scholarly journals Impact of Low Birth Weight on Early Vascular Aging and Cardiometabolic Phenotypes in Later Life Among Cameroonian Adults

2020 ◽  
Vol 5 (4) ◽  
pp. 30-41
Author(s):  
Daniel Lemogoum ◽  
Philippe van de Borne ◽  
Michel P. Hermans ◽  
Danielle Christiane Kedy Mangamba ◽  
Aurel Sikamo ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Glucose Homeostasis ◽  
Later Life ◽  
Multivariate Regression Analysis ◽  
Vascular Aging ◽  
Oscillometric Device ◽  
Altered Glucose ◽  
Male Sex ◽  
The Difference

Background Evidence suggests that low birth weight (LBW) is associated with increased cardiovascular and metabolic risk in adulthood, including increased arterial stiffness, a marker of early vascular aging (EVA) assessable by pulse wave velocity (PWV), obesity and glucose homeostasis abnormalities. The present study aimed to explore the late impact of LBW on PWV and cardiometabolic phenotypes among young adult Cameroonians. Methods The study evaluated 120 subjects (mean age: 26 ± 5 years; 54% male sex) at the Cameroon Heart Institute, Douala, Cameroon, between January and June 2018. Birth weight (BW) and gestational age, sociodemographic, anthropometrics and fasting capillary blood glucose were recorded in all participants. Blood pressure (BP) and PWV were measured using an automatic oscillometric device (Mobil-O-Graph®). Multiple-adjusted linear regression was used to determine predictive factors for PWV. For assessment of potential impact of BW on EVA, PWV was adjusted for age, sex, body mass index (BMI) and mean arterial pressure (MAP). Results 28 participants (23.3%) of the study sample had LBW (<3000g). There was no gender difference between LBW or normal birth weight patients (NBW; controls). Age- and MAP-adjusted PWV (aPWV) were higher in women with LBW compared to NBW (5.6 m/s and 5.3 m/s respectively, P = 0.038). In men, aPWV was similar in LBW and NBW. In this study population, aPWV was higher (on average +15 cm/s) in LBW than in controls, although the difference was not statistically significant (P=0.083). Multivariate regression analysis showed age, male sex, BMI and MAP were independent determinants of PWV, but not LBW. Compared to NBW controls, the prevalence of overweight/obesity, impaired glucose homeostasis and diabetes was higher in LBW: 42.9% vs 37%; 10.7% vs 3.3%, and 3.6 % vs 1.1%, respectively. Moreover, compared with controls, LBW individuals who were overweight/obese in adulthood had a much higher mean fasting capillary glucose (1.54 ±0.17 g/l vs 0.87 ±0.11 g/l in NBW, p=0.003). Conclusion This study suggests that although LBW is associated with increased aortic stiffness in young adulthood, mainly in women, the association was predominantly driven by aging, MAP, BMI and male sex. In adulthood, LBW subjects exhibited higher obesity indices and altered glucose homeostasis.

scholarly journals Effect of maternal anaemia on birth weight of term babies

2018 ◽  
Vol 5 (3) ◽  
pp. 1019
Author(s):  
Mohandas Nair ◽  
Gireesh S. ◽  
Rubeena Yakoob ◽  
Cheriyan N. C.
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Head Circumference ◽  
Adult Life ◽  
Anthropometric Measures ◽  
Maternal Anaemia ◽  
Medical College ◽  
Anemia During Pregnancy ◽  
The Difference ◽  
Long Term Impact

Background: Low birth weight is the major determinant of mortality, morbidity and disability in infancy and childhood and has a long-term impact on health outcome in adult life. The objectives of this study were to study the relationship between maternal anemia and birth weight of babies and to study anthropometric measures of babies born to anemic and non-anemic mothers and to correlate the timing of anemia with birth weight of babies.Methods: Term babies born in Institute of Maternal and Child Health, Government Medical College, Kozhikode from November 2014 to October 2016 fulfilling the criteria were divided into 2 groups, cases (term babies with birth weight <2500g) and controls (term babies with weight >2500g) and studied and their maternal hemoglobin values were compared.Results: Maternal anaemia in all three trimesters was found to be more in cases compared to controls. Mean 1st trimester hemoglobin of cases was 10.68 g/dl which was significantly lower when compared to controls. Mean 2nd trimester hemoglobin of cases was 10.36 g/dl compared to 11.47 g/dl in controls. Mean 3rd trimester hemoglobin of cases was 10.42 g/dl which was also significantly lower compared to 11.32 g/dl in controls. SGA babies were also found to be more in cases, 89%, compared to 18% in controls. The difference in head circumference between two groups was not statistically significant. Mean length of babies were higher in controls compared to cases. Mothers with anemia at any time during pregnancy was found to have 4.3 times higher risk of giving birth to low birth weight babies compared to non-anemic mothersConclusion: Anemia during pregnancy is a risk factor for low birth weight and SGA, independent of the trimester. Length of babies born to anaemic mothers is also low. But it does not have a significant effect on head circumference of babies.

