Association between interleukin-8 −251A/T polymorphism and the risk of tuberculosis: A meta-analysis

Objective The relationship between interleukin-8 ( IL8) −251A/T polymorphism and tuberculosis (TB) risk remains controversial. Therefore, the present meta-analysis was performed by retrieving relevant studies from the available literature. Methods We comprehensively searched three databases to identify eligible literature on the relationship of IL8 −251A/T polymorphism with TB risk, calculated pooled odds ratios (OR) with 95% confidence intervals (CI), and subsequent evaluated the heterogeneity and publication bias. Results We found that IL8 −251A/T polymorphism increased TB risk (AA vs. TT: OR = 2.86, 95%CI: 1.46–5.60; AT vs. TT: OR = 1.64, 95%CI: 1.15–2.34; dominant model: OR = 1.88, 95%CI: 1.24–2.86; recessive model: OR = 1.77, 95%CI: 1.17–2.69). Subgroup analyses based on race revealed that the IL8 −251A/T polymorphism might be associated with the risk of TB in African but not Asian individuals. Conclusion The IL8 −251A/T polymorphism might be related to the risk of TB. Nevertheless, large-scale studies should be performed to confirm the role of IL8 −251A/T polymorphism on TB risk.

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Effects of ANRIL variants on the risk of ischemic stroke: a meta-analysis

Bioscience Reports ◽

10.1042/bsr20182127 ◽

2019 ◽

Vol 39 (5) ◽

Cited By ~ 1

Author(s):

Cheng Tan ◽

Junzhi Liu ◽

Jun Wei ◽

Shoujun Yang

Keyword(s):

Ischemic Stroke ◽

Confidence Intervals ◽

Meta Analysis ◽

Recessive Model ◽

Individual Susceptibility ◽

Non Coding Rna ◽

Increased Risk ◽

Subgroup Analyses ◽

The Relationship ◽

Allele Model

Abstract Background : Several studies investigated the relationship between antisense non-coding RNA in the INK4 locus (ANRIL) variants and the risk of ischemic stroke (IS), yet whether ANRIL variants are associated with IS remain controversial. Therefore, we performed the present study to obtain a more conclusive result. Methods: Literature retrieval was conducted in PubMed, Medline and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: Eighteen studies were enrolled for analyses. Pooled overall analyses showed that rs2383206 (recessive model: P=0.002, OR = 1.22, 95%CI 1.08–1.38; allele model: P=0.003, OR = 0.90, 95%CI 0.84–0.96) and rs10757274 (allele model: P=0.006, OR = 0.91, 95%CI 0.86–0.97) variants were significantly associated with an increased risk of IS. Further subgroup analyses by ethnicity revealed that rs2383206, rs10757274 and rs10757278 variants were all significantly correlated with an increased risk of IS in Asians. Additionally, rs10757278 polymorphism was also significantly correlated with an increased risk of IS in Caucasians. Conclusions: Our findings indicated that rs2383206, rs10757274 and rs10757278 variants may impact individual susceptibility to IS in Asians. Moreover, rs10757278 polymorphism may also impact individual susceptibility to IS in Caucasians.

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Association of miR-146a polymorphism rs2910164 and type 2 diabetes risk: a meta-analysis

Journal of International Medical Research ◽

10.1177/0300060520931313 ◽

2020 ◽

Vol 48 (8) ◽

pp. 030006052093131

Author(s):

Liqing Cheng ◽

Min Zhou ◽

Dongmei Zhang ◽

Bing Chen

Keyword(s):

