Sterility and performance of open and closed extracorporeal circuits after long-term dry-wet setups

Perfusion ◽  
2020 ◽  
pp. 026765912093789
Author(s):  
Joseph Deptula ◽  
Catrina McGrath ◽  
Thomas Preston ◽  
Hayden Miller ◽  
Bianca Yen ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Statistical Significance ◽  
Blood Gases ◽  
Free Hemoglobin ◽  
Randomized Clinical Study ◽  
Minute Post ◽  
Extracorporeal Circuits ◽  
Clinically Significant ◽  
Run Up ◽  
And Performance

Background: The timeframe for safely using previously setup dry, crystalloid, and blood-primed extracorporeal circuits has long been debated. This study was undertaken to determine a safe deviation from standardized recommendations. Methods: Open (cardiopulmonary bypass) circuits and closed extracorporeal membrane oxygenation circuits were setup dry for up to 60 days and wet primed for up to 6 weeks with one control inoculated with Escherichia coli. Open circuits were cultured daily, closed circuits weekly. Circuits were primed with blood, albumin, heparin, NaHCO3, and CaCl2. Baseline pCO2, pO2, hemoglobin, lactate dehydrogenase, and plasma free hemoglobin were measured. Circuits were recirculated at a blood flow of 6 Liters/minute with a sweep gas of 1 Liter/minute at 100% FiO2 for 1 minute. Post oxygenator blood gases were collected at 8-, 16-, and 24-hour intervals. Results: There was no observed compromise to the sterility of the circuits and no clinically significant gas exchange abnormalities observed over the duration of the study period. Statistical significance (p < 0.01) was seen in free hemoglobin and lactate dehydrogenase levels, most significant in between the 16- and 24-hour time point in the closed systems intentionally inoculated with E. coli. Conclusion: Open and closed circuits can be safely setup dry for up to 60 days. Open, wet-primed circuits can be used safely up to 5 days. Closed, wet-primed circuits can be used safely up to 6 weeks. Blood-primed circuits can be safely run up to 16 hours prior to patient use but should be validated in a randomized clinical study.

scholarly journals The association between values and performance in a mining corporation. Empirical study and insights for Managing by Values (MBV) model

2017 ◽  
Vol 33 (2) ◽  
pp. 145-164
Author(s):  
Anita Zbieg ◽  
Jan Kudełko ◽  
Agata Juzyk ◽  
Leszek Zaremba
Keyword(s):  
Organizational Culture ◽  
Empirical Study ◽  
Work Performance ◽  
Statistical Significance ◽  
Work Satisfaction ◽  
Mining Industry ◽  
Assessment Instrument ◽  
Research Results ◽  
General Management ◽  
And Performance

Abstract The paper presents result of an empirical study in which presence of values among workers of two mining squads characterized by different level of work performance has been compared. Values have been measured by two scales: Mining Values Scale (MVS) and Organizational Culture Assessment Instrument (OCAI). The squad with higher performance had significantly higher level of five out of nine values measured by (MVS); while none of the values measured by OCAI have been differentiating the squads with a statistical significance. The results suggest that Managing by Values (MBV) model for a mining corporation should rather be based on values specific for the mining industry rather than general management value set proposed by OCAI. Research results suggest also an association between presence of certain values and work satisfaction among workers.

scholarly journals ANALYSIS OF RELATIONSHIPS BETWEEN INTELLECTUAL CAPITAL AND MEASUREMENT PERFORMANCE INDICATORS OF THE PHARMACEUTICAL COMPANIES IN TEHRAN STOCK EXCHANGE

2015 ◽  
Vol 37 ◽  
pp. 58
Author(s):  
Hadi Kord Javadi ◽  
Zahra Kohandel ◽  
Khadije Fardi
Keyword(s):  
Performance Measurement ◽  
Intellectual Capital ◽  
Stock Exchange ◽  
Statistical Significance ◽  
Value Added ◽  
Two Dimensions ◽  
Pharmaceutical Companies ◽  
Statistical Population ◽  
And Performance ◽  
Spearman Test

