Protein intake for low-birth-weight infants

1969 ◽  
Vol 74 (6) ◽  
pp. 1016-1020 ◽  
Author(s):  
Warren M. Cox ◽  
L.J. Filer
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Protein Intake ◽  
Low Birth Weight Infants

Eleven Plasma Proteins as Indicators of Protein Nutritional Status in Very Low Birth Weight Infants

PEDIATRICS ◽  
1990 ◽  
Vol 86 (6) ◽  
pp. 916-921 ◽  
Author(s):  
Staffan K. T. Polberger ◽  
Göran A. Fex ◽  
Irene E. Axelsson ◽  
Niels C. R. Räihä
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Nutritional Status ◽  
Protein Intake ◽  
Plasma Proteins ◽  
Very Low Birth Weight ◽  
Binding Protein ◽  
Plasma Concentrations ◽  
Retinol Binding Protein ◽  
Low Birth Weight Infants

Concentrations of 11 plasma proteins were measured in 28 healthy, growing, very low birth weight, appropriate-for-gestational-age infants fed varying levels of human milk protein intake (range 1.7 to 3.9 g/kg per day). Significant positive correlations were found between ween mean protein intake and concentrations of 7 of the plasma proteins studied (transthyretin, retinol-binding protein, and transferrin: P < .001; vitamin D-binding protein and apolipoprotein B: P < .01; albumin and apolipoprotein A I: P < .05). A weak negative correlation with mean protein intake was seen for the plasma level of orosomucoid, whereas no significant correlations were found for the plasma concentrations of fibronectin and α1-antichymotrypsin. Protein intake, not energy intake, constituted the main contribution to the changes in the concentrations of transthyretin, retinol-binding protein, and transferrin. The levels of plasma transthyretin and transferrin were also strongly correlated with weight and length growth of the infants during the study as well as with other indicators of protein nutritional status such as preprandial concentrations of plasma amino acids and serum and urine urea. These data indicate that of the 11 plasma proteins studied, transthyretin, transferrin, and retinol-binding protein are the most suitable to evaluate protein nutritional status in very low birth weight infants.

scholarly journals Does enteral protein intake affect renal glomerular and tubular functions in very low birth weight infants?

2013 ◽  
Vol 80 (11) ◽  
pp. 355-360 ◽  
Author(s):  
Hayriye Gozde Kanmaz ◽  
Banu Mutlu ◽  
Omer Erdeve ◽  
Fuat Emre Canpolat ◽  
Serife Suna Oguz ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Protein Intake ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Tubular Functions

scholarly journals Plasma alkaline ribonuclease (EC 3.1.4.22) and nitrogen retention in low-birth-weight infants

1978 ◽  
Vol 40 (3) ◽  
pp. 459-464 ◽  
Author(s):  
P. H. Scott ◽  
H. M. Berger ◽  
Caroline Kenward ◽  
P. Scott ◽  
B. A. Wharton
Keyword(s):  
Body Weight ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Protein Intake ◽  
Significant Positive Correlation ◽  
Nitrogen Retention ◽  
Low Birth Weight Infants ◽  
N Retention ◽  
Alkaline Ribonuclease ◽  
Biochemical Measurements

1. Nitrogen retention was determined by classical N balance techniques in fourteen rapidly growing low-birth-weight infants receiving 3 g protein/kg body-weight and during their 3rd week of life. This was compared with plasma free alkaline ribonuclease (EC3.1.4.22; RNase) activity and other biochemical measurements of protein nutrition.2. Plasma RNase showed a significant positive correlation with N retention and a corresponding negative correlation with urine urea-N. These results were unexpected and suggest a different relationship between RNase and N retention in infants compared with that found by other workers in children and adults.3. The most likely explanation of this apparent anomaly is that in all instances high activities of plasma RNase are associated with a need to conserve N. In the infants studied this may indicate some measure of ‘protein economy’ and they could therefore benefit from a higher protein intake.

scholarly journals The role of serum and urinary urea in the evaluation of enteral protein intake in adequate and small-for-gestational-age very low birth weight infants

2005 ◽  
Vol 123 (6) ◽  
pp. 261-265
Author(s):  
Silvana Darcie ◽  
Cléa Rodrigues Leone
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Protein Intake ◽  
Very Low Birth Weight ◽  
Pearson Correlation ◽  
Serum Urea ◽  
Low Birth Weight Infants ◽  
Vlbw Infants

