scholarly journals Undernutrition when young and the risk of poor renal function in adulthood in women with diabetes in Shanghai, China

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110166
Author(s):  
Qiaojing Qin ◽  
Kaili Chang ◽  
Qing Wu ◽  
Weifeng Fan ◽  
Yong Gu ◽  
...  
Keyword(s):  
Renal Function ◽  
Young Adulthood ◽  
Estimated Glomerular Filtration Rate ◽  
Binary Logistic Regression ◽  
Control Group ◽  
Adult Women ◽  
Regression Analyses ◽  
Poor Renal Function ◽  
Exposure Age ◽  
Adolescence And Young Adulthood

Objective To evaluate the effect of undernutrition when young on the risk of poor renal function in adulthood in women with diabetes mellitus. Methods We studied diabetic women born between 1921 and 1958 who were exposed to the 1959-to-1962 Chinese famine when they were 0 to 37 years old. Exposure age was classified as young adulthood (18 to 37 years), adolescence (10 to 17 years), or childhood (0 to 9 years). The Adolescence group, which was provided with the largest amount of food during the famine, was used as the control group, and variance and binary logistic regression analyses were performed. Results The prevalences of low estimated glomerular filtration rate (eGFR) in the Childhood, Adolescence, and Young adulthood groups were 5.26%, 22.39%, and 79.24%, respectively. The risk of low eGFR for the Young adulthood group (odds ratio [OR] 1.65, 95% confidence interval [CI] 1.10, 2.48), but not for the Childhood group (OR 1.10, 95% CI 0.68, 1.78), was higher than that for the Adolescence group after adjustment for potential confounders. Conclusions Undernutrition during young adulthood significantly increases the risk of renal dysfunction in adult women with diabetes. Therefore, the nutrition of less affluent young women should be improved.

scholarly journals The Application of 99mTc-DTPA Renal Dynamic Imaging to Measuring Renal Function of Children with Acute Lymphoblastic Leukemia after Induction Therapy

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Lidan Wang ◽  
Kailan Chen ◽  
Qiong Xu
Keyword(s):  
Renal Function ◽  
Acute Lymphoblastic Leukemia ◽  
Induction Therapy ◽  
Estimated Glomerular Filtration Rate ◽  
Lymphoblastic Leukemia ◽  
Kidney Injury ◽  
Binary Logistic Regression ◽  
Dynamic Imaging ◽  
High Dose ◽  
Renal Functions

Purpose. The study was aimed at assessing renal functions of children with acute lymphoblastic leukemia (ALL) after induction therapy by 99mTc-DTPA renal dynamic imaging Gates method (GFRGates) and investigating whether renal function after induction therapy will affect the occurrence of high-dose methotrexate- (HDMTX-) induced acute kidney injury (AKI). Methods. Children with newly diagnosed ALL were enrolled. Renal functions before the administration of HDMTX were assessed by estimated glomerular filtration rate (eGFR) and GFRGates, respectively, before the first cycle of HDMTX after induction therapy. The areas under the ROC curve were used to assess covariates’ ability to predict HDMTX-induced AKI. Results. 102 children with ALL were included in the study. A stepwise backward binary logistic regression showed that only standardized GFRGates was an independent risk factor for HDMTX-induced AKI ( p = 0.018 , odds ratio 0.985, 95% CI 0.972-0.997). The area under the ROC of standardized GFRGates was 0.679 ( p = 0.012 , 95% CI 0.554-0.804). Conclusion. Standardized GFRGates showed that the normal renal function of children is not enough to be used as a cutoff point to predict HDMTX-induced AKI in ALL children receiving HDMTX. More attention and supportive care should be given to the children with standardized GFRGates lower than the cutoff value to avoid the HDMTX-induced AKI.

scholarly journals Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age

2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
Maria Elfving ◽  
Johan Svensson ◽  
Sami Oikarinen ◽  
Björn Jonsson ◽  
Per Olofsson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adulthood ◽  
Immunoglobulin M ◽  
Control Group ◽  
Enterovirus Infection ◽  
Group 14 ◽  
Serum Samples ◽  
Specific Immunoglobulin ◽  
Adolescence And Young Adulthood

Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22–17.6), as compared to boys of IgM-negative mothers (P<.025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.

scholarly journals A low serum iron level is a potential predictor of poor renal function in patients following laparoscopic sleeve gastrectomy: a retrospective study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tien-Chou Soong ◽  
I.-Jung Feng ◽  
Jen-Yin Chen ◽  
I.-Wen Chen ◽  
Hong-Yi Tong ◽  
...  
Keyword(s):  
Renal Function ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Serum Iron ◽  
Large Scale ◽  
Iron Level ◽  
Regression Analyses ◽  
Serum Iron Level ◽  
Poor Renal Function ◽  
Significant Difference

