scholarly journals Multiple metastases after surgery for a rare vulvar malignant melanoma combined with immunotherapy: a case report

2020 ◽  
Vol 48 (11) ◽  
pp. 030006052096539
Author(s):  
Wenjing Li ◽  
Jingzhi Song ◽  
Yiming Sun ◽  
Zhumei Cui
Keyword(s):  
Radiation Therapy ◽  
Case Report ◽  
Malignant Melanoma ◽  
Rare Case ◽  
Clinical Characteristics ◽  
Treatment Plan ◽  
Primary Treatment ◽  
Primary Treatment Modality ◽  
Multiple Metastases ◽  
Standardized Diagnostic

We herein describe the preoperative and postoperative clinical data of a patient with a rare case of vulvar malignant melanoma and discuss her clinical characteristics and prognosis. After surgical resection and immunotherapy, the patient’s illness continued to worsen. She then received local vulvar radiotherapy. However, further treatment was discontinued because of intolerable complications of radiotherapy, and the patient died about 18 months postoperatively. Management of vulvar malignant melanoma is challenging. No unified, effective, and standardized diagnostic and treatment plan has been established for this disease. Surgery remains the primary treatment modality for locally resectable vulvar malignant melanoma. Radiation therapy and chemotherapy do not benefit survival. Encouragingly, however, immunotherapy and targeted therapy have shown clinical efficacy in metastatic vulvar malignant melanoma.

scholarly journals Low-Grade Endometrial Stromal Sarcoma in a 22-Year-Old Maiden Female: A Rare Case Report from Syria

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Lana Nseir ◽  
Georget Mansour ◽  
Junior Makhoul ◽  
Luna Skaf ◽  
Mohammad Ziad Dahhan ◽  
...  
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Treatment Plan ◽  
Endometrial Stromal Sarcoma ◽  
Abnormal Uterine Bleeding ◽  
Low Grade ◽  
Stromal Sarcoma ◽  
Rapid Enlargement ◽  
Rare Case Report ◽  
Immunohistochemical Studies

Endometrial stromal sarcoma (ESS) is a rare and challenging type of endometrial tumor, constituting only about 0.2% of all uterine malignancies and occurring in women 42–58 years of age. ESS is usually misdiagnosed as leiomyoma. They both have nonspecific symptoms, which makes the diagnosis of ESS difficult to achieve. As the ESS is infrequently encountered, optimal management is quite debatable. Here, we report a rare case of a 22-year-old Syrian female who presented with abnormal uterine bleeding; the preoperative diagnosis suggested leiomyoma while histopathological and immunohistochemical studies confirmed the diagnosis of LG-ESS stage IIA. Therefore, the treatment plan was shifted from a conservative myomectomy to a total hysterectomy with both adnexa. The aim of this case report is to draw attention to this uncommon tumor at young age of patients as well as to have awareness of the necessity to suspect this diagnosis especially with the presentation of rapid enlargement of uterine leiomyoma.

scholarly journals Intramedullary spinal cord metastases of malignant melanoma: A rare case report on paraplegia in palliative care

2019 ◽  
Vol 25 (3) ◽  
pp. 468
Author(s):  
Arunangshu Ghoshal ◽  
Rutula Sonawane ◽  
Anuja Damani ◽  
MaryAnn Muckaden ◽  
JayitaK Deodhar
Keyword(s):  
Spinal Cord ◽  
Palliative Care ◽  
Case Report ◽  
Malignant Melanoma ◽  
Rare Case ◽  
Intramedullary Spinal Cord ◽  
Rare Case Report

scholarly journals Primary lung cancer with metastasis to the ipsilateral breast-a case report

2017 ◽  
Vol 6 (1) ◽  
pp. 334 ◽  
Author(s):  
Abdalla Saad Abdalla Al-Zawi ◽  
Andrzej Ratajczak ◽  
Philip Idaewor ◽  
Mohamed Elamass ◽  
Anita Lazarevska ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Malignant Melanoma ◽  
Rare Case ◽  
Primary Lung Cancer ◽  
Left Breast ◽  
Contralateral Breast ◽  
Ipsilateral Breast ◽  
Breast Lump ◽  
Breast Metastases

The metastasis of extra-mammary malignancy to breast is extremely rare; literature reports the incidence between 0.4-1.3%. Primary sites include the contralateral breast, leukaemia, lymphoma, malignant melanoma, sarcoma, lung, prostate, ovary, colon and the stomach. Here we present a rare case in which lung cancer was found to metastasise to the breast. Initially the patient presented with chest symptoms and a left breast lump was detected clinically. The radiological and histological investigations confirmed the diagnosis of primary lung cancer with breast metastases. Prognosis of such cases is generally poor.

scholarly journals Unilateral Maxillary Sinusitis Caused By Dental Bur, A case Report

