Primary Clear Cell Adenocarcinoma of the Head and Neck: A Population-Based Analysis

2020 ◽  
Vol 162 (4) ◽  
pp. 498-503 ◽  
Author(s):  
Laith Mukdad ◽  
Albert Y. Han ◽  
Karam Badran ◽  
Jose E. Alonso ◽  
Hassan B. Nasser ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Salivary Glands ◽  
Clear Cell ◽  
Distant Metastases ◽  
Surgical Excision ◽  
Tumor Grade ◽  
Clear Cell Adenocarcinoma ◽  
Advanced Stage ◽  
Nodal Disease

Objective To characterize the epidemiology and clinicopathologic determinants of survival following the diagnosis of clear cell adenocarcinoma in the head and neck region. Study Design Retrospective cohort study. Setting The Surveillance, Epidemiology, and End Results registry (1994 to 2014). Subjects and Methods A total of 173 cases were identified. Study variables included age, sex, race, tumor subsite, tumor stage, tumor grade, surgical excision, and regional and distant metastases. Survival measures included overall survival (OS) and disease-specific survival (DSS). Results Median age at diagnosis was 63 years, 48% were female, and 80.2% were white. Fourteen percent of patients presented with regional lymph node metastases, while 3.3% of patients presented with distant metastases. Most of the tumors presented in the oral cavity, salivary glands, and pharynx. Kaplan-Meier analysis demonstrated OS and DSS of 77.2% and 83.7% at 5 years, respectively. Median OS after diagnosis was 153 months. Bivariate analysis showed that surgical excision was associated with 5-fold increased OS and DSS, whereas advanced age, high tumor grade, advanced stage, larger tumor size, nodal disease, and distant metastases were all significant predictors of decreased OS and DSS. Conclusions Clear cell adenocarcinoma is a rare neoplasm that typically affects white individuals in their early 60s, with a generally favorable prognosis. It most commonly arises in the oral cavity, major salivary glands, and pharynx. Surgical excision is associated with 5-fold survival benefit, whereas advanced age, high tumor grade, advanced stage, nodal disease, and distant metastases are independently associated with worse OS and DSS.

Patterns of Care and Outcome of Clear Cell Carcinoma of the Head and Neck

2019 ◽  
Vol 161 (1) ◽  
pp. 98-104 ◽  
Author(s):  
Jamie Oliver ◽  
Peter Wu ◽  
Clifford Chang ◽  
Dylan Roden ◽  
Binhuan Wang ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Salivary Glands ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Tumor Grade ◽  
Low Grade ◽  
Major Salivary Gland ◽  
Positive Margins

Objective Clear cell carcinoma (CCC) is a rare salivary gland malignancy, believed to be generally low grade. We investigated CCC epidemiology and clinical behavior, using the National Cancer Database (NCDB). Study Design Retrospective cohort study. Setting NCDB. Subjects and Methods All CCCs of the salivary glands were selected between 2004 and 2015. Patient demographics, tumor characteristics, treatments, and survival were analyzed. Cox regression analyses were performed in treated patients. Results We identified 268 patients with CCC. Median age was 61 (21-90) years. Most were female (145, 54%). The most common site was oral cavity (119, 44%), followed by major salivary glands (68, 25%) and oropharynx (41, 15%). Most tumors were low grade (81, 68%) and stages I to II (117, 60.6%). Nodal (36, 17.5%) and distant metastases (6, 2.4%) were rare. Most were treated by surgery alone (134, 50.0%), followed by surgery and radiotherapy (69, 25.7%). Five-year overall survival (OS) was 77.6% (95% CI, 71.4%-84.2%). In univariate analysis, older age, major salivary gland and sinonasal site, stages III to IV, high grade, and positive margins were associated with worse OS. In multivariate analysis, only high tumor grade (hazard ratio [HR], 5.76; 95% CI, 1.39-23.85; P = .02), positive margins (HR, 4.01; 95% CI, 1.20-13.43; P = .02), and age ≥60 years (HR, 3.45; 95% CI, 1.39-8.55; P = .01) were significantly associated with OS. Conclusion We report the largest series of clear cell carcinomas of the head and neck. Outcomes are generally favorable following surgical-based treatments. In this series, pathologic tumor grade is associated with worse survival. Routine evaluation and reporting of tumor grade might better guide physicians in recommending appropriate treatments in this rare malignancy.