http://dx.doi.org/10.5902/2179460X19440Intellectual Capital is the most precious possession of companies in modern economy; therefore, Intellectual Capital of industrial centers is ever-increasingly changing to become the chief indicators both in company operations and in improving its ability to manage the organization capitals. In the main, the current study aims to investigate the relationship between the Intellectual Capital and performance measurement. In this research, the independent variable is the intellectual capital having three dimensions of human, structure and physical capitals, and the dependent variable is the organization operation with two dimensions of economical and accounting which are going to be assessed in this study. The Statistical population is the pharmaceutical companies admitted in the Tehran Stock Exchange from 1387 to 1391 amounting to 30 companies in total. This research investigates the time span from the beginning of 1387 up to the end of year, 1391. Data relevant to variables has been collected by the software of the Stock Exchange. The collection of data has been carried out by means of SPSS. In this study, the researcher used the descriptive and inferential statistics (Spearman test) and the results show that the hypotheses are a s follows 1. There is statistical significance between intellectual capital and performance measurement, 2. There is no statistical significance between the intellectual capital and ROR of the owners’ salary, 3. There is no statistical significance between the intellectual capital and the ROR of the properties, 4. There is statistical significance between the intellectual capital and the value added of the market, 5. There statistical significance between the intellectual capital and economic value added.

scholarly journals A Reappraisal of Rhythmic Coma Patterns in Children

2005 ◽  
Vol 32 (4) ◽  
pp. 518-523 ◽  
Author(s):  
Rajesh RamachandranNair ◽  
Rohit Sharma ◽  
Shelly K. Weiss ◽  
Hiroshi Otsubo ◽  
Miguel A. Cortez
Keyword(s):  
Statistical Significance ◽  
Prognostic Significance ◽  
Favourable Outcome ◽  
Category Scale ◽  
Rhythmic Pattern ◽  
Performance Category ◽  
Exact Test ◽  
Significant Difference ◽  
Overall Performance ◽  
Clinically Significant

ABSTRACT:Objective:This study was designed to determine the prevalence of rhythmic coma patterns in comatose children and to ascertain the prognostic significance of reactive rhythmic coma patterns.Methods:We retrospectively analyzed and classified electroencephalogram (EEGs) in comatose children between two months and 18 years of age during the period 1996 - 2003 according to modified Young's classification. Outcome at one-year was scored according to the Paediatric Cerebral and Overall Performance Category Scale. Outcomes were compared using Fisher's exact test and Mann-Whitney test.Results:Analysis of 63 electroencephalogram (EEG) records in 38 patients showed rhythmic patterns in 19 records (30.2%; 9 alpha, 4 spindle, 4 theta and 2 beta coma patterns, total number of children = 14). Aetiology and outcome of alpha coma patterns and other rhythmic coma patterns were similar. In five children, one type of rhythmic pattern changed to another. Records with reactive rhythmic coma 66.7% (6/9), were associated with favourable outcome. Sixty percent of the records (6/10 records in seven children) with non-reactive pattern were associated with unfavourable outcome. This clinically significant difference did not reach statistical significance (lower Paediatric Cerebral and Overall Performance Category Scale score p= 0.14; favourable outcome p=0.19).Conclusion:Rhythmic coma patterns in comatose children are not uncommon. Aetiology, reactivity and outcome of individual patterns are similar and thus make the rhythmic coma patterns distinct EEG signatures in comatose children. There was a clinically significant better outcome with reactive rhythmic coma patterns.

What matters for keeping or losing support in televised debates

2021 ◽  
pp. 026732312110467
Author(s):  
Pascal D. König ◽  
Thomas Waldvogel
Keyword(s):  
Real Time ◽  
Time Response ◽  
Preference Change ◽  
Policy Issues ◽  
Personal Issue ◽  
Party Identity ◽  
Run Up ◽  
And Performance ◽  
Performance Perceptions ◽  
Televised Debates

What leads citizens to change their candidate preferences during televised debates? The present paper addresses this question with real-time response and panel survey data from respondents recruited in the run-up to the 2017 German national election. Probing the importance of party identity and performance perceptions formed during the debate, the analysis more closely examines several core determinants than has previously been done with real-time response data. The findings suggest, first, that only a strong or very strong party identity is an effective barrier to candidate preference change. Second, beyond party identity, ratings of candidates’ issue-specific statements on policy issues show a very strong effect, albeit regardless of personal issue importance. Third, this influence of candidate ratings does not seem to be mediated through changes in valence perceptions. Rather, viewers seem to form a general impression of the candidates which cannot be reduced to performance perceptions regarding policy issues.

