U-shaped curve of psychosis according to cannabis use: New evidence from a snowball sample

2016 ◽  
Vol 30 (12) ◽  
pp. 1331-1338 ◽  
Author(s):  
Antía Brañas ◽  
María L Barrigón ◽  
Nathalia Garrido-Torres ◽  
Salvador Perona-Garcelán ◽  
Juan F Rodriguez-Testal ◽  
...  
Keyword(s):  
Social Exclusion ◽  
Age Of Onset ◽  
Clinical Sample ◽  
Cannabis Use ◽  
Psychotic Experiences ◽  
Snowball Sampling ◽  
Negative Dimension ◽  
Alcohol And Other Drugs ◽  
New Evidence ◽  
The Relationship

Background: The aim of this study was to investigate the relationship between psychotic-like experiences (PLEs) assessed using the Community Assessment of Psychic Experience (CAPE) questionnaire and the pattern of cannabis use in a non-clinical sample collected by snowball sampling. Methods: Our sample was composed of 204 subjects, distributed into three groups by their cannabis use pattern: 68 were non-cannabis users, 40 were moderate cannabis users and 96 were daily cannabis users. We assessed the psychotic experiences in each group with the CAPE questionnaire; and then controlled for the effect of possible confounding factors like sex, age, social exclusion, age of onset of cannabis use, alcohol use and other drug use. Results: We found a significant quadratic association between the frequency of cannabis use and positive (β = −1.8; p = 0.004) and negative dimension scores (β = −1.2; p = 0.04). The first-rank and mania factors showed a significant quadratic association ( p < 0.05), while the voices factor showed a trend ( p = 0.07). Scores for the different groups tended to maintain a U-shape in their values for the different factors. When we adjusted for gender, age, social exclusion, age of onset of cannabis use, and use of alcohol and other drugs, only the first-rank experiences remained significant. Conclusions: We found there was a U-shaped curve in the association between cannabis use and the positive and negative dimensions of the CAPE score. We also found this association in mania and first-rank experiences.

scholarly journals Associations of cannabis and cigarette use with psychotic experiences at age 18: findings from the Avon Longitudinal Study of Parents and Children

2014 ◽  
Vol 44 (16) ◽  
pp. 3435-3444 ◽  
Author(s):  
S. H. Gage ◽  
M. Hickman ◽  
J. Heron ◽  
M. R. Munafò ◽  
G. Lewis ◽  
...  
Keyword(s):  
Illicit Drugs ◽  
Cannabis Use ◽  
Similar Degree ◽  
Cigarette Use ◽  
Psychotic Experiences ◽  
Parents And Children ◽  
Independent Effects ◽  
Almost All ◽  
The Relationship ◽  
Avon Longitudinal Study

Background.A clearer understanding of the basis for the association between cannabis use and psychotic experiences (PEs) is required. Our aim was to examine the extent to which associations between cannabis and cigarette use and PEs are due to confounding.Method.A cohort study of 1756 adolescents with data on cannabis use, cigarette use and PEs.Results.Cannabis use and cigarette use at age 16 were both associated, to a similar degree, with PEs at age 18 [odds ratio (OR) 1.48, 95% confidence interval (CI) 1.18–1.86 for cannabis and OR 1.61, 95% CI 1.31–1.98 for cigarettes]. Adjustment for cigarette smoking frequency (OR 1.27, 95% CI 0.91–1.76) or other illicit drug use (OR 1.25, 95% CI 0.91–1.73) substantially attenuated the relationship between cannabis and PEs. The attenuation was to a lesser degree when cannabis use was adjusted for in the cigarette PE association (OR 1.42, 95% CI 1.05–1.92). However, almost all of the participants used cannabis with tobacco, including those who classed themselves as non-cigarette smokers.Conclusions.Teasing out the effects of cannabis from tobacco is highly complex and may not have been dealt with adequately in studies to date, including this one. Complementary methods are required to robustly examine the independent effects of cannabis, tobacco and other illicit drugs on PEs.

scholarly journals Cannabis Use, Schizotypy and Kamin Blocking Performance

2021 ◽  
Vol 12 ◽  
Author(s):  
Christopher Dawes ◽  
Andrea Bickerdike ◽  
Cian O'Neill ◽  
Sarah Carneiro Pereira ◽  
John L. Waddington ◽  
...  
Keyword(s):  
Associative Learning ◽  
Clinical Sample ◽  
Cannabis Use ◽  
First Episode ◽  
Cross Sectional ◽  
Schizotypal Personality ◽  
Increased Risk ◽  
History Of ◽  
Aberrant Salience ◽  
The Relationship