AbstractThis study aimed to assess the association of serum iron level (Iron) with the estimated glomerular filtration rate (eGFR) after bariatric surgery (BS). We reviewed 210 patients with mean age of 39.1 ± 10.6 years (body mass index, 41.4 ± 5.5 kg/m2) undergoing BS. The primary outcome was the relationship between Iron and eGFR at 12-month after surgery. Multiple linear regression analyses were performed using postoperative eGFR as dependent variables and using Iron and other variables (i.e., age) as independent variables. At 12-month follow-up, 94 patients were analyzed. BMI significantly decreased, whereas serum iron level significantly increased. Although the percentage of patients with eGFR of < 90 mL/min/1.73 m2 increased during the study period, no significant difference was found in postoperative 12-month eGFR. No correlations were noted between Iron and eGFR at baseline and postoperative 1 and 6 months, whereas a significant relationship was observed between Iron and postoperative 12-month eGFR. Multiple linear regression analyses revealed that Iron and presence of diabetes were the independent predictors of postoperative 12-month eGFR. This pilot study showed a positive association of postoperative serum iron level with renal function in this patient population. Further large-scale trials are needed to confirm the findings.

scholarly journals Borderline Personality Disorder in Young People: Associations with Support and Negative Interactions in Relationships with Mothers and a Best Friend

2021 ◽  
Author(s):  
Christel Hessels ◽  
Tessa van den Berg ◽  
Sofie A. Lucassen ◽  
Odilia M. Laceulle ◽  
Marcel A.G. van Aken
Keyword(s):  
Personality Disorder ◽  
Young People ◽  
Young Adulthood ◽  
Borderline Personality ◽  
Regression Analyses ◽  
Maternal Report ◽  
Best Friend ◽  
Adolescence And Young Adulthood ◽  
Negative Interactions

Abstract Background:Impaired interpersonal functioning has been highlighted as a core feature of borderline personality disorder (BPD). Adolescence and young adulthood form important developmental stages within both the emergence of BPD and the development of interpersonal functioning, which takes place mostly in relationships with parents and friends. This study aimed to: (i) investigate relations between BPD symptoms and both supportive and negative interactions with mothers and best friends; (ii) investigate whether the relations were moderated by age; (iii) test the robustness of our findings by comparing the results based on self-reports with results from a subsample in which supportive and negative interactions with mothers were rated by the mother.Methods312 young people referred to mental healthcare completed self-report measures on BPD and supportive and negative interactions. Multiple regression analyses were conducted to examine the relations between BPD features and perceived supportive and negative interactions with mothers and best friend, and to investigate whether these relations were moderated by age. Robustness of our findings was studied in a subsample (n = 104) by using a multi-informant design in maternal report on supportive and negative interactions with mothers. ResultsMultiple regression analyses demonstrated that negative interactions with mothers as well as with a best friend were related to more BPD symptoms in young people. Supportive interactions were not related to BPD symptoms. Both BPD and quality of relations were not related to age. In a subsample in which supportive and negative interactions with mothers were rated by the mother, the maternal report showed slightly different results. In this model, both supportive and negative interactions with a best friend were positively related, whereas interactions with mothers were not related to BPD symptoms in young people.ConclusionsResults highlight the importance of relationships with mothers and a best friend during adolescence and young adulthood. Given that BPD often emerges during this developmental phase, future research is needed to clarify how quality of relationships could alter pathways toward BPD in young people.

scholarly journals Borderline personality disorder in young people: associations with support and negative interactions in relationships with mothers and a best friend

2022 ◽  
Vol 9 (1) ◽  
Author(s):  
Christel J. Hessels ◽  
Tessa van den Berg ◽  
Sofie A. Lucassen ◽  
Odilia M. Laceulle ◽  
Marcel A. G. van Aken
Keyword(s):  
Personality Disorder ◽  
Young People ◽  
Young Adulthood ◽  
Borderline Personality ◽  
Regression Analyses ◽  
Maternal Report ◽  
Best Friend ◽  
Adolescence And Young Adulthood ◽  
Negative Interactions

