Histological Features of Postnatal Development of the Eye in White Rabbits

2020 ◽  
pp. 019262332091546
Author(s):  
Yoshinori Yamagiwa ◽  
Masaaki Kurata ◽  
Hiroshi Satoh
Keyword(s):  
Optic Nerve ◽  
Anterior Segment ◽  
Postnatal Period ◽  
Histological Structure ◽  
Retinal Layer ◽  
Histological Changes ◽  
Ocular Development ◽  
Histological Features ◽  
Fundamental Knowledge ◽  
Ophthalmic Drug

Rabbits are frequently used in studies assessing the toxicity of ophthalmic drugs; however, the postnatal histological changes that occur in the rabbit eye have not been fully described. To characterize postnatal ocular development in white rabbits, a histological investigation of the eyes and eyelids was sequentially performed between postnatal days (PNDs) 1 and 42. The eyes opened during PNDs10 to 12. Significant changes prior to eyelid opening included the proliferation of uveal and optic nerve cells, regression of the lenticular vasculature, and thinning of the retina with a decreasing number of retinal cells. After eyelid opening, several significant changes occurred in the anterior segment, including thickening of the cornea and the development of lacrimation-related tissues in the eyelid and conjunctiva. Additionally, the differentiation of retinal layer-derived cells and optic nerve thickening occurred. The lens size continued to increase throughout the postnatal period. The histological structure of the eyes and eyelids was nearly mature by PNDs28 to 42. This study characterizes the postnatal changes in the histological features of the eyes in juvenile white rabbits, providing fundamental knowledge on the appropriate design of histological studies of the eyes in juvenile rabbits, particularly ophthalmic drug evaluations.

scholarly journals Histological Structure of Reproductive Organ of Freshwater Female Crab, Barytelphusa Cunicularis (West-Wood)

2016 ◽  
Vol 5 (3) ◽  
pp. 161 ◽  
Author(s):  
Atul R. Chourpagar ◽  
Rumana Shaikh ◽  
G. K. Kulkarni
Keyword(s):  
Heavy Metals ◽  
Mercuric Chloride ◽  
Sublethal Concentration ◽  
Reproductive Organ ◽  
Histological Structure ◽  
Female Crab ◽  
Histological Changes ◽  
Yolk Granules ◽  
The Mean ◽  
Mean Concentration

<em>Mercury concentrations were recorded in water and tissue of Barytelphusa cunicularis from Pimpalwadi site (Jaikwadi Dam) near Aurangabad. The level of heavy metals in the ovary and spermatheca of crabs was investigated using Atomic Absorption Spectrophotometer (AAS). The mean concentration of mercury in the crab was 0.9 ±0.001 µg/g. A histopathological alteration in ovary and spermatheca was also studied. Several histological changes were noted in the ovary tissue i. e. Distortion of yolk granules, vacuolization, slight necrosis in the oocytes in the ovary and vacuolization observe in lumen, granular substances, sperm mass and spermathecal fluid was evenly distributed in the crab was observed after exposed to sublethal concentration (24<sup>th</sup> of LC<sub>50</sub>:1/5<sup>th</sup> 0.208 ppm) of mercuric chloride.</em>

scholarly journals The histological features of striped muscle in relation to its functional activity

1929 ◽  
Vol 104 (731) ◽  
pp. 371-411 ◽  
Keyword(s):  
Functional Activity ◽  
Present Knowledge ◽  
Contractile Properties ◽  
Striking Difference ◽  
Histological Structure ◽  
Histological Features ◽  
Striped Muscle ◽  
Functional Differences ◽  
Longitudinal Striation ◽  
Red Muscle

Analysis of the reflex behaviour of striped muscles involves data drawn from their histological structure, and the present observations deal with the differences in microscopical and macroscopical structure of muscles of different contractile properties. Stefano Lorenzini (55) mentioned the striking difference in colour between certain muscles of the limb in the rabbit as long ago as 1678. The classic investigations of Ranvier (63, 64, 65, 66, 67, 68), however, revealed most of the present knowledge of red and pale muscle. He showed that this redness was associated with slowness of contraction, and with the genesis of tetanus at lower rates of stimulus. Moreover, these functional differences were shown to be associated with a difference in histological structure, a relatively larger amount of granular sarcoplasm and more distinct longitudinal striation in the case of red muscle. Later studies (1, 57, 43, 72, 49) revealed the occurrence of these granular and longitudinally striated fibres in muscles in many species, and also that these fibres were not always associated with redness of pigmentation (57). The histology of muscle in the higher mammalian forms has shown that both granular “sarcoplasmic” and clear “aplasmic” fibres occur side by side in the same muscle, and these two types of fibre have been homologised with the red pale muscles of the rabbit (29, 30, 43, 73, 42).

