scholarly journals Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis

2019 ◽  
Vol 20 (1) ◽  
pp. 147032031882392 ◽  
Author(s):  
Nina Liu ◽  
Youmin Wang
Keyword(s):  
Diabetic Nephropathy ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Recessive Model ◽  
Random Effects Model ◽  
Dominant Model ◽  
Study Results ◽  
Subgroup Analyses ◽  
Agt Gene ◽  
T174m Polymorphism

Objective: Although the angiotensinogen ( AGT) gene T174M polymorphism has been implicated in the pathogenesis of diabetic nephropathy (DN), study results have been inconsistent. The present meta-analysis was conducted to determine the correlation of AGT T174M polymorphism with DN. Methods: We retrospectively extracted relevant studies from Embase as well as PubMed databases. Additionally, a fixed- or random-effects model was employed for calculation of pooled odds ratio (OR) along with 95% confidence interval (CI). Results: In total, we identified six studies (1179 cases and 927 controls) regarding the AGT gene T174M polymorphism. The pooled ORs for the association between the AGT T174M polymorphism and DN risk were not statistically significant under all genetic models (M vs T: OR = 1.22, 95% CI = 0.84–1.75; MM vs TT: OR = 1.94, 95% CI = 0.93–4.04; MT vs TT: OR = 1.11, 95% CI = 0.76–1.63; the dominant model: OR =1.19, 95% CI = 0.80–1.77; the recessive model: OR = 1.94, 95% CI = 0.93–4.03). Subgroup analyses based on the type of race showed the M allele of the AGT T174M polymorphism increased DN risk in Asians, but not in Caucasians. Conclusions: Our study indicated that the T174M polymorphism in the AGT gene was associated with DN in Asians.

scholarly journals Association between miR-499 rs3746444 polymorphism and ischemic stroke : A systematic review and meta-analysis

2019 ◽  
Author(s):  
Xiang Hong Liu ◽  
Mei Ling Liu ◽  
Rong Lin ◽  
Yaping Xing ◽  
Tingli Zhao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sensitivity Analysis ◽  
Ischemic Stroke ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Recessive Model ◽  
Dominant Model ◽  
Statistical Association ◽  
Large Heterogeneity ◽  
Allelic Model

Abstract Background: To explore the generic association between miR-499 rs3746444 polymorphism and ischemic stroke (IS). Methods: We performed a systematic review and meta-analysis, odds ratio (OR) and 95% confidence intervals (CIs) were used to estimate the association quantitively. Results: A total of 6 studies (involving 2569 IS cases and 2645 controls) were included. miR-499 (rs3746444) polymorphism showed a statistically significant association with IS risk in the allelic model (G allele vs A allele), the dominant model (GG+AG vs AA), the recessive model (GG vs AG+AA) and the homozygote model (GG vs AA). ORs of the above 4 models were 1.20 (95%CI: 1.02, 1.40), 1.21 (95%CI: 1.01, 1.46), 1.40 (95%CI: 1.04, 1.88), 1.48 (95%CI: 1.10, 2.00) respectively. The I square of the allelic model and the dominant model was 58% and 59%, indicating large heterogeneity among included studies. By sensitivity analysis, I square of the two models dropped to 34.5% and 38.4%, the ORs were 1.26 (95%CI: 1.13, 1.42) and 1.28 (95%CI: 1.12, 1.46), there was still a statistical association between miR-499 (rs3746444) polymorphism and IS. The heterozygote model (AG vs AA) was not statistically significant, the OR was 1.18 (95%CI: 0.99, 1.42), the I square was 54%. Notably, by sensitivity analysis, I square of the heterozygote model dropped to 34.6%, the OR was 1.25 (95%CI: 1.08, 1.43), indicating a statistically significant association between miR-499 (rs3746444) polymorphism and IS. There was no publication bias for all the models by Egger's test. Conclusion: miR-499 (rs3746444) polymorphisms is associated with the increase of IS risk.

scholarly journals Lack of association between polymorphism of IL-2 -330T/G and pulmonary tuberculosis among Caucasians

2020 ◽  
Vol 26 (5) ◽  
pp. 398-402
Author(s):  
Haibo Ge ◽  
Shi Chen ◽  
Jia Zhu
Keyword(s):  
Pulmonary Tuberculosis ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Recessive Model ◽  
Dominant Model ◽  
Pulmonary Tb ◽  
Increased Risk ◽  
The Relationship ◽  
Allele Model ◽  
Combined Data