Type 2 Diabetes ◽

Gene Polymorphisms ◽

Disease Duration ◽

Genetic Model ◽

Meta Analysis ◽

Confounding Factors ◽

Dominant Model ◽

Subgroup Analyses

Objective Circulating miR-146a is aberrantly expressed in patients with type 2 diabetes (T2D), probably resulting from gene polymorphisms. However, the role of polymorphism rs2910164 in T2D pathogenesis remains controversial. Thus, we designed a meta-analysis to investigate the association between rs2910164 and T2D. Methods PubMed and Embase were searched for eligible papers in English published through September 2, 2019. Random or fixed effect models were used to determine risk estimates according to heterogeneities. Results Four studies, involving 2,069 patients and 1,950 controls, were included. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to pool the effect size. The pooled ORs and 95% CIs were 1.501 (0.887–2.541), 1.102 (0.931–1.304), 1.276 (0.900–1.811), 1.204 (0.878–1.652), 1.238 (0.880–1.740), and 1.350 (0.904–2.016) under the homozygote, heterozygote (CG vs. GG and CC vs. CG), dominant, allele, and recessive models, respectively. Heterogeneity was detected in most genetic models, with subgroup analyses performed by ethnicity, genotyping method, and disease duration. The co-dominant model was determined to be the most appropriate genetic model. Conclusions Our findings suggested that polymorphism rs2910164 is not correlated with T2D susceptibility. However, the results should be interpreted with caution because of confounding factors.

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Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320318823927 ◽

2019 ◽

Vol 20 (1) ◽

pp. 147032031882392 ◽

Cited By ~ 1

Author(s):

Nina Liu ◽

Youmin Wang

Keyword(s):

Diabetic Nephropathy ◽

Odds Ratio ◽

Meta Analysis ◽

Recessive Model ◽

Random Effects Model ◽

Dominant Model ◽

Study Results ◽

Subgroup Analyses ◽

Agt Gene ◽

T174m Polymorphism

Objective: Although the angiotensinogen ( AGT) gene T174M polymorphism has been implicated in the pathogenesis of diabetic nephropathy (DN), study results have been inconsistent. The present meta-analysis was conducted to determine the correlation of AGT T174M polymorphism with DN. Methods: We retrospectively extracted relevant studies from Embase as well as PubMed databases. Additionally, a fixed- or random-effects model was employed for calculation of pooled odds ratio (OR) along with 95% confidence interval (CI). Results: In total, we identified six studies (1179 cases and 927 controls) regarding the AGT gene T174M polymorphism. The pooled ORs for the association between the AGT T174M polymorphism and DN risk were not statistically significant under all genetic models (M vs T: OR = 1.22, 95% CI = 0.84–1.75; MM vs TT: OR = 1.94, 95% CI = 0.93–4.04; MT vs TT: OR = 1.11, 95% CI = 0.76–1.63; the dominant model: OR =1.19, 95% CI = 0.80–1.77; the recessive model: OR = 1.94, 95% CI = 0.93–4.03). Subgroup analyses based on the type of race showed the M allele of the AGT T174M polymorphism increased DN risk in Asians, but not in Caucasians. Conclusions: Our study indicated that the T174M polymorphism in the AGT gene was associated with DN in Asians.

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Association between BRCA1 polymorphisms rs799917 and rs1799966 and breast cancer risk: a meta-analysis

Journal of International Medical Research ◽

10.1177/0300060519826819 ◽

2019 ◽

Vol 47 (4) ◽

pp. 1409-1416

Author(s):

Meiming Yang ◽

Xiaoli Du ◽

Feng Zhang ◽

Shifang Yuan

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Confidence Intervals ◽

Subgroup Analysis ◽

Meta Analysis ◽

Recessive Model ◽

Dominant Model ◽

Odds Ratios

Background Several studies have reported correlations between BRCA1 polymorphisms rs799917 and rs1799966 with the risk of breast cancer (BC). However, this relationship remains controversial. Methods We conducted a meta-analysis of seven studies to assess the associations between BRCA1 rs799917 and rs1799966 and BC risk, with the aim of more accurately determining the potential correlation. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated to evaluate the correlation of rs799917 and rs1799966 with BC risk. Results There was no overall correlation between BRCA1 rs799917 and BC risk (TT vs CC: OR = 0.87, 95% CI = 0.66–1.16; CT vs CC: OR = 1.02, 95% CI = 0.89–1.15; dominant model: OR = 0.99, 95% CI = 0.88–1.11; recessive model: OR = 0.87, 95% CI = 0.65–1.16). Subgroup analysis by ethnicity also revealed no significant correlation between rs799917 and BC risk in either Asians or Caucasians. There was also no significant association between BRCA1 rs1799966 and BC risk (GG vs AA: OR = 0.70, 95% CI = 0.33–1.47; AG vs AA: OR = 0.68, 95% CI = 0.35–1.30; dominant model: OR = 0.76, 95% CI = 0.49–1.06; recessive model: OR = 0.82, 95% CI = 0.49–1.36). Conclusion BRCA1polymorphisms rs799917 and rs1799966 were not significantly associated with BC risk in this meta-analysis.

