Effect of Oral Vitamin E on Oxy-Free Radical Status in Acute Myocardial Infarction

1995 ◽  
Vol 3 (3-4) ◽  
pp. 117-122 ◽  
Author(s):  
Mahesh Chandra ◽  
Vivek Gupta ◽  
Anil Kumar Rath ◽  
Arvind Kumar Vaish ◽  
Rikhab Chand Srimal ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Free Radical ◽  
Vitamin E ◽  
Superoxide Anion ◽  
Antioxidant Effect ◽  
Oral Vitamin ◽  
Matched Healthy Control ◽  
The Status ◽  
Healthy Control

The present work was conducted to study the status of oxidative stress (oxy-free radicals) in 24 patients with acute myocardial infarction and 12 matched healthy control patients and furthermore evaluate the effect of oral vitamin E on altered oxyfree radicals in these patients. The parameters assessed for oxy-free radical status were superoxide anion and malonyldialdehyde. These were found to be increased during acute myocardial infarction and this increment had a normalizing trend with the passage of time. It was found that the administration of vitamin E accelerated the normalizing trend of both superoxide anion and malonyldialdehyde. Thus, vitamin E has an antioxidant effect in acute myocardial infarction.

Free-radical activity after primary coronary angioplasty in acute myocardial infarction

1994 ◽  
Vol 127 (6) ◽  
pp. 1443-1449 ◽  
Author(s):  
Ever D. Grech ◽  
Christopher M. Bellamy ◽  
Malcolm J. Jackson ◽  
Ronald A. Muirhead ◽  
E.Brian Faragher ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Free Radical ◽  
Coronary Angioplasty ◽  
Primary Coronary Angioplasty ◽  
Free Radical Activity

scholarly journals Study on oxidative stress and antioxidant level in patients of acute myocardial infarction before and after regular treatment

2015 ◽  
Vol 40 (2) ◽  
pp. 79-84 ◽  
Author(s):  
T Bashar ◽  
N Akhter
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vitamin E ◽  
Plasma Vitamin ◽  
Regular Treatment ◽  
Before And After ◽  
The Difference ◽  
Plasma Vitamin E

In acute myocardial infarction (AMI), lack of oxygen delivery to myocardium leads to generation of reactive oxygen species (ROS) which play an important role in the pathogenesis of AMI. Endogenous anti-oxidants protect the myocardial tissues from the deleterious effect of free radical mediate injury. The study evaluates the extent of oxidative stress and antioxidant status against ROS in AMI patients and amelioration of oxidative stress after regular treatment and also assesses the association between oxidative stress and risk factors for atherosclerosis like dyslipidemia and diabetes mellitus (DM).The study was conducted on 72 AMI patients and age and sex matched 18 healthy controls. Patients were assigned to four groups, AMI without dyslipidemia or DM, with dyslipidemia, with DM and with both dyslipidemia and DM. Plasma malondialdehyde (MDA) and GSH content and vitamin E levels were determined on admission into hospital and on the 5th day of treatment. Plasma MDA level increased significantly (p<0.001) and erythrocyte GSH and plasma vitamin E levels were decreased (p<0.001) in all the groups of patients as compared to control. On the 5th day of regular treatment MDA level reduced (p<0.001) and GSH and vitamin E levels increased (p<0.001) in patients. The plasma MDA level was significantly higher (p<0.001) in patients with both dyslipidemia and DM or with only DM in comparison to patients without dyslipidemia and DM. The difference in the GSH level between patients with risk factors and without risk factors was not significant. It may be conclude that an imbalance exists between oxidant and antioxidant molecules in AMI patients which shift towards oxidative side and regular treatment restores this balance. There may be some association between oxidative stress in AMI and risk factors like dyslipidemia and diabetes mellitus.Bangladesh Med Res Counc Bull 2014; 40 (2): 79-84

scholarly journals Oxidative Stress and Antioxidant Status in Patients of acute Myocardial Infarction before and after Regular Treatment

2015 ◽  
Vol 10 (2) ◽  
pp. 60-65 ◽  
Author(s):  
Tahmina Bashar ◽  
Nargis Akhter
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vitamin E ◽  
Antioxidant Status ◽  
Plasma Vitamin ◽  
Regular Treatment ◽  
Before And After ◽  
Plasma Vitamin E

In acute myocardial infarction (AMI), generation of free radicals contribute to its pathogenesis. We evaluated the extent of oxidative stress and its amelioration in AMI patients after regular treatment and assessed its association with risk factors like dyslipidemia and diabetes mellitus (DM). Plasma MDA level increased (p<0.001) and erythrocyte GSH and plasma vitamin E levels decreased (p<0.001) in AMI patients. On the 5th day of regular treatment MDA level reduced (p<0.001) and erythrocyte GSH and vitamin E levels increased (p<0.001). The rise in MDA and fall in vitamin E levels were significant (p<0.001) in patients with both dyslipidemia and DM in comparison to patients without dyslipidemia or DM. It is concluded that an imbalance exists between oxidant and antioxidant molecules in AMI patients which shifts towards oxidative side and treatment restores this balance. There may be some association between oxidative stress in AMI and risk factors like dyslipidemia and diabetes mellitus.University Heart Journal Vol. 10, No. 2, July 2014; 60-65

Potent Free Radical Scavenging Activity of Propol Isolated from Brazilian Propolis

1997 ◽  
Vol 52 (11-12) ◽  
pp. 828-833 ◽  
Author(s):  
Purusotam Basnet ◽  
Tetsuya Matsuno ◽  
Richard Neidlein
Keyword(s):  
Free Radical ◽  
Vitamin E ◽  
Superoxide Anion ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Water Extract ◽  
Free Radical Scavenging ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Brazilian Propolis