This meta-analysis was conducted to assess the consistency and strength of the relationship between polymorphism of IL-2 -330T/G and susceptibility to pulmonary tuberculosis (TB). PubMed, Web of Knowledge and CNKI were searched to find eligible studies about the relationship between IL-2 -330T/G polymorphism and susceptibility to pulmonary TB. A total of eight studies comprising 971 cases and 1519 controls were grouped together for the purpose of elucidating the relationship between polymorphism of IL-2 -330T/G and pulmonary TB susceptibility. The allele model (G vs. T: odds ratio (OR) = 1.34; 95% confidence interval (CI) 1.05–1.71, Phet = 0.001) and the recessive model (GG+GT vs. TT: OR = 1.60; 95% CI 1.08–2.38, Phet = 0.0001) showed an increased risk of development of pulmonary TB. However, the homozygous model (GG vs. TT: OR = 1.74; 95% CI 0.98–3.09, Phet = 0.0005) and the dominant model (GG vs. TT + TG: OR = 1.30; 95% CI = 0.80-2.14, Phet =  0.001) failed to show an increased incidence of pulmonary TB. When analysis was stratified by ethnicity, no obvious associations were identified in the Caucasian subgroup under all four genetic models. Additionally, heterogeneity disappeared in the analysis of Caucasian subgroup. Our combined data suggested that there was no association between IL-2 -330T/G polymorphism and pulmonary TB among Caucasians.

scholarly journals Association between interleukin-8 −251A/T polymorphism and the risk of tuberculosis: A meta-analysis

2020 ◽  
Vol 48 (5) ◽  
pp. 030006052091787
Author(s):  
Qin Hu ◽  
Haibo Hua ◽  
Lihong Zhou ◽  
Xingwu Zou
Keyword(s):  
Confidence Intervals ◽  
Large Scale ◽  
Meta Analysis ◽  
Recessive Model ◽  
Interleukin 8 ◽  
Dominant Model ◽  
Subgroup Analyses ◽  
Relationship Of ◽  
The Relationship

Objective The relationship between interleukin-8 ( IL8) −251A/T polymorphism and tuberculosis (TB) risk remains controversial. Therefore, the present meta-analysis was performed by retrieving relevant studies from the available literature. Methods We comprehensively searched three databases to identify eligible literature on the relationship of IL8 −251A/T polymorphism with TB risk, calculated pooled odds ratios (OR) with 95% confidence intervals (CI), and subsequent evaluated the heterogeneity and publication bias. Results We found that IL8 −251A/T polymorphism increased TB risk (AA vs. TT: OR = 2.86, 95%CI: 1.46–5.60; AT vs. TT: OR = 1.64, 95%CI: 1.15–2.34; dominant model: OR = 1.88, 95%CI: 1.24–2.86; recessive model: OR = 1.77, 95%CI: 1.17–2.69). Subgroup analyses based on race revealed that the IL8 −251A/T polymorphism might be associated with the risk of TB in African but not Asian individuals. Conclusion The IL8 −251A/T polymorphism might be related to the risk of TB. Nevertheless, large-scale studies should be performed to confirm the role of IL8 −251A/T polymorphism on TB risk.

Factor XIII Val34Leu Polymorphism Is Protective Against Venous Thromboembolism; a Meta-Analysis.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3512-3512
Author(s):  
Josdalyne L. Anderson ◽  
Dimitrios Scarvelis ◽  
Steven Doucette ◽  
Philip S. Wells
Keyword(s):  
Venous Thromboembolism ◽  
Random Effects ◽  
Odds Ratio ◽  
Factor Xiii ◽  
Meta Analysis ◽  
Random Effects Model ◽  
Dominant Model ◽  
Weinberg Equilibrium ◽  
Risk Profiling ◽  
Hardy Weinberg Equilibrium

