scholarly journals Correlation between lower extremity arterial disease and skeletal muscle mass in patients with type 2 diabetes mellitus

2020 ◽  
Vol 48 (3) ◽  
pp. 030006051989748
Author(s):  
Yinghui Zhang ◽  
Lemeng Ren ◽  
Fengjie Zheng ◽  
Xianghua Zhuang ◽  
Dongqing Jiang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Skeletal Muscle ◽  
Uric Acid ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Arterial Disease ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Lower Extremity Arterial Disease

Objectives To evaluate skeletal muscle mass in patients with both type 2 diabetes mellitus (T2DM) and concomitant lower extremity arterial disease (LEAD) and determine the contribution of skeletal muscle mass to macrovascular diseases. Methods In total, 112 patients with T2DM were divided into the T2DM and T2DM + LEAD groups. Hepatic function, renal function, uric acid, blood glucose, and glycated hemoglobin (HbA1C) were measured. Dual-energy X-ray absorptiometry was used to measure visceral fat area and skeletal muscle mass index (SMI). Results Waist-to-hip ratio, uric acid, and body fat percentage were significantly higher in the T2DM+LEAD group than in the T2DM group; SMI was significantly lower in the T2DM+LEAD group than in the T2DM group. There were no significant differences in albumin, creatinine, fasting blood glucose, HbA1C, or blood lipids. Uric acid, SMI, and body fat percentage were significantly positively correlated with T2DM and concomitant LEAD. Logistic regression analyses suggested that SMI is an independent risk factor for LEAD in T2DM (odds ratio = 1.517; 95% confidence interval: 1.082–2.126). Conclusions Skeletal muscle mass is lower in patients with T2DM and concomitant LEAD than in patients with T2DM who do not exhibit LEAD. SMI is an important risk factor for LEAD.

scholarly journals Association between skeletal muscle mass and insulin secretion in patients with type 2 diabetes mellitus

2014 ◽  
Vol 61 (3) ◽  
pp. 281-287 ◽  
Author(s):  
Kanako Shishikura ◽  
Keiji Tanimoto ◽  
Satoshi Sakai ◽  
Yoshimi Tanimoto ◽  
Jungo Terasaki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Secretion ◽  
Muscle Mass ◽  
Skeletal Muscle Mass

scholarly journals The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Chen-Ning Wu ◽  
Kai-Jen Tien
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Geriatric Syndrome ◽  
Contributing Factors ◽  
Antidiabetic Agents ◽  
The Impact

Sarcopenia is a geriatric syndrome characterized by decline of skeletal muscle mass and function. Contributing factors include nutritional, genetic, inflammatory, and endocrinal factors. The reported prevalence of sarcopenia in type 2 diabetes mellitus is high, especially in patients with poor glycemic control. Additionally, antidiabetic agents may alter the balance between protein synthesis and degradation through various mechanisms of skeletal muscle mass regulation. This study reviewed the literature on the pathogenesis of sarcopenia in diabetes mellitus and the current understanding of whether antidiabetic agents contribute positively or negatively to sarcopenia and muscle wasting.

scholarly journals Changes and Risk Factors of Skeletal Muscle Mass and Strength in Patients with Type 2 Diabetes over 60 Years Old: A Cross-Sectional Study from China

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Liming Hou ◽  
Yan Liu ◽  
Xing Li ◽  
Cong Huo ◽  
Xin Jia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Muscle Strength ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Education Level ◽  
Diabetic Patients

Objective. The accelerate loss of skeletal muscle mass, strength, and function, named sarcopenia, is a progressive and generalised skeletal muscle disorder, and it is always associated with increased outcomes including falls, frailty, and disability. Diabetes mellitus is associated with significant muscle and physical complications. We aimed at clarifying the changes and risk factors of skeletal muscle mass and strength in elderly with type 2 diabetes. Methods. The study consisted of patients with type 2 diabetes ( n = 120 ) and an older general population ( n = 126 ). The skeletal muscle mass and muscle strength, as well as the serum levels of chronic inflammation, oxidative stress, homocysteine, and insulin-like factor-1 were assessed, and the correlation and regression analysis were conducted to evaluate outcomes. Results. T2DM patients exhibited lower muscle strength compared with the non-T2DM subjects ( P < 0.01 ). Among T2DM patients, serum IGF-1 levels were positively correlated with muscle strength ( r = 0.255 , P < 0.01 ) and muscle mass ( r = 0.209 , P < 0.05 ), levels of 8-OHdG were inversely correlated with muscle strength ( r = − 0.252 , P < 0.01 ), and there was a negative association between HCY and muscle mass ( r = − 0.185 , P < 0.05 ). Muscle mass and strength of patients with higher education level were significantly higher than those with lower education level ( P < 0.05 ), in male patients, muscle mass and muscle strength were significantly lower in smokers ( P < 0.01 ), and muscle mass was lower in chronic drinkers ( P < 0.05 ). Conclusions. These findings suggest that diabetic patients may be more susceptible to sarcopenia at an older age. And it also provides evidences that among elderly with diabetes mellitus, oxidative damage and HCY as well as IGF-1 are important predictors of age-dependent sarcopenia.

