scholarly journals Association of Dairy Protein Intake During Pregnancy with Birth Weight

2018 ◽  
Vol 39 (2_suppl) ◽  
pp. S54-S59 ◽  
Author(s):  
David C. Clark
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Fetal Programming ◽  
Protein Intake ◽  
Maternal Diet ◽  
Later Life ◽  
Gestational Weight ◽  
Weight Protein ◽  
Dairy Protein ◽  
Reduced Risk

Background: One in 4 children globally is stunted. Stunting is associated with reduced cognitive development, reduced productivity, and chronic disease in later life. Objective: To explore the association between maternal diet during pregnancy and low birth weight, which increases the risk of stunting. Methods: Current literature pertaining to maternal diet and low birth weight was reviewed. Results: Low birth weight and small for gestational age are risk factors for stunting. Dietary pattern studies show an association between moderate dairy protein intake and increased birth weight and reduced risk of low birth weight. Protein-to-carbohydrate ratios are important factors in relation to gestational weight gain and fetal programming. There is evidence suggesting that whey protein could play a role in fetal lean body mass and reduced risk of low birth weight. Conclusions: Maternal diet is associated with birth weight.

Podocyte endowment and the impact of adult body size on kidney health

2021 ◽  
Author(s):  
Luise Anne Cullen-McEwen ◽  
James van der Wolde ◽  
Kotaro Haruhara ◽  
Leon Tribolet ◽  
John Dowling ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Maternal Nutrition ◽  
Maternal Diet ◽  
Later Life ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Podocyte Loss ◽  
The Impact ◽  
Fat Feeding

Low birth weight is a risk factor for chronic kidney disease (CKD), while adult podocyte depletion is a key event in the pathogenesis of glomerulosclerosis. However, whether low birth weight due to poor maternal nutrition is associated with low podocyte endowment and glomerulosclerosis in later life is not known. Female Sprague-Dawley rats were fed a normal (NPD, 20%) or low (LPD, 8%) protein diet from 3 weeks before mating until postnatal day 21 (PN21), when kidneys from some male offspring were taken for quantitation of podocyte number and density in whole glomeruli using immunolabeling, tissue clearing and confocal microscopy. Remaining offspring were fed a normal or high fat diet until 6 months to induce catch-up growth and excessive weight gain, respectively. At PN21, podocyte number per glomerulus was 15% lower in low birth weight (LPD) than normal birthweight (NPD) offspring, with this deficit greater in outer glomeruli. Surprisingly, podocyte number in LPD offspring increased in outer glomeruli between PN21 and 6 months, although an overall 9% podocyte deficit persisted. Postnatal fat feeding to LPD offspring did not alter podometric indices or result in glomerular pathology at 6 months, whereas fat feeding in NPD offspring was associated with far greater body and fat mass as well as podocyte loss, reduced podocyte density, albuminuria and glomerulosclerosis. This is the first report that maternal diet can influence podocyte endowment. Our findings provide new insights into the impact of low birth weight, podocyte endowment and postnatal weight on podometrics and renal health in adulthood.

scholarly journals Probiotics to prevent necrotising enterocolitis and nosocomial infection in very low birth weight preterm infants

2017 ◽  
Vol 117 (7) ◽  
pp. 994-1000 ◽  
Author(s):  
J. Uberos ◽  
E. Aguilera-Rodríguez ◽  
A. Jerez-Calero ◽  
M. Molina-Oya ◽  
A. Molina-Carballo ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Necrotising Enterocolitis ◽  
Stage Ii ◽  
Preterm Neonates ◽  
Probiotic Supplementation ◽  
Late Onset Sepsis ◽  
Reduced Risk

AbstractThe aim of the study was to determine whether routine probiotic supplementation (RPS) with Lactobacillus rhamnosus GG (LGG) or Lactobacillus acidophilus +Lactobacillus bifidum is associated with reduced risk of necrotising enterocolitis (NEC)≥Stage II in preterm neonates born at ≤32 weeks’ gestation. We conducted a retrospective cohort study on the effect of probiotic supplementation in very low birth weight infants in our neonatal unit by comparing two periods: before and after supplementation. The incidence of NEC≥Stage II, late-onset sepsis and all-cause mortality was compared for an equal period ‘before’ (Period I) and ‘after’ (Period II) RPS with LGG or L. acidophillus+L. bifidum. Multivariate logistic regression analysis was conducted to adjust for relevant confounders. The study population was composed of 261 neonates (Period I v. II: 134 v. 127) with comparable gestation duration and birth weights. In <32 weeks, we observed a significant reduction in NEC≥Stage II (11·3 v. 4·8 %), late-onset sepsis (16 v. 10·5 %) and mortality (19·4 v. 2·3 %). The benefits in neonates aged ≤27 weeks did not reach statistical significance. RPS with LGG or L. acidophillus+L. bifidum is associated with a reduced risk of NEC≥Stage II, late-onset sepsis and mortality in preterm neonates born at ≤32 weeks’ gestation.

