scholarly journals Lights and shadows of schizophrenia therapy research: Lessons from oral risperidone and olanzapine

2020 ◽  
Vol 34 (5) ◽  
pp. 574-579
Author(s):  
Eraldo F Nicotra ◽  
Daniele Lecca ◽  
Gianluca Casu ◽  
Mario Palomba ◽  
Annesha Sil ◽  
...  
Keyword(s):  
Atypical Antipsychotics ◽  
Antipsychotic Drugs ◽  
Time Dependent ◽  
Research Articles ◽  
Clinical Effects ◽  
Independent Research ◽  
Systematic Analysis ◽  
Oral Risperidone ◽  
Dramatic Decline ◽  
Shape Pattern

Background: Recently, patents of several atypical antipsychotics have reached their expiration date. Aims: The purpose of the study was to highlight whether modifications of economic/scientific factors may be associated with possible changes in ongoing clinical research on antipsychotic drugs. Methods: A large systematic analysis was used to depict the time-dependent distribution of published research articles addressing the clinical properties of oral risperidone and olanzapine conventional tablets, two largely prescribed atypical antipsychotics for which the patents have already expired in most of the countries. Results: The systematic analysis indicated that the time-dependent distribution of the selected research articles followed a wave-shape pattern. A dramatic decline of primary and secondary analyses investigating the clinical effects of oral risperidone and olanzapine has occurred in the last decade, complemented by an expected strong reduction in the numbers of industrial-supported clinical studies and a smaller, but significant, decline in the amount of independent research articles. Conclusions: To date, greater involvement of independent research seems to be the only realistic chance to properly continue the investigation on the clinical properties of oral risperidone and olanzapine conventional tablets, as well as those of other off-patent antipsychotic drugs. However, the limits and potentialities of independent research in accomplishing such a demanding and enduring scientific effort should be addressed.

Scientific Research Articles

2021 ◽  
pp. 195-219
Author(s):  
John Blake
Keyword(s):  
Community Of Practice ◽  
Scientific Research ◽  
Scientific Writing ◽  
Research Articles ◽  
Common Language ◽  
Systematic Analysis ◽  
Internal Review ◽  
Publication Success ◽  
Scientific Research Articles ◽  
Research Institute

Error-free scientific research articles are more likely to be accepted for publication than those permeated with errors. This chapter identifies, describes, and explains how to avoid 22 common language errors. Scientists need to master the genre of scientific writing to conform to the generic expectations of the community of practice. Based on a systematic analysis of the pedagogic literature, five categories of errors were identified in scientific research articles namely accuracy, brevity, clarity, objectivity, and formality. To gain a more in-depth understanding of the errors, a corpus investigation of scientific articles was conducted. A corpus of 200 draft research articles submitted for internal review at a research institute with university status was compiled, annotated, and analyzed. This investigation showed empirically the types of errors within these categories that may impinge on publication success. In total, 22 specific types of language errors were identified. These errors are explained, and ways for overcoming each of them are described.

FORWARD-RATE VOLATILITIES AND THE SWAPTION MATRIX: WHY NEITHER TIME-HOMOGENEITY NOR TIME-DEPENDENCE ARE ENOUGH

2006 ◽  
Vol 09 (05) ◽  
pp. 705-746 ◽  
Author(s):  
RICCARDO REBONATO
Keyword(s):  
Markov Chain ◽  
Market Volatility ◽  
Time Dependent ◽  
Forward Rate ◽  
Systematic Analysis ◽  
Option Markets ◽  
Markov Chain Approach ◽  
Major Market ◽  
Volatility Model

This work presents the first systematic analysis of the whole swaption matrix by fitting a parsimonious, nonlinear, financially-inspired volatility model to market data. The study uses several years of data spanning period of major market volatility. We find that the quality of the fits is good (on average of the same magnitude as the bid-offer spread), and better when a displaced-diffusion approach is chosen, but some systematic shortcomings are observed and discussed. The analysis suggests that a two-regime Markov chain approach may be more successful and better financially motivated. More generally, the present study highlights the shortcomings of purely time-dependent or time-homogenous approaches. These findings should be applicable to other option markets as well. Finally, we find that the present (nonlinear) model vastly outperforms PCA-based approaches when in comes to predicting moves in implied volatilities.

scholarly journals Hydrocortisone-induced anti-inflammatory effects in immature human enterocytes depend on the timing of exposure

2016 ◽  
Vol 310 (11) ◽  
pp. G920-G929 ◽  
Author(s):  
Samuli Rautava ◽  
W. Allan Walker ◽  
Lei Lu
Keyword(s):  
Gene Expression ◽  
Cdna Microarray ◽  
Inflammatory Responses ◽  
Expression Patterns ◽  
Time Dependent ◽  
Gene Expression Patterns ◽  
Clinical Effects ◽  
Human Gut ◽  
Physiological Basis ◽  
Tnf Α

