Plethysmographic Measurement of Venous Flow Resistance and Venous Capacity in Humans with Primary Lymphoedema

1990 ◽  
Vol 5 (1) ◽  
pp. 37-40 ◽  
Author(s):  
B. J. F. Klein Rouweler ◽  
J. P. Kuiper ◽  
A. J. M. Brakkee
Keyword(s):  
Deep Vein Thrombosis ◽  
Strain Gauge ◽  
Flow Resistance ◽  
Clinical Severity ◽  
Venous Flow ◽  
Vein Thrombosis ◽  
Venous Capacity ◽  
Deep Vein ◽  
Diagnostic Criterion ◽  
Normal Potential

Venous flow resistance ( Rv) and venous capacity ( C10) was measured by strain-gauge plethysmography in patients with primary lympoedema of the legs. In the calf, Rv was significantly higher than normal and increased with the clinical severity of the oedema, while C10 was significantly lower than normal. Potential causes are discussed. No indications were found that the specificity of Rv, when used as a diagnostic criterion for recent deep vein thrombosis, is influenced by primary lymphoedema.

Venous Flow Resistance and Venous Capacity in Humans with Primary Varicosis of the Long Saphenous Vein

1990 ◽  
Vol 5 (1) ◽  
pp. 31-35 ◽  
Author(s):  
B. J. F. Klein Rouweler ◽  
J. P. Kuiper ◽  
A. J. M. Brakkee
Keyword(s):  
Deep Vein Thrombosis ◽  
Saphenous Vein ◽  
Strain Gauge ◽  
Flow Resistance ◽  
Venous Flow ◽  
Vein Thrombosis ◽  
Long Saphenous Vein ◽  
Venous Capacity ◽  
Deep Vein ◽  
Diagnostic Criterion

Venous flow resistance ( Rv) and venous capacity ( C10) was measured by strain-gauge plethysmography in patients with primary truncal varicosis of the long saphenous vein (LSV). Rv tended to be lower than normal, notably in measurements taken at the foot, but significant differences were hardly demonstrable. C10 in the calf and the foot were significantly higher than normal. Physical and morphological abnormalties of the LSV with relevance to Rv and C10 are discussed. It was demonstrated that the contribution of the LSV to venous haemodynamics amounts to about 10%. It is considered unlikely that the sensitivity of Rv, when used as a diagnostic criterion for recent deep vein thrombosis, is influenced by the LSV.

Plethysmographic Measurement of Venous Flow Resistance and Venous Capacity in Humans with Deep Venous Thrombosis

1990 ◽  
Vol 5 (1) ◽  
pp. 21-29 ◽  
Author(s):  
B. J. F. Klein Rouweler ◽  
J. P. Kuiper ◽  
A. J. M. Brakkee
Keyword(s):  
Flow Resistance ◽  
Strain Gauges ◽  
Confidence Limits ◽  
Venous Flow ◽  
Vein Thrombosis ◽  
Venous Capacity ◽  
High Level ◽  
Deep Vein ◽  
Diagnostic Criterion

Venous flow resistance ( Rv) and venous capacity ( C10)2 was studied in humans with deep vein thrombosis (DVT) using strain-gauge plethysmography. Rv was found to be significantly higher than normal while C10 was significantly lower, notably in measurements at the calf-level. In a follow-up study it was demonstrated that Rv usually decreased sharply within the first few months after the acute event while C10 increased. Rv usually returned to (high-level) non-thrombotic values, while C10 returned to (low-level) normal values. The sensitivity of Rv when used as a diagnostic criterion for recent proximal DVT was assessed retrospectively. For proximal DVT, the sensitivity of Rv-prox (measured with strain-gauges around the calf) was 95% (95% confidence limits 83–99%) and for distal DVT, the sensitivity of Rv-dist (measured with strain-gauges around the foot) was 36% (95% confidence limits 13–65%). The specificity for Rv was 100% (95% confidence limits Rv-prox: 90–100%; Rv-dist: 59–100%). Influencing factors for sensitivity and specifity are discussed.

