Risk Factors of Cancer of the Larynx: Results of the Heidelberg Case—Control Study

1992 ◽  
Vol 107 (4) ◽  
pp. 577-582 ◽  
Author(s):  
Heinz Maier ◽  
Ulrike Gewelke ◽  
Andreas Dietz ◽  
Wolf-Dieter Heller
Keyword(s):  
Risk Factors ◽  
Laryngeal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
German Population ◽  
Epidemiologic Evidence ◽  
First Case ◽  
Carcinoma Of The Larynx ◽  
Control Study

Squamous cell carcinoma of the larynx is a multifactorial disease. It is firmly linked to several environmental risk factors. In the meanwhile, a considerable amount of epidemiologic evidence has been built up to implicate chronic consumption of alcohol and tobacco, occupation, diet, and social status in the etiology of the laryngeal cancer. Herein is a report from the first case-control study on the role of these risk factors conducted in a German population of patients with laryngeal cancer.

scholarly journals Risk factors for sporadic Campylobacter infection: an all-Ireland case-control study

2009 ◽  
Vol 14 (7) ◽  
Author(s):  
K Danis ◽  
M Di Renzi ◽  
W O’Neill ◽  
B Smyth ◽  
P McKeown ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Population Attributable Fraction ◽  
Case Control ◽  
Control Measures ◽  
Safety Education ◽  
First Case ◽  
The Republic ◽  
Campylobacter Infection ◽  
Control Study

We report the findings of the first case-control study conducted in both the Republic of Ireland and Northern Ireland to determine risk factors for sporadic Campylobacter infections. A total of 197 cases and 296 case-nominated controls matched for age, were included. Based on Population Attributable Fraction (PAF), the most important risk factors were consuming chicken [adjusted matched (am) OR 6.8; 95%CI 2.1-21.9], consuming lettuce (amOR 3.3; 95%CI 1.5-7.1) and eating in takeaways (amOR=3.1; 95%CI 1.4-6.6). Contact with sheep (amOR=11; 95%CI 1.6-78), peptic ulcer (amOR=19; 95%CI 3.8-93.7), hiatus hernia (amOR=20.3; 95%CI 2.3-183.3), lower bowel problems (amOR=4.5; 95%CI 1.2-16.8) were also independently associated with infection. Mains water supply showed protective effect (amOR=0.2; 95 CI 0.1-0.9). The findings highlight the continued need for consumer food safety education and further control measures throughout the food chain on the island of Ireland.

scholarly journals MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Feriha Fatima Khidri ◽  
Yar Muhammad Waryah ◽  
Faiza Kamran Ali ◽  
Hina Shaikh ◽  
Ikram Din Ujjan ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Case Control Study ◽  
Protective Role ◽  
Case Control ◽  
Amplification Refractory Mutation System ◽  
World Population ◽  
Single Nucleotide Variants ◽  
First Case ◽  
Control Study

Abstract Background To study the role of single nucleotide variants (SNVs) of genes related to preeclampsia in Pakistani pregnant women. Methods After ethical approval and getting informed consent; 250 pregnant women were enrolled and equally divided into two groups (125 preeclamptic cases and 125 normotensive pregnant women). Demographic details and medical history were recorded, and 10 ml blood sample was obtained for DNA extraction. The tetra-primer amplification refractory mutation system (ARMS) assays were developed for assessing the variants of three preeclampsia related genes; F5, MTHFR and VEGFA. An association of six SNVs; F5:c.1601G > A (rs6025), F5:c.6665A > G (rs6027), MTHFR: c.665C > T (rs1801133), MTHFR: c.1286A > C (rs1801131), VEGFA: c.-2055A > C (rs699947) and VEGFA: c.*237C > T (rs3025039) with preeclampsia was determined by using different genetic models. Results Genotyping of the SNVs revealed that patients with MTHFR:c.665C > T, have increased susceptibility to preeclampsia (CT versus CC/TT: OR = 2.79, 95% CI = 1.18–6.59; P* = 0.046 and CT/TT vs CC: OR = 2.91, 95% CI = 1.29–6.57; P* = 0.0497, in overdominant and dominant models, respectively), whereas F5:c.6665A > G, (A/G vs AA/GG: OR = 0.42, 95% CI = 0.21–0.84; P* = 0.038 in overdominant model) and MTHFR:c.1286A > C, (CC versus AA: OR = 0.36, 95% CI = 0.18–0.72; P* = 0.0392 in codominant model) have significantly decreased risk for preeclampsia. F5:c.1601G > A, VEGFA: c.-2055A > C and VEGFA: c.*237C > T variants revealed no relationship with the disease. Conclusion This is the first case control study describing the protective role of F5:c.6665A > G against preeclampsia in any world population. In addition, the present study confirmed the association and role of MTHFR gene variations in the development of preeclampsia in Pakistani patients. Further genetic studies may be required to better understand the complex genetic mechanism of SNVs in preeclampsia related genes in pregnant women.