Adapting Altman's model to predict the performance of the Palestinian industrial sector

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Bahaa Awwad ◽  
Bahaa Razia
Keyword(s):  
Stock Exchange ◽  
Statistical Significance ◽  
Multiple Linear Regression Model ◽  
Industrial Sector ◽  
Main Hypothesis ◽  
Content Type ◽  
Independent Variables ◽  
Industrial Companies ◽  
And Performance ◽  
The Relationship

PurposeThis study aims to adopt the Altman model in order to predict the performance of industrial companies listed on the Palestinian Stock Exchange during the period of time between 2013 and 2017.Design/methodology/approachThe study sample consisted of 12 industrial companies listed on the Palestine Stock Exchange, and their financial disclosure period extended for 5 years. Multiple linear regression model was used in the analysis to determine the relationship between the independent variables and the dependent variable where the independent variables were (X1, X2, X3). This study is based on one basic assumption, which is that the Altman's model cannot predict the performance of the Palestinian industrial sector.FindingsThe results of the analysis proved the negation of the zero main hypothesis. This means that Altman's model can predict the performance of the Palestinian industrial sector at the level of statistical significance (a = 0.05), as well as the existence of a statistically significant relationship between each of the independent variables (X2, X4, X5) and the dependent variable (Log (Z-score)). Hence, the relationship of X1 and X3 with the dependent variable was not statistically significant.Social implicationsThis paper highlights different challenges that face the adaption of Atman's model and performance prediction in the Palestinian industrial sector. The findings of the analysis have the potential to help future researchers in examining and dealing with new challenges.Originality/valueThis paper presents a vital review of adopting Altman's model in the Palestinian industrial sector. A number of recommendations have been made, the most important of which is that most of the companies are located in the red zone. The Altman's model must be adapted in order to fit the Palestinian environment according to the results of statistical analysis and according to a proposed model, which is Log (Z) = −0.653 + 0.72X2 + 0.18X4 + 0.585X5.

scholarly journals Performance and Return to Sport After Hip Arthroscopic Surgery in Major League Baseball Players

2019 ◽  
Vol 7 (2) ◽  
pp. 232596711982583 ◽  
Author(s):  
Robert A. Jack ◽  
Kyle R. Sochacki ◽  
Takashi Hirase ◽  
Justin Vickery ◽  
Patrick C. McCulloch ◽  
...  
Keyword(s):  
Major League Baseball ◽  
Statistical Significance ◽  
Arthroscopic Surgery ◽  
Return To Sport ◽  
Control Group ◽  
P Value ◽  
Postoperative Performance ◽  
Significant Difference ◽  
Major League ◽  
And Performance

Background: Femoroacetabular impingement (FAI) is a common cause of hip pain that may lead to decreased performance in Major League Baseball (MLB) players. Purpose: To determine the (1) return-to-sport (RTS) rate in MLB players after hip arthroscopic surgery for FAI; (2) postoperative career length, innings pitched (IP) (pitchers), and plate appearances (PA) (position players); (3) preoperative and postoperative performance; and (4) postoperative performance compared with control players matched by position, age, years of experience, and performance. Study Design: Cohort study; Level of evidence, 3. Methods: MLB athletes who underwent hip arthroscopic surgery for FAI and matched controls were identified. Demographic and performance data were collected. RTS was defined as playing in at least 1 MLB game after surgery. Continuous variables of each group were compared using a 2-tailed paired-samples Student t test for normally distributed data. The chi-square test was used to analyze categorical data. The Bonferroni correction was used to control for multiple comparisons, with statistical significance defined by a P value of ≤.007. Results: A total of 50 players (57 surgeries) were analyzed (mean age, 30.4 ± 3.9 years; mean MLB experience at the time of surgery, 7.0 ± 4.6 years). Pitchers (31 surgeries; 54.4%) represented the largest proportion of players analyzed. Of these players, 42 (47 surgeries; 82.5%) were able to RTS at a mean of 8.3 ± 4.1 months. The overall 1-year MLB career survival rate of players undergoing FAI surgery was 78.9%. Players in the control group were in MLB a similar number of years (4.0 ± 2.9 years) to players who underwent surgery (3.3 ± 2.4 years) ( P > .007). There was no significant decrease in IP or PA per season after surgery ( P > .007). There was no significant difference in performance for pitchers and nonpitchers compared with matched controls after surgery ( P > .007). Conclusion: The RTS rate for MLB athletes after hip arthroscopic surgery for FAI was high. There were similar IP, PA, and career lengths postoperatively compared with preoperatively and with matched controls. There was no significant difference in performance for pitchers and nonpitchers compared with matched controls after surgery.