Cannabis use has been associated with increased risk for a first episode of psychosis and inappropriate assignment of salience to extraneous stimuli has been proposed as a mechanism underlying this association. Psychosis-prone (especially schizotypal) personality traits are associated with deficits in associative learning tasks that measure salience allocation. The aim of this study was to examine the relationship between history of cannabis use and Kamin blocking (KB), a form of selective associative learning, in a non-clinical sample. Additionally, KB was examined in relation to self-reported schizotypy and aberrant salience scale profiles. A cross-sectional study was conducted in 307 healthy participants with no previous psychiatric or neurological history. Participants were recruited and tested using the Testable Minds behavioural testing platform. KB was calculated using Oades' “mouse in the house task”, performance of which is disrupted in schizophrenia patients. Schizotypy was measured using the Schizotypal Personality Questionnaire (SPQ), and the Aberrant Salience Inventory (ASI) was used to assess self-reported unusual or inappropriate salience. The modified Cannabis Experience Questionnaire (CEQm) was used to collect detailed history of use of cannabis and other recreational drugs. Regression models and Bayesian t-tests or ANOVA (or non-parametric equivalents) examined differences in KB based on lifetime or current cannabis use (frequent use during previous year), as well as frequency of use among those who had previously used cannabis. Neither lifetime nor current cannabis use was associated with any significant change in total or trial-specific KB scores. Current cannabis use was associated with higher Disorganised SPQ dimension scores and higher total and sub-scale values for the ASI. A modest positive association was observed between total KB score and Disorganised SPQ dimension scores, but no relationships were found between KB and other SPQ measures. Higher scores on “Senses Sharpening” ASI sub-scale predicted decreased KB score only in participants who have not engaged in recent cannabis use. These results are discussed in the context of our understanding of the effects of long-term cannabis exposure on salience attribution, as well as inconsistencies in the literature with respect to both the relationship between KB and schizotypy and the measurement of KB associative learning phenomena.

Exploring the Causal Relationship Between Cannabis and Schizophrenia: What is the Role of Genes and Environment?

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
R. Kuepper ◽  
I. Myin-Germeys ◽  
M. Konings ◽  
R. van Winkel ◽  
J. van Os ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Cannabis Use ◽  
Comt Gene ◽  
Differential Sensitivity ◽  
Frequent Use ◽  
Gene Environment ◽  
Genes And Environment ◽  
New Evidence ◽  
Moderating Role

Frequent use of cannabis has been associated with poor outcome in patients with psychosis or schizophrenia, and research has become more and more interested in the question whether cannabis may actually cause psychosis or schizophrenia. Since only a minority of cannabis users eventually develops psychosis or schizophrenia, cannabis is suggested to be a component cause, potentially interacting with environmental as well as genetic factors. However, little is known about this putative interaction. Recent research in our group has therefore focused on differential sensitivity to cannabis and its psychosis-inducing effects. Experimental and observational work for instance showed that a functional polymorphism within the COMT gene moderates the acute effects of cannabis on psychosis outcome. In this presentation new evidence from epidemiological work is presented, showing gene-environment interactions within the cannabis-psychosis association. These results point to a moderating role for both age of onset of cannabis use and childhood trauma. Also a certain haplotype within the COMT gene was found to increase the risk of developing schizophrenia after adolescent cannabis use. Complex gene-environment interactions as well as interactions between cannabis and other environmental risk factors seem to underlie the cannabis-psychosis relationship. Possible biological mechanisms such as sensitization processes that may underlie these interactions will be discussed.

scholarly journals F190. EFFECT OF SELECTED GENE VARIANTS ON THE RELATIONSHIP BETWEEN EARLY CANNABIS USE AND AGE OF ONSET OF PSYCHOSIS

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S295-S295
Author(s):  
Rohit Lodhi ◽  
Yabing Wang ◽  
Gina McIntyre ◽  
David Rossolatos ◽  
Sudhakar Sivapalan ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Cannabis Use ◽  
Gene Variants ◽  
The Relationship

scholarly journals Early, Chronic, and Acute Cannabis Exposure and Their Relationship With Cognitive and Behavioral Harms

2021 ◽  
Vol 12 ◽  
Author(s):  
Hugo López-Pelayo ◽  
Eugènia Campeny ◽  
Clara Oliveras ◽  
Jürgen Rehm ◽  
Jakob Manthey ◽  
...  
Keyword(s):  
Online Survey ◽  
Motor Vehicle ◽  
Age Of Onset ◽  
Pearson Correlation ◽  
Two Dimensions ◽  
Cannabis Use ◽  
Categorical Variables ◽  
Five Dimensions ◽  
Custom Made ◽  
The Relationship