scholarly journals Traditional and Commercial Alcohols as Risk Factors for Esophageal Cancer in Tanzania

2020 ◽  
Vol 6 (Supplement_1) ◽  
pp. 36-36
Author(s):  
Alexandra Keir ◽  
Geoffrey Buckle ◽  
Larry Akoko ◽  
William Mgisha ◽  
Julius Mwaiselage ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Secondary Analysis ◽  
Case Control ◽  
First Case ◽  
Increased Risk ◽  
Context Specific ◽  
Control Study

PURPOSE Esophageal cancer (EC) is one of the most common cancers in East Africa; however, risk factors that underly the high incidence in this region are not well understood. We aimed to investigate the association between exposure to specific alcohol subtypes and EC in Tanzania. METHODS We performed a secondary analysis of data from a hospital-based, case-control study conducted at Muhimbili National Hospital and Ocean Road Cancer Institute in Dar es Salaam, Tanzania. Cases of EC were identified between 2014 and 2016. Hospital controls were identified from patients with nonmalignant conditions and matched 1:1 for gender and age (± 10 years). Interviews were conducted using a survey with culturally relevant and context-specific questions on alcohol and smoking exposure. Conditional logistic regression analyses were applied to evaluate specific associations of potential exposures and EC. RESULTS A total of 473 EC cases and 473 controls were enrolled. Alcohol consumption was reported in 61% and 64% of cases and controls, respectively. Neither ‘current use of alcohol (any type)’, nor ‘ever use’ were associated with EC; however, local brew consumption was associated with increased EC risk (odds ratio [OR], 2.01; 95% CI, 1.53 to 2.66; P < .01). Increased risk was observed with consumption of gongo (OR, 2.91), komoni (OR, 2.41), wanzuki (OR, 2.40), kindi (OR, 3.13), and kangara (OR, 2.86). Smoking increased EC risk; however, it did not significantly modify the association between EC and alcohol subtypes. CONCLUSION This is the first case-control study to report a detailed analysis of alcohol exposures as a potential risk factor for EC in Tanzania. Although combined measures of alcohol use were not found to be associated with EC, several types of locally brewed alcohols emerged as risk factors. Additional research is needed to investigate these findings and examine the carcinogenic role of ingredients and/or contaminants, as well as any interactions with other putative risk factors in this region.

Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study

2000 ◽  
Vol 111 (2) ◽  
pp. 534-539 ◽  
Author(s):  
Christine Heller ◽  
Rosemarie Schobess ◽  
Karin Kurnik ◽  
Ralf Junker ◽  
Gudrun Gunther ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Case Control Study ◽  
Case Control ◽  
Prothrombotic Risk Factors ◽  
Neonates And Infants ◽  
Control Study

scholarly journals Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study

2000 ◽  
Vol 111 (2) ◽  
pp. 534-539 ◽  
Author(s):  
Christine Heller ◽  
Rosemarie Schobess ◽  
Karin Kurnik ◽  
Ralf Junker ◽  
Gudrun Günther ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Case Control Study ◽  
Case Control ◽  
Prothrombotic Risk Factors ◽  
Neonates And Infants ◽  
Control Study

Role of Foods in Sporadic Listeriosis. I. Case-Control Study of Dietary Risk Factors

1992 ◽  
Vol 47 (9) ◽  
pp. 614-615 ◽  
Author(s):  
ANNE SCHUCHAT ◽  
KATHERINE A. DEAVER ◽  
JAY D. WENGER ◽  
BRIAN D. PLIKAYTIS ◽  
LAURENE MASCOLA ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Dietary Risk Factors ◽  
Dietary Risk ◽  
Control Study
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