Is Low Birth Weight an Antecedent of CKD in Later Life? A Systematic Review of Observational Studies

2009 ◽  
Vol 54 (2) ◽  
pp. 248-261 ◽  
Author(s):  
Sarah L. White ◽  
Vlado Perkovic ◽  
Alan Cass ◽  
Choon Lan Chang ◽  
Neil R. Poulter ◽  
...  
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Observational Studies ◽  
Later Life

scholarly journals A Systematic Review and Meta-analysis on the Prevalence of Low Birth Weight Infants in Iran

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Maryam Sabbaghchi ◽  
Rostam Jalali ◽  
Masoud Mohammadi
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Meta Analysis ◽  
Knowledge Network ◽  
Low Birth Weight Infants ◽  
Policy Makers ◽  
Total Prevalence ◽  
High Prevalence ◽  
The Difference

Background. Low birth weight is a significant index for survival, intrauterine growth, and mortality in infants. Thus, this study is aimed at determining the prevalence of low birth weight in Iranian infants through a systematic review and meta-analysis. Methods. This study was performed by meta-analysis from January 2000 to December 2019. The studies relevant to the topic have been obtained through search in databases of Scopus, ScienceDirect, SID, Magiran, Barakat Knowledge Network System, Medline (PubMed), and Google Scholar. Heterogeneity of the studies has been assessed by the I 2 index, and data analysis was done using Comprehensive Meta-Analysis software. Results. By investigating 14 articles and 93924 infants, the total prevalence of low birth weight in infants in Iran was achieved at 8.5% (95% CI: 7.3-9.9%) according to the meta-analysis; the most prevalence of low birth weight was in infants in Hamedan at 19.1% (95% CI: 21.2-17.2%) in 2007, and the lowest prevalence of low birth weight was in infants in Tonekabon at 4.2% (95% CI: 3.4-5.2%) in 2005, and also, by increasing the sample size, the prevalence of low birth weight increases, by which the difference is statistically significant ( P < 0.05 ). Conclusion. Due to the high prevalence of low birth weight in infants in Iran, health policy-makers must take effective attempts in order to reduce it in infants.

scholarly journals Birth weight and psychological distress at age 45–51 years

2005 ◽  
Vol 187 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Nicola J. Wiles ◽  
Tim J. Peters ◽  
David A. Leon ◽  
Glyn Lewis
Keyword(s):  
Psychological Distress ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Direct Effect ◽  
Gestational Age ◽  
Affective Disorders ◽  
Later Life ◽  
Adult Mental Health ◽  
Early Life Factors ◽  
Childhood Factors

BackgroundIt is unclear whether the effect of low birth weight on common affective disorders in later life is director mediated through childhood factors.AimsTo determine whether birth weight has a direct effect on psychological distress in adulthood not mediated by childhood IQ or behavioural problems.MethodParticipants (n=5572) of the Aberdeen Children of the 1950s study had data on birth weight for gestational age and adult psychological distress. Logistic regression was used to examine the association between these factors, with adjustment for confounders and potential childhood mediators.ResultsChildren born full term but weighing less than 5.5 lb had increased odds of psychological distress in later life after adjustment for potential confounders (OR=1.49, 95% CI 1.01–2.20). Further adjustment for childhood IQ and behaviour did not attenuate the association. A 1 s.d. decrease in birth weight for gestational age was associated with a 4% increased odds of psychological distress in adulthood (OR=1.04, 95% CI 0.97–1.12).ConclusionsLow birth weight for gestational age, particularly atterm, was associated with adult psychological distress. This was not mediated by childhood factors, suggesting a direct effect of early life factors on adult mental health. A neurodevelopmental pathway may therefore be implicated.

