nose, nasal obstruction and frequent episodes of rhinorrhea since 4 months before admission. Nasoendoscopic evaluation showedhuge nasal polyps filling the left nasal cavity, pushing the septum and narrowing the right nasal cavity. Histopathology result was edematous polyp with necrosis and massive bleeding without signs of malignancy. Management: Patient was managed in two stages operations. First, nasal polyp removal by FESS technique in general anesthesia, and the second stage four months later, was septorhinoplasty for aesthetic bridge reconstruction. Conclusion: Nasal polyps could be related to Woakes syndrome, characterized by broadening of nasal bridge which needs functional and aesthetic surgery. Keyword: Woakes Syndrome, nasal polyps, Functional Endoscopic Sinus Surgery, Septorhinoplasty ABSTRAKLatar Belakang: Polip hidung besar yang meluas dalam sinus paranasal dapat menyebabkan erosi dinding sinus dan menyebabkan cacat wajah akibat tekanan terus-menerus atau peradangan kronis. Fenomena ini sangat langka dan disebut sebagai sindrom Woakes. Sindrom ini terdiri dari beberapa gejala termasuk kerusakan dinding sinus etmoid yang menyebabkan hidung melebar, aplasia sinus frontal dan bronkiektasis. Tujuan: Untuk memberikan informasi yang lengkap tentang diagnosis dan penatalaksanaan Woakes Syndrome. Kasus: Seorang anak laki-laki 16 tahun dengan deformitas hidung kiri, hidung tersumbat dan pilek berulang sejak 4 bulan. Evaluasi nasoendokopi menunjukkanpolip hidung masif mengisi rongga hidung kiri, mendorong septum dan menyempitkan rongga hidung kanan. Pemeriksan histo-patologi memperlihatkan polip edematosa dengan nekrosis dan perdarahan masif tanpa tanda-tanda keganasan. Penatalaksanaan: Pada pasien dilakukan dua tahap tindakan. Pertama, dilakukan Bedah Sinus Endoskopik Fungsional (BSEF) dan polipektomi dalam anestesi umum, dan empat bulan kemudian pasien menjalani septorinoplasti untuk rekonstruksi wajah. Kesimpulan: Polip hidung pada kasus ini kemungkinan terkait dengan sindrom Woakes, ditandai dengan pelebaranpyramid hidung yang membutuhkan tindakan operasi fungsional dan estetika.Kata kunci: sindroma Woakes, polip hidung, Bedah Sinus Endoskopik Fungsional, Septorinoplasti.

Sublabial rhinotomy with septal transfixion as an approach to the nasal fossa, paranasal sinuses and nasopharynx

1989 ◽  
Vol 103 (7) ◽  
pp. 661-663 ◽  
Author(s):  
B. J. G. Bingham ◽  
M. V. Griffiths
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Frontal Sinus ◽  
Nasal Septum ◽  
Inferior Turbinate ◽  
Lateral Rhinotomy ◽  
The Poor ◽  
Poor Access ◽  
History Of ◽  
Sublabial Approach

AbstractA sublabial incision with septal transfixion and mid-face degloving is described as an approach to the nasal cavity, paranasal sinuses and nasopharynx. A brief history of the development of the technique is given. The results of nine cases are presented. These cases have had good tumour clearance, excellent cosmetic results and the minimum of complications. The sublabial approach is most useful in children and women, particularly those with intermediate grade tumours. The advantages of the approach compared to the lateral rhinotomy incision include: superior access to the floor of the nose, inferior turbinate and anterior nasal septum; access to both sides of the nasal septum and the absence of a facial scar. The limitations of the sublabial technique are the poor access to frontal sinus and the cribriform plate.

Benign Nasal Polyps Causing Bone Destruction in the Nasal Cavity and Paranasal Sinuses

1978 ◽  
Vol 88 (4) ◽  
pp. 675-679 ◽  
Author(s):  
David P. Winestock ◽  
Philip C. Bartlett ◽  
Fred K. Sondheimer
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Nasal Polyps ◽  
Bone Destruction
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