Presentation of Wegener's Granulomatosis in Young Patients

1986 ◽  
Vol 94 (3) ◽  
pp. 368-371 ◽  
Author(s):  
Lucinda A. Halstead ◽  
Collin S. Karmody ◽  
Sheldon M. Wolff
Keyword(s):  
Head And Neck ◽  
Wegener’S Granulomatosis ◽  
Medical Center ◽  
Nasal Congestion ◽  
Age Groups ◽  
Young Patients ◽  
Wegener's Granulomatosis ◽  
Upper Respiratory Tract ◽  
Presenting Symptoms ◽  
Number Of Patients

We have reviewed 50 cases of Wegener's granulomatosis, seen at the New England Medical Center Hospital between 1970 and 1984, and were impressed that 10 (20%) of these patients were under 25 years of age, with ages ranging from 13 to 23 years. Closer examination of this younger group revealed striking differences in their presenting symptoms and organ Involvement when compared to the older group of patients. The presentation of these young patients was varied, with no single predominant symptom. Patients presented with otalgia and otitis media or hearing loss, fulminant sinusitis, arthralgias, and even corneal ulcers. Only one patient had “typical” rhinitis and nasal congestion. This group also had a disproportionate number of patients with involvement of the oral cavity, skin, and trachea. Biopsy of these sites frequently demonstrated necrotizing vasculitis. Three of our 50 patients had intracranial involvement, leading to transient hemiplegia in the first, permanent hemiplegia in the second, and a seizure disorder in the third. Two of these patients were in the younger age group. The proportion of patients with limited and generalized Wegener's granulomatosis was the same in both the younger and older age groups. All the younger patients, however, had manifestations of the disease in the head and neck, while four of the older patients had no symptoms in the upper respiratory tract. The number of young patients in our study emphasizes the fact that Wegener's granulomatosis, indeed, occurs in the younger patient and with a greater frequency than previously supposed. This study suggests that in the teenager and young adult, with an unusual constellation of symptoms of the head and neck and accompanying systemic problems, a diagnosis of Wegener's granulomatosis should be seriously considered.

scholarly journals Clinicopathological review of epithelial ovarian tumors in young females and reproductive and survival outcome: Ten years expierence from a tertiary center

2016 ◽  
Author(s):  
Kusum Lata ◽  
Nutan Agarwal ◽  
Neerja Bhatla ◽  
Alka Kriplani
Keyword(s):  
Age Groups ◽  
Young Patients ◽  
Stage Iv ◽  
Progression Free Survival ◽  
Survival Outcome ◽  
Ovarian Tumors ◽  
Tertiary Referral Hospital ◽  
Young Females ◽  
Presenting Symptoms ◽  
Tertiary Center

Objective: To find out the prevalence of epithelial ovarian tumors in young females and correlation with reproductive and survival outcome. Design: Retrospective study. Setting: Tertiary referral hospital. Methods: A retrospective analysis of females from 9-35 year of age group treated for ovarian tumors between January 2003 to July 2013 was performed. Variables studied included age, presenting symptoms, imaging, tumor markers, surgical findings, type of surgery, histopathology reports and follow-up. Main Outcome Measures: Histopathological variant, FIGO stage, reproductive and survival outcome. Results: A total of 155 patients were found to have ovarian tumors. Mean age at time of diagnosis was 24.9 ± 1.8 years (range 9-35). Clinical presentation in majority of the cases was abdominal pain in 68 (43.8%), ascites in 13 (8.3%) mass in abdomen in 25 (16%), followed by irregular menstrual cycles in 15 (9.6%), infertility in 18 (11.6%) 12 (7.7%) were found to be incidental on ultrasound examination while 4 women were found to have virilising symptoms. There were 76 (49.1%) cases of epithelial ovarian tumors, 6 (0.03%) of borderline tumors and 30 (19.3%) were of malignant ovarian tumors while 40 (25.8%) were benign. Stage IA (N = 80), Stage I 8 (n = 2), Stage III (N = 6) and Stage IV (N = 12). Females were further subdivided into three age groups 9-15 years, 15-25 years and 25 to 35 years for determining outcome of epitheliail tumors. Reproductive and survival outcome were studied in each stage. Conclusions: Limited data exists about the histological type distribution, surgical treatment and overall survival of epithelial ovarian tumors in women aged below 35 years. Young patients have higher overall progression-free survival and a better clinical outcome than older patients. Any women presenting with pain and nonspecific symptoms should be investigated and evaluated properly.