scholarly journals Performance and return to sport after hip arthroscopy for femoracetabular impingement syndrome in National Hockey League players

2019 ◽  
Author(s):  
Kyle R Sochacki ◽  
Robert A Jack ◽  
Takashi Hirase ◽  
Justin Vickery ◽  
Joshua D Harris
Keyword(s):  
Hip Arthroscopy ◽  
Statistical Significance ◽  
Return To Sport ◽  
Performance Data ◽  
National Hockey League ◽  
Control Group ◽  
P Value ◽  
Career Length ◽  
Operative Performance ◽  
And Performance

Abstract Femoroacetabular impingement (FAI) syndrome is a common cause of hip pain in National Hockey League (NHL) players that may lead to decreased performance. The purpose of this study was to determine the (i) return to sport (RTS) rate in NHL players following hip arthroscopy for FAI, (ii) post-operative career length and games per season, (iii) pre- and post-operative performance and (iv) post-operative performance compared with control players. NHL athletes who underwent hip arthroscopy for FAI and matched controls were identified based on position, age (±1 year), years of experience (±1 year) and performance data prior to the surgery date. Demographic and performance data were collected. RTS was defined as playing in at least one NHL game after surgery. A Bonferroni correction was used to control for multiple comparisons with statistical significance defined by a P-value ≤ 0.007. Seventy players (77 surgeries) were analysed (mean age 29.4 ± 4.5 years; mean 8.8 ± 4.7 years NHL experience at the time of surgery). Sixty-three players (70 surgeries, 90.9%) RTS at an average of 6.8 ± 4.1 months. The 1-year NHL career survival rate for players undergoing surgery was 84.4%. Players in the control group (4.4 ± 2.7 years) had longer careers (P = 0.00002) than players that underwent surgery (3.3 ± 2.5 years). There was no significant (P > 0.007) decrease in post-operative performance compared with pre-operatively and with matched controls. The RTS rate for NHL athletes after hip arthroscopy for FAI is above 90% at less than 1 year. Following surgery, if a player returns to the NHL, then their post-operative performance is similar to pre-operatively and controls, but their careers are approximately one season less than controls.

scholarly journals The Effects of an Eight over Cricket Bowling Spell upon Pace Bowling Biomechanics and Performance within Different Delivery Lengths

Sports ◽  
2019 ◽  
Vol 7 (9) ◽  
pp. 200
Author(s):  
Samuel J. Callaghan ◽  
Robert G. Lockie ◽  
Warren A. Andrews ◽  
Walter Yu ◽  
Robert F. Chipchase ◽  
...  
Keyword(s):  
Whole Body ◽  
Ground Reaction Forces ◽  
Continuous Variables ◽  
Load Monitoring ◽  
Reaction Forces ◽  
Run Up ◽  
And Performance ◽  
Cricket Bowling ◽  
Shoulder Kinematics ◽  
Release Speed

Pace bowlers must often perform extended bowling spells with maximal ball release speed (BRS) while targeting different delivery lengths when playing a multi-day match. This study investigated the effect of an eight over spell upon pace bowling biomechanics and performance at different delivery lengths. Nine male bowlers (age = 18.8 ± 1.7 years) completed an eight over spell, while targeting different lengths (short: 7–10 m, good: 4–7 m, full: 0–4 m from the batter’s stumps, respectively) in a randomized order. Trunk, knee and shoulder kinematics and ground reaction forces at front foot contact (FFC), as well as run-up velocity and BRS were measured. Paired sample t-tests (p ≤ 0.01), Hedges’ g effect sizes, and statistical parametrical mapping were used to assess differences between mean variables from the first and last three overs. No significant differences (p = 0.05–0.98) were found in any discrete or continuous variables, with the magnitude of difference being trivial-to-medium (g = 0.00–0.73) across all variables. Results suggest pace bowlers sustain BRS through a single eight over spell while tolerating the repeatedly high whole-body biomechanical loads as suggested by maintaining the kinematics or technique at the assessed joints during FFC. Practically, the findings are advantageous for bowling performance and support current bowling load monitoring practices.