Background: Cannabis is the third most consumed drug worldwide. Thus, healthcare providers should be able to identify users who are in need for an intervention. This study aims to explore the relationship of acute, chronic, and early exposure (AE, CE, and EE) to cannabis with cognitive and behavioral harms (CBH), as a first step toward defining risky cannabis use criteria.Methods: Adults living in Spain who used cannabis at least once during the last year answered an online survey about cannabis use and health-related harms. Cannabis use was assessed in five dimensions: quantity on use days during the last 30 days (AE), frequency of use in the last month (AE), years of regular use (YRCU) (CE), age of first use (AOf) (EE), and age of onset of regular use (AOr) (EE). CBH indicators included validated instruments and custom-made items. Pearson correlations were calculated for continuous variables, and Student's t-tests for independent samples were calculated for categorical variables. Effect sizes were calculated for each of the five dimensions of use (Cohen's d or r Pearson correlation) and harm outcome. Classification and Regression Trees (CART) analyses were performed for those dependent variables (harms) significantly associated with at least two dimensions of cannabis use patterns. Lastly, logistic binary analyses were conducted for each harm outcome.Results: The mean age of participants was 26.2 years old [standard deviation (SD) 8.5]. Out of 2,124 respondents, 1,606 (75.6%) reported at least one harm outcome (mean 1.8 and SD 1.5). In our sample, using cannabis on 3 out of 4 days was associated with an 8-fold probability of scoring 4+ on the Severity Dependence Scale (OR 8.33, 95% CI 4.91–14.16, p &lt;0.001), which is indicative of a cannabis use disorder. Also, a start of regular cannabis use before the age of 25 combined with using cannabis at least once per month was associated with a higher probability of risky alcohol use (OR 1.33, 95% CI 1.12–1.57, p = 0.001). Besides, a start of regular cannabis use before the age of 18 combined with a period of regular use of at least 7.5 years was associated with a higher probability of reporting a motor vehicle accident (OR 1.81, 95% CI 1.41–2.32, p &lt; 0.0001). Results were ambiguous regarding the role that age of first use and milligrams of THC per day of use might play regarding cannabis-related harms.Conclusions: The relationship among AE, CE, and EE with CBH indicators is a complex phenomenon that deserves further studies. The pattern of cannabis use should be carefully and widely evaluated—(not just including frequency but also other dimensions of pattern of use)—in research (preferably in longitudinal studies) to assess cannabis-related harms.

scholarly journals Schizotypy and psychosis-like experiences from recreational cannabis in a non-clinical sample

2008 ◽  
Vol 38 (9) ◽  
pp. 1267-1276 ◽  
Author(s):  
E. Barkus ◽  
S. Lewis
Keyword(s):  
Individual Differences ◽  
Clinical Sample ◽  
Cannabis Use ◽  
Psychotic Symptoms ◽  
Subjective Experiences ◽  
After Effects ◽  
Schizotypal Personality ◽  
Patterns Of Use ◽  
The Individual ◽  
The Relationship

BackgroundThe relationship between cannabis use and psychosis is still a matter for debate. Accounting for the individual differences in subjective experiences to recreational cannabis use in the general population may hold some clues to the aetiological relationship between cannabis and psychotic symptoms. We hypothesized that schizotypy would account for the individual differences in subjective experiences after cannabis use but not in patterns of use.MethodIn a sample of 532 young people who had used cannabis at least once, we examined the relationship between the Cannabis Experiences Questionnaire (CEQ) and the Schizotypal Personality Questionnaire (SPQ). Additionally, we examined the psychometric properties of the CEQ.ResultsWe replicated our previously reported findings that schizotypy was associated with increased psychosis-like experiences and after-effects, but also found that high-scoring schizotypes reported more pleasurable experiences when smoking cannabis. Using new subscales derived from principal components analysis (PCA), we found that the psychosis-like items were most related to varying rates of schizotypy both during the immediate use of cannabis and in the after-effects of cannabis use. High-scoring schizotypes who used cannabis experienced more psychosis-like symptoms during and after use.ConclusionsOur results suggest that cannabis use may reveal an underlying vulnerability to psychosis in those with high schizotypal traits.