Head and Neck Involvement in Wegener's Granulomatosis

1989 ◽  
Vol 10 (02) ◽  
pp. 133-135 ◽  
Author(s):  
Thomas McDonald ◽  
Louis Weiland ◽  
Richard DeRemee
Keyword(s):  
Head And Neck ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis

Head and neck manifestations of Wegener's granulomatosis

2003 ◽  
Vol 36 (4) ◽  
pp. 685-705 ◽  
Author(s):  
Samuel P. Gubbels ◽  
André Barkhuizen ◽  
Peter H. Hwang
Keyword(s):  
Head And Neck ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis

Effect of young age (<50) on clinical, pathologic features and survival of patients with colorectal cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14025-e14025
Author(s):  
Jamal Zidan ◽  
Jehad Abu Salah ◽  
Adi Sharabi-Nov
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Medical Center ◽  
Young Patients ◽  
Young Group ◽  
Old Patients ◽  
Pathological Characteristics ◽  
Pathologic Features ◽  
Number Of Patients ◽  
Significant Difference

e14025 Background: Colorectal cancer is one of the most common malignancies in both men and women in Israel. Most patients with colon cancer are older than 50 years of age. However young patients are not rare. There is no consensus in the literature regarding the behavior of this disease in young patients. Clinical and pathological characteristics of colon cancer patients treated at Oncology Institute in Ziv Medical Center were retrospectively analyzed. The aim of the present study is to compare clinical and pathological features of colon cancer between young and old patients. Methods: A total of 200 patients with colon cancer were treated at our institute during 8 years. Twenty five (12.5%) of them were <50 years age (young patients) at diagnosis. All clinical and pathological characteristics were taken retrospectively from the hospital files. In situations where the pathological findings were not noted in the chart, review of the stored tumor was requested from the pathology department. Acceptable statistical methods were used for statistical calculations. Results: Among the 200 patients 25 (12.5%) were <50 years age at diagnosis (mean age 41 years) and 175 were >50 years (mean age 70 years). Males were 56% of the young group and 60.1% of the old one. Arab patients were 52% of the young and only 12.6% of the old group although total number of Arabs was 35 of 200 patients. No significant difference was found in stage of tumor at diagnosis between the young group (YG) and the old group (OG). Twenty percent of YG had distant metastases compared to 26.5% in the OG. Histopathological grade 3 tumors were found in 33.3% of the YG versus 7.7% in the OG. Surgery and chemotherapy were done in 96% and 88% in YG versus 95.4% and 69.7% in the OG respectively. In a median follow up period of 96 months 35% of young patients died of their disease compared to 33.1% of the old patients. Conclusions: Young patients with colon cancer were diagnosed at the same stage of the disease as old patients. More tumors were high grade in YG. More patients were candidates for chemotherapy in the YG. Significantly more Arab patients were young at the time of diagnosis than Jewish patients. Further studies with higher number of patients are suggested to clarify our findings.

scholarly journals CLINICAL OBSERVATION OF THE PATIENT WITH WEGENER'S GRANULOMATOSIS

2017 ◽  
Vol 1 (66) ◽  
pp. 89-97
Author(s):  
Валерий Войцеховский ◽  
Valeriy Voytsekhovskiy ◽  
Марина Погребная ◽  
Marina Pogrebnaya ◽  
Николай Гоборов ◽  
...  
Keyword(s):  
Clinical Picture ◽  
Wegener’S Granulomatosis ◽  
Clinical Observation ◽  
Wegener's Granulomatosis ◽  
Tracheobronchial Tree ◽  
Acute Onset ◽  
Upper Respiratory Tract ◽  
Biopsy Material ◽  
Adequate Treatment ◽  
Upper Respiratory