The immature human gut has a propensity to exaggerated inflammatory responses that are thought to play a role in the pathogenesis of necrotizing enterocolitis (NEC). Prenatal exposure to corticosteroids has been reported to reduce the risk of NEC, while postnatal dexamethasone treatment is associated with adverse neurodevelopmental outcomes in preterm infants. The aim of this study was to investigate the direct role of hydrocortisone in gene expression patterns and inflammatory responses in immature human enterocytes. Time-dependent hydrocortisone effects in nontransformed primary human fetal intestinal epithelial cell line H4 were investigated by cDNA microarray. Fetal intestinal organ culture and cell culture experiments were conducted. Inflammatory responses were induced by stimulation with IL-1β and TNF-α with and without hydrocortisone. IL-8 and IL-6 expression and secretion were measured as functional readout. Here we report time-dependent hydrocortisone-induced changes in gene expression patterns detected by cDNA microarray. Hydrocortisone significantly attenuated IL-1β-induced inflammatory responses in the immature human gut when administered at the time of the proinflammatory insult: IL-1β-induced IL-8 and IL-6 secretion in the fetal ileum as well as H4 cells were significantly reduced. Hydrocortisone also inhibited IL-8 secretion in response to TNF-α. In contrast, TNF-α-induced IL-8 secretion was not reduced in cells treated with hydrocortisone for 48 h before stimulation. Our observations provide a physiological basis for understanding the differential clinical effects of corticosteroids in the immature human gut depending on the timing of treatment.

Sexual Dysfunction and Psychotropic Medications

CNS Spectrums ◽  
2006 ◽  
Vol 11 (S9) ◽  
pp. 24-30 ◽  
Author(s):  
Glen L. Stimmel ◽  
Mary A. Gutierrez
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Functioning ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Atypical Antipsychotics ◽  
Antipsychotic Drugs ◽  
Psychotropic Medications ◽  
Self Report ◽  
Dopamine Antagonist ◽  
Seizure Disorders ◽  
Rule Out

AbstractPsychotropic drugs are often associated with sexual dysfunction. The frequency of antidepressant-associated sexual dysfunction is greatly underestimated in clinical trials that rely on patient self-report of these adverse events. Direct inquiry reveals that delayed orgasm/ejaculation occurs in ≥50% and anorgasmia in at least one third of patients given selective serotonin reuptake inhibitors. Antidepressant-induced sexual dysfunction can be successfully managed. A different antidepressant without significant sexual effects, such as bupropion or mirtazapine, can often be substituted. Other strategies involve drug holidays or adjunctive therapy with drugs such as sildenafil. Dopamine antagonist antipsychotic drugs are most commonly associated with decreased libido. The newer atypical antipsychotics, with less effect on dopamine, are less commonly associated with sexual dysfunction. Sexual dysfunction is commonly reported with seizure disorders, and many anticonvulsant drugs affect levels of sex hormones. Because sexual dysfunction can be related to many factors, care must be taken to establish the patient's baseline sexual functioning before the initiation of psychotropic drug therapy and to rule out other etiologies before drugs are implicated as causative.

Antipsychotics-induced leukopenia and neutropenia: A case report and review of literature

2016 ◽  
Vol 33 (S1) ◽  
pp. S546-S546 ◽  
Author(s):  
H. Maatallah ◽  
H. Ben Ammar ◽  
M. Said ◽  
A. Aissa
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Atypical Antipsychotics ◽  
Antipsychotic Drugs ◽  
Psychotic Symptoms ◽  
Review Of Literature ◽  
Blood Cell Count ◽  
Life Threatening ◽  
Dsm Iv ◽  
Competing Interest

IntroductionAntipsychotic drugs effectively control psychotic symptoms, but may cause important side effects, significantly increasing morbidity and mortality. Hematologic abnormalities are frequent and may be life-threatening in some patients. Many prospective investigations confirmed neutropenia as a frequent occurrence with virtually all atypical antipsychotics.Objective and methodsDefine epidemiological, clinical and therapeutic characteristics of antipsychotics – induced leukopenia and neutropenia through a case report and a review of literature.Case reportPatient 28 years old native of Tunis, with family history: brother who suffer of undifferentiated schizophrenia. Since the age of 16 years he has been followed for disorganized schizophrenia (DSM IV). He was initially put under Haldol Decanoate (2 months), fluphenazine (2 months), amisulpride (3 months), sulpride (2 months), olanzapine (3 months), Rispreridone (1 month), aripiprazole (5 months) leukopenia/neutropenia is occurring during treatment with each molecule and which promptly resolved after discontinuation. Reduced white blood cell count has also been reported after addition of lithium. Actually an ECT is proposed for this patient.ConclusionThis case report shows the importance of hematological monitoring during the course of typical or atypical treatment.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Amantadine in the Treatment of Sexual Inactivity in Schizophrenia Patients Taking Atypical Antipsychotics—The Pilot Case Series Study