scholarly journals Impact of Low Birth Weight on Early Vascular Aging and Cardiometabolic Phenotypes in Later Life Among Cameroonian Adults

2020 ◽  
Vol 5 (4) ◽  
pp. 30-41
Author(s):  
Daniel Lemogoum ◽  
Philippe van de Borne ◽  
Michel P. Hermans ◽  
Danielle Christiane Kedy Mangamba ◽  
Aurel Sikamo ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Glucose Homeostasis ◽  
Later Life ◽  
Multivariate Regression Analysis ◽  
Vascular Aging ◽  
Oscillometric Device ◽  
Altered Glucose ◽  
Male Sex ◽  
The Difference

Background Evidence suggests that low birth weight (LBW) is associated with increased cardiovascular and metabolic risk in adulthood, including increased arterial stiffness, a marker of early vascular aging (EVA) assessable by pulse wave velocity (PWV), obesity and glucose homeostasis abnormalities. The present study aimed to explore the late impact of LBW on PWV and cardiometabolic phenotypes among young adult Cameroonians. Methods The study evaluated 120 subjects (mean age: 26 ± 5 years; 54% male sex) at the Cameroon Heart Institute, Douala, Cameroon, between January and June 2018. Birth weight (BW) and gestational age, sociodemographic, anthropometrics and fasting capillary blood glucose were recorded in all participants. Blood pressure (BP) and PWV were measured using an automatic oscillometric device (Mobil-O-Graph®). Multiple-adjusted linear regression was used to determine predictive factors for PWV. For assessment of potential impact of BW on EVA, PWV was adjusted for age, sex, body mass index (BMI) and mean arterial pressure (MAP). Results 28 participants (23.3%) of the study sample had LBW (<3000g). There was no gender difference between LBW or normal birth weight patients (NBW; controls). Age- and MAP-adjusted PWV (aPWV) were higher in women with LBW compared to NBW (5.6 m/s and 5.3 m/s respectively, P = 0.038). In men, aPWV was similar in LBW and NBW. In this study population, aPWV was higher (on average +15 cm/s) in LBW than in controls, although the difference was not statistically significant (P=0.083). Multivariate regression analysis showed age, male sex, BMI and MAP were independent determinants of PWV, but not LBW. Compared to NBW controls, the prevalence of overweight/obesity, impaired glucose homeostasis and diabetes was higher in LBW: 42.9% vs 37%; 10.7% vs 3.3%, and 3.6 % vs 1.1%, respectively. Moreover, compared with controls, LBW individuals who were overweight/obese in adulthood had a much higher mean fasting capillary glucose (1.54 ±0.17 g/l vs 0.87 ±0.11 g/l in NBW, p=0.003). Conclusion This study suggests that although LBW is associated with increased aortic stiffness in young adulthood, mainly in women, the association was predominantly driven by aging, MAP, BMI and male sex. In adulthood, LBW subjects exhibited higher obesity indices and altered glucose homeostasis.

Is Low Birth Weight an Antecedent of CKD in Later Life? A Systematic Review of Observational Studies

2009 ◽  
Vol 54 (2) ◽  
pp. 248-261 ◽  
Author(s):  
Sarah L. White ◽  
Vlado Perkovic ◽  
Alan Cass ◽  
Choon Lan Chang ◽  
Neil R. Poulter ◽  
...  
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Observational Studies ◽  
Later Life

Eleven Plasma Proteins as Indicators of Protein Nutritional Status in Very Low Birth Weight Infants

PEDIATRICS ◽  
1990 ◽  
Vol 86 (6) ◽  
pp. 916-921 ◽  
Author(s):  
Staffan K. T. Polberger ◽  
Göran A. Fex ◽  
Irene E. Axelsson ◽  
Niels C. R. Räihä
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Nutritional Status ◽  
Protein Intake ◽  
Plasma Proteins ◽  
Very Low Birth Weight ◽  
Binding Protein ◽  
Plasma Concentrations ◽  
Retinol Binding Protein ◽  
Low Birth Weight Infants

Concentrations of 11 plasma proteins were measured in 28 healthy, growing, very low birth weight, appropriate-for-gestational-age infants fed varying levels of human milk protein intake (range 1.7 to 3.9 g/kg per day). Significant positive correlations were found between ween mean protein intake and concentrations of 7 of the plasma proteins studied (transthyretin, retinol-binding protein, and transferrin: P &lt; .001; vitamin D-binding protein and apolipoprotein B: P &lt; .01; albumin and apolipoprotein A I: P &lt; .05). A weak negative correlation with mean protein intake was seen for the plasma level of orosomucoid, whereas no significant correlations were found for the plasma concentrations of fibronectin and α1-antichymotrypsin. Protein intake, not energy intake, constituted the main contribution to the changes in the concentrations of transthyretin, retinol-binding protein, and transferrin. The levels of plasma transthyretin and transferrin were also strongly correlated with weight and length growth of the infants during the study as well as with other indicators of protein nutritional status such as preprandial concentrations of plasma amino acids and serum and urine urea. These data indicate that of the 11 plasma proteins studied, transthyretin, transferrin, and retinol-binding protein are the most suitable to evaluate protein nutritional status in very low birth weight infants.