scholarly journals Ocular imaging findings of bilateral optic disc pit in a child

2013 ◽  
Vol 5 (2) ◽  
pp. 258-261 ◽  
Author(s):  
Abdullah Ozkaya ◽  
Z Alkin ◽  
AT Taylan ◽  
A Demirok
Keyword(s):  
Visual Acuity ◽  
Optic Nerve ◽  
Nerve Fiber ◽  
Optic Disc ◽  
Anterior Segment ◽  
Rare Condition ◽  
Optic Disc Pit ◽  
Fiber Layer ◽  
Retinal Nerve Fiber

Background: To report a rare condition of bilateral optic disc pit in a child. Case description: A ten-year-old female was admitted with a complaint of headache. Visual acuity was 20/20 in both eyes (OU). Anterior segment examination was normal in OU. Fundus examination revealed optic disc pit (ODP) located temporally with a diameter of 1/5 disc diameter in OU. Intraocular pressure was within normal limits in both eyes. Macular optical coherence tomography (OCT) showed a loss of retinal tissue at the site corresponding to the ODP in both eyes. Retinal nerve fiber OCT revealed decreased RNFL thickness at the temporal side of the optic nerve, corresponding to the ODP in both eyes. The patient and patient’s parents were informed about the disease and called for follow-up examinations every 6 months. In addition, the family was informed about optic pit maculopathy (OPM) and, they were told to return immediately if the patient ever complained of decreased vision in either of her eyes. After a follow-up period of 12 months, visual acuity remained stable, and no complications secondary to ODP were detected. Conclusion: Optic disc pit is diagnosed incidentally unless it is complicated with OPM. The retinal nerve fiber layer thickness is decreased at the side of the optic nerve corresponding to the ODP. Nepal J Ophthalmol 2013; 5(10): 258-261 DOI: http://dx.doi.org/10.3126/nepjoph.v5i2.8739

Histological changes during progression of adenoid cystic carcinoma

1992 ◽  
Vol 106 (11) ◽  
pp. 1016-1020 ◽  
Author(s):  
Yuzo Yamamoto ◽  
Tetsuro Saka ◽  
Kazuo Makimoto ◽  
Hiroaki Takahashi
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Poor Prognosis ◽  
Early Stage ◽  
Primary Tumour ◽  
Reverse Direction ◽  
Histological Changes ◽  
Histological Features ◽  
Metastatic Lesions ◽  
Adenoid Cystic ◽  
Histological Transformation

AbstractEight cases of adenoid cystic carcinoma were reviewed to determine whether and how the histological features of the tumour vary with the progress of the disease. The tumours were classified by their histological patterns as tubular, cribriform, trabecular or solid. The relative amount of each pattern seen in routine light microscopic sections was calculated histomorphometrically and compared in the primary tumour and recurrent and/or metastatic lesions in the same case. In the early stage, the tubular pattern predominated. Later, the highest percentage shifted to the cribriform, then to the trabecular and finally, in the late stage, to the solid pattern. There was no reverse direction of histological transformation from the solid to the tubular pattern. These results may help to explain previous reports that the tubular pattern usually represents a favourable prognosis, the solid pattern a poor prognosis and the cribriform pattern an intermediate prognosis.

scholarly journals Lgr4 in Ocular Development and Glaucoma

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Stefan Siwko ◽  
Li Lai ◽  
Jinsheng Weng ◽  
Mingyao Liu
Keyword(s):  
Anterior Segment ◽  
Cell Loss ◽  
Retinal Ganglion ◽  
Leucine Rich Repeat ◽  
Full Understanding ◽  
Ocular Development ◽  
Anterior Segment Dysgenesis ◽  
Rieger Syndrome ◽  
G Protein Coupled ◽  
Retinal Vascularization

The leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4, also called GPR48) plays a key role in multiple developmental processes, and mice lackingLgr4display anterior segment dysgenesis leading to early-onset glaucomatous retinal ganglion cell loss as well as defective eyelid formation. This paper will review Lgr4 signaling and its regulation of the Axenfeld-Rieger syndrome genePitx2, a crucial developmental transcription factor. In addition, Wnt signaling plays an important role in eye development, with Norrin functioning to activate the Wnt receptor Frizzled 4 required for proper retinal vascularization. Recent discoveries identifying Lgr4 as a receptor for Norrin highlight the potential for Lgr4 function in retinal vascularization. Finally, several unanswered questions impeding a full understanding of Lgr4 in glaucoma are considered as avenues for further research.