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Meta-Analysis of the Relationship between XRCC1-Arg399Gln and Arg280His Polymorphisms and the Risk of Prostate Cancer

Scientific Reports ◽

10.1038/srep09905 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 10

Author(s):

Jie Yan ◽

Xiantao Wang ◽

Hui Tao ◽

Zengfu Deng ◽

Wang Yang ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Risk ◽

Meta Analysis ◽

Prostate Cancer Risk ◽

Recessive Model ◽

Dominant Model ◽

Xrcc1 Arg399gln ◽

Increased Risk ◽

Arg399gln Polymorphism ◽

The Relationship

Abstract Prostate cancer is one of the most common noncutaneous malignancies in Western countries. Because there has been a debate regarding the relationship between the XRCC1-Arg399Gln and Arg280His polymorphisms and prostate cancer risk, we therefore performed this meta-analysis. The electronic databases PubMed, EMBASE and Medline were searched prior to October 1, 2014. An odds ratio and 95% confidence interval were used to calculate association. Heterogeneity was tested by both a chi-square test and I2statistic. Funnel plots and Egger’s test were used to assess publication bias. All statistical analyses were performed using STATA 12.0 software. A significant association between the XRCC1-Arg399Gln polymorphism and prostate cancer risk was found under a homozygote model and a recessive model. A significant association between XRCC1-Arg280His and prostate cancer risk was found under a heterozygote model and a dominant model. Overall, the results of this meta-analysis show that the XRCC1-Arg399Gln polymorphism may be associated with an increased risk for prostate cancer under the homozygote model and the recessive model. And XRCC1-Arg280His polymorphism is likely to be related with prostate cancer risk under the heterozygote model and the dominant model. Additional larger well-designed studies are needed to validate our results.

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Lack of association between polymorphism of IL-2 -330T/G and pulmonary tuberculosis among Caucasians

Innate Immunity ◽

10.1177/1753425919891579 ◽

2020 ◽

Vol 26 (5) ◽

pp. 398-402

Author(s):

Haibo Ge ◽

Shi Chen ◽

Jia Zhu

Keyword(s):

Pulmonary Tuberculosis ◽

Odds Ratio ◽

Meta Analysis ◽

Recessive Model ◽

Dominant Model ◽

Pulmonary Tb ◽

Increased Risk ◽

The Relationship ◽

Allele Model ◽

Combined Data

This meta-analysis was conducted to assess the consistency and strength of the relationship between polymorphism of IL-2 -330T/G and susceptibility to pulmonary tuberculosis (TB). PubMed, Web of Knowledge and CNKI were searched to find eligible studies about the relationship between IL-2 -330T/G polymorphism and susceptibility to pulmonary TB. A total of eight studies comprising 971 cases and 1519 controls were grouped together for the purpose of elucidating the relationship between polymorphism of IL-2 -330T/G and pulmonary TB susceptibility. The allele model (G vs. T: odds ratio (OR) = 1.34; 95% confidence interval (CI) 1.05–1.71, Phet = 0.001) and the recessive model (GG+GT vs. TT: OR = 1.60; 95% CI 1.08–2.38, Phet = 0.0001) showed an increased risk of development of pulmonary TB. However, the homozygous model (GG vs. TT: OR = 1.74; 95% CI 0.98–3.09, Phet = 0.0005) and the dominant model (GG vs. TT + TG: OR = 1.30; 95% CI = 0.80-2.14, Phet = 0.001) failed to show an increased incidence of pulmonary TB. When analysis was stratified by ethnicity, no obvious associations were identified in the Caucasian subgroup under all four genetic models. Additionally, heterogeneity disappeared in the analysis of Caucasian subgroup. Our combined data suggested that there was no association between IL-2 -330T/G polymorphism and pulmonary TB among Caucasians.