Abstract Controversy over whether the factor XIII Val34Leu polymorphism confers protection against venous thromboembolism (VTE) is a persistent debate in the current thrombosis literature. If an accurate estimate of the protective effect were established, routine screening for this mutation in patients with VTE could provide more precise individual risk-profiling, but presently, it remains undetermined whether it is worthwhile to screen for this polymorphism. We performed a meta-analysis to determine whether the 34Leu allele of the factor XIII gene is associated with a decreased risk of VTE. Studies were identified by searching MEDLINE (1966 through to June Week 2 2004) followed by a manual search of reference lists from previously retrieved articles, symposia proceedings, and abstracts from major thrombosis conferences. Studies were selected for review if they involved unselected objectively diagnosed VTE patients with factor XIII Val34Leu genotypes reported and were a case-controlled study. Inclusion decisions, quality assessment and data extraction were conducted by two reviewers and consensus was achieved by discussion or by a third independent reviewer. Hardy-Weinberg equilibrium of the study control populations were verified. Four of the studies did not report whether they had verified Hardy-Weinberg equilibrium (Balogh, Catto, Margaglione, and Zidane). Authors were contacted for missing data. Forty-five studies were reviewed for eligibility and ten studies met the inclusion criteria. Pooled Odds Ratios and their 95% confidence intervals (CI) were determined using the method of DerSimonian-Laird. Prior to pooling, heterogeneity testing was performed using the Breslow-Day statistic and was insignificant (p = 0.06) which validated testing our FXIII 34Leu recessive model using the random effects model. Funnel plots ruled out the possibility of publication bias. The random effects model gave a combined odds ratio of 0.75 (95% CI= 0.55 to 1.01). Testing our dominant model using a random effects model gave a combined odds ratio of 0.86 (95% CI=0.76 to 0.98). Heterogeneity testing was insignificant (p=0.16). Our meta-analysis found significantly lower odds of VTE with the presence of FXIII 34Leu allele using a dominant model (i.e. the presence of at least one Leu allele). This polymorphism should be given consideration as part of routine risk profiling in patients at risk for VTE.

scholarly journals Associations Between M235T Polymorphism in the AGT Gene and Cancer: An Updated Systematic Review and A Meta-analysis

2021 ◽  
Author(s):  
Jun-Yan Kou ◽  
Jing Huang
Keyword(s):  
Cancer Risk ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Recessive Model ◽  
Cancer Type ◽  
Dominant Model ◽  
Digestive Cancer ◽  
Agt Gene ◽  
The Relationship ◽  
M235t Polymorphism

Abstract Background: We assessed the relationship between AGT gene M235T polymorphism and the susceptibility to cancer by performing an updated meta-analysis.Methods: This study retrospectively searched related articles in the electronic databases. Afterwards, we determined combined odds ratios (ORs) and related 95% confidence intervals (CIs) by the fixed- or random-effects model.Results: The present meta-analysis enrolled altogether 9 articles. On the whole, the relationship between AGT M235T polymorphism and the cancer risk was not significant among the entire population(TT vs MM:OR=1.28,95%CI=0.80-2.04;TM vs MM: OR=0.90, 95%CI = 0.53-1.52;Recessive model: OR= 1.13, 95%CI = 0.83-1.52; Dominant model: OR=0.93, 95%CI =0.55-1.57). But the relationship of AGT M235T polymorphism with the digestive cancer risk was significant upon subgroup analysis stratified according to cancer type (TT vs MM:OR=1.68,95%CI=1.11-2.54;TM vs MM: OR=1.34, 95%CI = 0.97-1.85;Recessive model: OR= 1.27, 95%CI = 0.95-1.70; Dominant model: OR=1.45, 95%CI =1.07-1.96).Conclusion: According to findings in the present meta-analysis, AGT M235T polymorphism may be possibly related to digestive cancer susceptibility.

scholarly journals Genetic Polymorphism rs6505162 in MicroRNA-423 May Not Be Associated with Susceptibility of Breast Cancer: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Zhi Li ◽  
Jin Wang ◽  
Hui-bing Chen ◽  
Xiao-Mei Guo ◽  
Xiao-Ping Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Meta Analysis ◽  
Recessive Model ◽  
Dominant Model ◽  
Knowledge Infrastructure ◽  
Subgroup Analyses ◽  
Caucasian Patients ◽  
Meta Analyses ◽  
Chinese National Knowledge Infrastructure ◽  
Allelic Model

Background. MicroRNA-423 (miR-423) rs6505162 polymorphism is found to be associated with breast cancer (BC) risk. However, the results were inconsistent. This study meta-analyzed the literature on possible association between rs6505162 polymorphism and BC risk. Methods. PubMed, Embase, Google Scholar, and the Chinese National Knowledge Infrastructure (CNKI) databases were systematically searched to identify relevant studies. Meta-analyses were performed to examine the association between rs6505162 polymorphism and BC. Results. None of the five genetic models suggested a significant association between rs6505162 polymorphism and BC risk: allelic model, OR 1.02, 95% CI 0.18–1.28, P = 0.85 ; recessive model, OR 0.99, 95% CI 0.72–1.38, P = 0.97 ; dominant model, OR 0.93, 95% CI 0.72–1.21, P = 0.60 ; homozygous model, OR 1.04, 95% CI 0.66–1.65, P = 0.87 ; and heterozygous model, OR 1.07, 95% CI 0.90–1.28, P = 0.45 . Similar results were obtained in subgroup analyses of Asian, Chinese, and Caucasian patients. Conclusion. The available evidence suggests no significant association between rs6505162 polymorphism and BC risk. These conclusions should be verified in large, well-designed studies.

