Vitamin D status is a determinant of skeletal muscle mass in obesity according to body fat percentage

Abstract Background: Examine the association of serum Lp(a) with sarcopenia in Chinese elderly.Methods: We conducted this study using 2015–2020 data from hospitalized Chinese people 60 years old and older. Total body fat percentage and appendicular skeletal muscle mass were assessed with a dual-energy X-ray absorptiometry scan. We classified the participants into four sarcopenia/obesity groups based on both total body fat percentage and appendicular skeletal muscle mass.Results: The analysis included data of 528 participants. the LP(a) level of sarcopenia was significantly higher than no sarcopenia, compared with obese or no obese groups. Furthermore, In the sarcopenic obesity group, the LP(a) level was highest. Correlation analysis showed that ASM/height2 was negatively correlated with LP(a). Logistic regression analysis showed that sarcopenia was positively associated with LP(a).Conclusions: Our study shows that sarcopenia appeared to be significantly associated with Lp(a) no matter the subjects had obesity or not.

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Vitamin D Status in Obesity Is Associated with Skeletal Muscle Mass Independent of Adiposity

10.1210/endo-meetings.2011.part1.p9.p1-207 ◽

2011 ◽

pp. P1-207-P1-207

Author(s):

Prapimporn Shantavasinkul ◽

Pariya Phanachet ◽

Orawan Puchaiwattananon ◽

La-or Chailurkit ◽

Boonsong Ongphiphadhanakul ◽

...

Keyword(s):

Skeletal Muscle ◽

Vitamin D ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Vitamin D Status

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Vitamin D Status Among Male Late Adolescents Living in Southern Switzerland: Role of Body Composition and Lifestyle

Nutrients ◽

10.3390/nu11112727 ◽

2019 ◽

Vol 11 (11) ◽

pp. 2727 ◽

Cited By ~ 3

Author(s):

Andrea Rabufetti ◽

Gregorio P. Milani ◽

Sebastiano A. G. Lava ◽

Valeria Edefonti ◽

Mario G. Bianchetti ◽

...

Keyword(s):

Physical Activity ◽

Vitamin D ◽

Body Fat ◽

Vitamin D Insufficiency ◽

Body Fat Percentage ◽

Vitamin D Status ◽

Late Adolescents ◽

Recreational Physical Activity ◽

Fat Percentage ◽

25 Hydroxy Vitamin D

Background: Poor vitamin D status is a worldwide health problem. Yet, knowledge about vitamin D status among adolescents in Southern Europe is limited. This study investigated concentrations and modulating factors of vitamin D in a healthy population of male late adolescents living in Southern Switzerland. Methods: All apparently healthy subjects attending for the medical evaluation before the compulsory military service in Southern Switzerland during 2014-2016 were eligible. Dark-skin subjects, subjects on vitamin D supplementation or managed with diseases or drugs involved in vitamin D metabolism were excluded. Anthropometric measurements (body height, weight, fat percentage, mid-upper arm and waist circumference) and blood sampling for total 25-hydroxy-vitamin D, total cholesterol and ferritin concentrations testing, were collected. Participants filled in a structured questionnaire addressing their lifestyle. Characteristics of the subjects with adequate (≥50 nmol/L–≤250 nmol/L) and insufficient (<50 nmol/L) vitamin D values were compared by Kruskal-Wallis test or χ2 test. Odds ratios for 25-hydroxy-vitamin D insufficiency were calculated by univariate and AIC-selected multiple logistic regression models. Results: A total of 1045 subjects volunteered to participate in the study. Insufficient concentrations of vitamin D were detected in 184 (17%). The season of measurement was the most significant factor associated with vitamin D levels and approximately 40% of subjects presented insufficient vitamin D concentrations in winter. After model selection, body fat percentage, frequency and site of recreational physical activity, and the seasonality were significantly associated with the risk of vitamin D insufficiency. Conclusions: Among healthy male late adolescents in Southern Switzerland, about one every fourth subject presents a poor vitamin D status in non-summer seasons. Body fat percentage, frequent and outdoor recreational physical activity are modulating factors of vitamin D status in this population.