Abstract We evaluated free radical scavenging activity of the water, methanol and chloroform ex­tracts of propolis in 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and xanthine-xanthine oxidase (XOD) generated superoxide anion assay systems. The free radical scavenging activity guided fractionation and chemical analysis led to the isolation of a new compound, propol {3-[4-hydroxy-3-(3-oxo-but-1-enyl)-phenyl]-acrylic acid) from the water extract, which was more potent than most common antioxidants such as vitamin C and vitamin E (α-tocopherol) in these assay systems.

scholarly journals Serum Apoprotein (ApoA1 and ApoB) in Myocardial infarction

1970 ◽  
Vol 26 (2) ◽  
pp. 62-66
Author(s):  
Khadija Akther Jhuma ◽  
MM Hoque
Keyword(s):  
Myocardial Infarction ◽  
Lipid Profile ◽  
Case Control Study ◽  
Profile Measurement ◽  
Specific Marker ◽  
Matched Healthy Control ◽  
Key Word ◽  
Healthy Control ◽  
The Mean ◽  
Control Study

30 diagnosed cases (Male26, Female 4) of MI (myocardial infarction) with the mean age of 55.5±9.8 years (range 40- 70 years) were included in a case control study to evaluate their apoprotein status. Serum apoA1 and apoB were measured and compared with those of age and sex matched healthy control subjects. Mean serum apoA1 concentration found significantly low in MI cases (91.84± 11.2 mg/dl) compared to control ( 123.2±10.5 mg/dl) and that of apoB found significantly high in MI cases( 135.3± 23.0 mg/dl ) compared to control (66.2±10.0 mg/dl).Serum apoB/apoA1 ratio of MI cases (1.49±0.3) also found significantly higher than that of control (0.54±0.1) .Since the serum apoA1 and apoB concentration stand for relatively more comprehensive measure of antiatherogenic and atherogenic potential respectively rather than the traditional lipid profile ; measurement of this apoprotein and their ratio may be more robust and specific marker for identification of individuals at risk of MI even in individuals with normal traditional lipid profile. Key word: ApoA1, ApoB, MI DOI: 10.3329/jbcps.v26i2.4181 J Bangladesh Coll Phys Surg 2008; 26: 62-66

scholarly journals A Preliminary Study of microRNA-208b after Acute Myocardial Infarction: Impact on 6-Month Survival

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Mostafa Alavi-Moghaddam ◽  
Mohammad Chehrazi ◽  
Shamila D. Alipoor ◽  
Maryam Mohammadi ◽  
Alireza Baratloo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Survival Time ◽  
Term Survival ◽  
Relative Expression ◽  
Kaplan Meier ◽  
Healthy Control ◽  
And Gender

Introduction. miRNAs contribute to a variety of essential biological processes including development, proliferation, differentiation, and apoptosis. Circulating microRNAs are very stable and have shown potential as biomarkers of cardiovascular disease. microRNA-208b expression was increased in the blood of patients with acute myocardial infarction (AMI) and has been proposed as a biomarker for early diagnosis. In this pilot study, we investigate the potential of circulating miR-208b as a prognostic biomarker of 6-month survival in AMI patients. Methods. Plasma samples from 21 patients and 8 age- and gender-matched healthy adults were collected, and circulating levels of miR-208b were detected using quantitative real-time PCR. Results. miR-208b levels were higher in healthy control subjects (9.6-fold; P≤0.05). Within the AMI patients, the levels of miR-208b were significantly lower in the survivor versus nonsurvivor group (fold change = 6.51 and 14.1, resp.; P≤0.05). The Kaplan-Meier curve revealed that the 6-month survival time was significantly higher among AMI patients with a relative expression of miR-208b lower than 12.38. The hazard ratio (HR) for the relative expression of miR-208b (<12.38 was the reference) was 5.08 (95% CI: 1.13–22.82; P=0.03). Conclusion. Our results showed that elevated miR-208b expression was associated with reduced long-term survival in AMI patients. These pilot data indicate the need for a large follow-up study to confirm whether miR-208b can be used as a predictor of 6-month survival time after AMI.

Serum Levels of Vascular Endothelial Growth Factor in Patients with Acute Myocardial Infarction Undergoing Reperfusion Therapy

1997 ◽  
Vol 92 (5) ◽  
pp. 453-454 ◽  
Author(s):  
Yoshinori Seko ◽  
Yasushi Imai ◽  
Shin Suzuki ◽  
Shuichi Kamijukkoku ◽  
Kazuya Hayasaki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Serum Levels ◽  
Reperfusion Therapy ◽  
Vascular Endothelial ◽  
Early Reperfusion ◽  
Healthy Control ◽  
Endothelial Growth Factor

1. Vascular endothelial growth factor, a potent angiogenic mitogen, is known to be induced in response to ischaemia as well as being secreted from tumour cells. However, the precise mechanism of vascular endothelial growth factor release in acute myocardial infarction and the effects of coronary reperfusion on the circulating levels of vascular endothelial growth factor are still unknown. 2. Nineteen patients with acute myocardial infarction who underwent early reperfusion therapy were studied. Serum levels of vascular endothelial growth factor before reperfusion were markedly increased as compared with those in 19 healthy control subjects [252.4 ± 158.1 pg/ml (mean ± SD) compared with undetectable]. After reperfusion, the serum vascular endothelial growth factor levels rapidly returned almost completely to the normal control range. 4. These data strongly suggest that the serum level of vascular endothelial growth factor is one of the most sensitive indicators of myocardial ischaemia.

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