Small cell carcinoma of the head and neck: Incidence and survival trends based on the Surveillance and Epidemiologic and End Results (SEER) analysis.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17508-e17508
Author(s):  
Marta Bean ◽  
Michael Goodman ◽  
Conor Ernst Steuer ◽  
Mihir Patel ◽  
Mark William McDonald ◽  
...  
Keyword(s):  
Propensity Score ◽  
Head And Neck ◽  
Salivary Glands ◽  
Tumor Grade ◽  
Population Based ◽  
Small Cell ◽  
Advanced Stage ◽  
Elderly Male ◽  
Cox Models ◽  
End Results

e17508 Background: Small cell carcinomas of the head and neck (SmCCHN) are rare neoplasms with an unfavorable prognosis. Population based data describing survival and prognostic factors for this malignancy are limited. Methods: Data was obtained from the US National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) database for the period 1973-2013. Patient and tumor related characteristics for SmCCHN were compared with squamous cell carcinomas (SCC) of the same anatomic sites. Survival for the two groups was compared by constructing Kaplan-Meier curves and Cox proportional hazard models with and without propensity score matching. Cox models results were expressed as hazard ratios (HR) and the corresponding 95% confidence interval (CI). Results: The dataset included 609 SmCCHN and 227943 cases of SCCHN. SCCHN patients with SmCCHN included significantly greater proportions of females and whites. SmCCHN was more likely to originate in the salivary glands and present with more advanced stage and grade. The overall 5 year and 10 year survival estimates were 27% and 18%, respectively. Corresponding values for SCCHN were 46% and 31%. The multivariable analyses adjusting for age, sex, race, marital status, year of diagnosis, stage, grade and receipt of radiation, the HR comparing SmCCHN to SCCHN was 1.53 (95% CI: 1.39-1.68). Elderly, male, black and not married persons had worse prognosis compared to their respective reference groups. Other factors independently associated with lower survival included more advanced stage and tumor grade, and earlier decades of diagnosis. In the propensity score matched analyses the corresponding HR was 1.27 (95% CI: 1.15-1.40). Conclusions: Compared to SCCHN, SmCCHN in addition to carrying a worse survival, is more likely to originate in the salivary glands, present with more advanced stage, and affect females and whites.

scholarly journals An Ambiguous Growth in Floor of the Mouth

2013 ◽  
Vol 4 (1) ◽  
pp. 51-54
Author(s):  
Sonal Vahanwala ◽  
Sukhjinder Kaur Khosa ◽  
Sandeep S Pagare ◽  
Chaitanya D Nayak
Keyword(s):  
Differential Diagnosis ◽  
Oral Cavity ◽  
Head And Neck ◽  
Salivary Glands ◽  
Soft Tissues ◽  
Surgical Excision ◽  
Diverse Group ◽  
Floor Of The Mouth ◽  
Physiological Alterations ◽  
Rare Lesion

ABSTRACT Pathologic growths of the oral soft tissues are fairly common and include a diverse group of reactive and neoplastic conditions. Enlargement of or in relation to salivary glands have many causes, chief among them being inflammatory, neoplastic or physiological alterations. Nonspecific enlargement without any detectable cause has been classified as idiopathic and has been rarely reported. We describe a case of a 23-year-old female patient with a growth in floor of the mouth that was treated with conservative surgical excision. The histopathological features and differential diagnosis of this rare lesion are described and discussed. The awareness of this lesion is important to highlight the variations in the hyperplasias found in oral cavity for avoiding diagnosis and treatment pitfalls. How to cite this article Khosa SK, Nayak CD, Vahanwala S, Pagare SS. An Ambiguous Growth in Floor of the Mouth. Int J Head and Neck Surg 2013;4(1):51-54.