scholarly journals Energy and Protein Intake During the Transition from Parenteral to Enteral Nutrition in Infants of Very Low Birth Weight

2018 ◽  
Vol 202 ◽  
pp. 38-43.e1 ◽  
Author(s):  
Gustave H. Falciglia ◽  
Karna Murthy ◽  
Jane L. Holl ◽  
Hannah L. Palac ◽  
Yuliya Oumarbaeva ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Enteral Nutrition ◽  
Protein Intake ◽  
Very Low Birth Weight

scholarly journals Stratified analysis of the correlation between gestational weight gain and birth weight for gestational age: a retrospective single-center cohort study in Japan

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Noriko SATO ◽  
Naoyuki MIYASAKA
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Weight Gain ◽  
Gestational Age ◽  
Cohort Analysis ◽  
University Hospital ◽  
Gestational Weight ◽  
Tokyo Medical ◽  
Newborn Size

Abstract Background Japan has an exceptionally high proportion of low-weight births and underweight women. It has been suggested that an appropriate increase in gestational weight gain (GWG) for underweight women will help to prevent low birth weight. The current strategy aims to raise the desired value of GWG equally for all pregnant women within the underweight category. However, it remains elusive whether or not the relationship between GWG and birth weight for gestational age (BW/GA) are uniformly equivalent for all the women. Methods We performed a retrospective cohort analysis of women who delivered their newborns at Tokyo Medical and Dental University Hospital from 2013 to 2017. First, in order to examine the direct effect of an increase or decrease in GWG on BW/GA, we analyzed the correlation between inter-pregnancy differences in GWG and BW/GA using a sub-cohort of women who experienced two deliveries during the study period (n = 75). Second, we dichotomized the main cohort (n = 1114) according to BW/GA to verify our hypothesis that the correlation between GWG and BW/GA differs depending on the size of the newborn. Results The inter-pregnancy difference in BW/GA was not correlated with that of GWG. However, the correlation between BW/GA of siblings was high (r = 0.63, p = 1.9 × 10− 9). The correlation between GWG and BW/GA in women who delivered larger-sized newborns was higher (r = 0.17, p = 4.1 × 10− 5) than that in women who delivered smaller-sized newborns (r = 0.099, p = 1.9 × 10− 2). This disparity did not change after adjustment for pre-pregnancy BMI. The mean birth weight in the dichotomized groups corresponded to percentile 52.0 and 13.4 of the international newborn size assessed by INTERGROWTH-21st standards. Conclusions In our study, GWG was positively correlated with BW/GA for heavier neonates whose birth weights were similar to the average neonatal weight according to world standards. However, caution might be required for low-birth-weight neonates because increased GWG does not always result in increased birth weight.

Protein intake for low-birth-weight infants

1969 ◽  
Vol 74 (6) ◽  
pp. 1016-1020 ◽  
Author(s):  
Warren M. Cox ◽  
L.J. Filer
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Protein Intake ◽  
Low Birth Weight Infants

Metabolic Acidosis and Renal Solute Load in Relation to the Protein Intake of Low Birth Weight Malaysian Neonates

1979 ◽  
Vol 15 (2) ◽  
pp. 101-106
Author(s):  
R. O. JOHNSON ◽  
B. H. JOHNSON ◽  
A. RAMAN ◽  
E. L. LEE ◽  
K. L. LAM
Keyword(s):  
Metabolic Acidosis ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Protein Intake

scholarly journals Birth weight and psychological distress at age 45–51 years

2005 ◽  
Vol 187 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Nicola J. Wiles ◽  
Tim J. Peters ◽  
David A. Leon ◽  
Glyn Lewis
Keyword(s):  
Psychological Distress ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Direct Effect ◽  
Gestational Age ◽  
Affective Disorders ◽  
Later Life ◽  
Adult Mental Health ◽  
Early Life Factors ◽  
Childhood Factors

BackgroundIt is unclear whether the effect of low birth weight on common affective disorders in later life is director mediated through childhood factors.AimsTo determine whether birth weight has a direct effect on psychological distress in adulthood not mediated by childhood IQ or behavioural problems.MethodParticipants (n=5572) of the Aberdeen Children of the 1950s study had data on birth weight for gestational age and adult psychological distress. Logistic regression was used to examine the association between these factors, with adjustment for confounders and potential childhood mediators.ResultsChildren born full term but weighing less than 5.5 lb had increased odds of psychological distress in later life after adjustment for potential confounders (OR=1.49, 95% CI 1.01–2.20). Further adjustment for childhood IQ and behaviour did not attenuate the association. A 1 s.d. decrease in birth weight for gestational age was associated with a 4% increased odds of psychological distress in adulthood (OR=1.04, 95% CI 0.97–1.12).ConclusionsLow birth weight for gestational age, particularly atterm, was associated with adult psychological distress. This was not mediated by childhood factors, suggesting a direct effect of early life factors on adult mental health. A neurodevelopmental pathway may therefore be implicated.

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