Influence Of RHCE Variant Genotypes On Anti-e Alloimmunization Risk In SCD Patients

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 2392-2392 ◽  
Author(s):  
Ross M Fasano ◽  
Mitchell G Bryski ◽  
Philippe Pary ◽  
Mohamadou Sene ◽  
Naomi L.C. Luban
Keyword(s):  
Statistical Significance ◽  
Compound Heterozygous ◽  
Exact Test ◽  
African Patient ◽  
Increased Risk ◽  
African Immigration ◽  
Two Generations ◽  
History Of ◽  
Clinically Significant ◽  
African Patients

Abstract Background A higher incidence of Red Blood Cell (RBC) alloimmunization exists in Sickle Cell Disease (SCD) than in any other multiply transfused population. The majority of the RBC alloantibodies are to Rh (D, C, c, E, e) and K antigens. Transfusing Rh and Kell matched RBCs substantially decreases alloimmunization rates in SCD patients; however clinically significant Rh antibodies with apparent common specificities persist as a result of altered RH alleles in SCD patients. Methods SCD patients with a history of ≥15 transfusions or having RBC alloantibody(ies) were consented and asked to complete an ethnicity survey defining patients as “African” (patient or both parents African-born), African American (parents and patient US-born), or other. RH genotyping was performed on all patients using RH Variant Beadchips (BioArray, Warren NJ). Medical records of patients were retrospectively reviewed and compared to RH genotype and ethnicity to determine the clinical impact of RH variants on alloimmunization. Fisher’s Exact test was used to determine statistical significance of correlations. Results Among 117 SCD patients genotyped, 67 (57.3%) had alloantibodies, with a median of 50 transfusion exposures. RHCE variant haplotype frequencies for (C)ces, ces, ceAR, ceMO and ces(340) were 6.8%, 20.1%, 0.9%, 1.3% and 0.4%, respectively. Twenty-two patients were either homozygous (7), compound-heterozygous (5), or heterozygous for these RHCE variant haplotypes with a conventional RH E allele in-trans (10). Of these, approximately 32% (7/22) formed an anti-e alloantibodies after a median of 6 Rhe+ RBC transfusion exposures compared to 7.3% (7/95) of all other patients (p=0.0048). No anti-e alloantibodies were detected in 15/22 patients within the RHCE variant subgroup after 1436 Rhe+ RBC transfusions (median 66 transfusions/patient), yielding an anti-e alloantibody frequency of 0.45/100 units. Fifty percent (11/22) of patient in the RHCE variant subgroup formed an autoantibody, compared with 24% (19/78) of all other patients (p=0.0345). Approximately 32% (8/25) of the “African” patients were homozygous or compound heterozygous for a variant, as opposed to 10.7% of “Non-African” patients (p=0.0312); only 12.5% (1/8) of African patients with RHCE variant subgroup formed anti-e alloantibodies versus 46% of “Non-African” patients this subgroup (p= NS). Conclusion SCD patients with RHCE variant haplotypes are at increased risk for the formation of clinically significant anti-e alloantibodies, which may be inaccurately identified as autoantibodies in the absence of RH genotyping. This implies that RH genotyping should be either incorporated into the standard RBC phenotype evaluation in all SCD patients, or at least into the evaluation of any SCD patient with an autoantibody that demonstrates “e” specificity. We report similar RHCE variant allele frequencies compared to previously published SCD population studies; however we found a higher prevalence of homozygous and compound heterozygous RHCE variant genotypes in SCD patients less then two generations removed from African immigration. Confounding factors for anti-e alloimmunization risk in SCD patients with RHCE variant genotypes other than antigen disparity exist which may explain why “African” patients within the RHCE variant subgroup demonstrated lower anti-e alloimmunization compared to other patients in this group. Further study is warranted to further characterize the immunogenic potential of high incidence Rh antigens in individuals with RH variants, and the immunogenetic variables that affect alloimmunization overall. Disclosures: Fasano: ApoPharma: Honoraria.

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