Diagnosis of Deep Vein Thrombosis by Combination of Doppler Ultrasound Flow Examination and Strain Gauge Plethysmography

1982 ◽  
Vol 47 (02) ◽  
pp. 141-144 ◽  
Author(s):  
H Bounameaux ◽  
B Krähenbühl ◽  
S Vukanovic
Keyword(s):  
Deep Vein Thrombosis ◽  
Negative Predictive Value ◽  
Doppler Ultrasound ◽  
Strain Gauge ◽  
Predictive Value ◽  
Lower Limbs ◽  
Vein Thrombosis ◽  
Non Invasive ◽  
Strain Gauge Plethysmography ◽  
Deep Vein

SummaryDoppler ultrasound flow examination, strain gauge plethysmography and contrast venography were performed in 160 lower limbs of 80 in-patients. Deep vein thrombosis (DVT) was suspected in 87 limbs. Using measurement of venous stop-flow pressure, the Doppler method had an overall sensitivity of 83%. By combined use of Doppler and Plethysmography, sensitivity was increased to 96%. Specificity was 62% and 51%, respectively. With a positive and a negative predictive value of 80% and 73%, respectively, the combination of both non-invasive methods cannot reliably replace venography in the diagnosis of DTV, although all (40/40) thromboses proximal to or involving the popliteal segment were detected by either Doppler and Plethysmography or both.After exclusion of 14 patients (18%) suffering from conditions known to alter the results of these non-invasive methods, the positive predictive value of abnormal findings in both Doppler and Plethysmography was increased to 94% for suspected limbs, whilst negative predictive value of both negative Doppler and Plethysmography was 90%, allowing the avoidance of venography in these patients.

The use of automated strain gauge plethysmography in the diagnosis of deep vein thrombosis

2002 ◽  
Vol 75 (896) ◽  
pp. 648-651 ◽  
Author(s):  
N A Maskell ◽  
S Cooke ◽  
D J Meecham Jones ◽  
J G Prior ◽  
R J A Butland
Keyword(s):  
Deep Vein Thrombosis ◽  
Strain Gauge ◽  
Vein Thrombosis ◽  
Strain Gauge Plethysmography ◽  
Deep Vein

Plethysmographic Measurement of Venous Flow Resistance and Venous Capacity in Human Legs. Part Two: Normal Values Related to Age, Sex and Site of Measurement

1989 ◽  
Vol 4 (4) ◽  
pp. 251-257 ◽  
Author(s):  
B.J.F. Klein Rouweler ◽  
A.J.M. Brakkee ◽  
J.P. Kuiper
Keyword(s):  
Strain Gauge ◽  
Flow Resistance ◽  
Normal Values ◽  
Age Dependency ◽  
Limb Volume ◽  
Venous Flow ◽  
Strain Gauge Plethysmography ◽  
Sex Dependency ◽  
Venous Capacity

This report presents normal values of venous flow resistance ( Rv) and venous capacity (C10) as measured in human limbs by strain-gauge plethysmography. No age dependency was found for either parameter. Rv was lower in males than in females and lower in left legs than in right legs. C10 was higher in males than in females and higher in left than in right legs. The left-right and sex dependency of the parameters cannot be explained by differences in limb volume. Correlations between selected parameters are presented.

Evaluation of Acute Deep Venous Thrombosis of the Lower Limb, Using an Automated Venous Occlusion Plethysmograph

1991 ◽  
Vol 6 (4) ◽  
pp. 241-248 ◽  
Author(s):  
Håkan Ahlström ◽  
Stefan Nilsson ◽  
Göran Hellers
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Strain Gauge ◽  
Lower Limb ◽  
False Negative ◽  
Venous Occlusion ◽  
Vein Thrombosis ◽  
Deep Vein

One-hundred-and-eleven consecutive patients who were referred for routine phlebography because of clinically suspected deep vein thrombosis (DVT) were also investigated with a new, simplified, computerized strain-gauge plethysmograph (Phlebotest, Eureka AB). An occlusion plethysmograph curve was obtained from each leg simultaneously. Four different numerical parameters were defined and determined from this curve. These parameters were correlated with the phlebographic diagnosis. Three of the parameters of the plethysmograph curve correlated well with the phlebographic diagnosis, which proved correct in 54 patients without DVT, including two false negative cases, and in 12 patients with thrombosis. In 45 patients, plethysmography alone was not sufficient to establish a diagnosis. The plethysmograph described is easy to handle and is suggested for use in selecting those patients, with or without thrombosis, who do not require supplementary phlebography.