Salivary glands

2020 ◽  
pp. 177-210
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Salivary Glands ◽  
Sjögren’S Syndrome ◽  
Oral Mucosa ◽  
Clinical Examination ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Minor Salivary Glands ◽  
Major Salivary Glands

There are three main pairs of major salivary glands in the head and neck, namely the parotid, submandibular, and sublingual salivary glands. In addition to these major glands there are numerous minor salivary glands distributed throughout the oral cavity. These minor salivary glands are situated in the adnexal layer of the oral mucosa. This chapter covers the relevant anatomy, physiology, taking a history, clinical examination, and investigations. It then goes on to discuss xerostomia, Sjögren’s syndrome, diffuse and localized gland swelling, sialolithiasis, ranula, and disorders of the minor salivary glands.

Xanthogranuloma

1989 ◽  
Vol 98 (10) ◽  
pp. 834-835 ◽  
Author(s):  
John G. Batsakis
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Salivary Glands ◽  
Giant Cells ◽  
Skin Lesions ◽  
Spontaneous Resolution ◽  
Infants And Children ◽  
Mucosal Lesions ◽  
In Infants And Children

The skin of the head and neck is an area of predilection for xanthogranuloma, formerly called nevoxanthoendothelioma. Spontaneous resolution is the usual course for this benign, nonneoplastic lesion that is composed of macrophages and Touton giant cells and occurs principally in infants and children. Mucosal lesions occur with or without skin lesions and in the head and neck affect the oral cavity, nasopharynx, and salivary glands.

Pleomorphic adenoma of the nasal septum

1999 ◽  
Vol 113 (5) ◽  
pp. 483-485 ◽  
Author(s):  
P. Jassar ◽  
N. D. Stafford ◽  
A. W. MacDonald
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Clinical Management ◽  
Nasal Septum ◽  
Rare Case ◽  
Minor Salivary Glands ◽  
Review Of The Literature ◽  
Upper Aerodigestive Tract

AbstractPleomorphic adenoma is the commonest benign tumour of the major salivary glands. It can also occur in minor salivary glands, mainly in the oral cavity, but also in other sites in the head and neck both within and outwith the upper aerodigestive tract. We present a rare case of pleomorphic adenoma of the nasal septum with consideration of the clinical management and a review of the literature.

Neonatal airway obstruction due to a massive lingual foregut duplication cyst

2020 ◽  
Vol 13 (10) ◽  
pp. e233907
Author(s):  
Sepehr Shabani ◽  
Bradley J Cheek ◽  
Katrin Post-Martens ◽  
Steven M Andreoli
Keyword(s):  
Oral Cavity ◽  
Airway Obstruction ◽  
Head And Neck ◽  
Alimentary Tract ◽  
Surgical Excision ◽  
Duplication Cyst ◽  
Respiratory Epithelium ◽  
Definitive Treatment ◽  
Foregut Duplication Cyst

Foregut duplication cysts (FDCs) are rare malformations arising along primitively derived alimentary tract. Head and neck cases comprise 0.3% of all FDCs with 60% occurring in the oral cavity. We present a case of neonatal airway obstruction secondary to a prenatally diagnosed massive lingual FDC. Definitive treatment requires surgical excision. Histologically, the cysts are lined gastric and respiratory epithelium. FDC should be a consideration in prenatally diagnosed masses affecting the oral cavity.

scholarly journals “AGGRESSIVE” CLEAR CELL CHONDROSARCOMA OF THE HARD PALATE

2017 ◽  
Vol 10 (5) ◽  
pp. 78
Author(s):  
Ajay M Bhandarkar ◽  
Balakrishnan Ramaswamy
Keyword(s):  
Soft Tissue ◽  
Oral Cavity ◽  
Head And Neck ◽  
Hard Palate ◽  
Clear Cell ◽  
Histopathological Analysis ◽  
Head And Neck Tumours ◽  
Clear Cell Chondrosarcoma ◽  
One Year

Chondrosarcomas constitute 1 to 3% of all head and neck tumours. 2% of all chondrosarcomas are of the “clear cell” variety which follow a locally aggressive, relatively indolent course without predominant invasion of soft tissue. We present a 45-year-old woman presented with a bleeding mass in the oral cavity with change of voice of one year duration with pain of one month duration and histopathological analysis revealed a clear cell chondrosarcoma.

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