scholarly journals Association between genetic polymorphism of the angiotensin-converting enzyme and diabetic nephropathy: a meta-analysis comprising 26,580 subjects

2011 ◽  
Vol 13 (1) ◽  
pp. 161-174 ◽  
Author(s):  
Furu Wang ◽  
Qiaoqiao Fang ◽  
Ningle Yu ◽  
Deyu Zhao ◽  
Yimei Zhang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Angiotensin Converting Enzyme ◽  
Meta Analysis ◽  
Recessive Model ◽  
Genetic Models ◽  
Dominant Model ◽  
Converting Enzyme ◽  
Asian Group ◽  
Stratified Analysis ◽  
Allele Contrast

Introduction: The effect of angiotensin-converting enzyme ( ACE) insertion/deletion (I/D) polymorphism on risk of diabetic nephropathy (DN) is still conflicting. The present meta-analysis was performed to evaluate the overall risk of this polymorphism associated with DN in different groups. Materials and methods: A predefined search was performed on 14,108 DN cases and 12,472 controls from 63 published studies by searching electronic databases and reference lists of relevant articles. Results: In this meta-analysis, we found a significant association between the ACE I/D polymorphism and the risk of DN for all genetic models (ID versus II: odds ratio [OR] = 1.12, 95% confidence interval [CI] 1.02–1.24; DD versus II: OR = 1.27, 95% CI 1.13–1.44; allele contrast: OR = 1.15, 95% CI 1.08–1.23; dominant model: OR = 1.18, 95% CI 1.07–1.31; and recessive model: OR = 1.18, 95% CI 1.08–1.30, respectively). In stratified analysis by ethnicity and DM type, we further found that the Asian group with type 2 diabetes mellitus (T2DM) showed a significant association for all genetic models (ID versus II: OR = 1.25, 95% CI 1.07–1.47; DD versus II: OR = 1.57, 95% CI 1.24–1.98; allele contrast: OR = 1.30, 95% CI 1.15–1.46; dominant model: OR = 1.37, 95% CI 1.10–1.69; and recessive model: OR = 1.34, 95% CI 1.15–1.56, respectively). Conclusions: Our study suggested that the ACE I/D polymorphism may contribute to DN development, especially in the Asian group with T2DM.

scholarly journals Comprehensive assessment for miRNA polymorphisms in hepatocellular cancer risk: a systematic review and meta-analysis

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Ben-Gang Wang ◽  
Li-Yue Jiang ◽  
Qian Xu
Keyword(s):  
Systematic Review ◽  
Hepatitis B Virus ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Hepatocellular Cancer ◽  
Recessive Model ◽  
Dominant Model ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
B Virus

MiRNA polymorphisms had potential to be biomarkers for hepatocellular cancer (HCC) susceptibility. Recently, miRNA single nucleotide polymorphisms (SNPs) were reported to be associated with HCC risk, but the results were inconsistent. We performed a systematic review with a meta-analysis for the association of miRNA SNPs with HCC risk. Thirty-seven studies were included with a total of 11821 HCC patients and 15359 controls in this meta-analysis. We found hsa-mir-146a rs2910164 was associated with a decreased HCC risk in the recessive model (P=0.017, OR = 0.90, 95% confidence interval (CI) = 0.83–0.98). While hsa-mir-34b/c rs4938723 was related with an increased HCC risk in the co-dominant model (P=0.016, odds ratio (OR) = 1.19, 95%CI = 1.03–1.37). When analyzing the Hepatitis B virus (HBV)-related HCC risk, hsa-mir-196a-2 rs11614913 was associated with a decreased HBV-related HCC risk in the co-dominant and allelic models. And hsa-mir-149 rs2292832 was found to be associated with a decreased HBV-related HCC risk in the dominant and recessive models. In conclusion, hsa-mir-146a rs2910164 and hsa-mir-34b/c rs4938723 could be biomarkers for the HCC risk while hsa-mir-196a-2 rs11614913 and hsa-mir-149 rs2292832 had potential to be biomarkers for HBV-related HCC risk.

scholarly journals Association between APE1 ASP148GLU and colorectal cancer risk: A meta-analysis