Abstract Background Impaired interpersonal functioning has been highlighted as a core feature of borderline personality disorder (BPD). Adolescence and young adulthood form important developmental stages within both the emergence of BPD and the development of interpersonal functioning, which takes place mostly in relationships with parents and friends. This study aimed to: (i) investigate relations between BPD symptoms and both supportive and negative interactions with mothers and best friends; (ii) investigate whether the relations were moderated by age; (iii) test the robustness of our findings by comparing the results based on self-reports with results from a subsample in which supportive and negative interactions with mothers were rated by the mother. Methods 312 young people referred to mental healthcare completed self-report measures on BPD and supportive and negative interactions. Multiple regression analyses were conducted to examine the relations between BPD features and perceived supportive and negative interactions with mothers and a best friend, and to investigate whether these relations were moderated by age. Robustness of our findings was studied in a subsample (n = 104), by using a multi-informant design in maternal report on supportive and negative interactions with mothers. Results Multiple regression analyses demonstrated that negative interactions with mothers as well as with a best friend were related to more BPD symptoms in young people. Supportive interactions were not related to BPD symptoms. Both BPD and quality of relations were not related to age. In a subsample in which supportive and negative interactions with mothers were rated by the mother, the maternal report showed slightly different results. In this model, both supportive and negative interactions with a best friend were positively related, whereas interactions with mothers were not related to BPD symptoms in young people. Conclusions Results highlight the importance of relationships with mothers and a best friend during adolescence and young adulthood. Given that BPD often emerges during this developmental phase, future research is needed to clarify how quality of relationships could alter pathways toward BPD in young people. Trial registration Not applicable.

scholarly journals Psychosocial functioning among regular cannabis users with and without cannabis use disorder

2017 ◽  
Vol 48 (11) ◽  
pp. 1853-1861 ◽  
Author(s):  
Katherine T. Foster ◽  
Brooke J. Arterberry ◽  
William G. Iacono ◽  
Matt McGue ◽  
Brian M. Hicks
Keyword(s):  
Young Adulthood ◽  
Psychosocial Functioning ◽  
Study Groups ◽  
The United States ◽  
Cannabis Use ◽  
Control Group ◽  
Cannabis Use Disorder ◽  
High Agreement ◽  
Psychosocial Impairment ◽  
Adolescence And Young Adulthood

AbstractBackgroundIn the United States, cannabis accessibility has continued to rise as the perception of its harmfulness has decreased. Only about 30% of regular cannabis users develop cannabis use disorder (CUD), but it is unclear if individuals who use cannabis regularly without ever developing CUD experience notable psychosocial impairment across the lifespan. Therefore, psychosocial functioning was compared across regular cannabis users with or without CUD and a non-user control group during adolescence (age 17; early risk) and young adulthood (ages 18–25; peak CUD prevalence).MethodWeekly cannabis users with CUD (n = 311), weekly users without CUD (n = 111), and non-users (n = 996) were identified in the Minnesota Twin Family Study. Groups were compared on alcohol and illicit drug use, psychiatric problems, personality, and social functioning at age 17 and from ages 18 to 25. Self-reported cannabis use and problem use were independently verified using co-twin informant report.ResultsIn both adolescence and young adulthood, non-CUD users reported significantly higher levels of substance use problems and externalizing behaviors than non-users, but lower levels than CUD users. High agreement between self- and co-twin informant reports confirmed the validity of self-reported cannabis use problems.ConclusionsEven in the absence of CUD, regular cannabis use was associated with psychosocial impairment in adolescence and young adulthood. However, regular users with CUD endorsed especially high psychiatric comorbidity and psychosocial impairment. The need for early prevention and intervention – regardless of CUD status – was highlighted by the presence of these patterns in adolescence.

scholarly journals Cessation of Bezafibrate in patients with chronic kidney disease improves renal function

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Boris Zingerman ◽  
Danny Ziv ◽  
Netta Feder Krengel ◽  
Asher Korzets ◽  
Ilan Matok
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Estimated Glomerular Filtration Rate ◽  
Renal Excretion ◽  
Intervention Group ◽  
Control Group ◽  
Comorbid Conditions ◽  
Laboratory Variables