scholarly journals Remodeling of the Heart of the Premature Child

2020 ◽  
Vol 75 (6) ◽  
pp. 631-637
Author(s):  
O. P. Kovtun ◽  
P. B. Tsyvian ◽  
T. V. Markova ◽  
T. V. Chumarnaya
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Adult Life ◽  
Later Life ◽  
Epidemiological Studies ◽  
Wall Structure ◽  
Early Postnatal Development ◽  
Cardiovascular Remodeling ◽  
Cardiovascular Morbidity And Mortality

Epidemiological studies consistently have suggested an association between low birth weight and increased rate of cardiovascular morbidity and mortality in adult life. Preterm birth, as one of the leading causes of the low birth weight, is associated with cardiovascular remodeling which consists of changes in heart chambers geometry and contraction-relaxation mode, ventricular hypertrophy, arterial wall structure and density changes. Several types of preterm birth are discussed: prematurity, associated with placental insufficiency and fetal growth restriction, preterm leaking of amniotic fluid, and twin pregnancy. DNA methylation process under the influence of epigenetic factors of the intrauterine and early postnatal development is suggested as a one of the main mechanism of cardiovascular remodeling in preterm infants. The other mechanisms of cardiovascular remodeling are discussed in terms of the modern intrauterine programming concept. The early diagnostics and prevention of cardiovascular diseases in preterm born children are discussed. The treatment during prenatal and early postnatal periods as well as prevention of the remodeling causes could diminish and even reverse the development of the negative cardiovascular events and diseases in later life according to the so called concept of one thousand days opportunities window.

Double Versus Single Phototherapy in Low Birth Weight Newborns

PEDIATRICS ◽  
1992 ◽  
Vol 90 (5) ◽  
pp. 674-677
Author(s):  
Paul C. Holtrop ◽  
Kathleen Ruedisueli ◽  
M. Jeffrey Maisels
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Bilirubin Level ◽  
Serum Bilirubin ◽  
Elevated Serum ◽  
Threshold Level ◽  
Serum Bilirubin Level ◽  
Total Serum ◽  
The Difference ◽  
To Receive

Conventional phototherapy systems that simultaneously irradiate the front and the back of the baby lower the serum bilirubin level more rapidly than one-sided systems, but they are impractical. Fiberoptic phototherapy makes it easy to administer conventional phototherapy from above while the infant lies on a fiberoptic phototherapy blanket. Newborns with birth weights less than 2500 g were randomly assigned to receive either single (n = 37) or double (n = 33) phototherapy. The groups were similar in clinical and laboratory characteristics. After 18 hours of therapy the serum bilirubin concentration declined by 31 ± 11% in the double and 16 ± 15% in the single phototherapy group (2.9 ± 1.1 vs 1.6 ± 1.4 mg/dL), and the difference in the total serum bilirubin levels after 18 hours of therapy was significant (double phototherapy group 7.1 ± 2.7 mg/dL vs single phototherapy group 8.2 ± 2.6 mg/dL). After 18 hours of treatment the serum bilirubin level was less than the phototherapy threshold level in 26 of 37 single phototherapy patients vs 32 of 33 double phototherapy patients. Double phototherapy was well tolerated. It is concluded that this type of double phototherapy is more effective than single phototherapy in low birth weight newborns. Double phototherapy may be useful when it is necessary to reduce an elevated serum bilirubin level as rapidly as possible or when the bilirubin level is rising with single phototherapy.

Birth Weight as an Indicator of Human Welfare

2015 ◽  
pp. 620-631 ◽  
Author(s):  
W. Peter Ward
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Infant Health ◽  
Later Life ◽  
Well Being ◽  
Human Welfare ◽  
Factors Affecting ◽  
Newborn Weight ◽  
Insulin Dependent ◽  
Nutritional Studies

Birth weight is a biometric measure of well-being widely used as an infant health indicator. It also offers insights into maternal and population health more generally. The most common measures of weight at birth are the mean and the proportion of low birth weight (LBW; less than 2,500 g) infants. LBW neonates experience higher risk of infant morbidity and mortality. Globally, LBW rates average 15%. Wealthy Western societies generally experience the highest mean weights whereas the lowest are found in some of the globe’s poorest nations. Factors affecting newborn weight fall into five categories: genetic, environmental, gestational, socioeconomic, and nutritional. Studies of birth weight concerned with change over time reveal important regional and temporal differences, notably during times of social and economic crisis. Numerous studies have identified relationships between low birth weight and a range of health problems in later life, including hypertension, coronary heart disease and non-insulin-dependent diabetes.

scholarly journals Which factors could explain the low birth weight paradox?