2020 ◽  
Vol 43 (4) ◽  
pp. E24-34
Author(s):  
Caizhao Lin ◽  
Yuewei Jin ◽  
Shaobing Cheng ◽  
Weibing Wang
Keyword(s):  
Colorectal Cancer ◽  
Meta Analysis ◽  
Additive Model ◽  
Recessive Model ◽  
Cochrane Library ◽  
Dominant Model ◽  
Common Cancer ◽  
Pcr Rflp ◽  
Subgroup Analyses ◽  
Ape1 Asp148glu

Background: Colorectal cancer (CRC) is recognized as one of the most common cancer globally. The association between CRC and apurinic endonuclease 1 (APE1) Asp148Glu polymorphism remains unclear; thus, this meta-analysis aimed to explore whether APE1 Asp148Glu polymorphism is related to CRC risk. Methods: Embase, PubMed, Cochrane library, CNKI and Wanfang databases were subject to a systematic search until April, 17, 2020 to evaluate the effect of APE1 Asp148Glu polymorphism on CRC risk. The associated strength was used to evaluate with odds ratios (ORs) with 95% confidence intervals (CIs) between Asp148Glu polymorphism and CRC risk. Subgroup analyses were also performed. Results: In total, 11 articles including 8,136 subjects (3,836 cases and 4,300 controls) were included. Five genetic models were analyzed, including the additive model (G vs. T), the heterozygote comparison (TG vs. TT), the homozygote comparison (GG vs. TT), the dominant model (TG+GG vs. TT), and the recessive model (GG vs. TG+TT). In these models, T refers to thymine and G refers to guanine. The APE1 Asp148Glu polymorphism in heterozygote comparison [OR (95%CI) = 1.36 (1.05, 1.75), P=0.019] and dominant model [OR (95%CI) =1.31 (1.07, 1.61), P=0.010] significantly increased CRC risk. No significant association was seen for the additive model [OR (95%CI) = 1.14 (1.00, 1.31), P=0.057], recessive model [OR (95%CI) = 0.97 (0.71, 1.31), P=0.826] or in homozygote comparison [OR (95%CI) = 1.15 (0.88, 1.52), P=0.309]. Moreover, CRC risk indicated a remarkable association with APE1 Asp148Glu polymorphism in the PCR-RFLP additive model, homozygote comparison and recessive model (PG) may be a potential risk factor for CRC.

FokI polymorphism of the vitamin D receptor (VDR) gene and susceptibility to tuberculosis: evidence through a meta-analysis

2021 ◽  
Author(s):  
Upendra Yadav ◽  
Pradeep Kumar ◽  
Vandana Rai
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Asian Population ◽  
Recessive Model ◽  
Dominant Model ◽  
Vdr Gene ◽  
Exact Relation ◽  
Significance Level

Abstract Background: Tuberculosis is one of the top ten causes of deaths worldwide. The deficiency of vitamin D was reported to be associated with the increased susceptibility of tuberculosis. Various previous reports were published to check the association of FokI polymorphism of the vitamin D receptor gene with tuberculosis risk. But their results were inconsistent so, we performed a meta-analysis to know the exact relation of the two.Methods: Different databases were screened up to November, 2020 with the keywords “Vitamin D receptor”, “VDR”, and “FokI”, along with “Tuberculosis” and “TB” to find the suitable articles. All the statistical analyses were performed by the Open Meta-Analyst program and all p-values were two-tailed with a significance level of 0.05.Results: No statistically significant association was observed in the allele contrast model (ORfvs.F= 1.11, 95%CI= 0.99-1.24, p= 0.05, I2= 73.46%), in the dominant model (ORff+Ffvs.FF= 1.11, 95%CI= 0.96-1.28, p= 0.14, I2= 71.39%), and in the co-dominant model (ORFfvs.FF= 1.05, 95%CI= 0.92-1.21, p= 0.41, I2= 65.97%). However, a significant association was found in the homozygote model (ORffvs.FF= 1.32, 95%CI= 1.03-1.69, p= 0.02, I2= 67.02%) and in the recessive model (ORFF+Ff vs.ff= 1.26, 95%CI= 1.03-1.54, p= 0.02, I2= 58.01%). Further analysis was performed on the bases of the ethnicity. In Asian population a significant association was found in the homozygote model (ORffvs.FF= 1.57, 95%CI= 1.12-2.21, p= 0.008, I2= 70.37%) and in the recessive model (ORFF+Ff vs.ff= 1.43, 95%CI= 1.08-1.89, p= 0.01, I2= 63.13%).Conclusion: In conclusion, a significant association of FokI with tuberculosis susceptibility was found in the overall analysis and in the Asian population.

Sign in / Sign up

Export Citation Format

Share Document