scholarly journals A study of histological changes in the Diaphragm of male albino mice administered with aqueous extract of chamomileflowers Chamomillarecutita

2017 ◽  
Vol 14 (3) ◽  
pp. 489-496
Author(s):  
Baghdad Science Journal
Keyword(s):  
Medicinal Plants ◽  
Aqueous Extract ◽  
Muscle Fiber ◽  
Respiratory System ◽  
Respiratory Muscles ◽  
Control Group ◽  
Histological Structure ◽  
Muscular Tissue ◽  
Histological Changes ◽  
Albino Mice

The chamomile is one of the most important medicinal plants recommended for treatment of asthma and some respiratory system diseases. This research was designed to research the effects of aqueous extract of chamomillarecutita on histological structure of Diaphragm of albino mice. The study included 40 male albino mice Musmusculus, their age ranged from (5-7) weeks.The mices were divided randomly to 5 groups and oral administered with 1 ml every day for 10 days:- First Group G1: consider as control group and treated with normal saline,Second Group G2: was treated with aqueous extract of chamomile with concentration of 3 gm /100 ml D.W, Third Group G3: was treated with aqueous extract of chamomile with concentration of 5 gm /100 ml D.W.Fourth Group G4: was treated with aqueous extract of chamomile with concentration of 7 gm /100 ml D.W and the Fifth Group G5: was treated with aqueous extract of chamomile with concentration of 10 gm /100 ml D.W. Theresults of microscopic examination of diaphragm sections of groups G3,G4 and G5 showed degenerative effects on muscular tissue in way of breaking of myofibrils differences in their sizes and degeneration of most of nuclei of muscle fiber and their migration to inside the muscle fiber , it has been found that these treatments cause an alteration in myofibril in fibrotic myofibril. From this study we conclude that low concentration of aqueous extract of chamomile have low side effect on major respiratory muscles and could be used in beneficial treatment to contact diseases of respiratory system but without longer duration.

scholarly journals A case of optic-nerve hypoplasia and anterior segment abnormality associated with facial cleft

2016 ◽  
Vol Volume 9 ◽  
pp. 207-212
Author(s):  
Tomoko Miyake ◽  
Shota Kojima ◽  
Tetsuya Sugiyama ◽  
Mari Ueki ◽  
Jun Sugasawa ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Anterior Segment ◽  
Optic Nerve Hypoplasia ◽  
Facial Cleft

scholarly journals The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, including subtle and less-well-recognised changes

2016 ◽  
Vol 69 (6) ◽  
pp. 463-471 ◽  
Author(s):  
Sangeetha N Kalimuthu ◽  
Stefano Serra ◽  
Neesha Dhani ◽  
Runjan Chetty
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Treatment Modality ◽  
Neoadjuvant Chemoradiation ◽  
Chemoradiation Therapy ◽  
Ductal Adenocarcinoma ◽  
Histopathological Changes ◽  
Borderline Resectable ◽  
Histological Changes ◽  
Histological Features ◽  
Therapy Treatment

Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal adenocarcinoma (PDAC). The constellation of histopathological changes secondary to chemoradiation is diverse and has been well documented, particularly in other gastrointestinal organs such as the oesophagus and colorectum. However, the histological changes specific to the pancreas have not been fully characterised and described. This review aims to provide a detailed catalogue of histological features associated with NCRT-treated PDAC and highlight any subtle, less-recognised changes.

Histological Changes in the Ovary of the Hopping-Mouse Notomys Alexis During Lactation.

1977 ◽  
Vol 25 (3) ◽  
pp. 401 ◽  
Author(s):  
WG Breed
Keyword(s):  
Post Partum ◽  
Histological Structure ◽  
Corpora Lutea ◽  
Fallopian Tubes ◽  
Histological Changes ◽  
Follicular Size

The histological structure of the ovary of the lactating hopping-mouse is described. Two sets of corpora lutea are usually present, one of which appears to degenerate fairly rapidly during lactation and is thus considered to be the corpora lutea of pregnancy. Spontaneous ovulation usually occurs after parturition; thus corpora lutea of lactation are formed which appear to remain healthy-looking throughout most of lactation. Oocytes were flushed from Fallopian tubes immediately after parturition, but then not again until at least day 10 of lactation. Vesicular follicles were not present after post-partum ovulation, but had usually developed by day 5. In females suckling three or more young, however, maximum follicular size did appear to be somewhat inhibited, compared to that in females suckling one young, from days 5 to 11 of lactation; by day 15 larger vesicular follicles had developed and recently formed corpora lutea were present in one individual.

Sign in / Sign up

Export Citation Format

Share Document