Adolescents’ self-mutilation - Relationship with dependent behaviour

2003 ◽  
Vol 62 (4) ◽  
pp. 241-249 ◽  
Author(s):  
M. Bolognini ◽  
B. Plancherel ◽  
J. Laget ◽  
P. Stéphan ◽  
O. Halfon
Keyword(s):  
Suicide Attempts ◽  
Clinical Sample ◽  
Control Sample ◽  
Clinical Population ◽  
Control Group ◽  
Clinical Group ◽  
Self Mutilation ◽  
Self Harm ◽  
Partial Overlap ◽  
The Relationship

The aim of this study, which was carried out in the French-speacking part of Switzerland, was to examine the relationship between suicide attempts and self-mutilation by adolescents and young adults. The population, aged 14-25 years (N = 308), included a clinical sample of dependent subjects (drug abuse and eating disorders) compared to a control sample. On the basis of the Mini Neuropsychiatric Interview ( Sheehan et al., 1998 ), DSM-IV criteria were used for the inclusion of the clinical population. The results concerning the occurrence of suicide attempts as well as on self-mutilation confirm most of the hypotheses postulated: suicidal attempts and self-mutilation were more common in the clinical group compared to the control group, and there was a correlation between suicide attempts and self-mutilation. However, there was only a partial overlap, attesting that suicide and self-harm might correspond to two different types of behaviour.

Perceived uniqueness: Locus of control, social exclusion, and choice

2019 ◽  
Vol 47 (11) ◽  
pp. 1-7
Author(s):  
Shichang Liang ◽  
Yaping Chang ◽  
XueBing Dong ◽  
Jinshan Wang
Keyword(s):  
Locus Of Control ◽  
Social Exclusion ◽  
Undergraduate Students ◽  
Social Inclusion ◽  
Personal Control ◽  
Central China ◽  
External Locus ◽  
Internal Locus Of Control ◽  
Uniqueness Results ◽  
The Relationship

We examined the influence of locus of control on the relationship between social exclusion and preference for distinctive choices. Participants were 212 undergraduate students at a university in Central China, who completed measures of social exclusion, locus of control, choice, and perceived uniqueness. Results showed that participants who believed that the environment controlled their fate (external locus of control) preferred more distinctive choices in a social exclusion context than in a social inclusion context, whereas participants who believed that they could control the environment (internal locus of control) preferred less distinctive choices. Further, perceived uniqueness mediated the effect of social exclusion and locus of control on choice. These results add to the literature on social exclusion and personal control.

Bridging the Gap between Political and Penal Legitimacy

2018 ◽  
Author(s):  
Ralph Henham
Keyword(s):  
Political Economy ◽  
Social Exclusion ◽  
Social Value ◽  
The Political ◽  
Institutional Reforms ◽  
Social Morality ◽  
Penal Policy ◽  
England And Wales ◽  
Sentencing Policy ◽  
The Relationship

This chapter argues that the relationship between penal policy and the political economy provides important insights into the political and institutional reforms required to minimize harsh and discriminatory penal policies. However, the capacity of sentencing policy to engage with this social reality in a meaningful way necessitates a recasting of penal ideology. To realize this objective requires a profound understanding of sentencing’s social value and significance for citizens. The greatest challenge then lies in establishing coherent links between penal ideology and practice to encourage forms of sentencing that are sensitive to changes in social value. The chapter concludes by explaining how the present approach taken by the courts of England and Wales to the sentencing of women exacerbates social exclusion and reinforces existing divisions in social morality. It urges fundamental changes in ideology and practice so that policy reflects a socially valued rationale for the criminalization and punishment of women.

The Alerting and Orienting Systems of Attention Are Modified by Cannabis Dependence

2021 ◽  
Vol 27 (6) ◽  
pp. 520-532
Author(s):  
Ivett E. Ortega-Mora ◽  
Ulises Caballero-Sánchez ◽  
Talía V. Román-López ◽  
Cintia B. Rosas-Escobar ◽  
Mónica Méndez-Díaz ◽  
...  
Keyword(s):  
Selective Attention ◽  
Control Systems ◽  
Executive Control ◽  
Age Of Onset ◽  
Relevant Information ◽  
Cannabis Use ◽  
Network Systems ◽  
Attention Network ◽  
Cannabis Dependence ◽  
Alerting System

AbstractAttention allows us to select relevant information from the background. Although several studies have described that cannabis use induces deleterious effects on attention, it remains unclear if cannabis dependence affects the attention network systems differently.Objectives:To evaluate whether customary consumption of cannabis or cannabis dependence impacts the alerting, orienting, and executive control systems in young adults; to find out whether it is related to tobacco or alcohol dependence and if cannabis use characteristics are associated with the attention network systems.Method:One-hundred and fifty-four healthy adults and 102 cannabis users performed the Attention Network Test (ANT) to evaluate the alerting, orienting, and executive control systems.Results:Cannabis use enhanced the alerting system but decreased the orienting system. Moreover, those effects seem to be associated with cannabis dependence. Out of all the cannabis-using variables, only the age of onset of cannabis use significantly predicted the efficiency of the orienting and executive control systems.Conclusion:Cannabis dependence favors tonic alertness but reduces selective attention ability; earlier use of cannabis worsens the efficiency of selective attention and resolution of conflicts.

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