Plethysmographic Measurement of Venous Flow Resistance and Venous Capacity in the Human Leg. Part One: Method

1989 ◽  
Vol 4 (4) ◽  
pp. 241-250 ◽  
Author(s):  
B.J.F. Klein Rouweler ◽  
A.J.M. Brakkee ◽  
J.P. Kuiper
Keyword(s):  
Knee Joint ◽  
Strain Gauge ◽  
Flow Resistance ◽  
Room Temperature ◽  
Muscle Tension ◽  
Calf Muscle ◽  
Venous Flow ◽  
Strain Gauge Plethysmography ◽  
Venous Capacity ◽  
Methodological Aspects

This report presents a study of the methodological aspects of the measurement of venous flow resistance ( Rv) and venous capacity (C10) in human legs as measured by strain-gauge plethysmography. The measurements are reproduceable within 10%, in subjects who are well-acclimatized to a room temperature of 28–30 °C. In measurements at the calf, extension of the knee joint may increase Rv by hundreds of percents, while high passive calf muscle tension may be associated with a decrease in Rv and an increase in C10. Inadequate acclimatization may increase Rv and decrease C10, notably in measurements at the foot. The determinants for Rv and C10 are discussed.

scholarly journals Concomitant Use of Diosmin/Hesperidin and Oral Rivaroxaban Increases Deep Vein Recanalization and Reduces the Incidence of Post-Thrombotic Syndrome in Patients with Proximal Deep Vein Thrombosis

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 986-986
Author(s):  
Kirill Lobastov ◽  
Iliya Schastlivtsev ◽  
Victor Barinov
Keyword(s):  
Deep Vein Thrombosis ◽  
Clinical Severity ◽  
Proximal Deep Vein Thrombosis ◽  
Control Groups ◽  
Vein Thrombosis ◽  
Post Thrombotic Syndrome ◽  
And Control ◽  
Deep Vein ◽  
The Impact

Abstract Aim: To assess the impact of long-term Diosmin/Hesperidin use in the treatment of proximal deep vein thrombosis (DVT). Methods: This study was a pilot randomized open-label study with blinded outcome assessor - enrolled patients with their first episodes of popliteal-femoral DVT confirmed by duplex ultrasound (DUS). All participants were randomized into two groups: 1.) control that received a standard treatment with oral Rivaroxaban, and 2.) experimental that required additional treatment with Diosmin/Hesperidin 450/50 mg twice a day. Both drugs were used for six months. Patients were followed-up for the whole treatment period with series DUS every two months in order to evaluate the degree of recanalization by popliteal (PV), superficial femoral (SFV), and common femoral (CFV) veins' compressibility. Thrombi extension was assessed by modified Marder score. At the end of the follow-up period, patients were assessed with Villalta and venous clinical severity scores. Post-thrombotic syndrome (PTS) was diagnosed in those who had ≥5 Villalta score. Results: Sixty patients were randomized to the control and experimental groups (n=30 in each group). There were 40 men and 20 women with mean age of 56.3±13.4. Clinically unprovoked DVT was recognized in 65% of cases and left side localization in 45%. The median of Marder baseline scores were 15.0±4.8 and 11.1±4.3 in the experimental and control groups, respectively (p=0.002). After six months of treatment, the Marder score decreased to 0.8±1.6 and 2.8±3.5 in the main control groups, respectively (p=0.006). The generalized linear model repeated measures found a greater reduction in the Marder score (р <0.0001) and increased speed of recanalization on SFV (р <0.0001) with a non-significant tendency in the CFV (p=0.130) and PV (p=0.204) in the experimental group compared to the control one. Full recanalization of the PV at six months was observed in 24 patients (80%), who had received Diosmin/Hesperidin, and only in 17 persons (57%) of the control group (p=0.047). The median of Villalta score in the group treated with Diosmin/Hesperidin was significantly lower compared to the control one (2.9±2.7 versus 5.8±3.0 [p <0.0001]). The same difference was found for VCSS score (2.3±1.9 versus 4.9±1.9 [p <0001]). According to the Villalta score, PTS was recognized in six patients (20%) and 17 patients (57%) in the experimental and control groups, respectively (p=0.004). Conclusion: Long-term treatment with Diosmin/Hesperidin can increase the speed of deep vein recanalization and reduce the incidence of PTS diagnosed at six months in patients with proximal DVT treated with oral rivaroxaban. Disclosures Lobastov: Bayer: Honoraria, Speakers Bureau; Servier: Honoraria, Speakers Bureau. Schastlivtsev:Bayer: Honoraria, Speakers Bureau; Servier: Honoraria, Speakers Bureau. Barinov:Bayer: Honoraria, Speakers Bureau; Servier: Honoraria, Speakers Bureau.

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