AbstractBezafibrate (BzF) is eliminated by renal excretion and dosage must be reduced in patients with chronic kidney disease (CKD). There is a concern that BzF causes a further deterioration in renal function in patients with CKD. This study assessed whether BzF discontinuation or dose reduction in CKD patients improves renal function. 117 CKD patients treated with BzF between 2009 and 2014 were studied for demographics, comorbid conditions and laboratory variables. Data compared 2 groups: an intervention group of 64 patients where recommendations regarding BzF administration was implemented and a control group of 37 patients. Follow-up was maintained for 12 months. In the intervention group, estimated glomerular filtration rate (eGFR) increased from 38 to 42 mL/min/1.73 m2 (p = 0.01); blood urea levels decreased from 81 to 77 mg/dL (p = 0.04). Serum creatinine decreased by more than 0.2 mg/dL in 45% of the intervention group, as compared to 19% of the control group (p < 0.01). Improvement in eGFR was seen exclusively in patients who stopped BzF completely (eGFR increased from 38 to 44 mL/min/1.73 m2). In the intervention group, TG level increased from 183 to 220 mg/dL (p < 0.001). BzF cessation in approximately 50% of patients with CKD was associated with an increase in eGFR.

scholarly journals Conversion from Standard-Release Tacrolimus to MeltDose® Tacrolimus (LCPT) Improves Renal Function after Liver Transplantation

2020 ◽  
Vol 9 (6) ◽  
pp. 1654 ◽  
Author(s):  
Johannes von Einsiedel ◽  
Gerold Thölking ◽  
Christian Wilms ◽  
Elena Vorona ◽  
Arne Bokemeyer ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Renal Impairment ◽  
Side Effect ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Intervention Group ◽  
Control Group ◽  
Drug Bioavailability

Renal impairment is a typical side effect of tacrolimus (Tac) treatment in liver transplant (LT) recipients. One strategy to avoid renal dysfunction is to increase the concentration/dose (C/D) ratio by improving drug bioavailability. LT recipients converted from standard-release Tac to MeltDose® Tac (LCPT), a novel technological formulation, were able to reduce the required Tac dose due to higher bioavailability. Hence, we hypothesize that such a conversion increases the C/D ratio, resulting in a preservation of renal function. In the intervention group, patients were switched from standard-release Tac to LCPT. Clinical data were collected for 12 months after conversion. Patients maintained on standard-release Tac were enrolled as a control group. Twelve months after conversion to LCPT, median C/D ratio had increased significantly by 50% (p < 0.001), with the first significant increase seen 3 months after conversion (p = 0.008). In contrast, C/D ratio in the control group was unchanged after 12 months (1.75 vs. 1.76; p = 0.847). Estimated glomerular filtration rate (eGFR) had already significantly deteriorated in the control group at 9 months (65.6 vs. 70.6 mL/min/1.73 m2 at study onset; p = 0.006). Notably, patients converted to LCPT already had significant recovery of mean eGFR 6 months after conversion (67.5 vs. 65.3 mL/min/1.73 m2 at study onset; p = 0.029). In summary, conversion of LT recipients to LCPT increased C/D ratio associated with renal function improvement.

scholarly journals Sex Differences in Cancer-Specific Survival Are Pronounced during Adolescence and Young Adulthood: A SEER Population-Based Study

Epidemiologia ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 391-401
Author(s):  
Iyad Sultan ◽  
Justin Z. Amarin ◽  
Razan Mansour ◽  
Hala Sultan ◽  
Maysa Al-Hussaini
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Older Adult ◽  
Young Adulthood ◽  
Malignant Tumors ◽  
Adult Women ◽  
Cancer Specific Survival ◽  
Survival Probabilities ◽  
Patients With Cancer ◽  
Adolescence And Young Adulthood

Sex differences in cancer survival may be related to hormonal changes during puberty and menopause; therefore, we investigated sex differences in the cancer-specific survival rates of children, adolescents and young adults (AYAs), and older adults with sex-nonspecific cancers. We interrogated the November 2019 submission of the SEER 18 database and included microscopically confirmed cases of first primary malignant tumors. We stratified the dataset into children (<15 years), AYAs (modified; 15–49 years), and older adults (≥50 years). For each age group, we used the Kaplan–Meier method to estimate the sex-stratified 5-year all-site cancer-specific survival probabilities. Of 3,386,276 eligible patients, 45,124 (1.3%) were children, 548,158 (16.2%) were AYAs, and 2,792,994 (82.5%) were older adults. The 5-year all-site cancer-specific survival probabilities were 84.0% (95% CI, 83.5%–84.5%) for boys, 84.8% (95% CI, 84.3%–85.3%) for girls, 70.4% (95% CI, 70.2%–70.6%) for male AYAs, 80.8% (95% CI, 80.6%–81.0%) for female AYAs, 52.0% (95% CI, 51.9%–52.1%) for older adult men, and 52.2% (95% CI, 52.1%–52.3%) for older adult women. The all-site survival rate for female patients with cancer is markedly higher than for male patients with cancer during adolescence and young adulthood, although this difference diminishes in older adulthood.

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