The Clinicopathologic Characteristics of Colorectal Cancer in Patients under 50 years of Age: Experience of an Oncology Center

Background/aim Colorectal cancer is seen mostly among patients older than 50 years of age. An aggressive behavior is a frequently cited as characteristic of colorectal cancer in young patients. The purpose of the present study was to reveal the clinicopathologic characteristics of colorectal cancer among patients under 50 years of age. Methods Two hundred and seventy-one patients with colorectal cancer admitted to our oncology center were evaluated, and clinicopathologic findings of the young and old patients were compared. Patient gender, site distribution, tumor stage classification, lymph node involvement, metastatic site, histologic classification, histologic differentiation, family history of malignant tumors, presenting symptoms and survival rates were compared. Results One hundred patients were 50 years of age or under. Clinical, histopathologic characteristics and overall survival of the two groups did not differ. A higher rate of familial cancer syndromes was detected among young patients. Conclusions The presentation and outcome of the disease in young patients do not differ from those of older patients. A significant family history of colorectal cancer in the young patients showed the need for screening whereas the outcome of metastatic disease was poor. In order to anticipate long survival, early detection and aggressive treatment is necessary.

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Clinical Characteristic of Young Indonesian Colorectal Cancer Patients: A Preliminary Study

Medicinus ◽

10.19166/med.v5i3.1171 ◽

2018 ◽

Vol 5 (3) ◽

Author(s):

Nata Pratama Lugito

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Young Patient ◽

General Hospital ◽

Clinical Characteristics ◽

Young Patients ◽

Old Patients ◽

Family History Of Cancer ◽

History Of ◽

History Of Cancer

Introduction: Colorectal cancer (CRC) is generally a disease of persons aged above 40 year-old. Controversies still exist regarding clinical characteristics of CRC in young persons. The aim of this study is to know the clinical characteristics of young CRC patients in Siloam General Hospital, Karawaci, Banten.Material And Methods: A total of 14 patients with diagnosis of CRC from December 2013 to January 2014 in Siloam General Hospital, Karawaci, Banten were studied cross – sectionally. The symptoms and signs, family history of cancer, diabetes, location of mass were collected and evaluated.Results: There were 5 (35.7%) cases of CRC patients aged below 40 year-old (young patients) and 9 (64.3%) above 40 years-old (old patients). The most common symptom was constipation followed by bloody diarrhea i.e. 57.1% and 42.9% consecutively. Constipation occurred in 2 and 6 young and old patients consecutively and in 3 and 3 young and old patients consecutively. In young patients, 2 (14.2%) had a history of cancer in the family compared to none in the old patients. According to the location of tumor in the colon 4 (28.5%) were in ascending colon with 2 and 2 in young and old patients consecutively, 3 (21.7%) were in descending colon with 2 and 1 in young and old patients consecutively, 8 (57.1%) were in rectum with 2 and 6 in young and old patients consecutively. One young patient had diabetes, and one other young patient had positive Clostridium difficile antigen and toxin.Conclusion: Approximately 35.7% cases CRC patient in our hospital was of young patients. Two patients were having family history of cancer. The location of mass was not specific for young CRC patients.Key words: colorectal cancer, young patients

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Tu1202 Failure to Record a Family History of Familial Cancer in Patients’ Notes is Associated With Early Stage Colorectal Cancer

Gastroenterology ◽

10.1016/s0016-5085(12)62995-3 ◽

2012 ◽

Vol 142 (5) ◽

pp. S-773

Author(s):

Koen Kessels ◽

Nicolette L. de Groot ◽

Herma Fidder ◽

Robin Timmer ◽

Mark Stolk ◽

...

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Early Stage ◽

Familial Cancer ◽

History Of

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Audit of subjects with family history of colorectal cancer attending a familial cancer service

Journal of Medical Screening ◽

10.1258/jms.2008.008082 ◽

2008 ◽

Vol 15 (4) ◽

pp. 211-212

Author(s):

Nicholas Ledlie ◽

Wendy Chorley ◽

Nicholas Hurst

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Familial Cancer ◽

Cancer Service ◽

History Of

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Extent of resection for curable colorectal cancer in young patients: A 27-year experience at a tertiary care centre

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.e15059 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. e15059-e15059

Author(s):