2019 ◽  
Vol 41 (2) ◽  
pp. 8-10
Author(s):  
Sahar Abdualkader Ismaeel ◽  
Saif Saadedeen Abdulrazaq
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Maxillary Antrum ◽  
Maxillary Sinusitis ◽  
Treatment Plan ◽  
The Other ◽  
Trauma Patients ◽  
Review Of Literature ◽  
Serious Infection ◽  
Careful Clinical Examination

the entrance of a foreign body (FB) into the maxillary antrum is common in trauma patients where bullets or any other materials trapped in the maxillary sinus; however, iatrogenic cause by a dentist that results in FB entrapment in the maxillary antrum is rare. All these FBs can cause sinusitis. If not treated properly they will cause serious infection, which may spread to the other paranasal sinuses. A careful clinical examination and treatment plan will prevent further complications. In this review, we present a rare case of dental bur (DB) found in the left maxillary antrum. A review of literature revealed only a few cases published which describe a dental bur dislodged in the maxillary antrum.

scholarly journals Errors in Implant Positioning Due to Lack of Planning: A Clinical Case Report of New Prosthetic Materials and Solutions

Materials ◽  
2020 ◽  
Vol 13 (8) ◽  
pp. 1883 ◽  
Author(s):  
Marco Tallarico ◽  
Roberto Scrascia ◽  
Marco Annucci ◽  
Silvio Mario Meloni ◽  
Aurea Immacolata Lumbau ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Plan ◽  
Survival Rates ◽  
Primary Treatment ◽  
High Survival ◽  
Adequate Treatment ◽  
Implant Position ◽  
Implant Positioning ◽  
Implant Placement

The achievement of the optimal implant position is a critical consideration in implant surgery, as it can facilitate the ideal prosthesis design and allow adequate oral hygiene maintenance. The switch from bone-driven to prosthetic-driven implant placement, through a comprehensive diagnosis and adequate treatment plan, is a prerequisite for long-term successful implant-based therapy. The aim of the present case report is to describe a step-by-step prosthetic retreatment of a patient with primary treatment failure due to incorrect dental implant placement. Although dental implants achieve high survival rates, the success of implant prosthetic therapy significantly relies on an appropriate implant position. Malpositioned implants can cause damage to vital structures, like nerves or vessels. Moreover, improper implant positioning can result in esthetic, biological, and technical complications and can, in extreme situations, render the desired prosthetic rehabilitation impossible to achieve.

Utility of prostate multiparametric MRI (mpMRI) for recurrent prostate cancer after radiation therapy and cryotherapy.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 71-71
Author(s):  
Evan Kovac ◽  
Andrei Purysko ◽  
J. Stephen Jones ◽  
Cristina Magi-Galluzzi ◽  
Eric A. Klein ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Prostate Biopsy ◽  
Prostate Volume ◽  
Univariate Analysis ◽  
Primary Treatment ◽  
Recurrent Prostate Cancer ◽  
Positive Biopsy ◽  
Primary Treatment Modality ◽  
Locally Recurrent

71 Background: We evaluated the accuracy of mpMRI for identifying locally recurrent prostate cancer after primary radiotherapy and cryotherapy. Methods: Between 2009-2015, 61 patients with evidence of rising PSA after external-beam radiotherapy (EBRT) (N = 33), brachytherapy (N = 6), and cryotherapy (N = 22) were evaluated for locally recurrent prostate cancer with mpMRI and prostate biopsy. Of these patients, 6 (10%) received androgen deprivation therapy (ADT) in combination with EBRT for a median of 24 months. Three of the cryotherapy patients received prior EBRT. Patients were identified from a prospective mpMRI database. All patients with a lesion of interest (LOI) underwent a ≥ 12-core, post-mpMRI cognitive fusion prostate biopsy. We excluded 16 patients with mpMRI who did not undergo prostate biopsy (5 positive, 11 negative). Results: Median age was 70 (IQR: 64-77). The median time from primary treatment to mpMRI was 5 years (IQR: 3-9) and the median PSA at mpMRI was 3.6 ng/mL (IQR: 2.1-5.5). Median prostate volume was 18.8 cc (IQR: 11.0-28.0 cc). mpMRI revealed lesions of interest (LOI) in 39 (64%) and 41 (67%) had biopsy-proven local recurrence. Of the 22 patients with negative mpMRI, 8 (36%) had a positive biopsy, with a median prostate volume of 19 cc, median maximum cancer length of 5 mm, median PSA of 2.5 and biopsy Gleason scores 3+3 (N = 1), 4+3 (N=2), 5+4 (N = 1), 5+5 (N = 1) and ungraded due to treatment effect (N = 3). Of the 39 patients with LOI on mpMRI, 33 (85%) had a positive biopsy. Table 1 summarizes the mpMRI and biopsy results. The sensitivity, specificity, PPV and NPV of mpMRI to predict cancer diagnosis at biopsy was 80.5%, 70.0%, 84.6% and 63.6%, respectively. On univariate analysis, gland size (p=0.367), PSA (p=0.872), biopsy Gleason score (p=0.892) and primary treatment modality (p=0.177) did not significantly predict discrepancy between mpMRI and biopsy findings. Conclusions: mpMRI reliably identifies prostate cancer recurrence after primary radiation therapy and cryoablation. [Table: see text]

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