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High skeletal muscle mass is associated with increased serum 25(OH)D levels in elderly

Zinc supplementation improves heme biosynthesis in rats exposed to lead ◽

10.18051/univmed.2017.v36.236-242 ◽

2017 ◽

Vol 36 (3) ◽

pp. 236

Author(s):

Verawati Sudarma ◽

Lukman Halim

Keyword(s):

Skeletal Muscle ◽

Body Mass Index ◽

Vitamin D ◽

Body Composition ◽

Waist Circumference ◽

Linear Regression ◽

Muscle Mass ◽

Body Fat ◽

Skeletal Muscle Mass ◽

Anthropometric Measurements

Background Low vitamin D has been associated with various health problems. Aging influences body composition, especially body fat and fat-free mass. Anthropometric measurements, such as body weight (BW), body mass index (BMI), body fat (BF), skeletal muscle mass (SMM), waist circumference (WC) and the waist-height ratio (WHtR) represent body composition which many studies proposed will influence serum vitamin D [25(OH)D]. The objective of the present study was to determine which anthropometric measurements were determinants of 25(OH)D levels in elderly. Methods A cross-sectional study was conducted involving 126 elderly (>60 years old) men and women at Pusat Santunan Dalam Keluarga (PUSAKA) Central Jakarta centers. Anthropometric measurements [body mass index (BMI), skeletal muscle mass (SMM), body fat (BF), and waist circumference (WC)] were determined by bioelectrical impedance analysis using the Omron body composition monitor with scales (HBF-375, Omron, Japan). Fasting blood samples were taken to measure 25(OH)D level by electrochemiluminescence immunoassay. Multivariate linear regression was used to analyze the data. Results The data showed that BMI, BF, and WC were higher than recommended, while SMM and serum 25(OH)D were lower. When the analysis was done based on sex, there were significant differences in BF, SMM, WHtR, and serum 25(OH)D. In the linear regression multivariate analysis of log 25(OH)D with age and body anthropometric measurements, only SMM reached significance level (β=0.019; p=0.025). Conclusions This study demonstrated a positive association between skeletal muscle mass and serum levels of vitamin D in elderly.

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Serum vitamin D status inversely associates with a prevalence of severe sarcopenia among female patients with rheumatoid arthritis

Scientific Reports ◽

10.1038/s41598-021-99894-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Hiroto Minamino ◽

Masao Katsushima ◽

Mie Torii ◽

Wataru Yamamoto ◽

Yoshihito Fujita ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Skeletal Muscle ◽

Vitamin D ◽

Muscle Mass ◽

Physical Performance ◽

Gait Speed ◽

Skeletal Muscle Mass ◽

Vitamin D Status ◽

Female Patients ◽

High Prevalence

AbstractSarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum 25-hydroxyvitamin D [25(OH)D] affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 female patients with RA (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait speed. Furthermore, multivariable logistic regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99–18.08).The same association was observed when the cut-off value was set at 20 ng/ml. In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH)D status. In conclusion, vitamin D status was inversely associated with severe sarcopenia, low physical performance, and low skeletal muscle mass. Modification of vitamin D status including vitamin D supplementation should be investigated as a therapeutic strategy for sarcopenic patients with RA.

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Correlation between lower extremity arterial disease and skeletal muscle mass in patients with type 2 diabetes mellitus

Journal of International Medical Research ◽

10.1177/0300060519897483 ◽

2020 ◽

Vol 48 (3) ◽

pp. 030006051989748

Author(s):

Yinghui Zhang ◽

Lemeng Ren ◽

Fengjie Zheng ◽

Xianghua Zhuang ◽

Dongqing Jiang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Skeletal Muscle ◽

Uric Acid ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Arterial Disease ◽

Body Fat Percentage ◽

Fat Percentage ◽

Lower Extremity Arterial Disease

Objectives To evaluate skeletal muscle mass in patients with both type 2 diabetes mellitus (T2DM) and concomitant lower extremity arterial disease (LEAD) and determine the contribution of skeletal muscle mass to macrovascular diseases. Methods In total, 112 patients with T2DM were divided into the T2DM and T2DM + LEAD groups. Hepatic function, renal function, uric acid, blood glucose, and glycated hemoglobin (HbA1C) were measured. Dual-energy X-ray absorptiometry was used to measure visceral fat area and skeletal muscle mass index (SMI). Results Waist-to-hip ratio, uric acid, and body fat percentage were significantly higher in the T2DM+LEAD group than in the T2DM group; SMI was significantly lower in the T2DM+LEAD group than in the T2DM group. There were no significant differences in albumin, creatinine, fasting blood glucose, HbA1C, or blood lipids. Uric acid, SMI, and body fat percentage were significantly positively correlated with T2DM and concomitant LEAD. Logistic regression analyses suggested that SMI is an independent risk factor for LEAD in T2DM (odds ratio = 1.517; 95% confidence interval: 1.082–2.126). Conclusions Skeletal muscle mass is lower in patients with T2DM and concomitant LEAD than in patients with T2DM who do not exhibit LEAD. SMI is an important risk factor for LEAD.

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