2006 ◽  
Vol 40 (4) ◽  
pp. 648-655 ◽  
Author(s):  
Antônio Augusto Moura da Silva ◽  
Heloisa Bettiol ◽  
Marco Antonio Barbieri ◽  
Luiz Gustavo Oliveira Brito ◽  
Márcio Mendes Pereira ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Cesarean Section ◽  
Maternal Smoking ◽  
Maternal Age ◽  
Smoking Habit ◽  
Northeastern Brazil ◽  
Southeastern Brazil ◽  
Study Objective ◽  
The Difference

OBJECTIVE: Low birth weight children are unusual among well-off families. However, in Brazil, low birth weight rate was higher in a more developed city than in a less developed one. The study objective was to find out the reasons to explain this paradox. METHODS: A study was carried out in two municipalities, Ribeirão Preto (Southeastern Brazil) and São Luís (Northeastern Brazil), which low birth weight rates were 10.7% and 7.6% respectively. Data from two birth cohorts were analyzed: 2,839 newborns in Ribeirão Preto in 1994 and 2,439 births in São Luís in 1997-1998. Multiple logistic regression analysis was performed, adjusted for confounders. RESULTS: Low birth weight risk factors in São Luís were primiparity, maternal smoking and maternal age less than 18 years. In Ribeirão Preto, the associated variables were family income between one and three minimum wages, maternal age less than 18 and equal to or more than 35 years, maternal smoking and cesarean section. In a combined model including both cohorts, Ribeirão Preto presented a 45% higher risk of low birth weight than São Luís. When adjusted for maternal smoking habit, the excess risk for low birth weight in Ribeirão Preto compared to São Luís was reduced by 49%, but the confidence interval was marginally significant. Differences in cesarean section rates between both cities contributed to partially explain the paradox. CONCLUSIONS: Maternal smoking was the most important risk factor for explaining the difference in low birth weight between both cities. The other factors contributed little to explain the difference in low birth weight rates.

Pubertal development and sexuality in female adolescents born preterm: a review of the literature

2011 ◽  
Vol 23 (3) ◽  
Author(s):  
Alexandra Paul ◽  
Rebecca Deans ◽  
Russell Viner ◽  
Sarah M. Creighton
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Pubertal Development ◽  
Later Life ◽  
Growth Restriction ◽  
Female Adolescents ◽  
Long Term Outcomes ◽  
The Impact

Abstract Introduction: Premature infants, especially very low birth weight infants, and fetal growth restriction are a challenge for healthcare professionals alike owing to the consequences of these conditions. Objective: To provide information for gynecologists, pediatricians and neonatologists to identify correct outcome expectations to help them plan their preventive and therapeutic actions. Searches were made on the MEDLINE database. Results: According to several follow-up studies, there is an increasing evidence for a link between early life exposures (prenatal and postnatal) and long-term outcomes. An adverse in utero environment will induce fetal reprogramming of neuroendocrine axes with permanent alterations of the physiology and metabolism of various body structures and functioning of neuroendocrine axes in later life, leading to a variety of different conditions, such as persistence of neurodevelopmental disability, changes in growth pattern, in body metabolism, in pubertal development, lower educational achievement and even psychological disturbances with possible alterations of sexual behavior in female adolescents and young adults. In addition, short-term transitory consequences can be also present, such as anomalies in genital appearance. Conclusions: Outcome studies on the impact that prematurity, low birth weight and intrauterine growth restriction have on pubertal development, sexuality and fertility are still scarce. Long-term outcomes of small for gestational age or preterm adolescents are complex and multifactorial, with interactions between genetic and environmental influences involving different pathways of adaptive responses during crucial phases of prenatal growth.

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