A brief review of the literature is devoted to the peculiarities of the clinical picture, diagnosis and treatment of Wegener's granulomatosis. The clinical observation of the patient with Wegener's granulomatosis is made from the personal practice of the authors. A complex differential diagnosis was made between pneumonia of different etiology, tuberculosis, lung cancer and granulomatous disease. Taking into account anamnesis and clinical picture of the disease (acute onset with fever, arthralgia, nasal and oral mucosa damage, lungs, kidneys, Raynaud's syndrome, hemorrhagic eruptions, digital vasculitis), histological examination of transbronchial lung tissue biopsy material diagnosed: Wegener's granulomatosis, a generalized form, with the lesions of the upper respiratory tract, tracheobronchial tree, lungs, heart, kidneys, an acute course. Despite adequate treatment, the disease progressed with the addition of various complications, and a lethal outcome was ascertained.

Symptom Analysis of Confirmed Covid-19 Patients Managed at Allied Hospitals of Rawalpindi Medical University, Pakistan

1970 ◽  
Vol 9 (4) ◽  
pp. 235-241
Author(s):  
Javeria Malik ◽  
Muhammad Khurram ◽  
Arsalan Manzoor Mughal ◽  
Noman Ahmed Chaudhary ◽  
Qaiser Aziz ◽  
...  
Keyword(s):  
Age Groups ◽  
Severe Pneumonia ◽  
Cross Sectional Study ◽  
Upper Respiratory Tract ◽  
Shortness Of Breath ◽  
Cross Sectional ◽  
Duration Of Symptoms ◽  
Presenting Symptoms ◽  
Persistent Cough ◽  
Medical University

Introduction Coronavirus can cause respiratory disease ranging from mild upper respiratory tract illness to severe pneumonia, severe acute respiratory distress syndrome, and death. The purpose of this research was to study the symptoms of confirmed Coronavirus disease (COVID-19) cases and their relationship with gender and age groups. Materials and Methods This observational cross-sectional study was conducted at Rawalpindi Institute of Urology and Transplantation (RIUT) that is the COVID-19 management center of Rawalpindi Medical University, Rawalpindi during the month of March 2020. Consecutive sampling methodology was used, and all real-time polymerase chain reaction (RT-PCR) confirmed patients of COVID-19 were included. Data regarding age, gender, and symptoms with onset was recorded and analyzed.  Results Thirty-five patients, 22 (62.9%) males, and 13 (37.1%) females were included. Seven (20%) patients were ≥60 years old, and 12 (34.8%) ≥40 years old. 21 (60%) were symptomatic and the rest of them were asymptomatic. The mean duration of symptoms was 2.8±1.1 days. Fever (13, 61.9%), persistent cough (12, 57.1%), sputum (6, 28.6%), shortness of breath (4, 19%), anorexia (3, 14.3%), fatigue (3, 14.3%), myalgia (1, 4.8%), were presenting symptoms. Cough, anorexia, and fatigue were significantly more frequent in the patients ≥40 of age. Anorexia and fatigue were common in the age groups ≥40 and ≥60 years. Myalgia was significantly frequent in patients aged ≥60 years. Conclusion Fever, persistent cough and shortness of breath are commonest symptoms of COVID 19 patients. COVID-19 can be asymptomatic in many cases.

The otological manifestations of Wegener's granulomatosis

1994 ◽  
Vol 108 (2) ◽  
pp. 144-146 ◽  
Author(s):  
J. E. Fenton ◽  
T. J. O'Sullivan
Keyword(s):  
Wegener’S Granulomatosis ◽  
Disease Process ◽  
Wegener's Granulomatosis ◽  
Review Of The Literature ◽  
Presenting Symptoms ◽  
The Common

AbstractThree cases of Wegener's granulomatosis are described in which the common presenting symptoms were those of aural discomfort and discharge. The otological manifestations of this disease process are discussed and a review of the literature is presented.

Nasal discharge and obstruction as presenting symptoms of Wegener's granulomatosis in childhood

1993 ◽  
Vol 27 (1) ◽  
pp. 91-95 ◽  
Author(s):  
Hendrik P. Verschuur ◽  
Paul A.A. Struyvenberg ◽  
Peter Paul G. van Benthem ◽  
Marion van Rossum ◽  
Idske Hiemstra ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Nasal Discharge ◽  
Presenting Symptoms
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