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Association between the Interleukin-10 -1082 G/A polymorphism and risk of hepatocellular carcinoma

African Health Sciences ◽

10.4314/ahs.v20i1.40 ◽

2020 ◽

Vol 20 (1) ◽

pp. 351-358

Author(s):

Yingwei Wang ◽

Peiyang Hu

Keyword(s):

Hepatocellular Carcinoma ◽

Meta Analysis ◽

Group Analysis ◽

Interleukin 10 ◽

Recessive Model ◽

Case Control Studies ◽

Exclusion Criteria ◽

Keywords Hepatocellular Carcinoma ◽

Relationship Of ◽

The Relationship

Background: Inconsistent results have been reported from studies investigating the relationship of the interleukin-10 (IL-10) -1082 G/A polymorphism and the susceptibility of hepatocellular carcinoma (HCC). Therefore, a thorough literature review of relatedstudies was performed in this meta-analysis to examine the association of the interleukin-10(IL-10) -1082 G/A poly- morphism with HCC susceptibility. Methods: Electronic databases were searched for literature on the relationship between interleukin-10(IL-10) -1082 G/A poly- morphism and the risk of HCC in accordance with the inclusion and exclusion criteria. The selected studies were analyzed using the Stata 12.0 software. Finally, the strength of the associations was evaluated using the odds ratio (OR) and 95% confidence intervals (95% CI). Results: A total of six case-control studies were enrolled into the current meta-analysis, which included a total of 911 patients and 1889 control subjects. Our data revealed no association between the IL-10 -1082 G/A polymorphism and the risk of HCC (GG vs AA:OR=0.84, 95%CI=0.57-1.25; AG vs AA:OR=0.85, 95%CI=0.70-1.05; Dominant model: OR=0.85, 95%CI=0.70- 1.03; and Recessive model: OR=0.92, 95%CI = 0.64-1.32). Similarly, no association was found in sub-group analysis based on ethnicity. Conclusion: The results of our study suggest no association between IL-10 -1082 G/A polymorphism and the risk of HCC. Keywords: Hepatocellular carcinoma; IL-10 polymorphism; risk analysis.

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Association of SLCO1B1 Polymorphisms and Atorvastatin Safety and Efficacy: A Meta-analysis

Current Pharmaceutical Design ◽

10.2174/1381612825666181219163534 ◽

2019 ◽

Vol 24 (34) ◽

pp. 4044-4050 ◽

Cited By ~ 1

Author(s):

Yaming Du ◽

Sizheng Wang ◽

Zhangyong Chen ◽

Shusen Sun ◽

Zhigang Zhao ◽

...

Keyword(s):

Statistical Tests ◽

Meta Analysis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipid Lowering ◽

Dominant Model ◽

Safety And Efficacy ◽

Atorvastatin Therapy ◽

Relationship Of ◽

The Relationship

Background: Atorvastatin is the best-selling statin in the market. However, some patients have to reduce drug doses or discontinue atorvastatin therapy mainly due to adverse drug reactions (ADRs). Genetic factors play an important role in the occurrence of ADRs. Aim: This study aimed to investigate the association between SLCO1B1 polymorphisms (c.521T>C or c.388A>G) and atorvastatin safety and efficacy. Methods: We systematically searched PubMed, Web of Science and Embase to screen relevant studies published before Sep 2018. This meta-analysis was performed to identify the relationship between SLCO1B1 c.521T>C or c.388A>G polymorphisms and atorvastatin-related ADRs by the odds ratios (ORs) and 95% confidence intervals (CIs). The relationship of SLCO1B1 polymorphisms and lipid-lowering effects [low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC)] was assessed in pooled data by calculating the mean difference (MD) with 95% CIs. All statistical tests were performed by the Review Manager 5.3 software. Results: A total of 13 studies involving 1,550 atorvastatin users were included in this analysis. There was a significant association between the SLCO1B1 c.521T>C polymorphism and atorvastatin-related ADRs associated with risk allele C (dominant model: OR=1.57, P=0.01). Allele C is associated with increased lipid-lowering efficacy in people with Hyperlipidemias as compared to allele T (LDL-C/dominant model: MD=6.19, P<0.00001 and (TC)/dominant model: MD=2.07, P=0.008). No association between the SLCO1B1 c.388A>G polymorphism and ADRs or efficacy was observed (P>0.05). Conclusion: SLCO1B1 c.521T>C polymorphism is a valuable biomarker for the evaluation of atorvastatin safety and efficacy.