2021 ◽  
Vol 14 (10) ◽  
pp. 947
Author(s):  
Marek Krzystanek ◽  
Anna Warchala ◽  
Beata Trędzbor ◽  
Ewa Martyniak ◽  
Katarzyna Skałacka ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Functioning ◽  
Preliminary Report ◽  
Atypical Antipsychotics ◽  
Antipsychotic Drugs ◽  
Short Form ◽  
Case Series ◽  
Reward System ◽  
Case Series Study ◽  
Series Study

Sexual dysfunctions in people with schizophrenia are more severe than in the general population and are an important element in the treatment of schizophrenia. The mechanism of sexual dysfunction in patients treated for schizophrenia may be related to the side effects of antipsychotic drugs (hyperprolactinemia, suppression of the reward system), but it may also be related to the pathogenesis of schizophrenia itself. The aim of the study was to present the possibility of using amantadine in the treatment of sexual dysfunction in schizophrenia without the concomitant hyperprolactinemia. In an open and naturalistic case series study, five men treated for schizophrenia in a stable mental state were described. All patients reported a prolonged lack of sexual desire and sexual activity prior to treatment with amantadine. After exclusion of hyperprolactinemia, patients received amantadine 100 mg in the evening. Sexual dysfunction was assessed using subscales of the 14-point Short Form of the Changes in Sexual Functioning Questionnaire (CSFQ-14). On subsequent visits after 1, 2 and 3 months of administration of amantadine, an improvement in sexual functioning was observed in all patients. Although this is only the preliminary report, amantadine may become a new indication for the treatment of sexual dysfunction in schizophrenia patients.

scholarly journals Comparative Efficacy and Safety of Antipsychotic Drugs for Tic Disorders: A Systematic Review and Bayesian Network Meta-Analysis

2018 ◽  
Vol 52 (01) ◽  
pp. 07-15 ◽  
Author(s):  
Chunsong Yang ◽  
Zilong Hao ◽  
Ling-Li Zhang ◽  
Cai-Rong Zhu ◽  
Ping Zhu ◽  
...  
Keyword(s):  
Symptom Score ◽  
Atypical Antipsychotics ◽  
Antipsychotic Drugs ◽  
Meta Analysis ◽  
Tic Disorders ◽  
Cochrane Library ◽  
Efficacy And Safety ◽  
Randomized Controlled ◽  
Mean Differences ◽  
Robust Evidence

Abstract Objective The purpose of this study was to evaluate the efficacy and safety of antipsychotic drugs for tic disorders (TDs) in a network meta-analysis. Methods PubMed, Embase, Cochrane Library, and 4 Chinese databases were searched. Randomized controlled trials (RCTs) evaluating the efficacy of antipsychotic drugs for TDs were included. Results Sixty RCTs were included. In terms of tic symptom score, compared with placebo, haloperidol, risperidone, aripiprazole, quetiapine, olanzapine, and ziprasidone can significantly improve tic symptom score (standardized mean differences [SMD] ranged from −12.32 to −3.20). Quetiapine was superior to haloperidol, pimozide, risperidone, tiapride, aripiprazole, and penfluridol for improving tic symptom score (SMD ranged from −28.24 to −7.59). Compared with tiapride, aripiprazole could significantly improve tic symptom score (SMD=−4.27). Compared with all other drugs, penfluridol was not effective. Atypical antipsychotics were generally well tolerated. Conclusions Atypical antipsychotics (risperidone and aripiprazole) appear to be the most robust evidence-based options for the treatment of TDs. Quetiapine may be a promising therapy. Ziprasidone and olanzapine are also effective, but the evidence is lacking. Further high-quality directly comparing different pharmacological treatment studies are justified.

The Importance of Serotonin-Dopamine Interactions in the Action of Clozapine

1992 ◽  
Vol 160 (S17) ◽  
pp. 22-29 ◽  
Author(s):  
Herbert Y. Meltzer
Keyword(s):  
Atypical Antipsychotic ◽  
Atypical Antipsychotics ◽  
Antipsychotic Drugs ◽  
Typical Antipsychotic ◽  
Atypical Antipsychotic Drugs ◽  
Clinical Dose ◽  
High Affinity ◽  
The Relationship

Clozapine has an affinity for the dopamine (DA) D2 receptor which is relatively weak but is in line with its average clinical dose when compared with typical neuroleptic drugs. A few atypical antipsychotic drugs may have high absolute affinities for the D2 receptor, but most are weak D2 blockers. The atypical antipsychotic drugs also differ from the typical antipsychotic drugs by a relatively high affinity for the serotonin (5-HT2) receptor. This is evident on both in vitro and in vivo binding to cortical 5-HT2 receptors. The atypical antipsychotics are best distinguished from the typical antipsychotics on the basis of the relationship between strong 5-HT2 and weak D2 affinities. High D1 receptor binding is not characteristic of the group of atypical drugs. A new group of putative atypical antipsychotic drugs with high affinities for 5-HT2 compared to D2 receptors is under study.

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