CONTEXT AND OBJECTIVE: Very low birth weight (VLBW) infants have special nutritional needs. There is a current tendency to individualize their protein needs. The objective of this study was to determine the suitability of serum and urinary urea as indicators for protein intake in adequate-for-gestational-age (AGA) and small-for-gestational-age (SGA) VLBW infants. DESIGN AND SETTING: Prospective study in the nursery attached to the Maternity Ward of the "Prof. Pedro de Alcântara" Children's Institute, Hospital das Clínicas, Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, Brazil. METHODS: Seventy-two VLBW infants (mean protein intake = 3.7 mg/kg/day) were enrolled in a prospective cohort study in two groups: AGA (n = 34) and SGA (n = 38). Blood samples, six-hour urine (6hUr) collections and urine sample tests (STUr) were obtained for urea and creatinine assays at three and five weeks of life. Statistical analysis: Student's t test, Pearson correlation and linear regression (p < 0.05). RESULTS: There were no differences between groups for serum urea, 6hUr and STUr, or between two assessments within each group. Serum urea correlated with 6hUr in both AGA and SGA, and to STUr in SGA; 6hUr correlated with STUr in both AGA and SGA. There was no correlation between protein intake and serum or urine urea. CONCLUSIONS: Serum and urinary urea did not reflect protein intake when mean intakes of 3.7 g/kg/day were used. Sample tests of urinary urea can be as reliable as urea from urine collected over longer periods.

scholarly journals Targeted Breast Milk Fortification for Very Low Birth Weight (VLBW) Infants: Nutritional Intake, Growth Outcome and Body Composition

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1156 ◽  
Author(s):  
Sumesh Parat ◽  
Praneeta Raza ◽  
May Kamleh ◽  
Dennis Super ◽  
Sharon Groh-Wargo
Keyword(s):  
Body Composition ◽  
Birth Weight ◽  
Breast Milk ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Protein Intake ◽  
Very Low Birth Weight ◽  
Fat Free Mass ◽  
Standard Group ◽  
Low Birth Weight Infants

Despite improvements in nutritional management, preterm infants continue to face high rates of postnatal growth restriction. Because variability in breast milk composition may result in protein and energy deficits, targeted fortification has been advocated. We conducted an interventional study to compare body composition and growth outcomes of very low birth weight infants fed targeted protein-fortified human milk (HM) with those fed standard fortified HM. If mother’s own milk was not available, donor milk was used. Weekly analysis of HM with mid-infrared spectroscopy was conducted and additional protein was added to the fortified HM to ensure a protein intake of 4 g/kg/day. Weekly anthropometric measurements were done. Prior to discharge or at 37 weeks, corrected age skinfold thickness (SFT) measurements as well as body composition measurement using air displacement plethysmography were done. Among 36 preterm infants enrolled, those in the targeted group (n = 17) received more protein and had a larger flank SFT at study end than those in the standard group (n = 19). A pilot post-hoc analysis of subjects having at least 30 intervention days showed a 3% higher fat-free mass in the targeted group. Use of a targeted fortification strategy resulted in a higher protein intake and fat-free mass among those receiving longer intervention.

Leucine kinetics in fed low-birth-weight infants: importance of splanchnic tissues

1992 ◽  
Vol 263 (2) ◽  
pp. E214-E220 ◽  
Author(s):  
B. Beaufrere ◽  
V. Fournier ◽  
B. Salle ◽  
G. Putet
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Protein Intake ◽  
Whole Body ◽  
Protein Catabolism ◽  
Low Birth Weight Infants ◽  
Precursor Pool ◽  
Leucine Kinetics ◽  
Human Milk Protein

Whole body Leu kinetics were determined in fed low-birth-weight (LBW) infants. To assess the importance of first-pass splanchnic extraction of ingested amino acids, two tracers were simultaneously infused by intravenous (L-[1-13C]Leu) and intragastric (L-[5,5,5-2H3]Leu) routes in 13 LBW infants [1,742 +/- 169 (SE) g] fed with protein-enriched human milk (protein intake 3.23 +/- 0.97 g.kg-1.day-1). Splanchnic extraction estimated from plasma [2H3]Leu appearance was 48.2 +/- 15.6% of Leu intake. Total Leu flux, endogenous Leu flux (index of protein catabolism), and nonoxidative Leu disposal (NOLD, index of protein synthesis) were 3.45 +/- 0.57, 1.90 +/- 0.74, and 2.54 +/- 0.62 mumol.kg-1.min-1, respectively. Higher estimates were obtained when using alpha-ketoisocaproate as a precursor pool. There was a wide individual variation of protein intake due to the use of human milk, and, over this range, Leu intake was correlated negatively with endogenous Leu flux (r = 0.88, P less than 0.01) whereas NOLD remained fairly constant. Thus, in LBW infants, 1) splanchnic extraction is two times as high as in adults and might reflect an elevated splanchnic protein turnover and 2) increasing protein intake probably promotes protein gain mainly by inhibiting protein catabolism.

Effects of early dietary protein intake on low-birth-weight infants: Evaluation at 3 years of age

1971 ◽  
Vol 78 (1) ◽  
pp. 126-129 ◽  
Author(s):  
Herbert I. Goldman ◽  
O. Bernard Liebman ◽  
Roslyn Freudenthal ◽  
Richard Reuben
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake ◽  
Low Birth Weight Infants
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