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Association of chemotactic chemokine ligand 5 rs2107538 polymorphism with tuberculosis susceptibility: A meta-analysis

Innate Immunity ◽

10.1177/1753425919891662 ◽

2019 ◽

Vol 26 (5) ◽

pp. 358-363

Author(s):

Yun-Feng Sheng ◽

Qi Qi

Keyword(s):

South African ◽

South Asian ◽

Meta Analysis ◽

Recessive Model ◽

Dominant Model ◽

Relevant Research ◽

African Populations ◽

Chemokine Ligand ◽

The Relationship ◽

South African Populations

A meta-analysis was carried out in this study by summarizing relevant research to evaluate the relationship between rs2107538 polymorphism in the chemotactic chemokine ligand 5 (CCL5) gene and tuberculosis (TB) susceptibility. Published studies were retrieved from PubMed, Embase, and CNKI databases using the keywords ‘CCL5’, ‘TB’, and ‘polymorphism’. Nine studies involving 2584 patients with TB and 2265 controls were included in the current meta-analysis. The combined results suggested that the CCL5 rs2107538 polymorphism was correlated with TB susceptibility (recessive model: OR = 1.45, 95% CI = 1.02–2.07). Subgroup analysis according to race indicated that such correlation could be detected in Caucasians (CT versus CC: OR = 1.53, 95% CI = 1.20–1.95; dominant model: OR = 1.58, 95% CI = 1.25–1.99), but not in East Asian, South Asian, and South African populations. In conclusion, the results of our meta-analysis suggest that CCL5 rs2107538 polymorphism might contribute to the risk of TB, especially in Caucasians. Well-designed studies with more subjects will be required for further validation of these results.

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The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

Scientific Reports ◽

10.1038/s41598-020-74203-9 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Zulvikar Syambani Ulhaq ◽

Gita Vita Soraya ◽

Budu ◽

Lely Retno Wulandari

Keyword(s):

Meta Analysis ◽

Pathological Process ◽

Ocular Disease ◽

Control Group ◽

Ocular Diseases ◽

Subgroup Analyses ◽

Ophthalmic Diseases ◽

The Relationship ◽

Larger Sample

Abstract Interleukin-6 (IL-6) is one of the key regulators behind the inflammatory and pathological process associated with ophthalmic diseases. The role of IL-6-174 G/C polymorphism as well as intraocular IL-6 levels among various eye disease patients differ across studies and has not been systematically reviewed. Thus, this study aims to provide a summary to understand the relationship between IL-6 and ophthalmic disease. In total, 8,252 and 11,014 subjects for IL-6-174 G/C and intraocular levels of IL-6, respectively, were retrieved from PubMed, Scopus and Web of Science. No association was found between IL-6-174 G/C polymorphisms with ocular diseases. Subgroup analyses revealed a suggestive association between the GC genotype of IL-6-174 G/C with proliferative diabetic retinopathy (PDR). Further, the level of intraocular IL-6 among ocular disease patients in general was found to be higher than the control group [standardized mean difference (SMD) = 1.41, 95% confidence interval (CI) 1.24–1.58, P < 0.00001]. Closer examination through subgroup analyses yielded similar results in several ocular diseases. This study thus indicates that the IL-6-174 G/C polymorphism does not predispose patients to ocular disease, although the GC genotype is likely to be a genetic biomarker for PDR. Moreover, intraocular IL-6 concentrations are related to the specific manifestations of the ophthalmic diseases. Further studies with larger sample sizes are warranted to confirm this conclusion.

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