scholarly journals Low skeletal muscle mass is associated with the risk of all-cause mortality in patients with type 2 diabetes mellitus

2019 ◽  
Vol 10 ◽  
pp. 204201881984297
Author(s):  
Hitomi Miyake ◽  
Ippei Kanazawa ◽  
Ken-ichiro Tanaka ◽  
Toshitsugu Sugimoto
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Type 2 Diabetes Mellitus ◽  
Muscle Mass ◽  
Body Mass ◽  
Skeletal Muscle Mass ◽  
Historical Cohort ◽  
All Cause Mortality

Background: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of muscle mass reduction. However, the association between muscle mass and mortality in T2DM remains unknown. Methods: This was a historical cohort study with the endpoint of all-cause mortality. This study included 163 Japanese men and 141 postmenopausal women with T2DM whose body compositions were evaluated using dual-energy X-ray absorptiometry. Low muscle mass was defined as a skeletal muscle mass index (SMI) of <7.0 kg/m2 for men and <5.4 kg/m2 for women. Results: During the 6-year follow-up period, 32 men and 14 women died. In a Cox regression analysis adjusted for age, T2DM duration, glycated hemoglobin, serum creatinine, fasting C-peptide, body mass index, and lean body mass were associated with the risk of mortality in men [hazard ratio (HR) = 1.81, 95% confidence interval (CI) = 1.00–3.28 per standard deviation (SD) decrease, p = 0.049] and women (HR = 4.53, 95% CI = 1.14–17.96 per SD decrease, p = 0.032). Neither fat mass nor bone mineral content was associated with mortality. Low SMI was associated with increased mortality in women (HR = 5.97, 95% CI = 1.04–34.37, p = 0.045), while the association between low SMI and mortality was marginal in men (HR = 2.38, 95% CI = 0.92–6.14, p = 0.074). Conclusions: Low muscle mass was independently associated with all-cause mortality in patients with T2DM. The preservation of skeletal muscle mass is important to protect patients with T2DM from increased mortality risk.

Vitamin D status is a determinant of skeletal muscle mass in obesity according to body fat percentage

Nutrition ◽  
2015 ◽  
Vol 31 (6) ◽  
pp. 801-806 ◽  
Author(s):  
Prapimporn Chattranukulchai Shantavasinkul ◽  
Pariya Phanachet ◽  
Orawan Puchaiwattananon ◽  
La-or Chailurkit ◽  
Tanarat Lepananon ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Muscle Mass ◽  
Body Fat ◽  
Skeletal Muscle Mass ◽  
Body Fat Percentage ◽  
Vitamin D Status ◽  
Fat Percentage

scholarly journals Relationships Between Serum Lipoprotein (a) And Sarcopenia In Elderly

2022 ◽  
Author(s):  
Ling-jie Xu ◽  
Ling-shan Zhou ◽  
Qian Xiao ◽  
Jin-liang Chen ◽  
Cheng Luo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Body Fat ◽  
Skeletal Muscle Mass ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Total Body Fat ◽  
Appendicular Skeletal Muscle ◽  
Total Body ◽  
Appendicular Skeletal Muscle Mass

Abstract Background: Examine the association of serum Lp(a) with sarcopenia in Chinese elderly.Methods: We conducted this study using 2015–2020 data from hospitalized Chinese people 60 years old and older. Total body fat percentage and appendicular skeletal muscle mass were assessed with a dual-energy X-ray absorptiometry scan. We classified the participants into four sarcopenia/obesity groups based on both total body fat percentage and appendicular skeletal muscle mass.Results: The analysis included data of 528 participants. the LP(a) level of sarcopenia was significantly higher than no sarcopenia, compared with obese or no obese groups. Furthermore, In the sarcopenic obesity group, the LP(a) level was highest. Correlation analysis showed that ASM/height2 was negatively correlated with LP(a). Logistic regression analysis showed that sarcopenia was positively associated with LP(a).Conclusions: Our study shows that sarcopenia appeared to be significantly associated with Lp(a) no matter the subjects had obesity or not.

Sign in / Sign up

Export Citation Format

Share Document