E. Al-sukhni ◽

P. F. Ridgway ◽

B. O’Connor ◽

R. S. McLeod ◽

C. J. Swallow

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Subtotal Colectomy ◽

Tertiary Care ◽

Young Patients ◽

Extent Of Resection ◽

Complete Resection ◽

Primary Site ◽

Segmental Resection ◽

History Of

e15059 Background: Patients diagnosed with colorectal cancer (CRC) under the age of 50 have an increased lifetime risk of developing metachronous primary tumours. Some familial GI cancer experts have recommended that younger patients with curable CRC undergo definitive subtotal colectomy at initial presentation. We sought to determine the compliance with these recommendations at our institution, the factors predictive of subtotal/total colectomy, and the influence of resection extent on survival. Methods: A case- control study utilised a prospective CRC database at Mount Sinai Hospital, Toronto. All patients under 50 who underwent initial resection of CRC with curative intent from 1979–2007 were included. Patients 50 or over were identified as controls. Type of resection was classified as complete (total/subtotal colectomy, proctocolectomy) or segmental. Results: From the database of over 1400 CRC cases, 201 patients were under age 50. 1182 controls were identified. The young patients had significantly higher rates of identifiable risk factors for CRC (IBD, FAP/HNPCC, family history of cancer) and were significantly more likely to undergo complete resection (23.38% vs 6.01%, OR 4.78). Interestingly, rectum was the primary site in 54.73% of young patients. Factors contributing to complete resection were site of disease (colon), IBD, and family history of CRC (Table). Four patients (2.6%) who underwent segmental resection developed metachronous disease at a median of 66.38 months post resection. No significant change in practice was noted over time. Conclusions: The majority of young patients with curable CRC underwent segmental resection only. Factors predictive of a complete resection included IBD, family history of CRC, and colonic primary site. Overall survival was not influenced by extent of resection. The authors support this pragmatic approach while more sophisticated estimates of tumor biology are being developed to guide the decision for more extensive prophylactic resection. [Table: see text] No significant financial relationships to disclose.

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Awareness and Uptake of Family Screening in Patients Diagnosed with Colorectal Cancer at a Young Age

Gastroenterology Research and Practice ◽

10.1155/2015/194931 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 6

Author(s):

Niamh M. Hogan ◽

Marion Hanley ◽

Aisling M. Hogan ◽

Margaret Sheehan ◽

Oliver J. McAnena ◽

...

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Young Patients ◽

High Risk Population ◽

Degree Relative ◽

Family Screening ◽

Screening Uptake ◽

Node Positive Disease ◽

History Of ◽

The Mean

Background. One-fifth of people who develop colorectal cancer (CRC) have a first-degree relative (FDR) also affected. There is a large disparity in guidelines for screening of relatives of patients with CRC. Herein we address awareness and uptake of family screening amongst patients diagnosed with CRC under age 60 and compare guidelines for screening.Study Design. Patients under age 60 who received surgical management for CRC between June 2009 and May 2012 were identified using pathology records and theatre logbooks. A telephone questionnaire was carried out to investigate family history and screening uptake among FDRs.Results. Of 317 patients surgically managed for CRC over the study period, 65 were under age 60 at diagnosis (8 deceased). The mean age was 51 (30–59). 66% had node positive disease. 25% had a family history of colorectal cancer in a FDR. While American and Canadian guidelines identified 100% of these patients as requiring screening, British guidelines advocated screening for only 40%. Of 324 FDRs, only 40.9% had been screened as a result of patient’s diagnosis.Conclusions. Uptake of screening in FDRs of young patients with CRC is low. Increased education and uniformity of guidelines may improve screening uptake in this high-risk population.

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Clinical, Pathological and Molecular Characteristics of Chilean Patients with Early-, Intermediate- and Late-Onset Colorectal Cancer

Cells ◽

10.3390/cells10030631 ◽

2021 ◽

Vol 10 (3) ◽

pp. 631

Author(s):

Karin Alvarez ◽

Alessandra Cassana ◽

Marjorie De La Fuente ◽

Tamara Canales ◽

Mario Abedrapo ◽

...

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Age Of Onset ◽

Late Onset ◽

Molecular Characteristics ◽

Family History Of Cancer ◽

Molecular Features ◽

Age Of Diagnosis ◽

History Of ◽

History Of Cancer

Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean patients according to the age of diagnosis: early- (≤50 years; EOCRC), intermediate- (51–69 years; IOCRC), and late-onset (≥70 years; LOCRC). The study included 426 CRC patients from Clinica Las Condes, between 2007 and 2019. A chi-square test was applied to explore associations between age of onset and clinicopathological characteristics. Body Mass Index (BMI) differences according to age of diagnosis was evaluated through t-test. Overall (OS) and cancer-specific survival (CSS) were estimated by the Kaplan–Meier method. We found significant differences between the age of onset, and gender, BMI, family history of cancer, TNM Classification of Malignant Tumors stage, OS, and CSS. EOCRC category was characterized by a family history of cancer, left-sided tumors with a more advanced stage of the disease but better survival at 10 years, and lower microsatellite instability (MSI), with predominant germline mutations. IOCRC has shown clinical similarities with the EOCRC and molecular similarities to the LOCRC, which agrees with other reports.

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